Progesterone vaginal ring as a new contraceptive option for lactating mothers: Evidence from a multicenter non-randomized comparative clinical trial in India

Objectives: Evaluate and compare contraceptive efficacy, safety, continuation rates and duration of lactational amenorrhea (LA) in married lactating women (20-35 years) using the progesterone vaginal ring (PVR) or Copper-T380A intrauterine device (IUD) during the first postpartum year. Study design: We conducted a one-year multicenter, non-randomized, non-inferiority, open-label, comparative trial at 20 centers in India and compared efficacy, safety, continuation and LA plus feeding patterns and growth/well-being of participants’ infants. Women used four 3-month PVRs consecutively (lost PVRs were not replaced) and were to breastfeed at least four times/day. We used Pearl Index (PI) and Kaplan Meier (K-M) rates to analyze pregnancy and K-M for continuation. Results: We enrolled 789 women (459 PVR, 330 IUD). Neither PI nor K-M one-year pregnancy rates differed significantly between groups (PI: PVR-0.62; IUD-0.35); (K-M: PVR-0.7; IUD-0.4, p=0.58). Continuation rates at 12 months were 78.5% (IUD) vs. 56.9% (PVR) (p \u3c 0.001). Ring expulsions and menorrhagia were the most common discontinuation among PVR/ IUD users respectively. The median duration of LA among PVR vs. IUD users was 405 vs. 120 days (p \u3c 0.001). Both groups reported similar adverse events (PVR: 24.2%; IUD: 23.0%); there were no serious adverse events among PVR users. Infants from both groups fed 12-7 times/day and grew at expected rates. Conclusions: Efficacy and safety outcomes were comparable among women in both groups. Continuation rates for PVR, a woman-controlled method, were shorter than IUD rates while PVR users maintained LA significantly longer than IUD users. Infant breastfeeding and growth patterns/well-being were favorable in both groups. Implications: PVR, a user-controlled device, offers an additional contraceptive choice for lactating women for one-year postpartum use and can help to address the unmet need for contraception among postpartum women while encouraging breastfeeding to enhance infant growth and well-being

Testing Non-Standard Interactions Between Solar Neutrinos and Quarks with Super-Kamiokande

Non-Standard Interactions (NSI) between neutrinos and matter affect the neutrino flavor oscillations. Due to the high matter density in the core of the Sun, solar neutrinos are suited to probe these interactions. Using the $277$ kton-yr exposure of Super-Kamiokande to $^{8}$B solar neutrinos, we search for the presence of NSI. Our data favors the presence of NSI with down quarks at 1.8$\sigma$, and with up quarks at 1.6$\sigma$, with the best fit NSI parameters being ($\epsilon_{11}^{d},\epsilon_{12}^{d}$) = (-3.3, -3.1) for $d$-quarks and ($\epsilon_{11}^{u},\epsilon_{12}^{u}$) = (-2.5, -3.1) for $u$-quarks. After combining with data from the Sudbury Neutrino Observatory and Borexino, the significance increases by 0.1$\sigma$

Neutron tagging following atmospheric neutrino events in a water Cherenkov detector

International audienceWe present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218±9 μs

Neutron Tagging following Atmospheric Neutrino Events in a Water Cherenkov Detector

International audienceWe present the development of neutron-tagging techniques in Super-Kamiokande IV using a neural network analysis. The detection efficiency of neutron capture on hydrogen is estimated to be 26%, with a mis-tag rate of 0.016 per neutrino event. The uncertainty of the tagging efficiency is estimated to be 9.0%. Measurement of the tagging efficiency with data from an Americium-Beryllium calibration agrees with this value within 10%. The tagging procedure was performed on 3,244.4 days of SK-IV atmospheric neutrino data, identifying 18,091 neutrons in 26,473 neutrino events. The fitted neutron capture lifetime was measured as 218 \pm 9 \mu s