1,361 research outputs found
The information of high-dimensional time-bin encoded photons
We determine the shared information that can be extracted from time-bin
entangled photons using frame encoding. We consider photons generated by a
general down-conversion source and also model losses, dark counts and the
effects of multiple photons within each frame. Furthermore, we describe a
procedure for including other imperfections such as after-pulsing, detector
dead-times and jitter. The results are illustrated by deriving analytic
expressions for the maximum information that can be extracted from
high-dimensional time-bin entangled photons generated by a spontaneous
parametric down conversion. A key finding is that under realistic conditions
and using standard SPAD detectors one can still choose frame size so as to
extract over 10 bits per photon. These results are thus useful for experiments
on high-dimensional quantum-key distribution system.Comment: 18 pages, 6 figure
Security of high-dimensional quantum key distribution protocols using Franson interferometers
Franson interferometers are increasingly being proposed as a means of
securing high-dimensional energy-time entanglement-based quantum key
distribution (QKD) systems. Heuristic arguments have been proposed that purport
to demonstrate the security of these schemes. We show, however, that such
systems are vulnerable to attacks that localize the photons to several
temporally separate locations. This demonstrates that a single pair of Franson
interferometers is not a practical approach to securing high-dimensional
energy-time entanglement based QKD. This observations leads us to investigate
the security of modified Franson-based-protocols, where Alice and Bob have two
or more Franson interferometers. We show that such setups can improve the
sensitivity against attacks that localize the photons to multiple temporal
locations. While our results do not constituting a full security proof, they do
show that a single pair of Franson interferometers is not secure and that
multiple such interferometers could be a promising candidate for experimentally
realizable high-dimensional QKD.Comment: 14 pages (single column format
The Band Excitation Method in Scanning Probe Microscopy for Rapid Mapping of Energy Dissipation on the Nanoscale
Mapping energy transformation pathways and dissipation on the nanoscale and
understanding the role of local structure on dissipative behavior is a
challenge for imaging in areas ranging from electronics and information
technologies to efficient energy production. Here we develop a novel Scanning
Probe Microscopy (SPM) technique in which the cantilever is excited and the
response is recorded over a band of frequencies simultaneously rather than at a
single frequency as in conventional SPMs. This band excitation (BE) SPM allows
very rapid acquisition of the full frequency response at each point (i.e.
transfer function) in an image and in particular enables the direct measurement
of energy dissipation through the determination of the Q-factor of the
cantilever-sample system. The BE method is demonstrated for force-distance and
voltage spectroscopies and for magnetic dissipation imaging with sensitivity
close to the thermomechanical limit. The applicability of BE for various SPMs
is analyzed, and the method is expected to be universally applicable to all
ambient and liquid SPMs.Comment: 32 pages, 9 figures, accepted for publication in Nanotechnolog
Avian malaria is absent in juvenile colonial herons (Ardeidae) but not Culex pipiens mosquitoes in the Camargue, Southern France
Apicomplexan blood parasites Plasmodium and Haemoproteus (together termed “Avian malaria”) and Leucocytozoon are widespread, diverse vector-transmitted blood parasites of birds, and conditions associated with colonial nesting in herons (Ardeidae) and other waterbirds appear perfect for their transmission. Despite studies in other locations reporting high prevalence of parasites in juvenile herons, juvenile Little Egrets (Egretta garzetta) previously tested in the Camargue, Southern France, had a total absence of malaria parasites. This study tested the hypotheses that this absence was due to insufficient sensitivity of the tests of infection; an absence of infective vectors; or testing birds too early in their lives. Blood was sampled from juveniles of four species shortly before fledging: Little Egret (n = 40), Cattle Egret (Bubulcus ibis; n = 40), Black-crowned Night-Heron (Nycticorax nycticorax, n = 40), and Squacco Heron (Ardeola ralloides; n = 40). Sensitive nested-Polymerase Chain Reaction was used to test for the presence of parasites in both birds and host-seeking female mosquitoes captured around the colonies. No malaria infection was found of in any of the heron species. Four different lineages of Plasmodium were detected in pooled samples of female Culex pipiens mosquitoes, including two in potentially infective mosquitoes. These results confirm that the absence of malaria parasites previously demonstrated in Little Egret is not due to methodological limitations. Although the prevalence of infection in mosquitoes was low, conditions within the colonies were suitable for transmission of Plasmodium. These colonial heron species may have evolved strategies for resisting malaria infection through physiological or behavioral mechanisms
The postcranial skeleton of monolophosaurus jiangi (dinosauria: Theropoda) from the Middle Jurassic of Xinjiang, China, and a review of Middle Jurassic Chinese theropods
The Middle Jurassic was a critical time in the evolution of theropod dinosaurs, highlighted by the origination and radiation of the large-bodied and morphologically diverse Tetanurae. Middle Jurassic tetanurans are rare but have been described from Europe, South America and China. In
particular, China has yielded a number of potential basal tetanurans, but these have received little detailed treatment in the literature. Here we redescribe the postcranial skeleton of one of the most complete Chinese Middle Jurassic theropods, Monolophosaurus. Several features confirmthe tetanuran affinities of Monolophosaurus, but the possession of ‘primitive’ traits such as a double-faceted pubic peduncle of the ilium and a hood-like supracetabular crest suggest a basal position within Tetanurae. This conflicts with most published cladistic analyses that place Monolophosaurus in a more derived position within Allosauroidea.We review the Middle Jurassic record of Chinese theropods and compare Monolophosaurus to other Middle Jurassic theropods globally. These comparisons suggest that Monolophosaurus and Chuandongocoelurus formed an endemic theropod clade limited to the Middle Jurassic of Asia. Other Middle Jurassic Chinese theropods deserve further study
First record of Mesozoic terrestrial vertebrates from Lithuania:Phytosaurs (Diapsida: Archosauriformes) of probable Late Triassic age, with a review of phytosaur biogeography
Comparison of Pittsburgh compound B and florbetapir in cross-sectional and longitudinal studies.
IntroductionQuantitative in vivo measurement of brain amyloid burden is important for both research and clinical purposes. However, the existence of multiple imaging tracers presents challenges to the interpretation of such measurements. This study presents a direct comparison of Pittsburgh compound B-based and florbetapir-based amyloid imaging in the same participants from two independent cohorts using a crossover design.MethodsPittsburgh compound B and florbetapir amyloid PET imaging data from three different cohorts were analyzed using previously established pipelines to obtain global amyloid burden measurements. These measurements were converted to the Centiloid scale to allow fair comparison between the two tracers. The mean and inter-individual variability of the two tracers were compared using multivariate linear models both cross-sectionally and longitudinally.ResultsGlobal amyloid burden measured using the two tracers were strongly correlated in both cohorts. However, higher variability was observed when florbetapir was used as the imaging tracer. The variability may be partially caused by white matter signal as partial volume correction reduces the variability and improves the correlations between the two tracers. Amyloid burden measured using both tracers was found to be in association with clinical and psychometric measurements. Longitudinal comparison of the two tracers was also performed in similar but separate cohorts whose baseline amyloid load was considered elevated (i.e., amyloid positive). No significant difference was detected in the average annualized rate of change measurements made with these two tracers.DiscussionAlthough the amyloid burden measurements were quite similar using these two tracers as expected, difference was observable even after conversion into the Centiloid scale. Further investigation is warranted to identify optimal strategies to harmonize amyloid imaging data acquired using different tracers
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease
Alzheimer's disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer's disease. Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (A beta) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18-94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant A beta pathology
Variability and change in the Canadian cryosphere
Abstract
During the International Polar Year (IPY), comprehensive observational research programs were undertaken to increase our understanding of the Canadian polar cryosphere response to a changing climate. Cryospheric components considered were snow, permafrost, sea ice, freshwater ice, glaciers and ice shelves. Enhancement of conventional observing systems and retrieval algorithms for satellite measurements facilitated development of a snapshot of current cryospheric conditions, providing a baseline against which future change can be assessed. Key findings include: 1. surface air temperatures across the Canadian Arctic exhibit a warming trend in all seasons over the past 40 years. A consistent pan-cryospheric response to these warming temperatures is evident through the analysis of multi-decadal datasets; 2. in recent years (including the IPY period) a higher rate of change was observed compared to previous decades including warming permafrost, reduction in snow cover extent and duration, reduction in summer sea ice extent, increased mass loss from glaciers, and thinning and break-up of the remaining Canadian ice shelves. These changes illustrate both a reduction in the spatial extent and mass of the cryosphere and an increase in the temporal persistence of melt related parameters. The observed changes in the cryosphere have important implications for human activity including the close ties of northerners to the land, access to northern regions for natural resource development, and the integrity of northern infrastructure
Chitayat-Hall and Schaaf-Yang syndromes: a common aetiology: expanding the phenotype of MAGEL2-related disorders
Chitayat-Hall syndrome, initially described in 1990, is a rare condition characterised by distal arthrogryposis, intellectual disability, dysmorphic features and hypopituitarism, in particular growth hormone deficiency. The genetic aetiology has not been identified.Background Chitayat-Hall syndrome, initially described in 1990, is a rare condition characterised by distal arthrogryposis, intellectual disability, dysmorphic features and hypopituitarism, in particular growth hormone deficiency. The genetic aetiology has not been identified.
Methods and results We identified three unrelated families with a total of six affected patients with the clinical manifestations of Chitayat-Hall syndrome. Through whole exome or whole genome sequencing, pathogenic variants in the MAGEL2 gene were identified in all affected patients. All disease-causing sequence variants detected are predicted to result in a truncated protein, including one complex variant that comprised a deletion and inversion.
Conclusions Chitayat-Hall syndrome is caused by pathogenic variants in MAGEL2 and shares a common aetiology with the recently described Schaaf-Yang syndrome. The phenotype of MAGEL2-related disorders is expanded to include growth hormone deficiency as an important and treatable complicationhe McLaughlin Centre, University of Toronto, Toronto, Canada, and Fondation Jeanne et Jean- Louis Lévesque (JLM). The Centre for Genetic Medicine, The Hospital for Sick Children, Toronto, Canada. FDL has a fellowship funded by FCT - Fundação para a Ciência e a Tecnologia (SFRH/BD/84650/2010)info:eu-repo/semantics/publishedVersio
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