Long term compression strength of mortars produced using coarse steel slag as aggregate

The paper reports on some experimental results obtained from the production of mortars prepared using a commercial cement, coarse steelmaking slag, superplasticizer and water. The behaviour of this reference composition was compared to that of some others containing further additives in order to investigate materials compressive strength after long time ageing. It has been demonstrated that an optimized water/cement ratio coupled with slag particles of size lower than 2.5 mm and proper protocol of preparation leads to the production of materials with good mechanical properties after 28, 90 and 180 days of ageing. The resulting materials therefore appeared as good candidates for civil engineering applications. However, the present research also demonstrates that the mortar samples of all of the compositions prepared suffer of decay and compressive strength decrease after long time ageing in water. In the present paper the results are explained taking account of materials residual porosity and alkali silica reaction which occurs in the sample

the interaction of peptides and proteins with nanostructures surfaces a challenge for nanoscience

Abstract The impact of nanotechnologies in biomedicine and biotechnology is becoming more and more evident. It imposes practical challenges, for instance, raising specific issues on the biocompatibility of nanostructures. Nanoparticles are characterized by a high surface-to-volume ratio, which makes them reactive to foreign species. Thus, when proteins or peptides approach an inorganic nanoparticle, as well as a flat surface, they are likely to interact with the substrate to some extent. This interaction is crucial for applications in drug delivery, imaging, diagnostics, implants, and other medical devices. Specifically, gold nanoparticles are highly versatile and particularly appealing. It is widely accepted that the surfaces of nanoparticles adsorb proteins either transiently in the soft corona layer or permanently in the hard corona layer. As a consequence, the protein structure and/or function may undergo profound adjustments or remain conserved. Detailing the interaction of different inorganic substrates with proteins and peptides at the atomic level, and designing ways to control the interaction, is the key for biomedical applications of nanoparticles, both from a fundamental viewpoint and for practical implementations. In the last decade, we have addressed protein–nanoparticle interactions, focusing on interfaces of gold surfaces and nanoparticles with amyloidogenic peptides and protein models. We have developed classical force fields, performed advanced molecular dynamics simulations, and compared computational outcomes with data from nuclear magnetic resonance experiments. Protein–gold complexes with differently coated gold nanoparticles have been modeled to explore the effects of charge and size on the protein structure. Our work unravels that a complex interplay between surface properties and characteristics of the biological adsorbate determines whether peptide conformation is influenced and whether protein aggregation is accelerated or inhibited by the presence of the substrate. General guidelines to cope with amyloidogenic proteins could be inferred: these can be essentially summarized with the necessity of balancing the hydrophobic and electrostatic interactions that the amyloidogenic proteins establish with the coating moieties

Cerium, gallium and zinc containing mesoporous bioactive glasscoating deposited on titanium alloy

Surface modification is one of the methods for improving the performance of medical implants inbiological environment. In this study, cerium, gallium and zinc substituted 80%SiO2-15%CaO-5%P2O5mesoporous bioactive glass (MBG) in combination with polycaprolactone (PCL) were coated over Ti6Al4 Vsubstrates by dip-coating method in order to obtain an inorganic\u2014organic hybrid coating (MBG-PCL).Structural characterization was performed using XRD, nitrogen adsorption, SEM-EDXS, FTIR. The MBG-PCL coating uniformly covered the substrate with the thickness found to be more than 1 m. Glass andpolymer phases were detected in the coating along with the presence of biologically potent elementscerium, gallium and zinc. In addition, in vitro bioactivity was investigated by soaking the coated samplesin simulated body fluid (SBF) for up to 30 days at 37\u25e6C. The apatite-like layer was monitored by FTIR, SEM-EDXS and ICP measurements and it formed in all the samples within 15 days except zinc samples. In thisway, an attempt was made to develop a new biomaterial with improved in vitro bioactive response dueto bioactive glass coating and good mechanical strength of Ti6Al4 V alloy along with inherent biologicalproperties of cerium, gallium and zinc

A participação popular no orçamento público: orçamento participativo em quatro municípios do sul do Brasil

Public budgeting functions have changed several times over the centuries, from mere legislative control instrument on the executive reaching more modern concepts, since it is seen as a planning tool, efficient management and, more recently, popular participation. Thus, this study has the objective of analyzing the discussion in the literature of some participatory budgeting experiences developed in Brazil since 1988 Constitution. It attempted to rescue some achievements obtained through citizen participation as well as the importance of participatory budgeting as a tool to ensure popular participation in drawing up government budget. There were analyzed experiences described in the literature on some participatory budgeting implementation in the municipalities of Porto Alegre (RS), Biguaçu (SC), Blumenau (SC), and Chapecó (SC). Those experiences demonstrate that participatory budgeting achievements outweigh mere public participation in budgeting, also influencing the development of public policies. However, government commitment, or lack of it, directly affects implementation and maintenance of participatory budgeting.As funções do orçamento público vêm sofrendo diversas alterações ao longo do tempo, passando de mero instrumento de controle do legislativo sobre o executivo chegando até conceitos mais modernos, uma vez que é encarado como ferramenta de planejamento, de gestão eficiente e, mais recentemente, de participação popular. Dessa forma, este trabalho tem o objetivo de analisar a discussão de algumas experiências de orçamento participativo desenvolvidas no sul do Brasil a partir da Constituição de 1988. Para tanto, buscou-se resgatar um pouco sobre as principais conquistas obtidas por meio da participação da sociedade, bem como a importância do orçamento participativo como ferramenta que garanta a participação popular na elaboração do orçamento público. Foram analisadas as experiências descritas na literatura sobre a implantação do orçamento participativo nos municípios de Porto Alegre (RS), Biguaçu (SC), Blumenau (SC) e Chapecó (SC). As análises dessas experiências demonstram que as conquistas com orçamento participativo superam a mera participação popular na elaboração dos orçamentos, influenciando a elaboração de políticas públicas. No entanto, o comprometimento governamental, ou a falta dele, afeta diretamente a implantação e a manutenção do orçamento participativo

An Exploratory Study of Field Failures

Field failures, that is, failures caused by faults that escape the testing phase leading to failures in the field, are unavoidable. Improving verification and validation activities before deployment can identify and timely remove many but not all faults, and users may still experience a number of annoying problems while using their software systems. This paper investigates the nature of field failures, to understand to what extent further improving in-house verification and validation activities can reduce the number of failures in the field, and frames the need of new approaches that operate in the field. We report the results of the analysis of the bug reports of five applications belonging to three different ecosystems, propose a taxonomy of field failures, and discuss the reasons why failures belonging to the identified classes cannot be detected at design time but shall be addressed at runtime. We observe that many faults (70%) are intrinsically hard to detect at design-time

Mappatura speditiva tridimensionale e multi-temporale mediante UAV. I casi di Pescara del Tronto e Accumoli

L’utilizzo dei Sistemi Aeromobili a Pilotaggio Remoto (SAPR), definiti anche come Unmanned Aerial Vehicles (UAVs), ha sicuramente ricoperto un ruolo centrale durante le diverse fasi di gestione dell’emergenza in Centro Italia a seguito del sisma del 2016. Per la prima volta questi sistemi sono stati utilizzati in maniera estensiva e continuativa durante le operazioni sul campo, grazie soprattutto alla presenza del Nucleo SAPR del Corpo Nazionale dei Vigili del Fuoco con il quale i diversi ricercatori del Politecnico di Torino hanno strettamente collaborato. Tali esperienze congiunte sono state fondamentali per definire le esigenze degli operatori sul campo e per mettere a punto delle strategie operative per la georeferenziazione dei blocchi fotogrammetrici, anche con strategia multi-temporale, atte a massimizzare il contributo derivante dall’impiego dei SAPR. In particolare, i prodotti fotogrammetrici derivati dalle acquisizioni effettuate con tali sensori sono stati analizzati per valutarne il contributo nelle fasi di damage assessment

Treatment of recurrent malignant gliomas with fotemustine monotherapy: impact of dose and correlation with MGMT promoter methylation

<p>Abstract</p> <p>Background</p> <p>In recurrent malignant gliomas (MGs), a high rate of haematological toxicity is observed with the use of fotemustine at the conventional schedule (100 mg/m²weekly for 3 consecutive weeks followed by triweekly administration after a 5-week rest period). Also, the impact of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status on fotemustine activity has never been explored in the clinical setting.</p> <p>Methods</p> <p>40 patients with recurrent pretreated MG were identified as being treated with fotemustine at doses ranging from 65 mg/m²to 100 mg/m². Patients were classified into 3 groups according to the dose of fotemustine received, from the lowest dosage received in group A, to the highest in group C. Analysis of MGMT promoter methylation in tumor tissue was successfully performed in 19 patients.</p> <p>Results</p> <p>Overall, 20% of patients responded to treatment, for a disease control rate (DCR, responses plus stabilizations) of 47.5%. Groups A and B experienced a response rate of 40% and 26.5% respectively, while the corresponding value for group C was 10%. Out of 19 patients, MGMT promoter was found methylated in 12 cases among which a DCR of 66.5% was observed. All 7 patients with unmethylated MGMT promoter were progressive to fotemustine.</p> <p>Conclusion</p> <p>Low-dose fotemustine at 65–75 mg/m²(induction phase) followed by 75–85 mg/m²(maintenance phase) has an activity comparable to that of the conventional schedule. By determination of the MGMT promoter methylation status patients might be identified who are more likely to benefit from fotemustine chemotherapy.</p

Brain metastases from solid tumors: disease outcome according to type of treatment and therapeutic resources of the treating center

<p>Abstract</p> <p>Background</p> <p>To evaluate the therapeutic strategies commonly employed in the clinic for the management of brain metastases (BMs) and to correlate disease outcome with type of treatment and therapeutic resources available at the treating center.</p> <p>Methods</p> <p>Four Cancer centres participated to the survey. Data were collected through a questionnaire filled in by one physician for each centre.</p> <p>Results</p> <p>Clinical data regarding 290 cancer patients with BMs from solid tumors were collected. Median age was 59 and 59% of patients had ≤ 3 brain metastases. A local approach (surgery and stereotactic radiosurgery) was adopted in 31% of patients. The local approach demonstrated to be superior in terms of survival compared to the regional/systemic approach (whole brain radiotherapy and chemotherapy, p = <.0001 for survival at 2 years). In the multivariate analysis local treatment was an independent prognostic factor for survival. When patients were divided into 2 groups whether they were treated in centers where local approaches were available or not (group A vs group B respectively, 58% of patients with ≤ 3 BMs in both cohorts), more patients in group A received local strategies although no difference in time to brain progression at 1 year was observed between the two groups of patients.</p> <p>Conclusions</p> <p>In clinical practice, local strategies should be integrated in the management of brain metastases. Proper selection of patients who are candidate to local treatments is of crucial importance.</p

Roadmap on thermoelectricity

The increasing energy demand and the ever more pressing need for clean technologies of energy conversion pose one of the most urgent and complicated issues of our age. Thermoelectricity, namely the direct conversion of waste heat into electricity, is a promising technique based on a long-standing physical phenomenon, which still has not fully developed its potential, mainly due to the low efficiency of the process. In order to improve the thermoelectric performance, a huge effort is being made by physicists, materials scientists and engineers, with the primary aims of better understanding the fundamental issues ruling the improvement of the thermoelectric figure of merit, and finally building the most efficient thermoelectric devices. In this Roadmap an overview is given about the most recent experimental and computational results obtained within the Italian research community on the optimization of composition and morphology of some thermoelectric materials, as well as on the design of thermoelectric and hybrid thermoelectric/photovoltaic devices

Engineering Reconnaissance Following the October 2016 Central Italy Earthquakes - Version 2

Between August and November 2016, three major earthquake events occurred in Central Italy. The first event, with M6.1, took place on 24 August 2016, the second (M5.9) on 26 October, and the third (M6.5) on 30 October 2016. Each event was followed by numerous aftershocks. As shown in Figure 1.1, this earthquake sequence occurred in a gap between two earlier damaging events, the 1997 M6.1 Umbria-Marche earthquake to the north-west and the 2009 M6.1 L’Aquila earthquake to the south-east. This gap had been previously recognized as a zone of elevated risk (GdL INGV sul terremoto di Amatrice, 2016). These events occurred along the spine of the Apennine Mountain range on normal faults and had rake angles ranging from -80 to -100 deg, which corresponds to normal faulting. Each of these events produced substantial damage to local towns and villages. The 24 August event caused massive damages to the following villages: Arquata del Tronto, Accumoli, Amatrice, and Pescara del Tronto. In total, there were 299 fatalities (www.ilgiornale.it), generally from collapses of unreinforced masonry dwellings. The October events caused significant new damage in the villages of Visso, Ussita, and Norcia, although they did not produce fatalities, since the area had largely been evacuated. The NSF-funded Geotechnical Extreme Events Reconnaissance (GEER) association, with co-funding from the B. John Garrick Institute for the Risk Sciences at UCLA and the NSF I/UCRC Center for Unmanned Aircraft Systems (C-UAS) at BYU, mobilized a US-based team to the area in two main phases: (1) following the 24 August event, from early September to early October 2016, and (2) following the October events, between the end of November and the beginning of December 2016. The US team worked in close collaboration with Italian researchers organized under the auspices of the Italian Geotechnical Society, the Italian Center for Seismic Microzonation and its Applications, the Consortium ReLUIS, Centre of Competence of Department of Civil Protection and the DIsaster RECovery Team of Politecnico di Torino. The objective of the Italy-US GEER team was to collect and document perishable data that is essential to advance knowledge of earthquake effects, which ultimately leads to improved procedures for characterization and mitigation of seismic risk. The Italy-US GEER team was multi-disciplinary, with expertise in geology, seismology, geomatics, geotechnical engineering, and structural engineering. The composition of the team was largely the same for the two mobilizations, particularly on the Italian side. Our approach was to combine traditional reconnaissance activities of on-ground recording and mapping of field conditions, with advanced imaging and damage detection routines enabled by state-of-the-art geomatics technology. GEER coordinated its reconnaissance activities with those of the Earthquake Engineering Research Institute (EERI), although the EERI mobilization to the October events was delayed and remains pending as of this writing (April 2017). For the August event reconnaissance, EERI focused on emergency response and recovery, in combination with documenting the effectiveness of public policies related to seismic retrofit. As such, GEER had responsibility for documenting structural damage patterns in addition to geotechnical effects. This report is focused on the reconnaissance activities performed following the October 2016 events. More information about the GEER reconnaissance activities and main findings following the 24 August 2016 event, can be found in GEER (2016). The objective of this document is to provide a summary of our findings, with an emphasis of documentation of data. In general, we do not seek to interpret data, but rather to present it as thoroughly as practical. Moreover, we minimize the presentation of background information already given in GEER (2016), so that the focus is on the effects of the October events. As such, this report and GEER (2016) are inseparable companion documents. Similar to reconnaissance activities following the 24 August 2016 event, the GEER team investigated earthquake effects on slopes, villages, and major infrastructure. Figure 1.2 shows the most strongly affected region and locations described subsequently pertaining to: 1. Surface fault rupture; 2. Recorded ground motions; 3. Landslides and rockfalls; 4. Mud volcanoes; 5. Investigated bridge structures; 6. Villages and hamlets for which mapping of building performance was performed