STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

Background: Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of the placenta with inadequate remodelling of the maternal spiral arteries. There is currently no effective therapy available. Some evidence suggests sildenafil citrate may improve uteroplacental blood flow, fetal growth, and meaningful infant outcomes. The objective of the Sildenafil TheRapy In Dismal prognosis Early onset fetal growth Restriction (STRIDER) collaboration is to evaluate the effectiveness of sildenafil versus placebo in achieving healthy perinatal survival through the conduct of randomised clinical trials and systematic review including individual patient data meta-analysis.  Methods: Five national/bi-national multicentre randomised placebo-controlled trials have been launched. Women with a singleton pregnancy between 18 and 30 weeks with severe fetal growth restriction of likely placental origin, and where the likelihood of perinatal death/severe morbidity is estimated to be significant are included. Participants will receive either sildenafil 25 mg or matching placebo tablets orally three times daily from recruitment to 32 weeks gestation.  Discussion: The STRIDER trials were conceived and designed through international collaboration. Although the individual trials have different primary outcomes for reasons of sample size and feasibility, all trials will collect a standard set of outcomes including survival without severe neonatal morbidity at time of hospital discharge. This is a summary of all the STRIDER trial protocols and provides an example of a prospectively planned international clinical research collaboration. All five individual trials will contribute to a pre-planned systematic review of the topic including individual patient data meta-analysis

Use of wild fish and other aquatic organisms as feed in aquaculture: a review of practices and implications in the Asia-Pacific

The solar-wind magnetosphere interaction primarily occurs at altitudes where the dipole component of Earth’s magnetic field is dominating. The disturbances that are created in this interaction propagate along magnetic field lines and interact with the ionosphere–thermosphere system. At ionospheric altitudes, the Earth’s field deviates significantly from a dipole. North–South asymmetries in the magnetic field imply that the magnetosphere–ionosphere–thermosphere (M–I–T) coupling is different in the two hemispheres. In this paper we review the primary differences in the magnetic field at polar latitudes, and the consequences that these have for the M–I–T coupling. We focus on two interhemispheric differences which are thought to have the strongest effects: 1) A difference in the offset between magnetic and geographic poles in the Northern and Southern Hemispheres, and 2) differences in the magnetic field strength at magnetically conjugate regions. These asymmetries lead to differences in plasma convection, neutral winds, total electron content, ion outflow, ionospheric currents and auroral precipitation