69 research outputs found
Two chromogranin A-derived peptides, chromofungin and catestatin, induce neutrophil activation via a store-operated channel-dependent mechanism
Field-level inference of cosmic shear with intrinsic alignments and baryons
We construct a field-based Bayesian Hierarchical Model for cosmic shear that
includes, for the first time, the important astrophysical systematics of
intrinsic alignments and baryon feedback, in addition to a gravity model. We
add to the BORG-WL framework the tidal alignment and tidal torquing model
(TATT) for intrinsic alignments and compare them with the non-linear alignment
(NLA) model. With synthetic data, we have shown that adding intrinsic
alignments and sampling the TATT parameters does not reduce the constraining
power of the method and the field-based approach lifts the weak lensing
degeneracy. We add baryon effects at the field level using the enthalpy
gradient descent (EGD) model. This model displaces the dark matter particles
without knowing whether they belong to a halo and allows for self-calibration
of the model parameters, which are inferred from the data. We have also
illustrated the effects of model misspecification for the baryons. The
resulting model now contains the most important physical effects and is
suitable for application to data
Measuring the cosmological bulk flow using the peculiar velocities of supernovae
We study large-scale coherent motion in our universe using the existing Type
IA supernovae data. If the recently observed bulk flow is real, then some
imprint must be left on supernovae motion. We run a series of Monte Carlo
Markov Chain runs in various redshift bins and find a sharp contrast between
the z 0.05 data. The$z < 0.05 data are consistent with the bulk
flow in the direction (l,b)=({290^{+39}_{-31}}^{\circ},
{20^{+32}_{-32}}^{\circ}) with a magnitude of v_bulk = 188^{+119}_{-103} km/s
at 68% confidence. The significance of detection (compared to the null
hypothesis) is 95%. In contrast, z > 0.05 data (which contains 425 of the 557
supernovae in the Union2 data set) show no evidence for bulk flow. While the
direction of the bulk flow agrees very well with previous studies, the
magnitude is significantly smaller. For example, the Kashlinsky, et al.'s
original bulk flow result of v_bulk > 600 km/s is inconsistent with our
analysis at greater than 99.7% confidence level. Furthermore, our best-fit bulk
flow velocity is consistent with the expectation for the \Lambda CDM model,
which lies inside the 68% confidence limit.Comment: Version published in JCA
The Milky Way's plane of satellites is consistent with LambdaCDM
Large scale structure and cosmolog
SIBELIUS-DARK: a galaxy catalogue of the local volume from a constrained realization simulation
Large scale structure and cosmologyGalaxie
Light propagation in statistically homogeneous and isotropic universes with general matter content
We derive the relationship of the redshift and the angular diameter distance
to the average expansion rate for universes which are statistically homogeneous
and isotropic and where the distribution evolves slowly, but which have
otherwise arbitrary geometry and matter content. The relevant average expansion
rate is selected by the observable redshift and the assumed symmetry properties
of the spacetime. We show why light deflection and shear remain small. We write
down the evolution equations for the average expansion rate and discuss the
validity of the dust approximation.Comment: 42 pages, no figures. v2: Corrected one detail about the angular
diameter distance and two typos. No change in result
Searching for a Cosmological Preferred Axis: Union2 Data Analysis and Comparison with Other Probes
We review, compare and extend recent studies searching for evidence for a
preferred cosmological axis. We start from the Union2 SnIa dataset and use the
hemisphere comparison method to search for a preferred axis in the data. We
find that the hemisphere of maximum accelerating expansion rate is in the
direction (\omm=0.19) while the hemisphere of
minimum acceleration is in the opposite direction
(\omm=0.30). The level of anisotropy is described by the normalized
difference of the best fit values of \omm between the two hemispheres in the
context of \lcdm fits. We find a maximum anisotropy level in the Union2 data of
\frac{\Delta \ommax}{\bomm}=0.43\pm 0.06. Such a level does not necessarily
correspond to statistically significant anisotropy because it is reproduced by
about of simulated isotropic data mimicking the best fit Union2 dataset.
However, when combined with the axes directions of other cosmological
observations (bulk velocity flow axis, three axes of CMB low multipole moments
and quasar optical polarization alignment axis), the statistical evidence for a
cosmological anisotropy increases dramatically. We estimate the probability
that the above independent six axes directions would be so close in the sky to
be less than . Thus either the relative coincidence of these six axes is a
very large statistical fluctuation or there is an underlying physical or
systematic reason that leads to their correlation.Comment: 10 pages, 7 figures. Accepted in JCAP (to appear). Extended analysis
with redshift tomography of SnIa, included errorbars and increased number of
axes. The Mathematica 7 files with the data used for the production of the
figures along with a Powerpoint file with additional figures may be
downloaded from http://leandros.physics.uoi.gr/anisotrop
On the anomalous large-scale flows in the Universe
Recent combined analyses of the CMB and galaxy cluster data reveal
unexpectedly large and anisotropic peculiar velocity fields at large scales. We
study cosmic models with included vorticity, acceleration and total angular
momentum of the Universe in order to understand the phenomenon. The Zeldovich
model is used to mimic the low redshift evolution of the angular momentum.
Solving coupled evolution equations of the second kind for density-contrast in
corrected Ellis-Bruni covariant and gauge-invariant formalism one can properly
normalize and evaluate integrated Sachs-Wolfe effect and peculiar velocity
field. The theoretical results compared to the observations favor a much larger
matter content of the Universe than that of the concordance model. Large-scale
flows appear anisotropic with dominant components placed in the plane
perpendicular to the axis of vorticity(rotation). The integrated Sachs-Wolfe
term has negative contribution to the CMB fluctuations for the negative
cosmological constant and it can explain the observed small power of the CMB TT
spectrum at large scales. The rate of the expansion of the Universe can be
substantially affected by the angular momentum if its magnitude is large
enough.Comment: 13 pages, 6 tables, 4 figures, 36 references; version to appear in
Eur. Phys. J.
Self-similarity and universality of void density profiles in simulation and SDSS data
The stacked density profile of cosmic voids in the galaxy distribution provides an important tool for the use of voids for precision cosmology. We study the density profiles of voids identified using the ZOBOV watershed transform algorithm in realistic mock luminous red galaxy (LRG) catalogues from the Jubilee simulation, as well as in void catalogues constructed from the SDSS LRG and Main Galaxy samples. We compare different methods for reconstructing density profiles scaled by the void radius and show that the most commonly used method based on counts in shells and simple averaging is statistically flawed as it underestimates the density in void interiors. We provide two alternative methods that do not suffer from this effect; one based on Voronoi tessellations is also easily able to account from artefacts due to finite survey boundaries and so is more suitable when comparing simulation data to observation. Using this method, we show that the most robust voids in simulation are exactly self-similar, meaning that their average rescaled profile does not depend on the void size. Within the range of our simulation, we also find no redshift dependence of the mean profile. Comparison of the profiles obtained from simulated and real voids shows an excellent match. The mean profiles of real voids also show a universal behaviour over a wide range of galaxy luminosities, number densities and redshifts. This points to a fundamental property of the voids found by the watershed algorithm, which can be exploited in future studies of voids
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping
Non-small cell lung cancers (NSCLC), in particular adenocarcinoma, are often mixed with normal cells. Therefore, low sensitivity of direct sequencing used for K-Ras mutation analysis could be inadequate in some cases. Our study focused on the possibility to increase the detection of K-Ras mutations in cases of low tumour cellularity. Besides direct sequencing, we used wild-type hybridisation probes and peptide-nucleic-acid (PNA)-mediated PCR clamping to detect mutations at codons 12 and 13, in 114 routine consecutive NSCLC frozen surgical tumours untreated by targeted drugs. The sensitivity of the analysis without or with PNA was 10 and 1% of tumour DNA, respectively. Direct sequencing revealed K-Ras mutations in 11 out of 114 tumours (10%). Using PNA-mediated PCR clamping, 10 additional cases of K-Ras mutations were detected (21 out of 114, 18%, P<0.005), among which five in samples with low tumour cellularity. In adenocarcinoma, K-Ras mutation frequency increased from 7 out of 55 (13%) by direct sequencing to 15 out of 55 (27%) by clamped-PCR (P<0.005). K-Ras mutations detected by these sensitive techniques lost its prognostic value. In conclusion, a rapid and sensitive PCR-clamping test avoiding macro or micro dissection could be proposed in routine analysis especially for NSCLC samples with low percentage of tumour cells such as bronchial biopsies or after neoadjuvant chemotherapy
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