Declining Inflation Persistence in Canada: Causes and Consequences

The persistence of both core and total consumer price index inflation in Canada has declined significantly since the 1980s. In addition to providing up-to-date estimates of inflation persistence, this article examines possible reasons for the decline suggested in the literature. The role played by monetary policy, through its effect on price- and wage-setting behaviour, is distinguished from possible changes to the structure of the economy that are independent of monetary policy. The authors also discuss the implications for monetary policy of low structural persistence in inflation, including the choice of an inflation-targeting regime versus a price-level-targeting regime.

Fitting Transporter Activities to Cellular Drug Concentrations and Fluxes: Why the Bumblebee Can Fly

A recent paper in this journal argued that reported expression levels, kcat and Km for drug transporters could be used to estimate the likelihood that drug fluxes through Caco-2 cells could be accounted for solely by protein transporters. It was in fact concluded that if five such transporters contributed ‘randomly’ they could account for the flux of the most permeable drug tested (verapamil) 35% of the time. However, the values of permeability cited for verapamil were unusually high; this and other drugs have much lower permeabilities. Even for the claimed permeabilities, we found that a single ‘random’ transporter could account for the flux 42% of the time, and that two transporters can achieve 10·10−6cm·s−1 90% of the time. Parameter optimisation methods show that even a single transporter can account for Caco-2 drug uptake of the most permeable drug. Overall, the proposal that ‘phospholipid bilayer diffusion (of drugs) is negligible’ is not disproved by the calculations of ‘likely’ transporter-based fluxes

Anti-Corruption Law in Local Government: Legal Issues related to Ordinance-Design and Municipal-Level Anti-Corruption Agencies in Macedonia

Macedonian municipalities should pass anti-corruption ordinances in order to reduce corruption. The paper reviews the legal issues involved in drafting such ordinances and provides legal advisors to local councils with the legal and economic analysis needed to tackle some of the more difficult and detailed questions. The most important issue revolves around the creation of a model ordinance which Macedonian municipalities (or the Association of Units of Local Self-Government of the Republic of Macedonia) could adopt in order to set-up and run municipal-level anti-corruption agencies. The location of such agencies as well as their competencies (to monitor conflicts of interests, oversee asset declarations, and conduct corruption risk-audits among others ) are analysed. The paper also provides legal interpretations of Macedonian legislation and their likely impact on municipal council ordinance design in the area of anti-corruption - providing the legal basis for positive administrative silence, the splitting of municipal procurement contracts, and (most controversially) qui tam rewards at the municipal level. A brief regulatory impact analysis of the ordinance shows a gain of Euro 162,900 in social welfare if such a programme were rolled-out in Macedonia.

Stronger at Depth: Jamming Grippers as Deep Sea Sampling Tools

In this work we experimentally demonstrate (a) that the holding strength of universal jamming grippers increases as a function of the jamming pressure to greater than three atmospheres, and (b) that jamming grippers can be used for deep sea grasping tasks in ambient pressures exceeding one hundred atmospheres, where such high jamming pressures can be readily achieved. Laboratory experiments in a pressurized, water filled test cell are used to measure the holding force of a \u27universal\u27 style jamming gripper as a function of the pressure difference between internal membrane pressure and ambient pressure. Experiments at sea are used to demonstrate that jamming grippers can be installed on, and operated from, remotely operated vehicles (ROVs) at depths in excess of 1200m. In both experiments, the jamming gripper consists of a latex balloon filled with a mixture of fresh water and ~200 micron glass beads, which are cheaply available in large quantities as sand blasting media. The use of a liquid, rather than gas, as the fluid media allows operation of the gripper with a closed loop fluid system; jamming pressure is controlled with an electrically driven water hydraulic cylinder in the lab, and with an oil hydraulic driven large-bore water hydraulic cylinder at sea

Are X-ray properties of loose groups different from those of compact groups?

We compare the X-ray properties of loose and compact galaxy groups, using a combined sample of 42 groups. We find that we are unable to separate loose and compact groups on the luminosity-temperature relation, the luminosity-velocity dispersion relation or the velocity dispersion-temperature relation using equally weighted errors. This suggests that the distinction between compact and loose groups is not a fundamental one, and we argue that a more useful distinction is that between X-ray bright and X-ray faint systems. Given their similarity in X-ray properties, we combine the loose and compact subsamples to derive relations based on the full sample. This provides the highest statistical quality results to date on the way in which the correlations in X-ray properties of low mass systems depart from those seen in rich clusters.Comment: 6 pages, 6 figures. Accepted for publication in MNRA

SBSI:an extensible distributed software infrastructure for parameter estimation in systems biology

Complex computational experiments in Systems Biology, such as fitting model parameters to experimental data, can be challenging to perform. Not only do they frequently require a high level of computational power, but the software needed to run the experiment needs to be usable by scientists with varying levels of computational expertise, and modellers need to be able to obtain up-to-date experimental data resources easily. We have developed a software suite, the Systems Biology Software Infrastructure (SBSI), to facilitate the parameter-fitting process. SBSI is a modular software suite composed of three major components: SBSINumerics, a high-performance library containing parallelized algorithms for performing parameter fitting; SBSIDispatcher, a middleware application to track experiments and submit jobs to back-end servers; and SBSIVisual, an extensible client application used to configure optimization experiments and view results. Furthermore, we have created a plugin infrastructure to enable project-specific modules to be easily installed. Plugin developers can take advantage of the existing user-interface and application framework to customize SBSI for their own uses, facilitated by SBSI’s use of standard data formats

Astro2020 Project White Paper: The Cosmic Accelerometer

We propose an experiment, the Cosmic Accelerometer, designed to yield velocity precision of $\leq 1$ cm/s with measurement stability over years to decades. The first-phase Cosmic Accelerometer, which is at the scale of the Astro2020 Small programs, will be ideal for precision radial velocity measurements of terrestrial exoplanets in the Habitable Zone of Sun-like stars. At the same time, this experiment will serve as the technical pathfinder and facility core for a second-phase larger facility at the Medium scale, which can provide a significant detection of cosmological redshift drift on a 6-year timescale. This larger facility will naturally provide further detection/study of Earth twin planet systems as part of its external calibration process. This experiment is fundamentally enabled by a novel low-cost telescope technology called PolyOculus, which harnesses recent advances in commercial off the shelf equipment (telescopes, CCD cameras, and control computers) combined with a novel optical architecture to produce telescope collecting areas equivalent to standard telescopes with large mirror diameters. Combining a PolyOculus array with an actively-stabilized high-precision radial velocity spectrograph provides a unique facility with novel calibration features to achieve the performance requirements for the Cosmic Accelerometer

Chemical and Physical Mechanisms of Fungal Bioweathering of Rock Phosphate

This research has investigated fungal transformations of rock phosphate (RP) by geoactive fungi, with particular emphasis on Aspergillus niger. Direct hyphal interaction with RP particles induced morphological and mineralogical changes, as revealed by scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. The formation of the oxalate mineral calcium oxalate monohydrate (whewellite, CaC2O4 center dot H2O) on RP surfaces showed that mycogenic oxalic acid was driving the chemical dissolution of apatite, with consequent phosphate release and secondary mineral formation. This was supported by abiotic testing of common fungal excreted organic acids which confirmed that oxalic acid was the only effective RP transforming agent and therefore responsible for the morphological and mineralogical changes observed in RP when exposed to fungal colonization. Cryogenic SEM provided evidence of fungal penetration and tunneling through RP particles demonstrating that physical interactions are also important for RP bioweathering, as well as biochemical mechanisms. These findings emphasize the important role of fungi in P cycling, with active participation in the transformation of mineral phosphates through physicochemical mechanisms and secondary oxalate biomineral formation

eHabitat: A Contribution to the Model Web for Habitat Assessments and Ecological Forecasting

In striving to improve the predictive capabilities of ecological forecasting we face three basic choices ¿ develop new models, improve existing ones or increase the connectivity of models so they can work together. The latter approach of chaining different interoperable models is of particular interest, as technical developments have made it increasingly viable to combine models that can answer more questions than the individual models alone, allowing users to address complex questions, often of a multi-disciplinary nature. This concept of a Model Web encourages the setting up of a dynamic network of interoperating models, communicating with each other using standardized web services. It is the purpose of this paper to introduce the potential contribution of e-Habitat to the Model Web. e-Habitat is conceived as a Web Processing Service for computing the likelihood of finding ecosystems with equal properties. By developing e-Habitat according to Model Web principles, end-users can define the thematic layers for input to the model from various sources. These input layers are discovered using standards-based catalogues, which are a fundamental component of Model Web and generic Spatial Data Infrastructures. e-Habitat integrates data ranging from remote sensing data to socio-economical indicators, thus offering a huge potential for multi-disciplinary modelling. We will show that e-Habitat can be used for the identification of habitats that are most vulnerable or of the optimal locations for monitoring stations or, when coupled with climate change model services, for ecological forecasting. As such, it is an excellent example of the Model Web in practice.JRC.H.3-Global environement monitorin