Laboratory simulations of astrophysical jets and solar coronal loops: new results

An experimental program underway at Caltech has produced plasmas where the shape is neither fixed by the vacuum chamber nor fixed by an external coil set, but instead is determined by self-organization. The plasma dynamics is highly reproducible and so can be studied in considerable detail even though the morphology of the plasma is both complex and time-dependent. A surprising result has been the observation that self-collimating MHD-driven plasma jets are ubiquitous and play a fundamental role in the self-organization. The jets can be considered lab-scale simulations of astrophysical jets and in addition are intimately related to solar coronal loops. The jets are driven by the combination of the axial component of the J×B force and the axial pressure gradient resulting from the non-uniform pinch force associated with the flared axial current density. Behavior is consistent with a model showing that collimation results from axial non-uniformity of the jet velocity. In particular, flow stagnation in the jet frame compresses frozen-in azimuthal magnetic flux, squeezes together toroidal magnetic field lines, thereby amplifying the embedded toroidal magnetic field, enhancing the pinch force, and hence causing collimation of the jet

Pentaquark searches at FOCUS

We find no evidence for high-energy photoproduction of pentaquarks at 1540 MeV/$c^2$, 1862 MeV/$c^2$, or 3099 MeV/$c^2$ using decay modes $pK_S^0$, $\Xi^-\pi^-$, and $D^{(*)-}p$, respectively.Comment: Proceedings from talk at 2004 DPF Meeting at University of California, Riversid

Post-Foucauldian governmentality: what does it offer critical social policy analysis?

This article considers the theoretical perspective of post-Foucauldian governmentality, especially the insights and challenges it poses for applied researchers within the critical social policy tradition. The article firstly examines the analytical strengths of this approach to understanding power and rule in contemporary society, before moving on to consider its limitations for social policy. It concludes by arguing that these insights can be retained, and some of the weaknesses overcome, by adopting a ‘realist governmentality’ approach (Stenson 2005, 2008). This advocates combining traditional discursive analysis with more ethnographic methods in order to render visible the concrete activity of governing, and unravel the messiness, complexity and unintended consequences involved in the struggles around subjectivity

Automated validation of genetic variants from large databases: ensuring that variant references refer to the same genomic locations

Summary: Accurate annotations of genomic variants are necessary to achieve full-genome clinical interpretations that are scientifically sound and medically relevant. Many disease associations, especially those reported before the completion of the HGP, are limited in applicability because of potential inconsistencies with our current standards for genomic coordinates, nomenclature and gene structure. In an effort to validate and link variants from the medical genetics literature to an unambiguous reference for each variant, we developed a software pipeline and reviewed 68 641 single amino acid mutations from Online Mendelian Inheritance in Man (OMIM), Human Gene Mutation Database (HGMD) and dbSNP. The frequency of unresolved mutation annotations varied widely among the databases, ranging from 4 to 23%. A taxonomy of primary causes for unresolved mutations was produced

Who are these youths? Language in the service of policy

In the 1990s policy relating to children and young people who offend developed as a result of the interplay of political imperatives and populist demands. The ‘responsibilisation’ of young offenders and the ‘no excuses’ culture of youth justice have been ‘marketed’ through a discourse which evidences linguistic changes. This article focuses on one particular area of policy change, that relating to the prosecutorial decision, to show how particular images of children were both reflected and constructed through a changing selection of words to describe the non-adult suspect and offender. In such minutiae of discourse can be found not only the signifiers of public attitudinal and policy change but also the means by which undesirable policy developments can be challenged

A Model-Based Analysis of GC-Biased Gene Conversion in the Human and Chimpanzee Genomes

GC-biased gene conversion (gBGC) is a recombination-associated process that favors the fixation of G/C alleles over A/T alleles. In mammals, gBGC is hypothesized to contribute to variation in GC content, rapidly evolving sequences, and the fixation of deleterious mutations, but its prevalence and general functional consequences remain poorly understood. gBGC is difficult to incorporate into models of molecular evolution and so far has primarily been studied using summary statistics from genomic comparisons. Here, we introduce a new probabilistic model that captures the joint effects of natural selection and gBGC on nucleotide substitution patterns, while allowing for correlations along the genome in these effects. We implemented our model in a computer program, called phastBias, that can accurately detect gBGC tracts about 1 kilobase or longer in simulated sequence alignments. When applied to real primate genome sequences, phastBias predicts gBGC tracts that cover roughly 0.3% of the human and chimpanzee genomes and account for 1.2% of human-chimpanzee nucleotide differences. These tracts fall in clusters, particularly in subtelomeric regions; they are enriched for recombination hotspots and fast-evolving sequences; and they display an ongoing fixation preference for G and C alleles. They are also significantly enriched for disease-associated polymorphisms, suggesting that they contribute to the fixation of deleterious alleles. The gBGC tracts provide a unique window into historical recombination processes along the human and chimpanzee lineages. They supply additional evidence of long-term conservation of megabase-scale recombination rates accompanied by rapid turnover of hotspots. Together, these findings shed new light on the evolutionary, functional, and disease implications of gBGC. The phastBias program and our predicted tracts are freely available. © 2013 Capra et al

The Effects of COVID-19 Restrictions on College Students Physical Activity and Mental Health

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Injection of Positrons into a Dense Electron Cloud in a Magnetic Dipole Trap

The creation of an electron space charge in a dipole magnetic trap and the subsequent injection of positrons has been experimentally demonstrated. Positrons (5eV) were magnetically guided from their source and injected into the trapping field generated by a permanent magnet (0.6T at the poles) using a cross field E $\times$ B drift, requiring tailored electrostatic and magnetic fields. The electron cloud is created by thermionic emission from a tungsten filament. The maximum space charge potential of the electron cloud reaches -42V, which is consistent with an average electron density of ($4 \pm 2$) $\times 10^{12}$ $\text{m}^{-3}$ and a Debye length of ($2 \pm 1$) $\text{cm}$. We demonstrate that the presence of this space potential does not hamper efficient positron injection. Understanding the effects of the negative space charge on the injection and confinement of positrons represents an important intermediate step towards the production of a confined electron-positron pair plasma