245 research outputs found
The Stability Balloon for Two-dimensional Vortex Ripple Patterns
Patterns of vortex ripples form when a sand bed is subjected to an
oscillatory fluid flow. Here we describe experiments on the response of regular
vortex ripple patterns to sudden changes of the driving amplitude a or
frequency f. A sufficient decrease of f leads to a "freezing" of the pattern,
while a sufficient increase of f leads to a supercritical secondary "pearling"
instability. Sufficient changes in the amplitude a lead to subcritical
secondary "doubling" and "bulging" instabilities. Our findings are summarized
in a "stability balloon" for vortex ripple pattern formation.Comment: 4 pages, 5 figure
Coalescence in the 1D Cahn-Hilliard model
We present an approximate analytical solution of the Cahn-Hilliard equation
describing the coalescence during a first order phase transition. We have
identified all the intermediate profiles, stationary solutions of the noiseless
Cahn-Hilliard equation. Using properties of the soliton lattices, periodic
solutions of the Ginzburg-Landau equation, we have construct a family of ansatz
describing continuously the processus of destabilization and period doubling
predicted in Langer's self similar scenario
Dynamical models for sand ripples beneath surface waves
We introduce order parameter models for describing the dynamics of sand
ripple patterns under oscillatory flow. A crucial ingredient of these models is
the mass transport between adjacent ripples, which we obtain from detailed
numerical simulations for a range of ripple sizes. Using this mass transport
function, our models predict the existence of a stable band of wavenumbers
limited by secondary instabilities. Small ripples coarsen in our models and
this process leads to a sharply selected final wavenumber, in agreement with
experimental observations.Comment: 9 pages. Shortened version of previous submissio
Proteomics of canine lymphoma identifies potential cancer-specific protein markers
Purpose: Early diagnosis of cancer is crucial for the success of treatment of the disease, and there is a need for markers whose differential expression between disease and normal tissue could be used as a diagnostic tool. Spontaneously occurring malignancies in pets provide a logical tool for translational research for human oncology. Lymphoma, one of the most common neoplasms in dogs, is similar to human non-Hodgkin's lymphoma and could serve as an experimental model system. Experimental Design: Thirteen lymph nodes from normal dogs and 11 lymph nodes from dogs with B-cell lymphoma were subjected to proteomic analysis using two-dimensional PAGE separation and matrix-assisted laser desorption/ionization time-of-flight analysis. Results: A total of 93 differentially expressed spots was subjected to matrix-assisted laser desorption/ionization time-of-flight tandem mass spectrometry analysis, and several proteins that showed differential expression were identified. Of these, prolidase (proline dipeptidase), triosephosphate isomerase, and glutathione S-transferase were down-regulated in lymphoma samples, whereas macrophage capping protein was up-regulated in the lymphoma samples. Conclusions: These proteins represent potential markers for the diagnosis of lymphoma and should be further investigated in human samples for validation of their utility as diagnostic markers
A particle model of rolling grain ripples under waves
A simple model is presented for the formation of rolling grain ripples on a
flat sand bed by the oscillatory flow generated by a surface wave. An equation
of motion is derived for the individual ripples, seen as "particles", on the
otherwise flat bed. The model account for the initial apperance of the ripples,
the subsequent coarsening of the ripples and the final equilibrium state. The
model is related to physical parameters of the problem, and an analytical
approximation for the equilibrium spacing of the ripples is developed. It is
found that the spacing between the ripples scale with the square-root of the
non-dimensional shear stress (the Shields parameter) on a flat bed. The results
of the model are compared with measurements, and reasonable agreement between
the model and the measurements is demonstrated.Comment: 9 pages incl. figures. Revised versio
A quantum spin transducer based on nano electro-mechancial resonator arrays
Implementation of quantum information processing faces the contradicting
requirements of combining excellent isolation to avoid decoherence with the
ability to control coherent interactions in a many-body quantum system. For
example, spin degrees of freedom of electrons and nuclei provide a good quantum
memory due to their weak magnetic interactions with the environment. However,
for the same reason it is difficult to achieve controlled entanglement of spins
over distances larger than tens of nanometers. Here we propose a universal
realization of a quantum data bus for electronic spin qubits where spins are
coupled to the motion of magnetized mechanical resonators via magnetic field
gradients. Provided that the mechanical system is charged, the magnetic moments
associated with spin qubits can be effectively amplified to enable a coherent
spin-spin coupling over long distances via Coulomb forces. Our approach is
applicable to a wide class of electronic spin qubits which can be localized
near the magnetized tips and can be used for the implementation of hybrid
quantum computing architectures
Merging paleobiology with conservation biology to guide the future of terrestrial ecosystems
Conservation of species and ecosystems is increasingly difficult because anthropogenic impacts are pervasive and accelerating. Under this rapid global change, maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized past states toward facilitating their adaptive and functional capacities, even as species ebb and flow individually. Developing effective strategies under this new paradigm will require deeper understanding of the long-term dynamics that govern ecosystem persistence and reconciliation of conflicts among approaches to conserving historical versus novel ecosystems. Integrating emerging information from conservation biology, paleobiology, and the Earth sciences is an important step forward on the path to success. Maintaining nature in all its aspects will also entail immediately addressing the overarching threats of growing human population, overconsumption, pollution, and climate change.Peer reviewe
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Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins
The clustering of platelet glycoprotein receptors with cytosolic YxxL and YxxM motifs, including GPVI, CLEC-2 and PEAR1, triggers activation via phosphorylation of the conserved tyrosine residues and recruitment of the tandem SH2 (Src homology 2) domain effector proteins, Syk and PI 3-kinase. We have modelled the clustering of these receptors with monovalent, divalent and tetravalent soluble ligands and with transmembrane ligands based on the law of mass action using ordinary differential equations and agent-based modelling. The models were experimentally evaluated in platelets and transfected cell lines using monovalent and multivalent ligands, including novel nanobody-based divalent and tetravalent ligands, by fluorescence correlation spectroscopy. Ligand valency, receptor number, receptor dimerisation, receptor phosphorylation and a cytosolic tandem SH2 domain protein act in synergy to drive receptor clustering. Threshold concentrations of a CLEC-2-blocking antibody and Syk inhibitor act in synergy to block platelet aggregation. This offers a strategy for countering the effect of avidity of multivalent ligands and in limiting off-target effects
Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mice. In the present study, we quantified the changes in collagen-dependent thrombus formation for 38 different strains of (genetically) modified mice, all measured with the same microfluidics chamber. The mice included were deficient in platelet receptors, protein kinases or phosphatases, small GTPases or other signaling or scaffold proteins. By standardized re-analysis of high-resolution microscopic images, detailed information was obtained on altered platelet adhesion, aggregation and/or activation. For a subset of 11 mouse strains, these platelet functions were further evaluated in rhodocytin- and laminin-dependent thrombus formation, thus allowing a comparison of glycoprotein VI (GPVI), C-type lectin-like receptor 2 (CLEC2) and integrin alpha(6)beta(1) pathways. High homogeneity was found between wild-type mice datasets concerning adhesion and aggregation parameters. Quantitative comparison for the 38 modified mouse strains resulted in a matrix visualizing the impact of the respective (genetic) deficiency on thrombus formation with detailed insight into the type and extent of altered thrombus signatures. Network analysis revealed strong clusters of genes involved in GPVI signaling and Ca2+ homeostasis. The majority of mice demonstrating an antithrombotic phenotype in vivo displayed with a larger or smaller reduction in multi-parameter analysis of collagen-dependent thrombus formation in vitro. Remarkably, in only approximately half of the mouse strains that displayed reduced arterial thrombosis in vivo, this was accompanied by impaired hemostasis. This was also reflected by comparing in vitro thrombus formation (by microfluidics) with alterations in in vivo bleeding time. In conclusion, the presently developed multi-parameter analysis of thrombus formation using microfluidics can be used to: (i) determine the severity of platelet abnormalities;(ii) distinguish between altered platelet adhesion, aggregation and activation;and (iii) elucidate both collagen and non-collagen dependent alterations of thrombus formation. This approach may thereby aid in the better understanding and better assessment of genetic variation that affect in vivo arterial thrombosis and hemostasis
Solid state quantum memory using the 31P nuclear spin
The transfer of information between different physical forms is a central
theme in communication and computation, for example between processing entities
and memory. Nowhere is this more crucial than in quantum computation, where
great effort must be taken to protect the integrity of a fragile quantum bit.
Nuclear spins are known to benefit from long coherence times compared to
electron spins, but are slow to manipulate and suffer from weak thermal
polarisation. A powerful model for quantum computation is thus one in which
electron spins are used for processing and readout while nuclear spins are used
for storage. Here we demonstrate the coherent transfer of a superposition state
in an electron spin 'processing' qubit to a nuclear spin 'memory' qubit, using
a combination of microwave and radiofrequency pulses applied to 31P donors in
an isotopically pure 28Si crystal. The electron spin state can be stored in the
nuclear spin on a timescale that is long compared with the electron decoherence
time and then coherently transferred back to the electron spin, thus
demonstrating the 31P nuclear spin as a solid-state quantum memory. The overall
store/readout fidelity is about 90%, attributed to systematic imperfections in
radiofrequency pulses which can be improved through the use of composite
pulses. We apply dynamic decoupling to protect the nuclear spin quantum memory
element from sources of decoherence. The coherence lifetime of the quantum
memory element is found to exceed one second at 5.5K.Comment: v2: Tomography added and storage of general initial state
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