No Association Between Consumption of Sweetened Beverages and Risk of Later-Onset Crohn's Disease or Ulcerative Colitis

Background & Aims: Consumption of sweetened beverages has been associated with inflammation based on measurements of C-reactive protein and tumor necrosis factor, as well as immune-mediated disorders including rheumatoid arthritis. We investigated associations with Crohn's disease (CD) or ulcerative colitis (UC). Methods: We conducted a prospective cohort study of 83,042 participants (age, 44–83 y) enrolled in the Cohort of Swedish Men or the Swedish Mammography Study. Dietary and lifestyle data were collected using a validated food frequency questionnaire at baseline in 1997. Diagnoses of CD and UC were ascertained from the Swedish Patient Register. We used Cox proportional hazards modeling to calculate hazard ratios and 95% CIs. Results: Through December of 2014, we confirmed 143 incident cases of CD (incidence rate, 11 cases/100,000 person-years) and 349 incident cases of UC (incidence rate, 28 cases/100,000 person-years) over 1,264,345 person-years of follow-up evaluation. Consumption of sweetened beverages was not associated with increased risk of CD (Ptrend = .34) or UC (Ptrend = .40). Compared with participants who reported no consumption of sweetened beverages, the multivariable-adjusted hazard ratios for 1 or more servings per day were 1.02 for CD (95% CI, 0.60–1.73) and 1.14 for UC (95% CI, 0.83–1.57). The association between consumption of sugar-sweetened beverages and risk of CD or UC were not modified by age, sex (cohort), body mass index, or smoking (all Pinteraction ≥ .12). Conclusions: In analyses of data from 2 large prospective cohort studies from Sweden, we observed no evidence for associations between consumption of sweetened beverages and later risk of CD or UC

TWO NEW PLOCENE SPECIES OF CYCLOSTEPHANOS (BACILLARIOPHYCEAE) WITH COMMENTS ON THE CLASSIFICATION OF THE FRESHWATER THALASSIOSIRACEAE 1

Two new species of the diatom genus Cyclostephanos Round are described from Pliocene fossil deposits in western North America. Cyclostephanos undatus is distinguished from other Cyclostephanos species by its tangentially undulate valve face; Cyclostephanos fenestratus is distinguished by its extremely shallow alveoli. This paper records previously unreported morphological detail of Cyclostephanos and speculates that structure of the punctum, labiate process and strutted process may enhance diagnosis of the freshwater genera of the Thalassiosiraceae Lebour emend. Hasle. Cyclostephanos undatus is similar to several Cyclotella species, but its external costae are raised and its alveolar morphology is similar to that of Cyclostephanos dubius (Fricke) Round. Cyclostephanos fenestratus is similar in external view to Stephanodiscus Ehrenb. However, the two species described here have flat cribra covering the mantle puncta and the labiate processes appear to lack external tubes, whereas Stephanodiscus species have domed mantle cribra and external tubes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65645/1/j.1529-8817.1986.tb04154.x.pd

High-intensity interval training for reducing blood pressure: a randomized trial vs. moderate-intensity continuous training in males with overweight or obesity

The optimal exercise-training characteristics for reducing blood pressure (BP) are unclear. We investigated the effects of 6-weeks of high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) on BP and aortic stiffness in males with overweight or obesity. Twenty-eight participants (18–45 years; BMI: 25–35 kg/m2) performed stationary cycling three times per week for 6 weeks. Participants were randomly allocated (unblinded) to work-matched HIIT (N = 16; 10 × 1-min intervals at 90–100% peak workload) or MICT (N = 12; 30 min at 65–75% peak heart rate). Central (aortic) and peripheral (brachial) BP and aortic stiffness was assessed before and after training. There were no significant group × time interactions for any BP measure (all p > 0.21). HIIT induced moderate reductions in central (systolic/diastolic ∆: −4.6/−3.5 mmHg, effect size d = −0.51/−0.40) and peripheral BP (−5.2/−4 mmHg, d = −0.45/−0.47). MICT induced moderate reductions in diastolic BP only (peripheral: −3.4 mmHg, d = −0.57; central: −3 mmHg, d = −0.50). The magnitude of improvement in BP was strongly negatively correlated with baseline BP (r = −0.66 to −0.78), with stronger correlations observed for HIIT (r = −0.73 to −0.88) compared with MICT (r = −0.43 to −0.61). HIIT was effective for reducing BP (~3–5 mmHg) in the overweight to obese cohort. Exercise training induced positive changes in central (aortic) BP. The BP-lowering effects of exercise training are more prominent in those with higher baseline BP, with stronger correlation in HIIT than MICT

The effect of high-intensity interval training and moderate-intensity continuous training on aerobic fitness and body composition in males with overweight or obesity: A randomized trial

The optimal exercise training characteristics for improving body composition in individuals with obesity are not clear. This study assessed the effects of 6-weeks of high-intensity interval training (HIIT) or moderate-intensity continuous training (MICT) on aerobic fitness and body composition in males with overweight or obesity. Twenty-eight participants (18–45 years; BMI: 25–35 kg/m2) performed stationary cycling 3 times per week for 6 weeks. Participants were randomly allocated to work-matched HIIT (N = 16) (10 × 1-min intervals at ~90% peak heart rate) or MICT (N = 12) (30 min at 65–75% peak heart rate). Maximal aerobic capacity (VO2peak) and body composition were assessed before and after 6-week training. Both HIIT and MICT induced moderate increases in aerobic fitness (Δ% VO2peak: HIIT 9 ± 8%, ES = 0.42; MICT: 7 ± 13%, ES = 0.32) and work capacity (Δ% peak workload: HIIT 13 ± 10%, ES = 0.69: MICT 17 ± 15%, ES = 0.76), but these changes did not differ significantly between the groups (all p > 0.16). The effects of HIIT or MICT on body composition outcomes were negligible to small across whole-body and all regional-specific sites (all effect sizes ES = −0.19 to 0.38) and did not differ significantly between the groups (all p > 0.21). Short-term (6-weeks) cycling training did not improve body composition in males with overweight or obesity. Improvements in aerobic fitness were comparable between work-matched HIIT and MICT

Genetic Algorithm in the Optimization of the Acoustic Attenuation System

[EN] It is well known that Genetic Algorithms (GA) is an optimization method which can be used in problems where the traditional optimization techniques are difficult to be applied. Sonic Crystals (SC) are periodic structures that present ranges of sound frequencies related with the periodicity of the structure, where the sound propagation is forbidden. This means that in the acoustic spectrum there are ranges of frequencies with high acoustic attenuation. This attenuation can be improved producing vacancies in the structure. In this paper we use a parallel implementation of a GA to optimize those structures, by means of the creation of vacancies in a starting SC, in order to obtain the best acoustic attenuation in a predetermined range of frequencies. The cost function used in GA is based on the Multiple Scattering Theory (MST), which is a self consistent method for calculating acoustic pressure in SCs. As a final result we achieve a quasi ordered structures that presents a high acoustic attenuation in a predetermined range of frequencies, independent of the periodicity of the SC.The authors acknowledge financial support provided by the Spanish MEC (Project No. MAT2006-03097) and by the Generalitat Valenciana (Spain) under Grant No. GV/2007/191. This work also has been partially supported by MEC (Spanish government) and FEDER funds: projects DPI2005-07835, DPI2004- 8383-C03-02 and GVA-026.Romero García, V.; Fuster García, E.; Sánchez Pérez, JV.; García Raffi, LM.; Blasco, X.; Herrero Durá, JM.; Sanchís Saez, J. (2007). Genetic Algorithm in the Optimization of the Acoustic Attenuation System. Lecture Notes in Computer Science. 4507:614-621. https://doi.org/10.1007/978-3-540-73007-1_74S6146214507Martínez-Sala, R., Sancho, J., Sánchez Pérez, J.V., Llinares, J., Meseguer, F.: Sound attenuation by sculpture. Nature (London) 387, 241 (1995)Hushwaha, M.S., Halevi, P., Martínez, G., Dobrynski, L., Djafari-Rouhani, B.: Theory of acoustic band structure of periodic elastic composites. Phys. Rev. B 49(4), 2313–2322 (1994)Liu, Z., Zhang, X., Mao, Y., Zhu, Y.Y., Yang, Z., Xhan, C.T., Sheng, P.: Locally resonatn sonic materials. Science 289, 1734 (2000)Hu, X., Chan, C.T., Zi, J.: Two dimensional sonic crystals with Helmholtz resonators. Phys. Rev. E 71, 055601 (2005)Umnova, O., Attenborough, K., Linton, C.M.: Effects of porous covering on sound attenuation by poriodi arrays of cylinders. J. Acoust. Soc. Am. 119, 278 (2006)Caballero, D., Sánchez-Dehesa, J., Martínez-Sala, R., Rubio, C., Sánchez Pérez, J.V.S., Sanchis, L., Meseguer, F.: Suzuki phase in two-dimensional sonic crystals. Phys. Rev. B 64, 064303 (2001)Hakansson, A., Sánchez-Dehesa, J., Sanchis, L.: Acoustic lens design by genetic algorithms. Phys. Rev. B 70, 214302 (2004)Romero-García, V., Fuster, E., García-Raffi, L.M., Sánchez-Pérez, E.A., Sopena, M., Llinares, J., Sánchez-Pérez, J.V.: Band gap creation using quasiordered strutures based on sonic crystals. Appl. Phys. Lett. 88, 174104-1 174104-3 (2006)Chen, Y.Y., Ye, Z.: Theoretical analysis of acoustic stop bands in two-dimensional periodic scattering arrays. Phys. Rev. E 64, 036616 (2001)Economou, E.N., Sigalas, M.M.: Classical wave propagation in periodic structures: Cermet versus network topology. Phys. Rev. B 48(18), 13434 (1993)Sigalas, M.M., Economou, E.N., Kafesaki, M.: Spectral gaps for electromagnietic and scalar waves: Possible explanation for certain differences. Phys. Rev. B 50(5), 3393 (1994)Goldberg, D.E.: Genetic Algorithms in search, optimization and machine learning. Addison-Wesley, London (1989)Bäck, T.: Evolutionaty Algorithms in theory and practice. Oxford University Press, New York (1996)Baker, J.E.: Reducing bias and inefficiency in the selection algorithm. In: Proc. Second International Conference on Genetic Algorithms (1987)Mühlenbein, H., Schlierkamp-Voosen, D.: Predictive Models for the Breeder Genetic Algorithm I. Continuous Parameter Optimization. Evolutionary Computation 1(1) (1993)Cantú-Paz, E.: A summary of resaearch on parallel genetic algorithms. Technical Report 95007, Illinois Genetic Algorithms Laboratory. IlliGAL (1995

Conformational effects on the Circular Dichroism of Human Carbonic Anhydrase II: a multilevel computational study

Circular Dichroism (CD) spectroscopy is a powerful method for investigating conformational changes in proteins and therefore has numerous applications in structural and molecular biology. Here a computational investigation of the CD spectrum of the Human Carbonic Anhydrase II (HCAII), with main focus on the near-UV CD spectra of the wild-type enzyme and it seven tryptophan mutant forms, is presented and compared to experimental studies. Multilevel computational methods (Molecular Dynamics, Semiempirical Quantum Mechanics, Time-Dependent Density Functional Theory) were applied in order to gain insight into the mechanisms of interaction between the aromatic chromophores within the protein environment and understand how the conformational flexibility of the protein influences these mechanisms. The analysis suggests that combining CD semi empirical calculations, crystal structures and molecular dynamics (MD) could help in achieving a better agreement between the computed and experimental protein spectra and provide some unique insight into the dynamic nature of the mechanisms of chromophore interactions

Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.

Recent reports have shown that the selective dopamine D(1)-like agonist SKF 83822 [which stimulates adenylate cyclase, but not phospholipase C] induces prominent behavioral seizures in mice, whereas its benzazepine congener SKF 83959 [which stimulates phospholipase C, but not adenylate cyclase] does not. To investigate the relative involvement of D(1) vs D(5) receptors in mediating seizures, ethological behavioral topography and cortical EEGs were recorded in D(1), D(5) and DARPP-32 knockout mice in response to a convulsant dose of SKF 83822. SKF 83822-induced behavioral and EEG seizures were gene dose-dependently abolished in D(1) knockouts. In both heterozygous and homozygous D(5) knockouts, the latency to first seizure was significantly increased and total EEG seizures were reduced relative to wild-types. The majority (60%) of homozygous DARPP-32 knockouts did not have seizures; of those having seizures (40%), the latency to first seizure was significantly increased and the number of high amplitude, high frequency polyspike EEG events was reduced. In addition, immunoblotting was performed to investigate downstream intracellular signalling mechanisms at D(1)-like receptors following challenge with SKF 83822 and SKF 83959. In wild-types administered SKF 83822, levels of ERK1/2 and GluR1 AMPA receptor phosphorylation increased two-fold in both the striatum and hippocampus; in striatal slices DARPP-32 phosphorylation at Thr34 increased five-fold relative to vehicle-treated controls. These findings indicate that D(1), and to a lesser extent D(5), receptor coupling to DARPP-32, ERK1/2 and glutamatergic signalling is involved in mediating the convulsant effects of SKF 83822

Lignin-first biorefining of Nordic poplar to produce cellulose fibers could displace cotton production on agricultural lands

Here, we show that lignin-first biorefining of poplar can enable the production of dissolving cellulose pulp that can produce regenerated cellulose, which could substitute cotton. These results in turn indicate that agricultural land dedicated to cotton could be reclaimed for food production by extending poplar plantations to produce textile fibers. Based on climate-adapted poplar clones capable of growth on marginal lands in the Nordic region, we estimate an environmentally sustainable annual biomass production of similar to 11 tonnes/ha. At scale, lignin-first biorefining of this poplar could annually generate 2.4 tonnes/ha of dissolving pulp for textiles and 1.1 m(3) biofuels. Life cycle assessment indicates that, relative to cotton production, this approach could substantially reduce water consumption and identifies certain areas for further improvement. Overall, this work highlights a new value chain to reduce the environmental footprint of textiles, chemicals, and biofuels while enabling land reclamation and water savings from cotton back to food production

Universal Rights and Wrongs

This paper argues for the important role of customers as a source of competitive advantage and firm growth, an issue which has been largely neglected in the resource-based view of the firm. It conceptualizes Penrose’s (1959) notion of an ‘inside track’ and illustrates how in-depth knowledge about established customers combines with joint problem-solving activities and the rapid assimilation of new and previously unexploited skills and resources. It is suggested that the inside track represents a distinct and perhaps underestimated way of generating rents and securing long-term growth. This also implies that the sources of sustainable competitive advantage in important respects can be sought in idiosyncratic interfirm relationships rather than within the firm itself

Liquid Chromatography Electron Capture Dissociation Tandem Mass Spectrometry (LC-ECD-MS/MS) versus Liquid Chromatography Collision-induced Dissociation Tandem Mass Spectrometry (LC-CID-MS/MS) for the Identification of Proteins

Electron capture dissociation (ECD) offers many advantages over the more traditional fragmentation techniques for the analysis of peptides and proteins, although the question remains: How suitable is ECD for incorporation within proteomic strategies for the identification of proteins? Here, we compare LC-ECD-MS/MS and LC-CID-MS/MS as techniques for the identification of proteins.Experiments were performed on a hybrid linear ion trap–Fourier transform ion cyclotron resonance mass spectrometer. Replicate analyses of a six-protein (bovine serum albumin, apo-transferrin,lysozyme, cytochrome c, alcohol dehydrogenase, and β-galactosidase) tryptic digest were performed and the results analyzed on the basis of overall protein sequence coverage and sequence tag lengths within individual peptides. The results show that although protein coverage was lower for LC-ECDMS/MS than for LC-CID-MS/MS, LC-ECD-MS/MS resulted in longer peptide sequence tags,providing greater confidence in protein assignment