Declaration of Independence: Mary Colum as Autobiographer

I N 1947, ten years before her death at the age of 7I, Mary Catherine Gunning Maguire Colum-Molly to her friends and her husband, the poet-dramatist Padraic Colum-published one ofthe most forthright and powerful protofeminist autobiographies ofthe twentieth century: Life and the Dream, a book that should not be as neglected as it is. What was or is the dream? It was a dream ofmany episodes: the hope ofa free, prosperous, peaceful, united Ireland; the fulfillment ofthe Irish Literary Revival which she so brilliantly chronicles as a participant-witness in the autobiography, and before in her masterwork of literary criticism: From These Roots: Ideas That Made Modern Literature (1937); and perhaps most of all a dream of equality for women in the male-dominated world of AngloIrish- American letters; for Colum never forgot that the Irish writer she admired most, really worshipped, her friend Yeats, had advised her not to follow a career in creative writing, her first love, but to pursue criticism, because women were better at that and a woman could never hope to succeed as a writer of fiction and verse

John Webster\u27s Imagery

This dissertation attempts two goals: to present for the first time a full and careful analysis of Webster\u27s imagery with respect to its function as a stylistic device for the economical presentation of character and exposition, the rapid establishment of mood, the skeletal structuring of the drama, the presentation of the thematic line, and the deepening of the significance of the drama without increasing the bulk; and to define freshly and more inclusively than has been done before, the methods used by Webster to achieve the above-mentioned effects

The Lymphovascular Embolus of Inflammatory Breast Cancer Expresses a Stem Cell-Like Phenotype

Inflammatory breast carcinoma (IBC) is a particularly lethal form of breast cancer characterized by exaggerated lymphovascular invasion, which is a phenotype recapitulated in our human xenograft MARY-X. MARY-X generated spheroids in vitro that resemble the embryonal blastocyst. Because of the resemblance of the spheroids to the embryonal blastocyst and their resistance to traditional chemotherapy/radiotherapy, we hypothesized that the spheroids expressed a stem cell-like phenotype. MARY-X spheroids expressed embryonal stem cell markers including stellar, rex-1, nestin, H19, and potent transcriptional factors, oct-4, nanog, and sox-2, which are associated with stem cell self-renewal and developmental potential. Most importantly, MARY-X spheroids expressed a cancer stem cell profile characterized by CD44+/CD24−/low, ALDH1, and most uniquely, CD133. A significant percentage of single cells of MARY-X exhibited distinct proliferative and morphogenic potencies in vitro. As few as 100 cells derived from single-cell clonogenic expansion were tumorigenic with recapitulation of the IBC phenotype. Prototype stem cell signaling pathways such as notch3 were active in MARY-X. The stem cell phenotype exhibited by MARY-X also was exhibited by the lymphovascular emboli of human IBC cases independent of their molecular subtype. This stem cell-like phenotype may contribute to the aggressive nature of IBC but also may lend itself to selective targeting