Bridging The CPA Exam Gap: Do Internships Matter?

In this paper we consider whether experience gained on the job through an internship results in knowledge that can help with passing the CPA exam. It would seem that a candidate for the CPA exam would be better prepared if they had the combination of education and practical experience. We examine the CPA exam performance of 72 graduate students that completed a public accounting internship prior to sitting for the CPA exam compared to 98 graduate students that did not complete an internship in public accounting. Our analysis indicates that on average students completing internships score higher on all parts of the CPA exam. In addition, on average, students completing internships had a higher overall pass rate for each section of the exam, with the pass rate for the Regulation (REG) section being significantly higher for students that have completed internships; we also find that on average students with internships pass 2 sections of the exam prior to graduation as compared to 1.69 for students that have not completed internships

The Use of Professional Seminars to Prepare Future Faculty for Teaching Basic Communication Courses

We focus in this essay on three substantive accomplishments of professional seminars that merit attention because of their ramifications for how we teach and learn in basic communication courses: (1) accomplishing teaching, research, and service as inter-related scholarly acts, (2) interlacing stories of our discipline with stories of learners’ lives, and (3) providing institutionalized support for teaching and learning. Additionally, we offer example reading lists and assignment sheets (see Appendices A, B, and C) in hopes that such resources might prove useful for other graduate programs committed to holistic preparation for students entering the academy

ATP synthase deficiency due to TMEM70 mutation leads to ultrastructural mitochondrial degeneration and is amenable to treatment.

TMEM70 is involved in the biogenesis of mitochondrial ATP synthase and mutations in the TMEM70 gene impair oxidative phosphorylation. Herein, we report on pathology and treatment of ATP synthase deficiency in four siblings. A consanguineous family of Roma (Gipsy) ethnic origin gave birth to 6 children of which 4 were affected presenting with dysmorphic features, failure to thrive, cardiomyopathy, metabolic crises, and 3-methylglutaconic aciduria as clinical symptoms. Genetic testing revealed a homozygous mutation (c.317-2A>G) in the TMEM70 gene. While light microscopy was unremarkable, ultrastructural investigation of muscle tissue revealed accumulation of swollen degenerated mitochondria with lipid crystalloid inclusions, cristae aggregation, and exocytosis of mitochondrial material. Biochemical analysis of mitochondrial complexes showed an almost complete ATP synthase deficiency. Despite harbouring the same mutation, the clinical outcome in the four siblings was different. Two children died within 60 h after birth; the other two had recurrent life-threatening metabolic crises but were successfully managed with supplementation of anaplerotic amino acids, lipids, and symptomatic treatment during metabolic crisis. In summary, TMEM70 mutations can cause distinct ultrastructural mitochondrial degeneration and almost complete deficiency of ATP synthase but are still amenable to treatment

DNA methylation-based classification of central nervous system tumours.

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology

Epithelial Ovarian Cancer

Epithelial ovarian cancer generally presents at an advanced stage and is the most common cause of gynaecological cancer death. Treatment requires expert multidisciplinary care. Population-based screening has been ineffective, but new approaches for early diagnosis and prevention that leverage molecular genomics are in development. Initial therapy includes surgery and adjuvant therapy. Epithelial ovarian cancer is composed of distinct histological subtypes with unique genomic characteristics, which are improving the precision and effectiveness of therapy, allowing discovery of predictors of response such as mutations in breast cancer susceptibility genes BRCA1 and BRCA2, and homologous recombination deficiency for DNA damage response pathway inhibitors or resistance (cyclin E1). Rapidly evolving techniques to measure genomic changes in tumour and blood allow for assessment of sensitivity and emergence of resistance to therapy, and might be accurate indicators of residual disease. Recurrence is usually incurable, and patient symptom control and quality of life are key considerations at this stage. Treatments for recurrence have to be designed from a patient's perspective and incorporate meaningful measures of benefit. Urgent progress is needed to develop evidence and consensus-based treatment guidelines for each subgroup, and requires close international cooperation in conducting clinical trials through academic research groups such as the Gynecologic Cancer Intergroup.status: publishe

La psicoterapia como proceso reconstructivo: implicaciones de las teorías integrativas para la investigación de resultados

Psychotherapy outcome research has failed to find consistent differences in effectiveness between differing approaches to therapy. This paper discusses the application of constructivist metatheory to psychotherapy research as a potential solution to this impasse. The lack of a coherent theoretical framework has limited previous research, resulting in poorly defined and conceptually indistinct comparison groups. Although Frank's (1982) common factors hypothesis provides a potential explanation for the effectiveness of divergent treatment approaches, it does not provide the comprehensive description of human change processes necessary to predict factors that may increase therapeutic effectiveness. Personal construct (Kelly, 1955) and compatible constructivist theories provide a more comprehensive heuristic framework that not only accounts for the effectiveness of divergent approaches but also suggests potential strategies for maximizing their effectiveness.La investigación de resultados en psicoterapia no ha conseguido encontrar diferencias consistentes entre la efectividad de diferentes enfoques terapéuticos. En este artículo se propone la aplicación de la metateoría constructivista a la investigación psicoterapéutica como posible salida ante este impasse. La falta de un marco teórico de referencia coherente ha limitado la investigación, dando lugar a grupos de comparación mal definidos y conceptualmente indistinguibles. A pesar de que la hipótesis de los factores comunes de Frank (1982) aporta una explicación potencial a la efectividad de enfoques de tratamiento divergentes, no facilita la descripción comprehensiva de los procesos de cambio humano necesaria para predecir los factores que pudieran incrementar la efectividad terapéutica. La teoría de constructos personales (Kelly, 1955) y otros enfoques constructivistas compatibles con ella, aportan un marco de referencia heurístico más com¬prehensivo que no sólo da cuenta de la efectividad de diferentes enfoques, sino que también sugiere estrategias potenciales para maximizar tal efectividad