199 research outputs found
La planificación estratégica y su relación con el desempeño docente en la I.E. Mixto Independencia, 2018
Analiza la vinculación entre variable “planificación estratégica y desempeño docente”, corresponde a una investigación básica, descriptiva correlacional, se utilizó muestra de 55 docentes para el tratamiento estadístico. los cuestionarios para recoger la información y para la fiabilidad el Alfa de Cronbach, resultando los instrumentos de muy buena aplicabilidad. se empleó software SPSS para el tratamiento estadístico. Entre planificación estratégica y desempeño docente se halló Rho = 0,788, buena, la correlación manifiesta entre a veces y siempre, en cuanto a la planeación curricular, resultó Rho = 0,746 buena, recomendando la mejora en planificar el currículo. En relación a gestionar los aprendizajes resultó rho = 0,760 buena, en los aprendizajes los actores educativos deben involucrase. En cuanto a sistemas de evaluación, el resultado fue rho = 0,674 buena, encontrándose a nivel intermedio referente las formas adecuadas para evaluar de parte del docente. Es importante el planeamiento como medida previa en el presente estudio cuya finalidad es incrementar el aprendizaje de los estudiantes
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In Situ Hybridization Assay-Based Small-Molecule Screening in Zebrafish
In vitro biochemical and cell-based small molecule screens have been widely used to identify compounds that target specific signaling pathways. But the identified compounds frequently fail at the animal testing stage, largely due to the in vivo absorption, metabolism and toxicity of chemicals. Zebrafish has recently emerged as a vertebrate whole organism model for small molecule screening. The in vivo bioactivity and specificity of compounds are examined from the very beginning of zebrafish screens. In addition, zebrafish is suitable for chemical screens at a large scale similar to cellular assays. This protocol describes an approach for in situ hybridization (ISH)-based chemical screening in zebrafish, which, in principle, can be used to screen any gene product. The described protocol has been used to identify small molecules affecting specific molecular pathways and biological processes. It can also be adapted to zebrafish screens with different readouts.Stem Cell and Regenerative Biolog
Síndrome de burnout y su influencia en la satisfacción laboral del personal sanitario de un hospital público de Cajamarca - Perú
Objetivo. Determinar la influencia del Síndrome de Burnout (SB) en la satisfacción laboral (SL) del personal sanitario de un hospital público en Cajamarca, Perú. Métodos. Se realizó un diseño transversal analítico. La población fueron trabajadores asistenciales sin restricción de edad y sexo. La recolección se hizo en el abril del 2023. La satisfacción laboral se midió mediante el cuestionario “Escala de Satisfacción Laboral” y el síndrome de Burnout mediante el “MBI-Human Services Survey (MBI-HSS)”. Se halló la asociación mediante el cálculo de la razón de prevalencia por medio de un análisis de regresión multivariado. Resultados. Se incluyeron a 132 sujetos, donde el 53% tenía menos 40 años y 7 de cada 10 eran mujeres. El 64 % era personal de enfermería entre técnicos y profesionales y de 3 de cada 4 tenían menos 5 años de trabajo. Del total de la muestra, el 49% presentó SB y el 31.8% presentó mala SL. La prevalencia de mala satisfacción laboral fue del 21.9% en aquellos con SB y del 41.2% entre aquellos que no presentaron SB (p=0.017). En el análisis multivariado la presencia de SB se asocia a una menor prevalencia de mala satisfacción laboral, disminuyendo en un 52% ajustado a edad y sexo (RP 0.48; IC95%; 0.29. a 0.81; p=0.006). Conclusión. En esta población, la presencia del Síndrome de Burnout se asocia a una menor prevalencia de la mala satisfacción laboral. Ser una población joven y de poco tiempo laboral podría interferir en la asociación. Se requieren estudios prospectivos para confirmar esta relación en poblaciones similares
Identification of Novel F2-Isoprostane Metabolites by Specific UDP-Glucuronosyltransferases
UDP-glucuronosyltransferases (UGTs) catalyze the conjugation of glucuronic acid with endogenous and exogenous lipophilic small molecules to facilitate their inactivation and excretion from the body. This represents approximately 35 % of all phase II metabolic transformations. Fatty acids and their oxidized eicosanoid derivatives can be metabolized by UGTs. F2-isoprostanes (F2-IsoPs) are eicosanoids formed from the free radical oxidation of arachidonic acid. These molecules are potent vasoconstrictors and are widely used as biomarkers of endogenous oxidative damage. An increasing body of evidence demonstrates the efficacy of measuring the β-oxidation metabolites of F2-IsoPs rather than the unmetabolized F2-IsoPs to quantify oxidative damage in certain settings. Yet, the metabolism of F2-IsoPs is incompletely understood. This study sought to identify and characterize novel phase II metabolites of 15-F2t-IsoP and 5-epi-5-F2t-IsoP, two abundantly produced F2-IsoPs, in human liver microsomes (HLM). Utilizing liquid chromatography-mass spectrometry, we demonstrated that glucuronide conjugates are the major metabolites of these F2-IsoPs in HLM. Further, we showed that these molecules are metabolized by specific UGT isoforms. 15-F2t-IsoP is metabolized by UGT1A3, 1A9, and 2B7, while 5-epi-5-F2t-IsoP is metabolized by UGT1A7, 1A9, and 2B7. We identified, for the first time, the formation of intact glucuronide F2-IsoPs in human urine and showed that F2-IsoP glucuronidation is reduced in people supplemented with eicosapentaenoic and docosahexaenoic acids for 12 weeks. These studies demonstrate that endogenous F2-IsoP levels can be modified by factors other than redox mechanisms
In Situ Fe and S isotope analyses in pyrite from the 3.2 Ga Mendon Formation (Barberton Greenstone Belt, South Africa): Evidence for early microbial iron reduction
International audienceOn the basis of phylogenetic studies and laboratory cultures, it has been proposed that the ability of microbes to metabolize iron has emerged prior to the Archaea/ Bacteria split. However, no unambiguous geochemical data supporting this claim have been put forward in rocks older than 2.7-2.5 giga years (Gyr). In the present work, we report in situ Fe and S isotope composition of pyrite from 3.28-to 3.26-Gyr-old cherts from the upper Mendon Formation, South Africa. We identified three populations of microscopic pyrites showing a wide range of Fe isotope compositions, which cluster around two δ 56 Fe values of −1.8‰ and +1‰. These three pyrite groups can also be distinguished based on the pyrite crystallinity and the S isotope mass-independent signatures. One pyrite group displays poorly crystallized pyrite minerals with positive Δ 33 S values > +3‰, while the other groups display more variable and closer to 0‰ Δ 33 S values with recrystallized pyrite rims. It is worth to note that all the pyrite groups display positive Δ 33 S values in the pyrite core and similar trace element compositions
The role, readiness to change and training needs of the Athlete Health and Performance team members to safeguard athletes from interpersonal violence in sport: a mini review
Safeguarding athletes from interpersonal violence (IV) in sport is an important topic of concern. Athlete Health and Performance (AHP) team members working with athletes have a professional, ethical, and moral duty to protect the health of athletes, prevent IV, and intervene when it occurs. However, little is known on their respective roles regarding IV in sport and their needs to fulfill their responsibility of safeguarding athletes. The aim of this review is to synthesize knowledge about the roles, readiness to change and training needs of AHP team members to navigate IV in sport. A total of 43 articles are included in the review. Results show that all AHP team members have a role to play in safeguarding athletes and should therefore be trained in the area of IV in sport. Overall, very little research has directly assessed AHP team members' needs to positively foster safety and eliminate IV in sport. There are common training needs for all types of AHP team members such as the ability to recognize signs and symptoms of IV in sport. However, there are also specific needs based on the role of the AHP team members such as ways of facilitating behavioural change for sport managers. Findings from this review are mostly experts' recommendations and should therefore be interpreted as such. The results of the review can guide the development of future research and recommendations
Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
Scope: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results: A case-control study nested in the prospective Three-City study includes participants aged &65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gen- der, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap-enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE-ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross-validated Area Under the Receiver Operating Curve = 75% [95% CI 70-80%] compared to 62% [95% CI 56-67%]. Conclusions: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging
Assessing the Quality of Decision Support Technologies Using the International Patient Decision Aid Standards instrument (IPDASi)
Objectives
To describe the development, validation and inter-rater reliability of an instrument to measure the quality of patient decision support technologies (decision aids).
Design
Scale development study, involving construct, item and scale development, validation and reliability testing.
Setting
There has been increasing use of decision support technologies – adjuncts to the discussions clinicians have with patients about difficult decisions. A global interest in developing these interventions exists among both for-profit and not-for-profit organisations. It is therefore essential to have internationally accepted standards to assess the quality of their development, process, content, potential bias and method of field testing and evaluation.
Methods
Scale development study, involving construct, item and scale development, validation and reliability testing.
Participants
Twenty-five researcher-members of the International Patient Decision Aid Standards Collaboration worked together to develop the instrument (IPDASi). In the fourth Stage (reliability study), eight raters assessed thirty randomly selected decision support technologies.
Results
IPDASi measures quality in 10 dimensions, using 47 items, and provides an overall quality score (scaled from 0 to 100) for each intervention. Overall IPDASi scores ranged from 33 to 82 across the decision support technologies sampled (n = 30), enabling discrimination. The inter-rater intraclass correlation for the overall quality score was 0.80. Correlations of dimension scores with the overall score were all positive (0.31 to 0.68). Cronbach's alpha values for the 8 raters ranged from 0.72 to 0.93. Cronbach's alphas based on the dimension means ranged from 0.50 to 0.81, indicating that the dimensions, although well correlated, measure different aspects of decision support technology quality. A short version (19 items) was also developed that had very similar mean scores to IPDASi and high correlation between short score and overall score 0.87 (CI 0.79 to 0.92).
Conclusions
This work demonstrates that IPDASi has the ability to assess the quality of decision support technologies. The existing IPDASi provides an assessment of the quality of a DST's components and will be used as a tool to provide formative advice to DSTs developers and summative assessments for those who want to compare their tools against an existing benchmark
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