Оптимізація макрологістичних мереж

We report on a Laser source, emitting in the mid-IR spectral range. A mode-locked Nd: YVO Laser is used as a pump Laser, followed by two nonlinear frequency conversion steps (OPG, DFG). The broad-band output beam is tunable between 9 ?m and 13 ?m, with average powers up to 10 mW. Further extension of the tuning range is possible

Spatial and temporal distribution of sperm whales (Physeter macrocephalus) within the Kaikoura submarine canyon in relation to oceanographic variables

The Kaikoura area is a valuable feeding spot for sperm whales with the presence of a submarine canyon close to shore. Male sperm whales can be found there year around, close to the shore and exhibiting almost constant foraging activities. This thesis investigates the distribution and habitat use, both spatially and temporally, of sperm whales (Physeter macrocephalus) within the Kaikoura submarine canyon, New Zealand. The primary aim was to determine which oceanographic variables and bathymetric features influence the sperm whale distribution patterns off Kaikoura. A theodolite was used to track surfacing and movement of sperm whales from a shore-based station. The accuracy of positions recorded by the theodolite was investigated by comparing theodolite measurements of an object of known position. A calibration technique was then developed as the vertical angle was not accurately determined by the theodolite. In addition to investigating the distribution of sperm whales, the daily abundance of sperm whales within the Kaikoura submarine canyon was estimated. Distance sampling and mark-resight models showed an average of 4 (SEM = 0.13) individuals present in the study area at any given time. The mark-resight technique using photo-identification was not possible from a shore-based station so a spatio-temporal model was built in order to track the identity of individuals. The model was tested using photo-identification of sperm whales collected from a boat-based station. Results showed that 88% of the modeled identifications corresponded to the photo-identification database. Sperm whales off Kaikoura were strongly associated with depth, slope and distance from the nearest coast. They were found in waters between 500 m to 1250 m deep and preferred shallower waters in winter. In spring, sperm whales occurred further from the coast, mainly in the Hikurangi Trough, north-east of the shore-based station. Generalized Additive Models (GAM) were used to identify significant oceanographic variables predicting the presence of sperm whales off Kaikoura. Models indicated that sea surface temperature (SST), chlorophylla (Chla) and distance from sea surface temperature fronts were all important parameters in predicting sperm whales presence. Results showed that sperm whales aggregated in the section of the study area with the lowest SST and near SST fronts. This study provides a detailed insight into the use of the Kaikoura submarine canyon by male sperm whales

Silylation of titanium-containing amorphous silica catalyst: effect on the alkenes epoxidation with H2O2

The surface of a Ti/SiO2 catalyst was silylated using hexamethyldisilazane (HMDS) and tetramethyldisilazane (TMDS) as silylating reagents in vapor phase. The silylation of silanol (Si–OH) on the catalysts was confirmed by diffuse reflectance UV-Vis, DRIFT spectroscopy and solid-state 29Si MAS NMR techniques. Silylation with TMDS improves the catalytic performance of Ti/SiO2 catalyst more significantly than with HMDS and this is mainly due to the steric bulk effects of trimethylsilyl groups from HMDS as compared to dimethylsilyl groups from TMDS. The silylation degree with TMDS was found to be higher than with HMDS and no changes in the silylation degree with TMDS was observed for silylation times longer than 2 h. Despite the silylation route employed, the silylated surface is hydrophobic which enhances not only in hydrogen peroxide efficiency but also and in selectivity to epoxide in the epoxidation of alkenes with H2O2. These effects are more evident when the hydrogen peroxide concentration is higher and particularly for the catalyst modified with TMDS.Peer reviewe

Sublethal necroptosis signaling promotes inflammation and liver cancer

It is currently not well known how necroptosis and necroptosis responses manifest in vivo. Here, we uncovered a molecular switch facilitating reprogramming between two alternative modes of necroptosis signaling in hepatocytes, fundamentally affecting immune responses and hepatocarcinogenesis. Concomitant necrosome and NF-κB activation in hepatocytes, which physiologically express low concentrations of receptor-interacting kinase 3 (RIPK3), did not lead to immediate cell death but forced them into a prolonged "sublethal" state with leaky membranes, functioning as secretory cells that released specific chemokines including CCL20 and MCP-1. This triggered hepatic cell proliferation as well as activation of procarcinogenic monocyte-derived macrophage cell clusters, contributing to hepatocarcinogenesis. In contrast, necrosome activation in hepatocytes with inactive NF-κB-signaling caused an accelerated execution of necroptosis, limiting alarmin release, and thereby preventing inflammation and hepatocarcinogenesis. Consistently, intratumoral NF-κB-necroptosis signatures were associated with poor prognosis in human hepatocarcinogenesis. Therefore, pharmacological reprogramming between these distinct forms of necroptosis may represent a promising strategy against hepatocellular carcinoma

Management and resistance in the digital newsroom

What happens when there is conflict between the profit motivations of a news outlet and the professional values of its journalists? Questions of managerial influence and journalistic autonomy have interested media scholars from the seminal work of Warren Breed onwards. However, there have only been a handful of studies since the introduction of audience metrics which, this research suggests, allow managers to more efficiently monitor and discipline their journalists. This article presents an ethnographic case study of a Reuters newswire bureau during a time of conflict between the management and journalists. The article outlines the strategies that management used to incentivize their journalists to change their reporting priorities. These included the strategic dissemination of audience metrics and praise, and the hiring and promotion of ‘appropriate’ journalists to positions of influence. These interventions changed who was considered a ‘good journalist’ at the newswire, disrupting existing hierarchies, and eventually changing the culture of the newsroom. The article draws on the insights of Pierre Bourdieu’s field theory to help explain how managerial power operates, and the role that individual journalists play producing and reinforcing newsroom norms

CURRENT Diagnosis and Trearment Phychiatry

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Towards a computational psychiatry of juvenile obsessive-compulsive disorder

Obsessive-Compulsive Disorder (OCD) most often emerges during adolescence, but we know little about the aberrant neural and cognitive developmental mechanisms that underlie its emergence during this critical developmental period. To move towards a computational psychiatry of juvenile OCD, we review studies on the computational, neuropsychological and neural alterations in juvenile OCD and link these findings to the adult OCD and cognitive neuroscience literature. We find consistent difficulties in tasks entailing complex decision making and set shifting, but limited evidence in other areas that are altered in adult OCD, such as habit and confidence formation. Based on these findings, we establish a neurocomputational framework that illustrates how cognition can go awry and lead to symptoms of juvenile OCD. We link these possible aberrant neural processes to neuroimaging findings in juvenile OCD and show that juvenile OCD is mainly characterised by disruptions of complex reasoning systems