Seismic Stratigraphy of the Eastern Equatorial Pacific Ocean: Paleoceanographic Implications

The collection of Leg 138 well-log and shipboard physical-property data, in conjunction with high-resolution seismic profiles, provides an opportunity to understand the paleoceanographic significance of seismic reflectors and to gain insight into the paleoceanographic evolution of the eastern equatorial Pacific Ocean. A series of eight reflectors or reflector packages were traced between two transects connecting five Leg 138 sites. By generating synthetic seismograms at each of these sites and comparing these to the field records, the origin of these seismic reflectors was determined in terms of physical-property variations and other core measurements. In particular, these reflectors were usually associated with sharp variations in density, which in turn, are related to variations in carbonate content. Intervals with moderate or poor nannofossil preservation indices were generally restricted to intervals below the reflectors traced in this study, suggesting that dissolution played little role in producing these reflectors. However, intervals with T. longissima mats were associated with many of the reflectors (R3-b, R4, R5-t, R5-b, R6) at the three sites (847, 849, and 850) where this diatom was encountered. This suggests that the reflectors found in this study are related to productivity events, although these events manifested themselves in a different way at the sites in which T. longissima mats were not observed. Interpreted seismic stratigraphic sections were compiled from the reflector horizon data for the two transects. Along the western transect, the section between reflectors R3 and R8 thins abruptly north of l°40\u27 to l°50\u27N, suggesting that this marks the northern limit of high equatorial productivity at that time (3.9-9.5 Ma), because the seafloor is reasonably constant in depth along this transect. Unfortunately, statements about sharp productivity gradients cannot be made for the eastern transect where sediment thinning corresponds to a deepening of the seafloor and thus may be related to variations in dissolution. Finally, six reflectors were found to be associated with major paleoceanographic events; three of these reflectors correspond to those found by Mayer et al. (1985,1986) in the central equatorial Pacific Ocean, suggesting that these correspond to Pacific-wide Oceanographic events. One of these reflectors (R8-b) is caused by a pervasive dissolution event as is its central equatorial counterpart. The others (R3-b and R5-t), however, appear to be the result of productivity events in the eastern equatorial Pacific that are synchronous with dissolution events in the central equatorial Pacific. We suggest that while localized high productivity creates low carbonate intervals (and thus reflectors) in the eastern equatorial Pacific, steep gradients in the CCD result in enhanced dissolution and low carbonate intervals (and thus reflectors) in the deeper central equatorial Pacifi

Progress and limits of PrP gene selection policy

Classical scrapie has proved to be a notoriously difficult disease to control due to a poor understanding of its natural history. The recognition of disease risk linkage to PrP genotype has offered the prospect of a disease control strategy, viz. genotyping and selective breeding, novel to veterinary medicine when first considered in the 1990s. The UK Spongiform Encephalopathy Advisory Committee recommended the exploitation of this approach in a voluntary, national programme to control classical scrapie and protect the public against food-borne exposure to bovine spongiform encephalopathy, should the national flock have been exposed via contaminated feed. The National Scrapie Plan for Great Britain was launched in 2001 and uptake has been widespread throughout the purebreeding sector of the sheep industry, with membership peaking at over 12 000 flocks in 2006. A total of 700 000 rams from 90 breeds have been genotyped. A comparison of ram lambs born in 2002 with those in 2006 shows evident changes in PrP genotype frequencies which are predicted to be associated with a reduction in disease risk. Various concerns have been raised regarding possible unintended consequences of widespread selection on PrP genotype, including impacts on other performance traits and possible effects on inbreeding and genetic diversity. To date, these concerns appear to be unfounded, as no consistent associations have been found with performance traits, nor are there likely to be any detectable impacts on inbreeding in mainstream breeds. Currently, semen banks have been implemented in Great Britain to store samples from animals of all common PrP genotypes, should these genotypes be required in the future. Various strategies to minimise future disease risks are discussed in the paper

Dead-time effects on the voltage spectrum of a PWM inverter

An inverter converts a direct-current power supply to an alternating-current power supply. This con- version is achieved by switching the output between the inputs at high frequency. The resulting output voltage may be described by a high-frequency train of variable-width pulses. Pulse widths are slowly modulated so that this output waveform contains a prescribed low-frequency component, which may then be isolated by an appropriate filtering regime. Techniques for determining the full harmonic spec- trum of input and output voltages and currents are well established, at least for an idealised mathematical model of the inverter. However, this model assumes that changes of inverter configuration can be ef- fected instantaneously, which is not quite the case in practice. In fact, a small amount of dead time must be incorporated into switching regimes in order to avoid short circuits of the input. Although dead time is an important feature of real power conversion devices, its effects on output voltage spectra have not previously been fully determined (except by imposing rather restrictive approximations). This situation is remedied in the present paper, in which we present closed-form expressions for the coefficients of the harmonic spectrum, corroborated by simulations

A self reporting scale for indicating emotional states of developmentally disabled adult horticultural workers

Call number: LD2668 .T4 1985 M667Master of Scienc

What's the best treatment for sebaceous cysts?

Punch biopsy excision appears to be superior to traditional wide elliptical excision for the treatment of sebaceous cysts when intervention is necessary (strength of recommendation [SOR]: B, based on 1 small randomized study). No rigorous metho- dological studies have compared punch biopsy excision of sebaceous cysts with the minimal excision technique

Soil properties associated with vegetation patches in a pinus ponderosa bunchgrass mosaic.

Since Euro-American settlement, fire exclusion and other factors have dramatically altered interior western coniferous forests. Once open and parklike, present day structure in many southwestern Pinus ponderosa forests consists of dense stands of young, small-diameter trees, with small patches of larger, old trees, and relict open bunchgrass areas. Our objectives were to assess differences in soil properties associated with these different vegetation patches. We examined soil morphological characteristics, pH, organic C concentration, total N concentration C:N ratio, and phytolith concentration from profiles within 6 transects (18 soil pedons) crossing patches of dense stands of small-diameter trees, patchs of old-growth trees, and open grassy areas. Results indicate that old-growth plots had significantly lower A horizon pH and thicker 0 horizons than grass plots. In general, we found vegetation patches had statistically similar C and N concentrations and C:N ratios for A and B horizons; however, C in the A horizon was positively correlated with 0 horizon accumulation (r2 = 0.79). Greater accumulation of organic C in the A horizon of forested areas contrasts with commonly reported results from mesic, mid-continental prairie forest ecosystems but is typical for many arid semiarid, and humid savanna ecosystems. Phytolith concentration was similar among old-growth pine, dense younger pine, and open grassy plots; the lack of a spatial pattern in phytolith distribution could indicate that grass cover was more spatially continuous in the past. Additionally this interpretation is consistent with current theories regarding historical vegetation change in these forests

Group Assessments to Help Build Online Learning Communities in Biomedical Science Distance Learning Programmes

Introduction: Biomedical Science distance learning courses offer flexibility in study while in employment. Asynchronous and self-learning approaches are common within such courses and often student-student interaction is limited. The aims of this study were to establish learning communities, develop confidence in participating in online teamwork and foster an appreciation of transferable skills including digital capabilities through remote group activities. Materials and Methods: Two cohorts of students (n = 20/n = 21) were enrolled in a microbiology module of an IBMS accredited MSc distance learning course. Groups of 4–5 students produced a digital output relating to current global infection-related issues, namely, assignment 1, production of a slide deck, which peers could use as learning resources and assignment 2, a voiceover PowerPoint debate, and infographic, voting assessment and peer/self-marking. Students also prepared reflections using written format and a FlipGrid video-recording. A qualitative content analysis was conducted on reflections from all students. Students completed a pre- and post-assignment survey focused on the development of transferable skills for the biomedical sector. Results: Students’ skills and confidence increased following completion of the group assignment, as evident from the pre- and post-questionnaire responses, namely, possession of digital skills and digital creation abilities (29% v 83%), applying for jobs which require digital skills (54% v 89%), talking about examples of using digital media during job interviews (21% v 78%) and demonstration of creativity during assignment tasks (33% v 90%). Critical thinking was more commonly demonstrated during the debate in comparison to the slide deck activity (p = 0.001). The importance of developing digital skills, was higher following completion of the group activities (p = 0.03). Students reflected on the value of the group activities in relation to knowledge acquisition (85%, 86%), collegiality (70%, 71%), digital skills development (80%, 90%), the fact that the activities were enjoyable (70%, 67%) and the development of peer interaction and support (50%, 67%) in relation to assignment 1 and 2, respectively. Discussion: Increasingly digital technologies are being used in the healthcare sector resulting in updated HCPC Standards of Proficiency. This study highlights that virtual group activities promote the establishment of supportive learning communities and the development of transferable skills including digital capabilities for application within the biomedical science workplace

Activation of extrasynaptic δ-GABAA receptors globally or within the posterior-VTA has estrous-dependent effects on consumption of alcohol and estrous-independent effects on locomotion

Recent reports support higher than expected rates of binge alcohol consumption among women and girls. Unfortunately, few studies have assessed the mechanisms underlying this pattern of intake in females. Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may selectively target tonic GABAergic inhibition mediated by GABAA receptor subtypes expressing the δ-subunit protein (δ-GABAARs). Indeed, administration of agonists that interact with these δ-GABAARs prior to alcohol access can abolish binge drinking behavior in male mice. These δ-GABAARs have also been shown to exhibit estrous-dependent plasticity in regions relevant to drug taking behavior, like the hippocampus and periaqueductal gray. The present experiments were designed to determine whether the estrous cycle would alter binge drinking, or our ability to modulate this pattern of alcohol use with THIP, an agonist with high selectivity and efficacy at δ-GABAARs. Using the Drinking-in-the-Dark (DID) binge-drinking model, regularly cycling female mice were given 2h of daily access to alcohol (20%v/v). Vaginal cytology or vaginal impedance was assessed after drinking sessions to track estrous status. There was no fluctuation in binge drinking associated with the estrous cycle. Both Intra-posterior-VTA administration of THIP and systemic administration of the drug was also associated with an estrous cycle dependent reduction in drinking behavior. Pre-treatment with finasteride to inhibit synthesis of 5α-reduced neurosteroids did not disrupt THIP's effects. Analysis of δ-subunit mRNA from posterior-VTA enriched tissue samples revealed that expression of this GABAA receptor subunit is elevated during diestrus in this region. Taken together, these studies demonstrate that δGABAARs in the VTA are an important target for binge drinking in females and confirm that the estrous cycle is an important moderator of the pharmacology of this GABAA receptor subtype