COBE Constraints on a Compact Toroidal Low-density Universe

In this paper, the cosmic microwave background (CMB) anisotropy in a multiply-connected compact flat 3-torus model with the cosmological constant is investigated. Using the COBE-DMR 4-year data, a full Bayesian analysis revealed that the constraint on the topology of the flat 3-torus model with low-matter-density is less stringent. As in compact hyperbolic models, the large-angle temperature fluctuations can be produced as the gravitational potential decays at the $\Lambda$-dominant epoch well after the last scattering. The maximum allowed number $N$ of images of the cell (fundamental domain) within the observable region at present is approximately 49 for $\Omega_m=0.1$ and $\Omega_\Lambda=0.9$ whereas $N\sim8$ for $\Omega_m=1.0$ and $\Omega_\Lambda=0$.Comment: 13 pages using RevTeX, 5 eps files, typos correcte

Interactive effects of nanoparticles with other contaminants in aquatic organisms: Friend or foe?

none3The increasing production and use of nanoparticles (NPs) will lead to their release into the aquatic environment, posing a potential threat to the health of aquatic organisms. Both in the water phase and in the sediments NPs could mix and interact with other pollutants, such as organic xenobiotics and heavy metals, leading to possible changes in their bioavailability/bioconcentration/toxicity. However, whether these interactive effects may lead to increased harmful effects in marine organisms is largely unknown. In this work, available data mainly obtained on carbon based NPs and n-TiO2, as examples of widespread NPs, in aquatic organisms are reviewed. Moreover, data are summarized on the interactive effects of n-TiO2 with 2,3,7,8-TCDD and Cd(2+), chosen as examples of common and persistent organic and inorganic contaminants, respectively, in the model marine bivalve Mytilus. The results reveal complex and often unexpected interactive responses of NPs with other pollutants, depending on type of contaminant and the endpoint measured, as well as differences in bioaccumulation. The results are discussed in relation with data obtained in freshwater organisms. Overall, information available so far indicate that interactive effects of NPs with other contaminants do not necessarily lead to increased toxicity or harmful effects in aquatic organisms.openCanesi, L; Ciacci, C; Balbi, TCanesi, L; Ciacci, C; Balbi,

Apparent Clustering of Intermediate-redshift Galaxies as a Probe of Dark Energy

We show the apparent redshift-space clustering of galaxies in redshift range of 0.2--0.4 provides surprisingly useful constraints on dark energy component in the universe, because of the right balance between the density of objects and the survey depth. We apply Fisher matrix analysis to the the Luminous Red Galaxies (LRGs) in the Sloan Digital Sky Survey (SDSS), as a concrete example. Possible degeneracies in the evolution of the equation of state (EOS) and the other cosmological parameters are clarified.Comment: 5 pages, 3 figures, Phys.Rev.Lett., replaced with the accepted versio

ISW effect in Unified Dark Matter Scalar Field Cosmologies: an analytical approach

We perform an analytical study of the Integrated Sachs-Wolfe (ISW) effect within the framework of Unified Dark Matter models based on a scalar field which aim at a unified description of dark energy and dark matter. Computing the temperature power spectrum of the Cosmic Microwave Background anisotropies we are able to isolate those contributions that can potentially lead to strong deviations from the usual ISW effect occurring in a $\Lambda$CDM universe. This helps to highlight the crucial role played by the sound speed in the Unified Dark Matter models. Our treatment is completely general in that all the results depend only on the speed of sound of the dark component and thus it can be applied to a variety of unified models, including those which are not described by a scalar field but relies on a single dark fluid.Comment: 15 pages, LateX file; one comment after Eq.(36) and formula (44) added in order to underline procedure and main results. Accepted for publication in JCAP; some typos correcte

Affine equation of state from quintessence and k-essence fields

We explore the possibility that a scalar field with appropriate Lagrangian can mimic a perfect fluid with an affine barotropic equation of state. The latter can be thought of as a generic cosmological dark component evolving as an effective cosmological constant plus a generalized dark matter. As such, it can be used as a simple, phenomenological model for either dark energy or unified dark matter. Furthermore, it can approximate (up to first order in the energy density) any barotropic dark fluid with arbitrary equation of state. We find that two kinds of Lagrangian for the scalar field can reproduce the desired behaviour: a quintessence-like with a hyperbolic potential, or a purely kinetic k-essence one. We discuss the behaviour of these two classes of models from the point of view of the cosmological background, and we give some hints on their possible clustering properties.Comment: 9 pages, 6 figures. Minor updates, accepted by CQ

Characterization of the main steps in first shell formation in Mytilus galloprovincialis: possible role of tyrosinase

Bivalve biomineralization is a highly complex and organized process, involving several molecular components identified in adults and larval stages. However, information is still scarce on the ontogeny of the organic matrix before calcification occurs. In this work, first shell formation was investigated in the mussel Mytilus galloprovincialis. The time course of organic matrix and CaCO3 deposition were followed at close times post fertilization (24, 26, 29, 32, 48 h) by calcofluor and calcein staining, respectively. Both components showed an exponential trend in growth, with a delay between organic matrix and CaCO3 deposition. mRNA levels of genes involved in matrix deposition (chitin synthase; tyrosinase- TYR) and calcification (carbonic anhydrase; extrapallial protein) were quantified by qPCR at 24 and 48 hours post fertilization (hpf) with respect to eggs. All transcripts were upregulated across early development, with TYR showing highest mRNA levels from 24 hpf. TYR transcripts were closely associated with matrix deposition as shown by in situ hybridization. The involvement of tyrosinase activity was supported by data obtained with the enzyme inhibitor N-phenylthiourea. Our results underline the pivotal role of shell matrix in driving first CaCO3 deposition and the importance of tyrosinase in the formation of the first shell in M. galloprovincialis

N = 2 Supersymmetry in a Hybrid Inflation Model

The slow roll inflation requires an extremely flat inflaton potential. The supersymmetry (SUSY) is not only motivated from the gauge hierarchy problem, but also from stabilizing that flatness of the inflaton potential against radiative corrections. However, it has been known that the Planck suppressed higher order terms in the K\"ahler potential receive large radiative corrections loosing the required flatness in the N = 1 supergravity. We propose to impose a global N = 2 SUSY on the inflaton sector. What we find is that the N = 2 SUSY Abelian gauge theory is exactly the same as the desired hybrid inflation model. The flat potential at the tree level is not our choice of parameters but a result of the symmetry. We further introduce a cut-off scale of the theory which is lower than the Planck scale. This lower cut-off scale suppresses the supergravity loop corrections to the flat inflaton potential.Comment: 12 page

Sterile neutrinos: direct mixing effects versus induced mass matrix of active neutrinos

Mixing of active neutrinos with sterile ones generate ``induced'' contributions to the mass matrix of active neutrinos $\sim m_S \sin^2\theta_{aS}$, where $m_S$ is the Majorana mass of the sterile neutrino and $\theta_{aS}$ is the active-sterile mixing angle. We study possible effects of the induced matrix which can modify substantially the implications of neutrino oscillation results. We have identified the regions of $m_S$ and $\sin^2\theta_{aS}$ where the induced matrix (i) provides the dominant structures, (ii) gives the sub-dominant effects and (iii) where its effects can be neglected. The induced matrix can be responsible for peculiar properties of the lepton mixing and neutrino mass spectrum, in particular, it can generate the tri-bimaximal mixing. We update and discuss bounds on the induced masses from laboratory measurements, astrophysics and cosmology. We find that substantial impact of the induced matrix is possible if $m_S \sim 0.1-1$ eV and $\sin^2\theta_{aS} \sim 10^{-3} - 10^{-2}$ or $m_S \geq 200$ MeV and $\sin^2\theta_{aS} \leq 10^{-9}$. The bounds can be relaxed in cosmological scenarios with low reheating temperature, if sterile neutrinos decay sufficiently fast, or their masses change with time.Comment: Figures updated, version to be published in Phys. Rev.

Phenotypical and molecular changes induced by carbamazepine and propranolol on larval stages of Mytilus galloprovincialis

The possible impact of carbamazepine (CBZ) and propranolol (PROP), two widespread pharmaceuticals in the aquatic environment, were investigated on morphology and gene transcription of early larvae of Mytilus galloprovincialis. Pharmaceuticals were first tested in a wide concentration range (from 0.01 to 1000 a) through the 48-hpf embryotoxicity assay. The results showed that both compounds significantly affected embryo development from environmental concentrations. Although similar EC50 were obtained, (congruent to 1 mu g/L) CBZ induced a progressive increase in embryo malformations, whereas PROP apparently showed greater impacts in terms of arrested development and embryo mortality at higher concentrations (>10 mu g/L). Transcriptional analyses of 17 genes involved in different physiological functions in mussels and/or in their response to environmental contaminants, were performed at 24 and 48 h pf at two selected concentrations of CBZ and PROP (0.01 and 1 mu g/L). Both compounds induced down-regulation of shell-specific and neuroendocrine related transcripts, while distinct effects were observed on antioxidant, lysosomal, and immune-related transcripts, also depending on the larval stage investigated. The results demonstrate that CBZ and PROP can affect development and gene transcription in mussel early larvae at environmental concentrations. (C) 2019 Elsevier Ltd. All rights reserved

In vivo immunomodulatory and antioxidant properties of nanoceria (nCeO2) in the marine mussel Mytilus galloprovincialis

Cerium nanoparticles (nCeO2) are increasingly utilized in a wide variety of industrial, environmental and biomedical applications, and are therefore expected to be released in the aquatic environment. Due to its peculiar redox properties, nCeO2 may present unique hazards to environmental and human health. Previous data showed that in the hemocytes of the marine bivalve Mytilus galloprovincialis, in vitro exposure to a particular type of nCeO2 (9 nm, characterized by negative ζ-potential, high H2O2 scavenging capacity and Ce3+/Ce4+ surface ratio) reduced basal ROS production, lysosomal membrane stability and phagocytic activity in the presence of hemolymph serum; the effects observed were partly ascribed to the formation of a SOD-protein corona in the hemolymph. In this work, the in vivo effects of this type of nCeO2 were investigated in mussels exposed to 100 μg/L nCeO2 for 96 h; several lysosomal, immune, inflammatory and antioxidant biomarkers were measured at cellular (hemocytes) and tissue (gills, digestive gland) level. Molecular responses were evaluated in hemocytes and digestive gland by determining expression of 11 selected genes related to known biological functions. The results show specific immunomodulatory and antioxidant effects of nCeO2 at different levels of biological organization in the absence of Cerium tissue accumulation. These data further support the redox mechanisms at the basis of the physiological effects of nCeO2. Finally, in order to evaluate the possible impact at the whole organism level, the effects of nCeO2 were evaluated in the 48 h embryotoxicity assay in a wide concentration range. However, nCeO2 exposure resulted in a small reduction in normal embryo development. Overall, the results demonstrate that in mussels nCeO2 can selectively modulate different physiological processes at different levels of biological organization