Antipoetika Ivane Sajko: Što ludilo, revolucija i pisanje imaju zajedničko?

Ivana Sajko is a young Croatian author (1975) whose theatre work is ascribed by contemporary anthologists to the so-called new Croatian drama (Rafolt 9). Leo Rafolt observes that, if such a notion can be recognized at all, its main features would include the authors’ experimental and destructive attitude towards conventional modes, as well as an increasing thematic occurrence of violence in written texts and on stage (9), thus making the new Croatian drama similar to the in-yer-face dramaturgy. The paper provides an overview of ideas which seem to prevail throughout Ivana Sajko’s theoretical and dramatic work, some of which represent an original and very personal approach to theatre and playwriting. In addition to this, the analysis of Sajko’s trilogy Archetype: Medea, Bomb-Woman, Europe in this paper will show Sajko’s perception and understanding of madness, revolution and limits of art, more precisely, writing through the female characters in these three monodramas

'Integration without transparency'? Reliance on the space to think in the European Council and Council

To justify the limited publicity of their sessions, members of the European Council and Council regularly argue that they require a 'space to think'. This article analyses the relative success of the plea for this 'space to think' in both legislative (Council) and non-legislative (European Council and Council) modes of decision-making. We consider the concept of the 'space to think' as well as the manner in which it is integrated into the theories of new intergovernmentalism and intergovernmental union. We then analyse how the European Council and Council have developed the 'space to think' in their daily practices. We find that, while the limited progress of transparency lends partial support to the new intergovernmentalism and intergovernmental union, the drivers underpinning the 'space to think' are not limited to non-legislative decision-making but are also increasingly found in the legislative procedure

Functional Assessment as Strategy Assessment for Teaching Academics

Functional assessment of aggressive, aberrant, and challenging behavior has dominated the literature with relatively little attention given to the potential utility of functional assessment in academics. The purpose of this article is to advocate functional strategy assessment as a procedure for acquiring data to support the formulation of intervention hypotheses by school-based personnel with the aim of improving the academic performance of students with emotional and behavioral disorders. A functional strategy assessment model is presented, and two case illustrations are employed to demonstrate the feasibility of this assessment model for use by practitioners. Examples of both an individual and small group functional strategy assessment techniques are proffered as well as tips to the teacher-diagnostician

Mobility Patterns and Lifestyles in Vienna – Case Study Liesing

The aim of the study is to understand the linkages between housing form, mobility patterns and lifestyle with focus on leisure activities, using the example of Vienna/Liesing. We analyse how mobility behaviour of daily and leisure activities is linked to mobility and leisure orientations as well as the availability of local recreational facilities, private or semi-private green spaces in the neighbourhood. The study shows that the general mobility orientations of residents in the district of Liesing to some degree contradict the reality of their daily transportation. It seems that in the case of trips to work and training the factors location, accessibility and travel time have more influence on mode choice than the factor lifestyle or mobility orientation. For leisure trips the correlation of lifestyle or housing form with mode choice becomes more important and overlays and stratifies the influence of locational factors

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DNA Double-Strand Breakage as an Endpoint to Examine Metal and Radionuclide Exposure Effects to Water Snakes on a Nuclear Industrial Site

This study examined metal levels (especially U and Ni) in the tail tissues of water snakes from contaminated (Tim’s Branch) and reference areas on the Department of Energy’s Savannah River Site (SRS). Home ranges of snakes were quantified to determine the ratio of the habitat that they use in relation to the contaminated areas to better estimate exposure Compared to conventional methods that do not. The exposure assessment indicated that water snakes in the contaminated areas could expect U exposure at 3–4 orders of magnitude greater than the Agency for Toxic Substances and Disease Registry’sMinimum Risk Level (MRL) from ingestion of amphibians and fish. Ni and U, in addition to Se, Mn, and Cu, were related to increased DNA double-strand breakage (DDSB) in water snakes.We report burdens for each metal individually, but the results of the DDSB indicated that these metals did not behave independently, but as a suite. If we did not have a secondary endpoint (DDSB), we might have assumed from the exposure predictions and tissue burden analyses that U was the sole metal of concern to water snakes in Tim’s Branch. These data also imply that these toxicants do not biomagnify at the spatial and temporal scale of this study

TRANSFORM – Governing the Smart City by Projects

With the recent ascendance of a sociology of public policy instruments (Le Gales & Lascoumes 2007), particular interest has been devoted towards understanding the emergence of the project as broadly indicative of wider transformations in strategic urban policy making (Pinson 2007, 2009, Beal 2010). Many Smart Cities are governed by research projects, and these are practically marked by an inherent tension. On one hand, the Smart City research project has the purpose of shaping consensus around acceptable “smart” urban futures, instituting new pluralist political spaces, in which scientific targets are always practically reversible if they do not fit consensus. On the other, the Smart city research project aims to scientifically evaluate what “right” choices have to be made to lead the city towards effective Smart City development in line with supranational targets and climate wisdoms. How can the Smart City research project shape consensus among a multiplicity of institutions, actors and groups while not compromising the scientific validity of the set targets and strategies? Drawing on the experiences of the project TRANSFORM in monitoring and shaping the transition strategies of six European cities, the aim of this paper is to elucidate some of the logics of strategic urban policy processes in their peculiar pathways towards the Smart City. In the course of the paper we would like to show how some of the tensions inherent in the role of Smart city research projects are practically addressed in the local framework of the project TRANSFORM and give a first tentative evaluation whether this has been successful so far. In the context of stagnant growth prospects and increased territorial competition, the urban project has become a primary vehicle for the promotion of local development. Newly build urban districts, such as Hamburg Hafencity or Aspern Seestadt in Vienna, mega events like the London Olympics, large scale revamps of urban public spaces such as the pedestrianization of Times Square, or the proliferation of cultural venues from the London Megadome to the old butcheries of Casablanca are prominent examples for the spread of the project form in urban policy making. Yet, while the urban project has become a preferred instrument of contemporary urban policy, it cannot be conceived of as a mere effect of the strategies it is embedded in but should be seen as a marker of the very advent of a project-based polis (Boltansky 1999) in which urban governance assumes the logic of the project itself. As has been argued elsewhere((Pinson 2005;2006; Brake 2000) it is a form of metropolitan governance whose primary purpose it is to shape consenus to scientificically elaborated urban development goals by substantively linking urban strategy and its implementation through the social mobilization of different actor constellations, thereby flexibly adjusting the strategic environment to changing external and internal circumstances, and monitoring the actions of local actors and their interests where they are generally segregated. Smart Cities are governed by research projects, and these are marked by an inherent tension. On one hand, the Smart City research project has the purpose of shaping consensus around an acceptable “smart” urban future instituting new pluralist political spaces, in which scientific targets are always practically reversible if they do not fit consensus. On the other, the Smart city research project aims to scientifically evaluate what “right” choices have to be made to lead the city towards effective Smart City development in line with supranational targets and climate wisdoms. How can the Smart City research project shape consensus among a multiplicity of institutions, actors and groups while not compromising the scientific validity of the set targets and strategies? Drawing on the experiences of the project TRANSFORM in monitoring and shaping the low-carbon transfromation strategies of six European cities, the aim of this paper is to elucidate some of the logics of strategic urban policy processes in their peculiar pathways towards the Smart City. Drawing on the experiences from the TRANSFORM cities in general and particularly from Vienna in formulating and experimenting their Smart City strategy, we would like to show how some of the tensions inherent in the role of Smart city research projects are practically addressed in the framework of the project TRANSFORM. In the first part we will provide a general theoretical background to the sociological analysis of the urban project, with particular focus on the challenges on the governance of local climate affairs. In the second part, we shall illustrate this by looking at the TRANSFORM project, first form a European perspective, then from the viewpoint of Vienna

Clinical, histopathological, and molecular features of mucosa-associated lymphoid tissue (MALT) lymphoma carrying the t(X;14) (p11;q32)/GPR34-immunoglobulin heavy chain gene

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De novo design of bioactive protein switches.

Allosteric regulation of protein function is widespread in biology, but is challenging for de novo protein design as it requires the explicit design of multiple states with comparable free energies. Here we explore the possibility of designing switchable protein systems de novo, through the modulation of competing inter- and intramolecular interactions. We design a static, five-helix 'cage' with a single interface that can interact either intramolecularly with a terminal 'latch' helix or intermolecularly with a peptide 'key'. Encoded on the latch are functional motifs for binding, degradation or nuclear export that function only when the key displaces the latch from the cage. We describe orthogonal cage-key systems that function in vitro, in yeast and in mammalian cells with up to 40-fold activation of function by key. The ability to design switchable protein functions that are controlled by induced conformational change is a milestone for de novo protein design, and opens up new avenues for synthetic biology and cell engineering

Meta-Analysis Reveals Challenges and Gaps for Genome-to-Phenome Research Underpinning Plant Drought Response

Severe drought conditions and extreme weather events are increasing worldwide with climate change, threatening the persistence of native plant communities and ecosystems. Many studies have investigated the genomic basis of plant responses to drought. However, the extent of this research throughout the plant kingdom is unclear, particularly among species critical for the sustainability of natural ecosystems. This study aimed to broaden our understanding of genome-to-phenome (G2P) connections in drought-stressed plants and identify focal taxa for future research. Bioinformatics pipelines were developed to mine and link information from databases and abstracts from 7730 publications. This approach identified 1634 genes involved in drought responses among 497 plant taxa. Most (83.30%) of these species have been classified for human use, and most G2P interactions have been described within model organisms or crop species. Our analysis identifies several gaps in G2P research literature and database connectivity, with 21% of abstracts being linked to gene and taxonomy data in NCBI. Abstract text mining was more successful at identifying potential G2P pathways, with 34% of abstracts containing gene, taxa, and phenotype information. Expanding G2P studies to include non-model plants, especially those that are adapted to drought stress, will help advance our understanding of drought responsive G2P pathways