Zero till in wheat from the gender perspective in Nepal

Different tillage practices such as zero-till direct-seeded rice (ZTDSR), zero-till maize (ZTM), and zero-till wheat (ZTW) were implemented in the farmer's field of Sunsari district were evaluated. However, the focus was on ZTW because of high its competitiveness with cheaper wheat from abroad. Focus Group Discussion (FGD), Famers households keeping records, field monitoring, key informant interviews were the primary source of data whereas literature and desktop review were done for secondary data. Zero till wheat operation scale out of the machine use had been increased, by 61.25% out of 109.63ha land in Bhokraha and 66.49 % out of 55.3ha of land in Kaptangunj. Whereas, a new node Chitaha was established with the initiation of non-respondent farmer's where the area occupied 26ha in the year of 2019 respectively as compared to the base year that of 2014. Yield advantage was not much higher with ZTW, the additional benefit of almost 34% over conventional till wheat (CTW) was sufficient enough for the farmers to decide to adopt zero tillage technology. Farmers perceived about 17% saving in seed requirement, 13% saving in irrigation amount and time, and 44% saving in total labor cost with ZTW to make it more profitable as compared to CTW. Among different methods of extension, farmers’ field day with 63% and field trial with 48% with women's participation shows the most effective method to create awareness. Although the percentage of the working hour for the female worker is higher the number of the total hour has been decreased for both the man and women and the total 303.64hr/ha has been saved

Impact of adoption of heat-stress tolerant maize hybrid on yield and profitability: Evidence from Terai region of Nepal

Abiotic stresses (drought, heat) are one of the major impediments to enhancing the maize productivity of marginal farmers in the facet of climate change. The present study attempts to investigate the impact of heat-tolerant maize hybrid on yield and income in the Terai region of Nepal. This study uses cross-sectional farm household-level data collected in August 2021 from a randomly selected sample of 404 rural households. We used a doubly robust inverse probability weighted regression adjustment method to obtain reliable impact estimates. Adoption of heat-tolerant hybrid increases yields by 16% and income by 44% in the spring season (a stress condition). Overall, yield increases by 12%, net income by 31%, saving of 40% in seed costs, and per capita food expenditure increases by 8.50%. Hence a conducive environment must be created for scaling up heat-tolerant maize varieties to increase productivity, minimize risk, and transform of the maize sector

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry(1,2). Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis(3), and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach(4), we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry(5). Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries.</p

Stroke genetics informs drug discovery and risk prediction across ancestries

Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were replicated (P < 0.05). Effect sizes were highly correlated across ancestries. Cross-ancestry fine-mapping, in silico mutagenesis analysis3, and transcriptome-wide and proteome-wide association analyses revealed putative causal genes (such as SH3PXD2A and FURIN) and variants (such as at GRK5 and NOS3). Using a three-pronged approach4, we provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC. A polygenic score integrating cross-ancestry and ancestry-specific stroke GWASs with vascular-risk factor GWASs (integrative polygenic scores) strongly predicted ischaemic stroke in populations of European, East Asian and African ancestry5. Stroke genetic risk scores were predictive of ischaemic stroke independent of clinical risk factors in 52,600 clinical-trial participants with cardiometabolic disease. Our results provide insights to inform biology, reveal potential drug targets and derive genetic risk prediction tools across ancestries

Socioeconomic Assessment of Mandarin Postharvest Loss: A Case of Gandaki Province, Nepal

This study focused on the socioeconomic assessment of mandarin postharvest loss in the Gandaki Province of Nepal. Two mandarin growing districts Tanahun and Syangja of Gandaki province were selected for study purposes. A simple random method of sampling was employed to select 45 mandarin farmers from each district making a total sample size of 90. Primary data were collected with the help of a pre-tested semi-structured interview schedule along with two focus group discussions and field observation of the mandarin orchard. Data were analyzed by using both descriptive and inferential statistics. This paper explored the mandarin production status, major post-harvest practices, marketing channels, and barriers to post-harvest technology adoption. The findings revealed that farmers were producing 5.4 tons of fresh mandarin each year earning around 50 thousand Nepalese rupees as profit from mandarin farming. Similarly, the result showed that the post-harvest loss was 8%-9% during the harvesting, grading, and packaging operation while a loss of 2%-3% was recorded during the transportation of mandarin from the production site to the wholesaler site. In total, loss ranging from 14%-18% was recorded in all chains of mandarin postharvest operations. Also, it was found that more than two-thirds (76.7%) of farmers practiced mandarin marketing based on preharvest contracts. The technical know-how of farmers about post-harvest technologies was a major challenge associated with the low adoption of mandarin post-harvest technologies. The concerned government agency, I/NGOs, and other organizations need to emphasize post-harvest loss issues by incorporating loss minimization activities in their program ensuring higher adoption of postharvest technologies by mandarin farmers and traders

Willingness to Pay (WTP) for Heat-Tolerant Maize Hybrids in the Mid-Western Terai Region of Nepal

High atmospheric temperatures can reduce maize production in different parts of Asia. Heat stress is the major driving force behind the need for varietal development that confers a heat tolerance trait (drought + heat tolerant) to maize hybrids. CIMMYT has developed heat-tolerant maize hybrids and deployed them in the market in collaboration with NARS partners. This study was conducted to estimate farmers’ willingness to pay for heat-tolerant maize hybrids in the Terai region of Nepal. A socioeconomic survey of 404 randomly selected maize-growing households was conducted to estimate farmers’ willingness to pay using the contingent valuation method. Given the economic importance of heat-tolerant maize hybrids in maize cultivation, the survey showed that the average WTP for heat-tolerant maize hybrids was 71% more than that for the current varieties in the market, including overall seed sources and subsidized seed. Without a subsidy, the farmers’ WTP price was at a 19% premium compared to the average price paid for conventional hybrids. Factors such as education, owning land, the interaction of hybrid adopters and owning land, soil depth, the number of goats/sheep, and the semi-pucca homes of households influenced the WTP for heat-tolerant maize hybrids. Heterogeneous demand was observed with respect to years of hybrid maize cultivation, farmers’ association with the network group, and the gender of the head of the household. In the context of climate change and global warming scenarios, Nepal’s agriculture policy should prioritize increasing domestic seed production and the distribution of heat-tolerant maize hybrids through a public–private partnership model

Plasma biomarkers predict cognitive trajectories in an ethnoracially and clinically diverse cohort: Mediation with hippocampal volume

IntroductionWe examine whether the association between key plasma biomarkers (amyloid β [aβ] 42/40, total tau (t-tau), neurofilament light [NfL]) and cognitive trajectories (executive function [EF] and episodic memory [EM]) is mediated through neurodegeneration.MethodsAll participants were recruited from the University of California, Davis-Alzheimer's Disease Research Center (n&nbsp;=&nbsp;473; baseline age range&nbsp;=&nbsp;49-95 years, 60% women). We applied an accelerated longitudinal design to test latent growth models for EF and EM, and path and mediation analyses. Age was centered at 75 years, and all models were adjusted for sex, education, and ethnicity.ResultsHV differentially mediated the association aβ 42/40 and NfL on EF and EM level and change. Hippocampal volume (HV) did not mediate the association between t-tau and cognitive performance.DiscussionNeurodegeneration as represented with HV selectively mediates the association between key non-invasive plasma biomarkers and cognitive trajectories in an ethnoracially and clinically diverse community-based sample

The State of US health, 1990-2010: Burden of diseases, injuries, and risk factors

Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the Organisation for Economic Co-operation and Development (OECD) countries. We used the systematic analysis of descriptive epidemiology of 291 diseases and injuries, 1160 sequelae of these diseases and injuries, and 67 risk factors or clusters of risk factors from 1990 to 2010 for 187 countries developed for the Global Burden of Disease 2010 Study to describe the health status of the United States and to compare US health outcomes with those of 34 OECD countries. Years of life lost due to premature mortality (YLLs) were computed by multiplying the number of deaths at each age by a reference life expectancy at that age. Years lived with disability (YLDs) were calculated by multiplying prevalence (based on systematic reviews) by the disability weight (based on population-based surveys) for each sequela; disability in this study refers to any short- or long-term loss of health. Disability-adjusted life-years (DALYs) were estimated as the sum of YLDs and YLLs. Deaths and DALYs related to risk factors were based on systematic reviews and meta-analyses of exposure data and relative risks for risk-outcome pairs. Healthy life expectancy (HALE) was used to summarize overall population health, accounting for both length of life and levels of ill health experienced at different ages. US life expectancy for both sexes combined increased from 75.2 years in 1990 to 78.2 years in 2010; during the same period, HALE increased from 65.8 years to 68.1 years. The diseases and injuries with the largest number of YLLs in 2010 were ischemic heart disease, lung cancer, stroke, chronic obstructive pulmonary disease, and road injury. Age-standardized YLL rates increased for Alzheimer disease, drug use disorders, chronic kidney disease, kidney cancer, and falls. The diseases with the largest number of YLDs in 2010 were low back pain, major depressive disorder, other musculoskeletal disorders, neck pain, and anxiety disorders. As the US population has aged, YLDs have comprised a larger share of DALYs than have YLLs. The leading risk factors related to DALYs were dietary risks, tobacco smoking, high body mass index, high blood pressure, high fasting plasma glucose, physical inactivity, and alcohol use. Among 34 OECD countries between 1990 and 2010, the US rank for the age-standardized death rate changed from 18th to 27th, for the age-standardized YLL rate from 23rd to 28th, for the age-standardized YLD rate from 5th to 6th, for life expectancy at birth from 20th to 27th, and for HALE from 14th to 26th. From 1990 to 2010, the United States made substantial progress in improving health. Life expectancy at birth and HALE increased, all-cause death rates at all ages decreased, and age-specific rates of years lived with disability remained stable. However, morbidity and chronic disability now account for nearly half of the US health burden, and improvements in population health in the United States have not kept pace with advances in population health in other wealthy nations