The Life of Edward Jenkins Harden

Edward Jenkins Earden was born November 19, 1813, in Bryan County, Georgia. He was married to Sophia Maxwell Harden and had seven children. While Teaching at Chatham Academy, he studied law and was licensed to practice in 1834. He became judge of the city court in 1845. From 1861-1865, he served as judge of the Confederate District Court of Georgia. At the conclusion of the war, he was appointed Corporation Lawyer for the city of Savannah, a position he retained until his death. In addition to his professional duties, he was the author of the notable work, The Life of Georgia Troup. He served as President of the Georgia Historical Society, President of the Board of Trustees of the Oglethorpe Medical College and a ruling elder of First Presbyterian Church. He died in Indian Springs, Georgia, April 19, 1873. He was buried the following day at Laurel Grove Cemetery, Savannah.https://digitalcommons.georgiasouthern.edu/sav-bios-lane/1222/thumbnail.jp

Doctor of Philosophy

dissertationWith the growing national dissemination of the electronic health record (EHR), there are expectations that the public will benefit from biomedical research and discovery enabled by electronic health data. Clinical data are needed for many diseases and conditions to meet the demands of rapidly advancing genomic and proteomic research. Many biomedical research advancements require rapid access to clinical data as well as broad population coverage. A fundamental issue in the secondary use of clinical data for scientific research is the identification of study cohorts of individuals with a disease or medical condition of interest. The problem addressed in this work is the need for generalized, efficient methods to identify cohorts in the EHR for use in biomedical research. To approach this problem, an associative classification framework was designed with the goal of accurate and rapid identification of cases for biomedical research: (1) a set of exemplars for a given medical condition are presented to the framework, (2) a predictive rule set comprised of EHR attributes is generated by the framework, and (3) the rule set is applied to the EHR to identify additional patients that may have the specified condition. iv Based on this functionality, the approach was termed the ‘cohort amplification' framework. The development and evaluation of the cohort amplification framework are the subject of this dissertation. An overview of the framework design is presented. Improvements to some standard associative classification methods are described and validated. A qualitative evaluation of predictive rules to identify diabetes cases and a study of the accuracy of identification of asthma cases in the EHR using frameworkgenerated prediction rules are reported. The framework demonstrated accurate and reliable rules to identify diabetes and asthma cases in the EHR and contributed to methods for identification of biomedical research cohorts

Parents living within the paradoxes of infant death from life-limiting anomaly: A grounded theory study

BACKGROUND: Life-limiting congenital anomalies are the leading cause of death of infants in the United States. Most of these infants die in intensive care units with limited access to adequate palliative/end-of-life care. There is an extensive knowledge gap about the experience of the parent of infants who died from life-limiting anomaly. PURPOSE: The aims of the study was to explore the process a parent goes through as they experience the birth, life and ultimate death of an infant from a life-limiting explore the process a parent goes through as they experience the birth, life and ultimate death of an infant from a life-limiting congenital anomaly and (b) develop a substantive theory to describe the process parenting an infant with a life-limiting congenital anomaly from birth to death. METHODS: Classic grounded methodology was used to analyze field notes of open-ended interviews with 11 parents whose infant died from a life-limiting congenital anomaly between the ages of 48 hours and 15 months. FINDINGS: The grounded theory Parents Living within the Paradoxes of Infant Death from Life-Limiting Anomaly describes the experience of parents from pregnancy to life after the infant\u27s death. The theory contains three stages and two cutting points. The first stage of the theory is living in innocence in which the pregnant/expectant parent anticipates or has a healthy baby. This stage ends with the first cutting point of getting the bad news or getting the diagnosis of a life-limiting anomaly. The second stage is being a good mom/dad in the new reality in which the parent experiences being the parent of a baby expected to die from a life-limiting anomaly. The second stage ends with the second cutting point, death of the baby. The final stage of the theory is going on describes how a parent goes on with life after the death of the baby. CONCLUSIONS: Parents living within the paradoxes of infant death from life-limiting anomaly has great implications for nursing in education, practice and research. This new grounded theory has the potential to assist in improving palliative and end-of-life care for infants

The characterization and role of aeolian deposition on water quality, McMurdo Dry Valleys, Antarctica

The connection of ecosystems by wind-driven transport of material has become a topic of increasing interest and importance. Less than 1% of dust transported worldwide is exported to the Southern Ocean and Antarctic cryosphere; however, aeolian transport on the Antarctic continent is predominantly locally derived from the abrasion of bedrock. The deposition of the aeolian material is integral to nutrient and solute dispersal in the Antarctic ecosystem. This is particularly true in the ice-free areas of Antarctica, such as the McMurdo Dry Valleys (MDV), where aeolian material deposited in the aquatic system is solubilized during the melt season. The material is predominantly locally-derived from the abrasion of bedrock. In this study, a two-step leaching experiment simulates the melt season and we quantify the flux of solutes and nutrients to the aquatic ecosystem. Soluble salts were removed from the aeolian material first during cold water leaching followed by an increase in carbonate and silicate dissolution during freeze–thaw. Major ion fluxes on glaciers and lakes are at least two orders of magnitude greater than nutrient fluxes. However, the fluxes derived from these experiments are less than the estimated flux from streams to lakes and probably represent minima. Aeolian redistribution of local soils is important because they are the only source of new solutes and nutrients to the aquatic ecosystem of the MDV

Antarctic streams as a potential source of iron for the Southern Ocean

Due to iron’s role in oceanic primary production, there has been great interest in quantifying the importance of Fe in regions where concentrations are very low and macronutrients, nitrate and phosphate, are available. Measurements of filterable (i.e., \u3c0.4 μm) Fe concentrations in streams from Taylor Valley, McMurdo Dry Valleys, Antarctica, suggest that coastal-zone stream Fe input to the Southern Ocean could potentially play an important role in primary production in nearshore regions. Filterable Fe (fFe) data from streams in the McMurdo Dry Valleys were used to represent glacier meltwater that flows through ice-free landscape with the potential of transporting Fe to the Antarctic coastal zone. Estimates of potential fFe flux to the Antarctic Peninsula region using our mean fFe concentration of 10.6 µg L–1 combined with an estimate of ice-free area for the Antarctic Peninsula result in an fFe flux of 1.2 × 107 g yr–1. Although small compared to iceberg and aeolian Fe fluxes, future stream input to the Southern Ocean could increase due to glacier retreat and melting, thus increasing the fFe flux from glacier meltwater streams

Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology – an update for the surgical oncologist

Adenocarcinoma of the oesophagus and gastro-oesophageal junction are rapidly increasing in incidence and have a well described sequence of carcinogenesis: the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. During recent years there have been changes in the knowledge surrounding disease progression, cancer management and histopathology specimen reporting. Tumours around the gastro-oesophageal junction (GOJ) pose several specific challenges. Numerous difficulties arise when the existing TNM staging systems for gastric and oesophageal cancers are applied to GOJ tumours. The issues facing the current TNM staging and GOJ tumour classification systems are reviewed in this article. Recent evidence regarding the importance of several histopathologically derived prognostic factors, such as circumferential resection margin status and lymph node metastases, have implications for specimen reporting. With the rising use of multimodal treatments for oesophageal cancer it is important that the response of the tumour to this therapy is carefully documented pathologically. In addition, several controversial and novel areas such as endoscopic mucosal resection, lymph node micrometastases and the sentinel node concept are being studied. We aim to review these aspects, with special relevance to oesophageal and gastro-oesophageal cancer specimen reporting, to update the surgical oncologist with an interest in upper gastrointestinal cancer

Site-Based Transdisciplinary Educational Partnerships: Development, Implementation, and Outcomes of a Collaborative Professional Preparation Program

In this article, we describe the conceptual framework, development, implementation, and outcomes of an experimental professional preparation program. University students from preparation programs in general education, educational administration, school psychology, and special education formed transdisciplinary cohorts that were placed in school settings to complete a variety of activities designed to foster greater collaboration among disciplines in serving children and youth at risk. We describe what was learned throughout the project as well as its operational structure, outcomes, and future directions for transdisciplinary professional development

Developing a Community-Designed Healthy Urban Food System

Learning About Food in Urban Communities is a comprehensive guide with Extension resources for Food Production, Food & Business, Food & Family, and Food & Community. This publication emerged as part of a 2-year community-planning project. An interdisciplinary OSU team worked with the Weinland Park community, in the central Ohio University District, to explore how food could be a catalyst for urban neighborhood development

Knowledge and Awareness Among Patients with Chronic Kidney Disease Stage 3

Knowledge is a prerequisite for changing behavior, and is useful for improving outcomes and reducing mortality rates in patients diagnosed with chronic kidney disease (CKD). The purpose of this article is to describe baseline CKD knowledge and awareness obtained as part of a larger study testing the feasibility of a self-management intervention. Thirty patients were recruited who had CKD Stage 3 with coexisting diabetes and hypertension. Fifty-four percent of the sample were unaware of their CKD diagnosis. Participants had a moderate amount of CKD knowledge. This study suggests the need to increase knowledge in patients with CKD Stage 3 to aid in slowing disease progression