Discocotyle ohridana n. Sp. (monogenea: Discocotylidae) on the gills of ohrid belvica salmothymus ohridanus (pisces: Salmonidae) from the lake ohrid, macedonia

Discocotyle ohridana n.sp. is described from the gills of Ohrid belvica Salmothymus ohridanus Steindachner, 1892; (syn. Acantholingua ohridana Hadzisce, 1961) from the Lake Ohrid, Macedonia. According our investigation the new species D. ohridana n.sp. differs 56.47% of observed S. ohridanus have been infected and average intensity of infestation is 2.84

History-based verification of functional behaviour of concurrent programs

Modular verification of the functional behaviour of a concurrent program remains a challenge. We propose a new way to achieve this, using histories, modelled as process algebra terms, to keep track of local changes. When threads terminate or synchronise in some other way, local histories are combined into global histories, and by resolving the global histories, the reachable state properties can be determined. Our logic is an extension of permission-based separation logic, which supports expressive and intuitive specifications. We discuss soundness of the approach, and illustrate it on several examples

Legalised non-consensual sterilisation - eugenics put into practice before 1945, and the aftermath. Part 1: USA, Japan, Canada and Mexico.

In the late 19th century, eugenics, a pseudo-scientific doctrine based on an erroneous interpretation of the laws of heredity, swept across the industrialised world. Academics and other influential figures who promoted it convinced political stakeholders to enact laws authorising the sterilisation of people seen as ‘social misfits’. The earliest sterilisation Act was enforced in Indiana, in 1907; most States in the USA followed suit and so did several countries, with dissimilar political regimes. The end of the Second World War saw the suspension of Nazi legislation in Germany, including that regulating coerced sterilisation. The year 1945 should have been the endpoint of these inhuman practices but, in the early post-war period, the existing sterilisation Acts were suspended solely in Germany and Austria. Only much later did certain countries concerned – not Japan so far - officially acknowledge the human rights violations committed, issue apologies, and develop reparation schemes for the victims’ benefit

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage; Plasmodium falciparum; and; Cryptosporidium parvum; in cell-culture studies. Target deconvolution in; P. falciparum; has shown that cladosporin inhibits lysyl-tRNA synthetase (; Pf; KRS1). Here, we report the identification of a series of selective inhibitors of apicomplexan KRSs. Following a biochemical screen, a small-molecule hit was identified and then optimized by using a structure-based approach, supported by structures of both; Pf; KRS1 and; C. parvum; KRS (; Cp; KRS). In vivo proof of concept was established in an SCID mouse model of malaria, after oral administration (ED; 90; = 1.5 mg/kg, once a day for 4 d). Furthermore, we successfully identified an opportunity for pathogen hopping based on the structural homology between; Pf; KRS1 and; Cp; KRS. This series of compounds inhibit; Cp; KRS and; C. parvum; and; Cryptosporidium hominis; in culture, and our lead compound shows oral efficacy in two cryptosporidiosis mouse models. X-ray crystallography and molecular dynamics simulations have provided a model to rationalize the selectivity of our compounds for; Pf; KRS1 and; Cp; KRS vs. (human); Hs; KRS. Our work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis

Оптимизация конструкции захвата для детали «Барабан»

Грузозахватные приспособления обычно применяются при производстве работ по подъему и перемещению грузов с применением грузоподъемных машин. Использование приспособлений позволяет реализовать максимальное удобство и безопасность производственного процесса. Грузозахватные приспособления конструируются для определенного этапа технологического процесса, для конкретного изделия. При проектировании таких приспособлений необходимо учитывать основные показатели оптимальности конструкции: прочность, надежность, простота, удобство и безопасность при эксплуатации, эргономичность. Кроме того, нужно стремиться к наименьшей массе и, соответственно, металлоемкости захвата. Конструкция грузозахватного приспособления, в основном, будет зависеть от назначенных технологом поверхностей, за которые можно крепиться и от максимальной высоты подъема крюка крана. В статье описана задача по конструированию захвата для детали «Барабан¬ в новом технологическом процессе. Рассмотрена конструкция существующего захвата, взятого за прототип. Приведен анализ различных вариантов конструктивных решений, созданных в процессе проектирования. Выбран вариант конструкции захвата, который в наибольшей степени соответствует требованиям технического задания. Конструкция этого модернизированного приспособления представляет собой захват с тремя лапами, удерживающими деталь, и подвес в виде траверсы. Разработанная конструкторская документация утверждена производством и отделом промышленной безопасности

The process of forest management plans preparation in the Republic of Macedonia: Does it comprise governance principles of participation, transparency and accountability?

Leaving the centralized and trying to embrace the market economy, the forestry sector of the country has been brought to a challenge of moving from government to the new trend of governance. The paper examines whether governance principles of participation, accountability and transparency are comprised in the process of preparation of forest management plans. By scrutinizing the prevailing governance theory through a relevant legislative content analyses and conducted in-depth interviews with relevant stakeholders, the paper provides findings about cooperative forest policy-making in the process of forest management plan preparation through self organizing networks of participants from policy and society. Results obtained from the Law on forests and other related secondary legislation show that only two entities are involved in the preparation process, whereas the Ministry of forestry, agriculture and water economy and the Public enterprise \u201cMacedonian Forest\u201d. On the other hand, results obtained from the conducted in-depth interviews and the legislation content analysis correspond to the situation where the governance principles of participation, transparency and accountability are not respected in the process of creation of forest management plans

Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins

The mitochondrial outer membrane contains two preprotein translocases: the general translocase of outer membrane (TOM) and the beta-barrel-specific sorting and assembly machinery (SAM). TOM functions as the central entry gate for nuclear-encoded proteins. The channel-forming Tom40 is a beta-barrel protein, whereas all Tom receptors and small Tom proteins are membrane anchored by a transmembrane alpha-helical segment in their N- or C-terminal portion. Synthesis of Tom precursors takes place in the cytosol, and their import occurs via preexisting TOM complexes. The precursor of Tom40 is then transferred to SAM for membrane insertion and assembly. Unexpectedly, we find that the biogenesis of alpha-helical Tom proteins with a membrane anchor in the C-terminal portion is SAM dependent. Each SAM protein is necessary for efficient membrane integration of the receptor Tom22, whereas assembly of the small Tom proteins depends on Sam37. Thus, the substrate specificity of SAM is not restricted to beta-barrel proteins but also includes the majority of alpha-helical Tom proteins