STRAIN DIFFERENCES IN THE EXPRESSION OF THE EPA-1-RESTRICTING ELEMENT

Epa-1-specific cytotoxic T lymphocytes (CTL) lyse epidermal cells (EC) of different Epa-1 + H-2 k strains, such as AKR, CBA, C58, and RF, at different levels. We used an H-2K k -specific monoclonal antibody (mAb) to test the hypothesis that this phenomenon is due to differences in the H-2-restricting element. Initially, we established the specificity of this mAb for the Epa-1-restricting element by demonstrating its capacity to inhibit the lysis of CBA EC by Epa-1-specific CTL. We then used it as the probe in a cellular radioimmunoassay to quantify the expression of the restricting element by EC of different H-2 k strains. We found that C58 and RF EC bound significantly less of the mAb than did CBA EC. Although AKR also bound less of the mAb than did CBA EC, the difference was not statistically significant. To examine the generality of this phenomenon, we quantified the expression of K k antigens on spleen cells (SC) of the same four strains. We found that RF SC, but not AKR or C58 SC, bound significantly less of the K k mAb than did CBA SC. Thus, the differential CTL lysis of Epa-1 + EC of different strains probably reflects differences in expression of the H-2-restricting element rather than of the nominal antigen.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75485/1/j.1744-313X.1987.tb00375.x.pd

Anthropogenic Impacts on Soil Microbial Processes in Coastal Wetlands: Nutrient Loading and Rising CO2 Levels

Atmospheric carbon dioxide (CO2) levels and global eutrophication are anthropogenic stressors impacting the environment of specific interest in wetland systems. Wetlands occupy a critical interface between terrestrial and aquatic environments. Fertilizer use for agriculture and treated wastewater disposal has increased nutrient loading to wetlands. Conflicting results on impacts of nitrogen loading to coastal wetland soils have been reported, though most studies have investigated short-term impacts of nutrient loading, not long-term integrated impacts. I investigated an 11-year period of nutrient loading on soils in an oligohaline coastal wetland. Nitrogen treatments of 0, 50, 200, and 1200 kg ha-1 yr-1 were paired with phosphorus treatments of 0, 131 kg ha-1 yr-1. I measured soil physiochemical characteristics, microbial biomass N (MBN), potentially mineralizable N rates (PMN), and denitrification rates. Total P increased with P additions. There were no significant differences in measures of soil microbial biomass or activity with N or P loading. Results suggest that after bioavailable nutrients are incorporated into the soil matrix, there are no lasting effects on measured microbial activities of these coastal marsh soils. I also investigated the impacts of increased CO2 levels on biogeochemical cycling and associated microbial activity. I conducted a 2-year experiment with CO2 treatment applications of 710 and 410 ppm applied to vegetated and non-vegetated wetland soils. I measured soil physiochemical properties, extracellular enzyme activity, MBN, PMN, and extractable NH4+. Phosphatase activity decreased (p = 0.09) with increased CO2 in the non-vegetated soils. PMN and extractable NH4+ varied significantly with the interaction between vegetation presence and CO2 (p=0.07, p=0.0001). Total P and organic matter content were significantly higher in the vegetated soils (p = 0.05, p=0.06). Higher bioavailable nutrient concentrations in non-vegetated soils under elevated CO2 indicate there is a mechanism to increase microbial activity under elevated CO2 conditions, with implications for carbon sequestration

Sustainable, Intelligent, Arcologic - A Futurist's Vision of Future Buildings

Future buildings are shaped by social, economic and technological forces that are at least partially already in existence. To mention a few: The need for energy efficiency and, more generally, for overall environmental efficiency during the whole life cycle of a building, the rising demands and convenience requirements of occupants, more frequent changes of use with reconstructions, renovations and refurbishments, and rather continuous integration of new information and communication technologies

Assessment of the use of Participatory Integrated Climate Services for Agriculture (PICSA) approach by farmers to manage climate risk in Mali and Senegal

Recently, a new approach to extension and climate information services, namely Participatory Integrated Climate Services for Agriculture (PICSA) has been developed. PICSA makes use of historical climate records,participatory decision-making tools and forecasts to help farmers identify and better plan livelihood options that are suited to local climate features and farmers’ own circumstances. This approach was implemented in 2016 in two sites in Senegal and Mali, with 57 and 47 farmers, respectively. At the end of the growing season, these farmers were surveyed to explore their perceptions on the use of the approach. In Senegal and Mali, respectively 97% and 76% of the respondents found the approach ‘very useful’. The approach enabled farmers to make strategic plans long before the season, based on their improved knowledge of local climate features. Moreover,evidence demonstrates that PICSA stimulated farmers to consider and then implement a range of innovations which included: (i) changes in timing of activities such as sowing dates, (ii) implementing soil and water management practices, (iii) selection of crop varieties, (iv) fertiliser management and (v) adaptation of plans for the season (farm size, etc.) to the actual resources available to them. The study also demonstrated the potential of farmer-to-farmer extension in scaling up the approach, which is of great interest especially in the current context of limited extension services in the West African region

Allograft and Xenograft Acceptance under FK‐506 and Other Immunosuppressant Treatment

We will focus on two issues, both involving, but not confined to FK-506: first, the meaning of the graft acceptance, which is, after all, the objective of immunosuppression for the transplant surgeon; and second, how to take the next great step of xenotransplantation

Sobre a consciência ambiental dos fiéis da Igreja Católica diante da crise ecológica : estudo sobre a percepção e responsabilidade socioambiental de um grupo de praticantes da Igreja

Trabalho de Conclusão de Curso (graduação)—Universidade de Brasília, Faculdade de Planaltina, 2017.Esta pesquisa tem como tema o estudo da consciência ambiental dos fiéis da igreja católica e a abordagem da encíclica Laudato Si sobre o cuidado da casa comum publicada pelo Papa Francisco em 2015. Diante da crise ecológica, é essencial a parceria entre instituições para a promoção da educação ambiental. A encíclica Laudato Si aborda sobre uma nova visão ecológica para os católicos, quebrando o paradigma do domínio do homem sobre a Terra. No entanto, eles entendem que são responsáveis pelo cuidado da criação, conforme suas crenças? O objetivo geral foi analisar se o paradigma do homem dominar a Terra conforme a fé cristã ainda prevalece. Os objetivos específicos pretendiam identificar se os católicos conheciam a encíclica, sua percepção diante dos problemas ambientais e se já participaram de ações de educação ambiental promovidas pela igreja. Por muitos séculos, acreditava-se no paradigma cristão que o homem deveria dominar a Terra e tirar todo o proveito necessário para seu crescimento, baseado na bíblia em Gênesis 1,28, acarretando um dano ambiental imensurável. A igreja católica atualmente rompeu esta concepção, ensinando que o homem deve guardar e cultivar a criação de Deus, conforme está em Gênesis 2,15, e que é responsabilidade do cristão ser um administrador fiel de toda a Terra, onde acredita que tudo foi criado por Deus. A educação ambiental possibilita essa abordagem em diversos segmentos, resultando na difusão da consciência ambiental, inclusive no religioso. A encíclica Laudato Si trouxe para os católicos uma reflexão necessária, abordando diversos assuntos que envolvem os problemas socioambientais. A metodologia utilizada foi pesquisa bibliográfica, pesquisa documental e pesquisa descritiva quantitativa por meio de levantamento de campo através de formulário online. Concluiu-se que todas as hipóteses foram rejeitadas, onde mais da metade dos fiéis pesquisados já ouviram falar da encíclica, acreditam que não são proprietários e nem dominadores da Terra; reconhecem serem responsáveis pelo cuidado do meio ambiente, no qual acreditam terem sido criados por Deus; estão cientes dos problemas ambientais que os cercam; e concordam em discutir meio ambiente e religião juntamente. Sugere-se a contínua difusão da encíclica, promoção de debates abertos com as comunidades locais, mudanças de hábitos ambientais, e criação de grupos de discussão para o desenvolvimento da conversão ecológica e da contemplação de toda a criação.This research studies the environmental conscience of the Catholic Church’s faithful and the approach of the encyclical letter Laudato Si on care for the common home published by Pope Francis in 2015. Faced with the ecological crisis, the partnership between institutions regarding the promotion of environmental education is essential. The Encyclical Laudato Si brought a new ecological vision for Catholics by breaking the paradigm of man's dominion over Earth. But do they understand that they are responsible for the care of creation, according to their beliefs? The general objective of the research was to analyze whether the paradigm of man dominating the Earth according to the Christian faith still prevails. The specific objectives were to identify whether Catholics knew the encyclical, their perception on environmental issues, and if they have already taken part in environmental education actions promoted by the church. For many centuries, it was believed in the Christian paradigm that man should dominate the earth and take full advantage of its growth, based on the bible in Genesis 1.28, resulting in an immeasurable environmental damage. The Catholic Church has broken this conception, preaching that man should keep and nurture the God’s creation, as it is in Genesis 2:15, and that it is the Christian's responsibility to be a faithful steward of the whole Earth, in which they believe that all was created by God. Environmental education enables this approach in several segments resulting in the diffusion of environmental awareness, including the religious one. The encyclical letter Laudato Si brought to the Catholics a necessary reflection, addressing many issues that involve socio-environmental problems. The methodology used was bibliographical, documentary, and quantitative descriptive research through surveys applied online. The research concluded that all the hypotheses have been rejected, where more than half of the faithful surveyed that have heard of the encyclical believe that they are not owners and do not dominate the Earth, recognize that they are responsible for the care of the environment, in which they believe they were created by God, are aware of the environmental problems that surround them and agree to discuss environment and religion together. The research suggests the continuous diffusion of the encyclical, promotion of open discussions with local communities, changes in environmental habits, creation of discussion groups for the development of ecological conversion and contemplation of all creation

Práticas abusivas das operadoras de planos de saúde: teoria, prática, jurisprudência

Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à Lei de Direitos Autorais, não disponibilizamos a obra na íntegra.Localização na estante: 368.382(81) F224p 3.ed

RODOLPHO VON IHERING E A COMISSÃO TÉCNICA DE PISCICULTURA DO NORDESTE: A DESCOBERTA DA TÉCNICA DA HIPOFISAÇÃO NO AÇUDE BODOCONGÓ EM CAMPINA GRANDE-PB (1934-1935)

RESUMOO objetivo deste artigo é discorrer sobre o Zoólogo Rodolpho von Ihering e os estudos realizados pela Comissão Técnica de Piscicultura do Nordeste, da qual foi chefe de 1932 a 1937 e, mais especificamente, sobre o período no qual a Comissão instalou sua sede em Campina Grande- PB, de 1934 a 1935. A Comissão surge como resposta às secas, tendo como principal objetivo amenizar a falta de recursos alimentícios para a população, através da produção de peixes nos açudes da região. Em Campina Grande, o principal açude estudado foi o Bodocongó, local onde o Zoólogo fez sua descoberta de reprodução de peixes pelo método da hipofisação. Primeiramente, discorremos sobre as viagens da Comissão realizadas na Paraíba e em Pernambuco. Posteriormente, fizemos uma breve contextualização histórica de Campina Grande na década de 1930. Por último, falamos sobre a Comissão Técnica de Piscicultura do Nordeste e os motivos de sua instalação em Campina Grande. Pudemos concluir que a vinda da Comissão teve incentivos de uma rede de paraibanos, além de a cidade se encontrar envolvida em um processo de crescimento e urbanização, contribuindo para que a Comissão pudesse desenvolver seus estudos e instalar a sede na cidade. Mas, tendo como principal ponto a proximidade com o açude Bodocongó, por suas condições, para obtenção dos resultados da pesquisa do Dr. Rodolpho e sua equipe. Nesse contexto, percebeu-se que a passagem da Comissão por Campina Grande foi muito produtiva deixando uma contribuição de valor nacional e internacional que é reconhecida e utilizada até hoje.ABSTRACTThe objective of this article is to discuss the Zoologist Rodolpho von Ihering and the studies carried out by the Technical Commission of Pisciculture of the Northeast, from which he headed from 1932 to 1937, and more specifically about the period in which the Commission installed its headquarters in Campina Grande - PB, from 1934 to 1935. The Commission emerges as a response to droughts, with the main objective of assuage the lack of food resources for the population, through the production of fish in the region’s lakes. In Campina Grande, the main reservoir studied was Bodocongó, where the zoologist made his discovery of fish breeding by the hypophysis method. First, we discuss the Commission’s travels in Paraíba and Pernambuco. Later, we made a brief historical contextualization of Campina Grande in the 1930s. Finally, we talk about a Technical Committee on Pisciculture in the Northeast and the reasons for its installation in Campina Grande. We were able to conclude that the Commission arrival had incentives from a network of locals, besides the city was involved in a process of growth and urbanization, contributing for the Commission so it could develop its studies and install a headquarters in the city. But having as main point the proximity to the Bodocongó lake, by its conditions, for results aquisition for the reasearch of Dr. Rodolpho and his team. In this context, it was noticed that the Commission’s presence in Campina Grande had much produtivity leaving a contribution of national and international value that is recognized and used nowdays

Psicanálise e Ciência: problematização da Bioética

O objetivo geral do artigo promover, seno iniciar, uma discusso sobre os obstculos e impasses conceituais que podem colocar em xeque a j consagrada legitimidade da Biotica em nossos dias. No mbito de seu enunciado, a Biotica definida como um saber que visa a determinar os riscos e os possveis danos que a cincia pode provocar em nossa compreenso da vida e da dignidade tica, medindo e restringindo, assim, os passos que sero dados pelas pesquisas biomdicas e biotecnolgicas. Esse enunciado possibilita a construo do objetivo especfico do artigo, que problematizar os conceitos que sustentam essa definio, a saber: tica, natureza humana e cincia. O trabalho encontra-se dividido em duas partes. Na primeira seo, demonstraremos que as noes de tica e natureza humana presentes no discurso dos bioeticistas contemporneos so falsas e inconsistentes, respectivamente. A tica falsificada nesse discurso quando reduzida a um mero problema de generalizao de valores morais e verdades jurdicas. J a noo de natureza humana inconsistente, uma vez que a definem conceitualmente como uma necessidade que sempre esteve presente no mundo, e no como um conceito historicamente determinado, que, por definio, estaria sempre atrelado s contingncias que tornam qualquer mundo humano possvel. Na segunda seo, apresentaremos o sentido da seguinte tese: a relao que a psicanlise mantm com a cincia de compatibilidade lgica. A partir das consequncias extradas dessa tese, o passo seguinte ser questionar a legitimidade de uma interveno tica no domnio cientfico