Parent stress and adaptive functioning of individuals with developmental disabilities

Research consistently indicates that parents of individuals with a developmental disability report considerably more stress associated with child characteristics than parents with typically developing children. It is commonly believed that the adaptive functioning of a child with a developmental disability plays a significant role in the stress a parent experiences. The present study examines adaptive functioning of individuals with a developmental disability, in an attempt to establish child characteristics that are predictors of parental stress. Participants consisted of a randomly selected group of 97 individuals (64 males, 33 females) with developmental disabilities, and their parents (90 mothers and 56 fathers) from across Ontario, Canada. Individuals with developmental disabilities ranged in age from 9.3 to 42.5 years, with an average age of 24.9 years (SD=8.6). The Full Scale IQ scores for participants with a developmental disability, ranged from 40 to 92, with a mean score of 53.9 (SD=12.7). Adaptive and Maladaptive Behaviour were assessed using the Adaptive Behavior Scales - Residential and Community Edition, Second Edition (Nihira, Leland & Lambert, 1993). The Parenting Stress Index, Third Edition (Abidin, 1995) was used as a measure of parental stress. The results established a relation between parental stress and adaptive behaviour of the child. Specifically, lower levels of adaptive functioning were predictive of higher levels of parental stress. The specific components of adaptive functioning that relate to parental stress are discussed

Sentinel Lymph Node Biopsy Does Not Improve Disease-Specific Survival in Elderly Patients with Intermediate Thickness Melanoma

Objective: To determine whether sentinel lymph node biopsy (SLNB) is associated with improved disease-specific survival among elderly patients with intermediate-thickness melanoma Design: Retrospective cohort study of prospectively-maintained tumor registry Setting: Single institution tertiary care center. P atients: Adults ≥ 70 years of age, who underwent surgical intervention for melanoma from 2000-2013. Main Outcome Measures: The primary outcomes were overall survival (OS) and disease-free survival (DFS). Other clinicopathologic variables measured included age, gender, anatomic site, histologic type, tumor thickness, presence of adverse features, receipt and result of SLNB, and receipt of completion lymph node dissection (CLND). Results: Ninety-one patients (mean age 80 years, 54% male) underwent wide excision of an intermediate-thickness melanoma. Forty-nine patients (54%) received a SLNB. Seven of these biopsies (14%) were positive, and five patients (71%) went on to receive CLND. Five-year OS was 41% in patients who did not receive SLNB and 52% in patients who did receive SLNB (Fig. 1A). However, 5-year DFS was 79% in patients who did not receive SLNB and 77% in patients who did receive SLNB (Fig. 1B). Conclusions: Among elderly patients with intermediate-thickness melanoma, patients who received SLNB had higher 5-year OS than those who did not receive SLNB. However, the 5-year DFS is similar between the two groups, which suggests that the OS differences are related to non-melanoma factors. Routine SLNB for intermediate-thickness melanoma patients may not significantly change the outcome for this age group, and clinical decision-making should consider individual patient comorbidities and goals of care

TextQ—A User Friendly Tool for Exploratory Text Analysis

As the amount of textual data available on the Internet grows substantially each year, there is a need for tools to assist with exploratory data analysis. Furthermore, to democratize the process of text analytics, tools must be usable for those with a non-technical background and those who do not have the financial resources to outsource their data analysis needs. To that end, we developed TextQ, which provides a simple, intuitive interface for exploratory analysis of textual data. We also tested the efficacy of TextQ using two case studies performed by subject matter experts—one related to a project on the detection of cyberbullying communication and another related to the user ofTwitter for influence operations. TextQ was able to efficiently process over a million social media messages and provide valuable insights that directly assisted in our research efforts on these topics. TextQ is built using an open access platform and object-oriented architecture for ease of use and installation. Additional features will continue to be added to TextQ, based on the needs and interests of the installed base

Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii

DNA repair is essential for cell viability and proliferation. In addition to reactive oxygen produced as a byproduct of their own metabolism, intracellular parasites also have to manage oxidative stress generated as a defense mechanism by the host. The spontaneous loss of DNA bases due to hydrolysis and oxidative DNA damage in intracellular parasites is great, but little is known about the type of DNA repair machineries that exist in these early-branching eukaryotes. However, it is clear, processes similar to DNA base excision repair (BER) must exist to rectify spontaneous and host-mediated damage in Toxoplasma gondii. Here we report that T. gondii, an opportunistic protozoan pathogen, possesses two apurinic/apyrimidinic (AP) endonucleases that function in DNA BER. We characterize the enzymatic activities of Toxoplasma exonuclease III (ExoIII, or Ape1) and endonuclease IV (EndoIV, or Apn1), designated TgAPE and TgAPN, respectively. Over-expression of TgAPN in Toxoplasma conferred protection from DNA damage, and viable knockouts of TgAPN were not obtainable. We generated an inducible TgAPN knockdown mutant using a ligand-controlled destabilization domain to establish that TgAPN is critical for Toxoplasma to recover from DNA damage. The importance of TgAPN and the fact that humans lack any observable APN family activity highlights TgAPN as a promising candidate for drug development to treat toxoplasmosis

The Forum: Spring 2006

Spring 2006 journal of the Honors Program at the University of North Dakota. The issue includes stories, poems, essays and art by undergraduate students.https://commons.und.edu/und-books/1059/thumbnail.jp

2021 DePaul University Library and Art Museum Climate Survey Report

In the fall of 2021, the DePaul University Library and Art Museum’s IDEA (Inclusion, Diversity, Equity, Accessibility) Committee decided to conduct a survey of the library’s climate to establish a baseline for its work. The survey was sent to all full and part-time library staff and ran for six weeks. One of the goals of the IDEA committee is to bring awareness of implicit biases, micro-aggressions, exclusionary practices, and structural racism and discrimination within Library and Art Museum operations, environment, and culture; to review, audit and propose internal polices and processes for the Library and Art Museum to implement IDEA and related principles. The aim of the 2022 climate survey was to establish a baseline for this work. The survey results will be used to inform what organizational changes, training, and programs will be most beneficial to the library staff. After looking at various tools used by other businesses and universities, the IDEA subcommittee performing the survey and writing the report decided to work with the tool developed by the University of Maryland Libraries (https://drum.lib.umd.edu/handle/1903/17439) to survey its staff. The survey was adapted to account for the different nature of the University of Maryland libraries – private vs. public, baccalaureate/masters vs. major research institution, etc. As a condition of using this survey, DePaul University Library and Art Museum must post its version of the survey and this report to the university’s institutional repository

Fiction Fix 13

https://digitalcommons.unf.edu/fiction_fix/1008/thumbnail.jp

Increased pain intensity is associated with greater verbal communication difficulty and increased production of speech and co-speech gestures

Effective pain communication is essential if adequate treatment and support are to be provided. Pain communication is often multimodal, with sufferers utilising speech, nonverbal behaviours (such as facial expressions), and co-speech gestures (bodily movements, primarily of the hands and arms that accompany speech and can convey semantic information) to communicate their experience. Research suggests that the production of nonverbal pain behaviours is positively associated with pain intensity, but it is not known whether this is also the case for speech and co-speech gestures. The present study explored whether increased pain intensity is associated with greater speech and gesture production during face-to-face communication about acute, experimental pain. Participants (N = 26) were exposed to experimentally elicited pressure pain to the fingernail bed at high and low intensities and took part in video-recorded semi-structured interviews. Despite rating more intense pain as more difficult to communicate (t(25) = 2.21, p = .037), participants produced significantly longer verbal pain descriptions and more co-speech gestures in the high intensity pain condition (Words: t(25) = 3.57, p = .001; Gestures: t(25) = 3.66, p = .001). This suggests that spoken and gestural communication about pain is enhanced when pain is more intense. Thus, in addition to conveying detailed semantic information about pain, speech and co-speech gestures may provide a cue to pain intensity, with implications for the treatment and support received by pain sufferers. Future work should consider whether these findings are applicable within the context of clinical interactions about pain

Fiction Fix 12

https://digitalcommons.unf.edu/fiction_fix/1004/thumbnail.jp

Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma

Background: Uveal melanoma is a disease that is distinct from cutaneous melanoma, with a low tumor mutational burden and a 1-year overall survival of approximately 50% in patients with metastatic uveal melanoma. Data showing a proven overall survival benefit with a systemic treatment are lacking. Tebentafusp is a bispecific protein consisting of an affinity-enhanced T-cell receptor fused to an anti-CD3 effector that can redirect T cells to target glycoprotein 100-positive cells. Methods: In this open-label, phase 3 trial, we randomly assigned previously untreated HLA-A*02:01-positive patients with metastatic uveal melanoma in a 2:1 ratio to receive tebentafusp (tebentafusp group) or the investigator's choice of therapy with single-agent pembrolizumab, ipilimumab, or dacarbazine (control group), stratified according to the lactate dehydrogenase level. The primary end point was overall survival. Results: A total of 378 patients were randomly assigned to either the tebentafusp group (252 patients) or the control group (126 patients). Overall survival at 1 year was 73% in the tebentafusp group and 59% in the control group (hazard ratio for death, 0.51; 95% confidence interval [CI], 0.37 to 0.71; P<0.001) in the intention-to-treat population. Progression-free survival was also significantly higher in the tebentafusp group than in the control group (31% vs. 19% at 6 months; hazard ratio for disease progression or death, 0.73; 95% CI, 0.58 to 0.94; P = 0.01). The most common treatment-related adverse events in the tebentafusp group were cytokine-mediated events (due to T-cell activation) and skin-related events (due to glycoprotein 100-positive melanocytes), including rash (83%), pyrexia (76%), and pruritus (69%). These adverse events decreased in incidence and severity after the first three or four doses and infrequently led to discontinuation of the trial treatment (2%). No treatment-related deaths were reported. Conclusions: Treatment with tebentafusp resulted in longer overall survival than the control therapy among previously untreated patients with metastatic uveal melanoma. (Funded by Immunocore; ClinicalTrials.gov number, NCT03070392; EudraCT number, 2015-003153-18.). Copyright © 2021 Massachusetts Medical Society