6 research outputs found
Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines
Get PDFA series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines.
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Synthesis of 3,5-diarylisoxazoles under solvent-free conditions using iodobenzene diacetate
No full textSynthesis and evaluation of anti-tubercular activity of 6-(4-substitutedpiperazin-1-yl) phenanthridine analogues
No full textAnti-proliferative activity, molecular modeling studies and interaction with calf thymus DNA of novel ciprofloxacin analogues
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