90 research outputs found
Polyurethane foams produced from pyrolysis oil - Production and possible application
© 2018 Elsevier Ltd Rigid polyurethane (PU) foams are widely used for instance in building insulation. Two component systems comprising of a polyol as component A and a diisocyanate as component B are generally applied. Both components are produced from fossil oil resources. The liquid products from fast pyrolysis of biomass contain a large variety of organic compounds with -OH functional groups. This gives rise to the idea to substitute the polyol component in PU foams with such biomass based intermediates. Pyrolysis condensates derived from woody and herbaceous biomass were dried and samples of PU foams were produced with varying amounts of condensate substituting the polyol component. Especially the foams made from condensates produced from straw showed good insulation properties, which were expressed as low thermal conductivity. Here, with a substitution degree of 80% a thermal conductivity of 0.0283 Wm−1K−1was achieved, which was 8% lower than for the foams produced from commercial components (0.0308 Wm−1K−1). Preliminary results for the measurement of compressive strength indicated that the required value of 150 kPa can easily be achieved, especially with a high degree of substitution. These results show a high potential for the application of bio-based intermediates in the building sector. Further research on other properties is necessary, but the main requirements for thermal conductivity are already met without optimization of the catalyst/stabilizer system
Impact of sex on the adaptation of adult mice to long consumption of sweet-fat diet
In rodents, the most adequate model of human diet-induced obesity is obesity caused by the consumption of a sweet-fat diet (SFD), which causes more pronounced adiposity in females than in males. The aim of this work was to determine the sex-associated effect of SFD on the expression of genes related to carbohydrate-lipid metabolism in adult mice. For 10 weeks, male and female С57Bl mice were fed a standard laboratory chow (Control group) or a diet, which consisted of laboratory chow supplemented with sweet cookies, sunflower seeds and lard (SFD group). Weights of body, liver and fat depots, blood concentrations of hormones and metabolites, liver fat, and mRNA levels of genes involved in regulation of energy metabolism in the liver, perigonadal and subcutaneous white adipose tissue (pgWAT, scWAT) and brown adipose tissue (BAT) were measured. SFD increased body weight and insulin resistance in mice of both sexes. Female mice that consumed SFD (SFD females) had a greater increase in adiposity than SFD males. SFD females showed a decreased expression of genes related to lipogenesis (Lpl) and glucose metabolism (G6pc, Pklr) in liver, as well as lipogenesis (Lpl, Slca4) and lipolysis (Lipe) in pgWAT, suggesting reduced energy expenditure. In contrast, SFD males showed increased lean mass gain, plasma insulin and FGF21 levels, expressions of Cpt1α gene in pgWAT and scWAT and Pklr gene in liver, suggesting enhanced lipid and glucose oxidation in these organs. Thus, in mice, there are sex-dependent differences in adaptation to SFD at the transcriptional level, which can help to explain higher adiposity in females under SFD consumtion
ЭВОЛЮЦИЯ И СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ ВЗАИМОДЕЙСТВИЯ ОБРАЗОВАНИЯ И СОЦИОКУЛЬТУРНЫХ ЦЕННОСТЕЙ
Introduction. The philosophical-axiological view on the dynamics of the formation and development of Russian education, which represents the main features of the society within which it functions and normally represents the “mold” of the culture that generated it (a fractal attribute): under present conditions it is the basic foundation of the domestic education. The goal is to analyze the historical conditions and problems of the relations between the educational model and the values and norms of culture and society; to show that the philosophical view on the specifics of the reflection in the education of the experience of sociocultural life activity provides an opportunity to theoretically comprehend the modern educational reality that develops in the super dynamic social conditions of the global information culture. Methodology and methods of research. Comparative characteristics of the dynamics of historical development of the Western and Russian models of education make it possible to carry out analysis using the methodological foundations of the philosophy of education (ontology, epistemology and axiology) and to determine the general strategies for building a new civil society with a value-humanistic type of consciousness. It is possible to predict the creation of a unified educational vector on the basis of recognition of the “European dimension in education” and the formation of an integral intellect of the human being (intellect, but not a resource of thinking, spiritual potential or educative values). The real modernization of education, in the modern sense, raises the question of training pedagogical personnel who have gone through the “individualization” or “essential transformation” path. Today, a constantly growing teacher is urgently needed, from which new ways of communication, open ness to innovation and moral ecology are required, which requires detailed analysis from the standpoint of the methodological possibilities of the philosophy of education. Practical significance. The historical and philosophical analysis proposed in the article, as well as the ontological and axiological tools, allow quickly assessing the current state of the problem of interaction between education and socio-cultural values. The material of the article can be useful to specialists dealing with the genesis of ontological and methodological foundations of the modern philosophy of education and the search for the ways of constructing a new educational vector. Scientific novelty and results. The article draws conclusions on the specifics and possibilities for expanding the range of presence of Russian education in the world space, and the autonomy of Russia’s own values in the education system. Praxiological analysis of the sociocultural realities of our time indicates that postmodern culture has ceased to be branch-based, and social development has become integrative. In unity, they are moving towards a new type of rationality and new ways of communication. The question remains open for the developing Russia: what socio-cultural priorities will need to evolve as the modern valueeducational guidelines?Введение. Философско-аксиологический взгляд на динамику становления и развитие российского образования, содержащего основные признаки социума, в котором оно функционирует, в норме представляющего собой «слепок» породившей его культуры (фрактальный признак) – фундамент отечественного образования. Цели – проанализировать исторические условия и проблемы взаимосвязи образовательной модели с ценностями и нормами культуры и общества; показать, что философский взгляд на специфику отражения в образовании опыта социокультурной жизнедеятельности дает возможность теоретически осмыслить современную образовательную реальность, развивающуюся в супердинамичных социальных условиях глобально-информационной культуры. Методология и методы исследования. Сравнительная характеристика динамики исторического развития западной и российской моделей образования позволяет сделать анализ с помощью методологических основ философии образования (онтологии, эпистемологии и аксиологии) и определить общие стратегии построения нового гражданского общества с ценностно-гуманистическим типом сознания. Спрогнозировать создание единого образовательного вектора представляется возможным на основе признания «европейского измерения в образовании» и становления интегрального интеллекта человека (интеллекта, но не ресурса мышления, духовного потенциала или воспитывающих ценностей). Реальная модернизация образования в современном понимании поднимает вопрос о подготовке педагогических кадров, прошедших путь «индивидуализации» или «сущностной трансформации». Сегодня остро необходим постоянно развивающийся педагог, знакомый с новыми способами коммуникации, открытый для инноваций и нравственной экологии, что требует детального анализа с позиции методологических возможностей философии образования. Практическая значимость. Предлагаемый в статье историко-философский анализ, а также онтологический и аксиологический инструментарий позволяют оперативно оценить современное состояние проблемы взаимодействия образования и социокультурных ценностей. Материал статьи может быть полезен специалистам, занимающимся вопросами генезиса онтологических и методологических оснований современной философии образования и поиска пути выстраивания нового образовательного вектора. Научная новизна и результаты. В статье делаются выводы о специфике и возможности расширения ареала присутствия отечественного образования в мировом пространстве, автономии собственных российских ценностей системы образования. Праксиологический анализ социокультурных реалий современности указывает на то, что постмодернистская культура перестала быть отраслевой, а социальное развитие стало интегративным. В единстве они движутся к новому типу рациональности и новым способам коммуникации. Для развивающейся России остается открытым вопрос: какие социокультурные приоритеты потребуется эволюционировать в качестве современных ценностных образовательных ориентиров?
New Integrated High-Resolution Dinoflagellate Cyst Stratigraphy and Litho- and Chemostratigraphy from the Paris and Dieppe–Hampshire Basins for the “Sparnacian”
The Paris Basin represents an historical cradle of Palaeogene stratigraphy, where during the nineteenth century the Palaeocene Series and the “Sparnacian Stage” were established. As highlighted by Aubry et al. (2005), whereas the chronostratigraphic connotation of the “Sparnacian Stage” has been controversial since its definition, modern studies of the late Palaeocene–early Eocene interval have revealed that the so-called “Sparnacian” deposits encompass a remarkable and short (~170 kyr) episode of the Cenozoic, the Palaeocene–Eocene Thermal Maximum (PETM, ~55.8–55.6 Ma). Dinoflagellate assemblages from the “Sparnacian” of the Dieppe–Hampshire and Paris basins do not contain the key species Apectodinium augustum, whereas it is present in the northern Belgian Basin Tienen Formation and is coeval there with the CIE and the Apectodinium acme interval. However, our calibration of the Apectodinium acme to the CIE in the Dieppe–Hampshire and Paris basins suggests its attribution to the A. augustum zone. The absence of species A. augustum in the Anglo–Paris Basin may be explained by its restriction to more offshore conditions
Entrepreneurial-intention constraint model: A comparative analysis among post-graduate management students in India, Singapore and Malaysia
YesAlthough literature on entrepreneurship has increasingly focused on intention-based models, not much emphasis has been laid on understanding the combined effect of contextual and situational factors along with support of university environment on the formation of entrepreneurial intention among students. In an effort to make up for this shortfall, by taking Theory of Planned Behavior as basic framework, the present study seeks to understand the influence of three of the most important factors, viz. (a) endogenous barriers, (b) exogenous environment, and (c) university environment and support on the entrepreneurial intention among management students. The study sample consisted of 1,097 students, wherein 526 students were from India, 252 from Singapore, and 319 were from Malaysia. The results indicates that along with positive attitude and perceived behavioral control that directly influences entrepreneurial intention, university environment and support and exogenous environment also have an indirect but significant impact on shaping of entrepreneurial intention among students. With this, it was found that exogenous environment was found to have a negative relationship with both attitude towards behavior and perceived behavioral control for all three countries.The full-text of this article will be released for public view at the end of the publisher embargo on 2 Jun 2018
Early to middle Eocene history of the Arctic Ocean from Nd-Sr isotopes in fossil fish debris, Lomonosov Ridge
Strontium and neodymium radiogenic isotope ratios in early to middle Eocene fossil fish debris (ichthyoliths) from Lomonosov Ridge (Integrated Ocean Drilling Program Expedition 302) help constrain water mass compositions in the Eocene Arctic Ocean between ∼55 and ∼45 Ma. The inferred paleodepositional setting was a shallow, offshore marine to marginal marine environment with limited connections to surrounding ocean basins. The new data demonstrate that sources of Nd and Sr in fish debris were distinct from each other, consistent with a salinity-stratified water column above Lomonosov Ridge in the Eocene. The 87Sr/86Sr values of ichthyoliths (0.7079–0.7087) are more radiogenic than Eocene seawater, requiring brackish to fresh water conditions in the environment where fish metabolized Sr. The 87Sr/86Sr variations probably record changes in the overall balance of river Sr flux to the Eocene Arctic Ocean between ∼55 and ∼45 Ma and are used here to reconstruct surface water salinity values. The ɛNd values of ichthyoliths vary between −5.7 and −7.8, compatible with periodic (or intermittent) supply of Nd to Eocene Arctic intermediate water (AIW) from adjacent seas. Although the Norwegian-Greenland Sea and North Atlantic Ocean were the most likely sources of Eocene AIW Nd, input from the Tethys Sea (via the Turgay Strait in early Eocene time) and the North Pacific Ocean (via a proto-Bering Strait) also contributed
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
Background: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods: The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings: We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation: Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding: Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health
Influence of 'Trichobilharzia regenti' (Digenea: Schistosomatidae) on the defence activity of 'Radix lagotis' (Lymnaeidae) haemocytes
Radix lagotis is an intermediate snail host of the nasal bird schistosome Trichobilharzia regenti. Changes in defence responses in infected snails that might be related to host-parasite compatibility are not known. This study therefore aimed to characterize R. lagotis haemocyte defence mechanisms and determine the extent to which they are modulated by T. regenti. Histological observations of R. lagotis infected with T. regenti revealed that early phases of infection were accompanied by haemocyte accumulation around the developing larvae 2–36 h post exposure (p.e.) to the parasite. At later time points, 44–92 h p.e., no haemocytes were observed around T. regenti. Additionally, microtubular aggregates likely corresponding to phagocytosed ciliary plates of T. regenti miracidia were observed within haemocytes by use of transmission electron microscopy. When the infection was in the patent phase, haemocyte phagocytic activity and hydrogen peroxide production were significantly reduced in infected R. lagotis when compared to uninfected counterparts, whereas haemocyte abundance increased in infected snails. At a molecular level, protein kinase C (PKC) and extracellular-signal regulated kinase (ERK) were found to play an important role in regulating these defence reactions in R. lagotis. Moreover, haemocytes from snails with patent infection displayed lower PKC and ERK activity in cell adhesion assays when compared to those from uninfected snails, which may therefore be related to the reduced defence activities of these cells. These data provide the first integrated insight into the immunobiology of R. lagotis and demonstrate modulation of haemocyte-mediated responses in patent T. regenti infected snails. Given that immunomodulation occurs during patency, interference of snail-host defence by T. regenti might be important for the sustained production and/or release of infective cercariae
Entrepreneurial intention among University students in Malaysia: integrating self-determination theory and the theory of planned behavior
The present study endeavors to develop a deeper understanding of the motivational processes involved in intentional entrepreneurial behavior. For this purpose, it integrates the social cognitive approach of the theory of planned behavior (TPB) and the organismic theory of motivation of self-determination theory (SDT). More specifically, it tests the role of basic psychological needs of autonomy, competence and relatedness as defined in SDT in shaping university students’ attitudes and intentions toward entrepreneurship. The sample of this study consisted of 438 (Males = 166, Females =272) 3rd and4th year university students from four Malaysian Public Universities. The results of the study show that the model strongly explains about 71% of the variance in entrepreneurial intention. Basic psychological needs of autonomy, competence and relatedness have a strong indirect impact on entrepreneurial intention via their attitudinal antecedents: attitude,subjective norm, and perceived behavioral control. This indicates a full-mediational model,where the attitudinal factors operated as transmitters of effects from the distal constructs ofSDT on entrepreneurial intention. These findings confirm that both SDT and the TPB provide complementary explanations of the motivational processes of entrepreneurial behavior. The study contributes to the existing knowledge by providing a theory-based understanding of the role of motivations in the formation of entrepreneurial intentions. It opens the way for future research to analyze how alternative motivations may affect new venture creation, survival and success
Lipid Interacting Regions in Phosphate Stress Glycosyltransferase atDGD2 from Arabidopsis thaliana
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