Increase housing provision of citizens as a priority direction of social and economic development of the region

Set out the results of the study provide citizens with housing as a priority direction of social and economic development of the market; showed the causes of low housing provision of citizens of the Belgorod region, made conclusions and identified measures to increase housing provision in the cities of RussiayesBelgorod State National Research Universit

The Challenge of Machine Learning in Space Weather Nowcasting and Forecasting

The numerous recent breakthroughs in machine learning (ML) make imperative to carefully ponder how the scientific community can benefit from a technology that, although not necessarily new, is today living its golden age. This Grand Challenge review paper is focused on the present and future role of machine learning in space weather. The purpose is twofold. On one hand, we will discuss previous works that use ML for space weather forecasting, focusing in particular on the few areas that have seen most activity: the forecasting of geomagnetic indices, of relativistic electrons at geosynchronous orbits, of solar flares occurrence, of coronal mass ejection propagation time, and of solar wind speed. On the other hand, this paper serves as a gentle introduction to the field of machine learning tailored to the space weather community and as a pointer to a number of open challenges that we believe the community should undertake in the next decade. The recurring themes throughout the review are the need to shift our forecasting paradigm to a probabilistic approach focused on the reliable assessment of uncertainties, and the combination of physics-based and machine learning approaches, known as gray-box.Comment: under revie

Genetic variability and structure of SNP haplotypes in the DMPK gene in Yakuts and other ethnic groups of northern Eurasia in relation to myotonic dystrophy

The genetic variability of the DMPK locus has been studied in relation to six SNP markers (rs2070736, rs572634, rs1799894, rs527221, rs915915, and rs10415988) in Yakuts with myotonic dystrophy (MD) in the Yakut population and in populations of northern Eurasia. Significant differences were observed in the allele frequencies between patients and a population sample of Yakuts for three SNP loci (rs915915, rs1799894, and rs0415988) associated with a high chance of disease manifestation. The odds ratios (OR) of MD development in representatives of the Yakut population for these three loci were 2.59 (95% CI, p = 0,004), 4.99 (95% CI, p = 0.000), and 3.15 (95% CI, p = 0.01), respectively. Haplotype TTTCTC, which is associated with MD, and haplotype GTCCTT, which was observed only in Yakut MD patients (never in MD patients of non-Yakut origin), were revealed. A low level of variability in the locus of DMRK gene in Yakuts (He = 0.283) compared with other examined populations was noted. An analysis of pairwise genetic relationships between populations revealed their significant differentiation for all the examined loci. In addition, a low level of differentiation in territorial groups of Yakut populations (FST = 0.79%), which was related to the high subdivision of the northern Eurasian population (FST = 11.83%), was observed

A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles

AbstractHepatitis B virus-like particles, icosahedral structures formed by multiple core protein dimers, are promising immune-enhancing vaccine carriers for foreign antigens. Insertions into the surface-exposed immunodominant loop are especially immunogenic. However, the need to conserve the particulate structure to ensure high immunogenicity imposes restraints on the nature of the heterologous sequence that can be inserted. We propose a new approach to constructing HBc particles linked to the target epitopes that relies on non-covalent interactions between the epitope and pre-assembled unmodified HBc particles. Interaction was enabled by fusion of the epitope to the GSLLGRMKGA peptide, binding to the spike tips. This peptide may be used as a “binding tag” allowing in vitro construction of HBc particles carrying the target peptide. Such virus-like particles carrying multiple copies of the extracellular domain of the M2 protein of different influenza strains appeared to be highly immunogenic and protected immunised mice against a lethal influenza challenge

Психологическая реабилитация онкологических больных: от истоков к современности

Cancer patients may suffer from severe distress that results in low mood, lack of energy and fatigue, and reduces the effectiveness of treatment. For a favorable outcome, they need rehabilitation to help them cope with the psychological effects of cancer. A psycho-oncologist is a specialist who provides psychological support and care for cancer patients and their relatives.The first studies demonstrating the efficacy of psychotherapy and rehabilitation in cancer patients were conducted in the last third of the 20th century both in Russia and overseas. Nowadays, available techniques used all over the world include cognitive behavioral therapy, art therapy, and creative visualization.Онкологические больные испытывают тяжелый дистресс, который снижает настроение, отнимает необходимую энергию и силу, снижает эффективность лечения. Для достижения благоприятного исхода заболевания необходима реабилитация, направленная на преодоление психологических последствий болезни. Психологическую помощь и поддержку онкологическим больным и их родственникам оказывает онкопсихолог.Первые исследования в нашей стране и за рубежом, демонстрирующие эффективность психотерапевтических методов в реабилитации онкологических больных, появились в последней трети XX века. В настоящее время во всем мире используются когнитивно-поведенческие методы психотерапии, арт-терапия, креативная визуализация

ЕФЕКТИВНІСТЬ ПЛАСТИНЧАТИХ ТЕПЛОУТИЛІЗАТОРІВ ТЕПЛОУТИЛІЗАЦІЙНИХ СИСТЕМ

The development and application of modern integrated methods for studying the efficiency of heat recovery systems and their individual elements enables ensuring their maximum efficiency. These methods are based on a combination of methods of exergic analysis with statistical methods of experiment planning, methods of the theory of linear systems, thermodynamics of irreversible processes, etc. A method is developed for calculating the losses of exergic power in heat conduction processes for a gas-air plate heat exchanger. Losses of exergic power occur when heat is transferred through the cross-section of the heat recovery plate. The methodology is based on a complex approach combining exergy methods with methods of thermodynamics of irreversible processes. The mathematical model of the investigated processes includes the exergy equation, the balance equation of exergy and entropy, the equation of continuity, the equation of phase motion, the energy equation, the balance equation for enthalpies, the Gibbs equation and the heat equation for boundary conditions of the third kind for an unbounded plate. A plate of a gas-air plate heat exchanger was modelled as an unlimited plate thickness. When obtaining formulas for calculating the losses of exergic power, the local differential equation of the exergy balance obtained earlier was used. In this equation, one of the terms determines the losses of exergy power, which are caused by the irreversibility of the processes. Such losses are related to thermal conductivity, phase viscosity, phase-to-phase heat transfer and friction between phases. On the basis of this equation and the solution of the heat equation under boundary conditions of the third kind, formulas are obtained for calculating the losses of exergy power. Calculations of total losses of exergic power in a gas-air plate heat exchanger and losses of exergic power in heat conduction processes under various operating conditions of the boiler are performed. It is established that losses of exergic power in heat conduction processes in a gas-air plate heat exchanger make up 8.6-11.6 % of the total losses of exergy power and depend on the operating mode of the boiler. Changing in the necessary direction the thermophysical characteristics of the gas-air plate heat exchanger, it is possible to reduce the loss of exergy power.Розроблено методику розрахунку втрат ексергетичної потужності у процесах теплопровідності під час передачі теплоти через поперечний переріз пластини газоповітряного пластинчастого теплоутилізатора за граничних умов третього роду. Методику засновано на комплексному підході, що поєднує ексергетичні методи з методами термодинаміки незворотних процесів. Математична модель досліджуваних процесів включає рівняння ексергії, рівняння балансу ексергії та ентропії, рівняння нерозривності трифазної термодинамічної системи при зміні концентрації однієї з фаз, рівняння руху фаз, рівняння енергій, рівняння балансу ентальпій, рівняння Гіббса і рівняння теплопровідності за граничних умов третього роду. Для отримання формул для розрахунку втрат ексергетичної потужності використано локальне диференціальне рівняння балансу ексергії. У цьому рівнянні одна зі складових визначає втрати ексергетичної потужності, зумовлені незворотністю процесів і пов'язані з теплопровідністю, в'язкістю фаз, міжфазним теплообміном і тертям між фазами. На підставі цього рівняння і рішення рівняння теплопровідності за граничних умов третього роду для необмеженої пластини, якою моделювалася пластина газоповітряного пластинчастого теплоутилізатора, отримано формули для розрахунку втрат ексергетичної потужності. Виконано розрахунки загальних втрат ексергетичної потужності в газоповітряному пластинчастому теплоутилізаторі за різних режимів роботи котла і втрат ексергетичної потужності у процесах теплопровідності. Встановлено, що втрати ексергетичної потужності у процесах теплопровідності в газоповітряному пластинчатому теплоутилізаторі становлять 8,6-11,6 % від загальних втрат ексергетичної потужності і залежать від режиму роботи котла

Low-temperature spin relaxation in n-type GaAs

Low-temperature electron spin relaxation is studied by the optical orientation method in bulk n-GaAs with donor concentrations from 10^14 cm^{-3} to 5x10^17 cm^{-3}. A peculiarity related to the metal-to-insulator transition (MIT) is observed in the dependence of the spin lifetime on doping near n_D = 2x10^16 cm^{-3}. In the metallic phase, spin relaxation is governed by the Dyakonov-Perel mechanism, while in the insulator phase it is due to anisotropic exchange interaction and hyperfine interactio

Kinetic-scale magnetic turbulence and finite Larmor radius effects at Mercury

We use a nonstationary generalization of the higher-order structure function technique to investigate statistical properties of the magnetic field fluctuations recorded by MESSENGER spacecraft during its first flyby (01/14/2008) through the near Mercury's space environment, with the emphasis on key boundary regions participating in the solar wind -- magnetosphere interaction. Our analysis shows, for the first time, that kinetic-scale fluctuations play a significant role in the Mercury's magnetosphere up to the largest resolvable time scale ~20 s imposed by the signal nonstationarity, suggesting that turbulence at this planet is largely controlled by finite Larmor radius effects. In particular, we report the presence of a highly turbulent and extended foreshock system filled with packets of ULF oscillations, broad-band intermittent fluctuations in the magnetosheath, ion-kinetic turbulence in the central plasma sheet of Mercury's magnetotail, and kinetic-scale fluctuations in the inner current sheet encountered at the outbound (dawn-side) magnetopause. Overall, our measurements indicate that the Hermean magnetosphere, as well as the surrounding region, are strongly affected by non-MHD effects introduced by finite sizes of cyclotron orbits of the constituting ion species. Physical mechanisms of these effects and their potentially critical impact on the structure and dynamics of Mercury's magnetic field remain to be understood.Comment: 46 pages, 5 figures, 2 table