Genetic variation in hepcidin expression and its implications for phenotypic differences in iron metabolism

At the core of iron homeostasis is hepcidin, a small acute phase antimicrobial peptide that now also appears to synchronously orchestrate the response of iron transporter and regulatory genes. In this perspective article, Drs Bayele and Srai discuss cis and trans acting factors that may influence hepcidin variation in humans and their potential role in iron metabolism control. See related papers on page 1293 and 1297

Bariatric Surgery Can Correct Iron Depletion in Morbidly Obese Women: A Link with Chronic Inflammation

International audienceObesity is associated with a chronic and low-grade inflammation which may cause hypoferremia as seen in patients with chronic inflammatory diseases. The aim of the present study was to investigate the relationship between iron status and markers of inflammation in morbidly obese women and the effect of bariatric surgery

Increased Adipose Tissue Expression of Hepcidin in Severe Obesity Is Independent From Diabetes and NASH

International audienceHepcidin is an acute-phase response peptide. We have investigated the possible involvement of hepcidin in massive obesity, a state of chronic low-grade inflammation. Three groups of severely obese patients with or without diabetes or nonalcoholic steatohepatitis were investigated