69 research outputs found

    Divining integrative medicine

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    Evolution of pathogenicity and sexual reproduction in eight Candida genomes

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    Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.publishe

    The interface between 'Erysiphe pisi' and its host

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    FileWeaver: Gestion Flexible de Fichiers avec Suivi Automatique des DĂ©pendances

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    International audienceKnowledge management and sharing involves a variety of specialized but isolated software tools, tied together by the files that these tools use and produce. We interviewed 23 scientists and found that they all had difficulties using the file system to keep track of, re-find and maintain consistency among related but distributed information. We introduce FileWeaver, a system that automatically detects dependencies among files without explicit user action, tracks their history, and lets users interact directly with the graphs representing these dependencies and version history. Changes to a file can trigger recipes, either automatically or under user control, to keep the file consistent with its dependants. Users can merge variants of a file, e.g. different output formats, into a polymorphic file, or morph, and automate the management of these variants. By making dependencies among files explicit and visible, FileWeaver facilitates the automation of workflows by scientists and other users who rely on the file system to manage their data
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