Application of the speed-duration relationship to normalize the intensity of high-intensity interval training

The tolerable duration of continuous high-intensity exercise is determined by the hyperbolic Speed-tolerable duration (S-tLIM) relationship. However, application of the S-tLIM relationship to normalize the intensity of High-Intensity Interval Training (HIIT) has yet to be considered, with this the aim of present study. Subjects completed a ramp-incremental test, and series of 4 constant-speed tests to determine the S-tLIM relationship. A sub-group of subjects (n = 8) then repeated 4 min bouts of exercise at the speeds predicted to induce intolerance at 4 min (WR4), 6 min (WR6) and 8 min (WR8), interspersed with bouts of 4 min recovery, to the point of exercise intolerance (fixed WR HIIT) on different days, with the aim of establishing the work rate that could be sustained for 960 s (i.e. 4×4 min). A sub-group of subjects (n = 6) also completed 4 bouts of exercise interspersed with 4 min recovery, with each bout continued to the point of exercise intolerance (maximal HIIT) to determine the appropriate protocol for maximizing the amount of high-intensity work that can be completed during 4×4 min HIIT. For fixed WR HIIT tLIM of HIIT sessions was 399±81 s for WR4, 892±181 s for WR6 and 1517±346 s for WR8, with total exercise durations all significantly different from each other (P<0.050). For maximal HIIT, there was no difference in tLIM of each of the 4 bouts (Bout 1: 229±27 s; Bout 2: 262±37 s; Bout 3: 235±49 s; Bout 4: 235±53 s; P>0.050). However, there was significantly less high-intensity work completed during bouts 2 (153.5±40. 9 m), 3 (136.9±38.9 m), and 4 (136.7±39.3 m), compared with bout 1 (264.9±58.7 m; P>0.050). These data establish that WR6 provides the appropriate work rate to normalize the intensity of HIIT between subjects. Maximal HIIT provides a protocol which allows the relative contribution of the work rate profile to physiological adaptations to be considered during alternative intensity-matched HIIT protocols

Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial.

INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age and the leading cause of anovulatory infertility. Women with PCOS have a 15-fold higher prevalence of infertility, compared with women without PCOS, independent of body mass index (BMI). A healthy lifestyle is recommended to improve overall health and fertility in PCOS but there is limited evidence on the isolated effects of exercise, especially for reproductive outcomes. Previous findings indicate superior metabolic health benefits after vigorous compared with moderate-intensity exercise. Our primary aim is to determine the effect of high-intensity interval training (HIT) on menstrual frequency, as a proxy of reproductive function, in women with PCOS. METHODS AND ANALYSIS: The study is a two-centre, randomised, controlled trial with three parallel groups. Women (n=64) from Trondheim (Norway) and Melbourne (Australia) with PCOS according to the Rotterdam criteria will be randomly allocated (1:1:1) to high-volume HIT, low-volume HIT or a control group with no exercise after stratifying for BMI < or ≥ 27 kg/m2 and study centre. Measurements for study end points will be undertaken at baseline, after a 16 week exercise intervention and at 12 months following baseline assessments. The primary outcome measure is menstruation frequency, measured as the number of self-reported menstrual bleedings divided by the number of expected menstrual bleedings during a 12-month period. Secondary outcome measurements include markers of cardiovascular, metabolic and reproductive health, as well as quality of life and adherence to and enjoyment of exercise. ETHICS AND DISSEMINATION: The Regional Committee Medical Research Ethics, Norway, and The Australian Catholic University Human Research Ethics Committee, Australia, have approved the trial protocol. This trial will provide new insight regarding the impact of exercise on fertility in PCOS. We expect this trial to contribute to new therapeutic exercise strategies as part of clinical care for women with PCOS. TRIAL REGISTRATION NUMBER: Clinical trial gov NCT02419482

Quantifying dissolution rates of Antarctic icebergs in open water

At any one time 130 000 icebergs are afloat in the Southern Ocean; 97% of these are too small to be registered in current satellite-based databases, yet the melting of these small icebergs provides a major input to the Southern Ocean. We use a unique set of visual size observations of 53 000 icebergs in the South Atlantic Ocean, the SCAR International Iceberg Database, to derive average iceberg dissolution rates. Fracture into two parts is the dominant dissolution process for tabular icebergs, with an average half-life of 30 days for icebergs <4 km length and 60 days for larger icebergs. Complete shatter producing many icebergs <1 km length is rare. A side attrition rate of 0.23 m d−1 combined with drift speed of 6 km d−1, or any proportional change in both numbers fits the observed changes in iceberg distribution. The largest injection into the Southern Ocean of fresh water and any iceberg-transported material takes place in a ~2.3 × 10⁶ km2 zone extending east-northeast from the Antarctic Peninsula to the Greenwich meridian. The iceberg contribution to salinities and temperatures, with maximum contribution north of the Weddell Sea, differs in some regions, from those indicated by tracking large icebergs

Winter peaks in heart failure: An inevitable or preventable consequence of seasonal vulnerability?

Climate change is a major contributor to annual winter peaks in cardiovascular events across the globe. However, given the paradoxical observation that cardiovascular seasonality is observed in relatively mild as well as cold climates, global warming may not be as positive for the syndrome of heart failure (HF) as some predict. In this article, we present our Model of Seasonal Flexibility to explain the spectrum of individual responses to climatic conditions. We have identified distinctive phenotypes of resilience and vulnerability to explain why winter peaks in HF occur. Moreover, we identify how better identification of climatic vulnerability and the use of multifaceted interventions focusing on modifiable bio-behavioural factors may improve HF outcomes

Sex differences in arterial hypertension.

There is strong evidence that sex chromosomes and sex hormones influence blood pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities differentially in females and males with essential arterial hypertension. The risk for CV disease increases at a lower BP level in females than in males, suggesting that sex-specific thresholds for diagnosis of hypertension may be reasonable. However, due to paucity of data, in particularly from specifically designed clinical trials, it is not yet known whether hypertension should be differently managed in females and males, including treatment goals and choice and dosages of antihypertensive drugs. Accordingly, this consensus document was conceived to provide a comprehensive overview of current knowledge on sex differences in essential hypertension including BP development over the life course, development of hypertension, pathophysiologic mechanisms regulating BP, interaction of BP with CV risk factors and co-morbidities, hypertension-mediated organ damage in the heart and the arteries, impact on incident CV disease, and differences in the effect of antihypertensive treatment. The consensus document also highlights areas where focused research is needed to advance sex-specific prevention and management of hypertension

Cardiovascular Health Does Not Change Following High-Intensity Interval Training in Women with Polycystic Ovary Syndrome

Introduction: polycystic ovary syndrome (PCOS) is associated with cardiovascular disease (CVD) risk factors. First-line therapy for PCOS is lifestyle changes including exercise. We compared CVD risk factors between women with and without PCOS and examined the responses to high-intensity interval training (HIIT). Methods: women with PCOS were randomized to HIIT (n = 41) or a non-exercise control group (n = 23) for 16 weeks. Women without PCOS (n = 15) were age- and BMI-matched to participants with PCOS and completed 16 weeks of HIIT. CVD markers included blood pressure, heart rate, flow-mediated endothelial function (FMD), carotid intima-media thickness (IMT), concentrations of lipids, glucose, insulin, and matrix metalloproteinase-9 (MMP-9). Results: resting heart rate was higher in women with PCOS than without PCOS (p =.011) and was reduced after HIIT in women with PCOS (−2.8 beats/min, 95% CI: −5.4, −0.2, p = 0.037). FMD was not significantly different between women with PCOS (5.5%, SD 4.1) and those without PCOS (8.2%, SD 3.9) at baseline. HIIT reduced time-to-peak dilatation of the brachial artery in women with PCOS compared with women without PCOS (−55 sec, 95% CI: −96, −13 p = 0.012). Conclusions: we found little difference in CVD risk factors between women with and without PCOS at baseline, but some indications of endothelial dysfunction in women with PCOS

ESA's Ice Sheets CCI: validation and inter-comparison of surface elevation changes derived from laser and radar altimetry over Jakobshavn Isbræ, Greenland – Round Robin results

In order to increase the understanding of the changing climate, the European Space Agency has launched the Climate Change Initiative (ESA CCI), a program which joins scientists and space agencies into 13 projects either affecting or affected by the concurrent changes. This work is part of the Ice Sheets CCI and four parameters are to be determined for the Greenland Ice Sheet (GrIS), each resulting in a dataset made available to the public: Surface Elevation Changes (SEC), surface velocities, grounding line locations, and calving front locations. All CCI projects have completed a so-called Round Robin exercise in which the scientific community was asked to provide their best estimate of the sought parameters as well as a feedback sheet describing their work. By inter-comparing and validating the results, obtained from research institutions world-wide, it is possible to develop the most optimal method for determining each parameter. This work describes the SEC Round Robin and the subsequent conclusions leading to the creation of a method for determining GrIS SEC values. The participants used either Envisat radar or ICESat laser altimetry over Jakobshavn Isbræ drainage basin, and the submissions led to inter-comparisons of radar vs. altimetry as well as cross-over vs. repeat-track analyses. Due to the high accuracy of the former and the high spatial resolution of the latter, a method, which combines the two techniques will provide the most accurate SEC estimates. The data supporting the final GrIS analysis stem from the radar altimeters on-board Envisat, ERS-1 and ERS-2. The accuracy of laser data exceeds that of radar altimetry; the Round Robin analysis has, however, proven the latter equally capable of dealing with surface topography thereby making such data applicable in SEC analyses extending all the way from the interior ice sheet to margin regions. This shows good potential for a~future inclusion of ESA CryoSat-2 and Sentinel-3 radar data in the analysis, and thus for obtaining reliable SEC estimates throughout the entire GrIS

Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition

Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention

Epigenetics in the primary and secondary prevention of cardiovascular disease: influence of exercise and nutrition

Increasing evidence links changes in epigenetic systems, such as DNA methylation, histone modification, and non-coding RNA expression, to the occurrence of cardiovascular disease (CVD). These epigenetic modifications can change genetic function under influence of exogenous stimuli and can be transferred to next generations, providing a potential mechanism for inheritance of behavioural intervention effects. The benefits of exercise and nutritional interventions in the primary and secondary prevention of CVD are well established, but the mechanisms are not completely understood. In this review, we describe the acute and chronic epigenetic effects of physical activity and dietary changes. We propose exercise and nutrition as potential triggers of epigenetic signals, promoting the reshaping of transcriptional programmes with effects on CVD phenotypes. Finally, we highlight recent developments in epigenetic therapeutics with implications for primary and secondary CVD prevention

Antarctic ice rises and rumples: Their properties and significance for ice-sheet dynamics and evolution

Locally grounded features in ice shelves, called ice rises and rumples, play a key role buttressing discharge from the Antarctic Ice Sheet and regulating its contribution to sea level. Ice rises typically rise several hundreds of meters above the surrounding ice shelf; shelf flow is diverted around them. On the other hand, shelf ice flows across ice rumples, which typically rise only a few tens of meters above the ice shelf. Ice rises contain rich histories of deglaciation and climate that extend back over timescales ranging from a few millennia to beyond the last glacial maximum. Numerical model results have shown that the buttressing effects of ice rises and rumples are significant, but details of processes and how they evolve remain poorly understood. Fundamental information about the conditions and processes that cause transitions between floating ice shelves, ice rises and ice rumples is needed in order to assess their impact on ice-sheet behavior. Targeted high-resolution observational data are needed to evaluate and improve prognostic numerical models and parameterizations of the effects of small-scale pinning points on grounding-zone dynamics