Artificial intelligence in biliopancreatic endoscopy: Is there any role?

Artificial intelligence (AI) research in endoscopy is being translated at rapid pace with a number of approved devices now available for use in luminal endoscopy. However, the published literature for AI in biliopancreatic endoscopy is predominantly limited to early pre-clinical studies including applications for diagnostic EUS and patient risk stratification. Potential future use cases are highlighted in this manuscript including optical characterisation of strictures during cholangioscopy, prediction of post-ERCP acute pancreatitis and selective biliary duct cannulation difficulty, automated report generation and novel AI-based quality key performance metrics. To realise the full potential of AI and accelerate innovation, it is crucial that robust inter-disciplinary collaborations are formed between biliopancreatic endoscopists and AI researchers

Assessing paleotemperature and seasonality during the early Eocene climatic optimum (EECO) in the Belgian basin by means of fish otolith stable O and C isotopes

The Paleogene greenhouse world comprises variable paleoclimate conditions providing an indispensable deep-time perspective for the possible effects of human-induced climate change. In this paper, paleotemperature data of the Early Eocene Climatic Optimum (EECO) from the mid-latitude marginal marine Belgian Basin are discussed. They are derived from fish otolith d18O compositions of four non-migratory species belonging to the families Congridae and Ophidiidae. Otoliths from several levels and localities within the middle to late Ypresian were selected. After manual polishing, bulk and incremental microsamples were drilled and analyzed by a mass spectrometer. A cross-plot of bulk otolith d18O vs. d13C results shows a discrepancy between both families used. Ophidiid data probably represent true bottom water temperatures of the Belgian Basin. The mean annual temperature (MAT) of the EECO is calculated at 27.5 °C, which is in line with other proxy results. However, variations in MAT up to 6 °C occur, suggesting a pronounced expression of climate variability in mid-latitude marginal basins. Incremental analyses revealed a ~9.5 °C mean annual range of temperatures, similar to modern seasonality. These results show that marginal marine environments such as the Belgian Basin are well suited to infer high-resolution paleoclimate variability

Intra- and intertaxon stable O and C isotope variability of fossil fish otoliths: an early Eocene test case

Knowledge of basic data variability is essential for the interpretation of any proxy-based paleotemperature record. To evaluate this for d18O stable isotope paleothermometry based on early Paleogene fish otoliths from marginal marine environments, an intra- and interspecific stable O and C isotope study was performed at a single locality in the southern North Sea Basin (Ampe Quarry, Egem, Belgium), where shallow marine sands and silts are exposed. The age of the deposits is early late Ypresian (ca. 50.9 Ma) and falls within the early Eocene climatic optimum (EECO) interval. In each of four fossiliferous levels sampled, the same three otolith species were analyzed (Platycephalus janeti, Paraconger papointi and “genus Neobythitinorum” subregularis). Intrataxon stable isotope spread amounts on average 2.50-3.00‰ for all taxa and is present in all levels. This implies that each sample level comprises substantial variability, which can be attributed to a combination of temporal and taphonomic effects. More importantly, intertaxon offsets of 4.60‰ in d13C and 2.20‰ in d18O between the mean values of the three otolith species are found, with “N.” subregularis representing more positive values relative to the other species. We hypothesize that freshwater influence of coastal waters is the most likely cause for these discrepancies. Similar analyses on two coastal bivalve species (Venericardia sulcata and Callista laevigata) corroborate this hypothesis. Accordingly, d18O values measured on “N.” subregularis otoliths probably represent a more open oceanic signal, and therefore seem well-suited for d18O stable isotope paleothermometry. This study highlights the importance of investigating data variability of a biogenic carbonate paleotemperature proxy at the species level, before applying paleotemperature equations and interpreting the outcome

Response of marine ecosystems to deep-time global warming: a synthesis of biotic patterns across the Paleocene-Eocene thermal maximum (PETM)

This paper provides a synthesis of the long- and short-term response of various marine ecosystems (deep oceans, pelagic, politic shelves and carbonate platforms) to the Paleocene-Eocene thermal maximum (PETM) and its broader paleoclimatic and paleoceanographic context. Despite the severity and sudden onset of global warming the PETM is not marked by a mass extinction event. The only major extinction is among bathyal to abyssal calcareous benthic foraminifera, including some calcareous agglutinated taxa. Coexisting non-calcareous deep water agglutinated foraminifera, ostracodes and trace fossils show prominent changes in composition, population structure and biodiversity, but there is no clear evidence of global extinctions. Except for the deep-sea calcareous benthic foraminiferal record, the PETM is best classified as a migration and origination event and was instrumental in kick-starting various short- and long-term evolutionary innovations in marine microfossil lineages. In pelagic and shallow shelf ecosystems, migration and origination during and after the PETM appears to precede extinction in the aftermath of the PETM. The response of most marine invertebrates (mollusks, echinoderms, brachiopods) to paleoclimatic and associated environmental changes (e.g., acidification, deoxygenation) during the PETM is virtually unknown as continuous high-resolution data of these groups spanning the PETM are unexplored and possibly not or hardly preserved. Yet information on these groups is required in order to improve assessments of the value of biotic records to deep-time global warming in the context of current climate change. In contrast, the relatively well-established response of Tethyan reef systems to late Paleocene-early Eocene global warming may provide a potential analog to a – possibly bleak - future of present-day coral reefs

Biotic impact of Eocene thermal maximum 2 in a shelf setting (Dababiya, Egypt)

The Paleocene-Eocene thermal maximum (PETM) initiated a global biotic event with major evolutionary impacts. Since a series of minor d13C and d18O excursions, indicative of hyperthermals, now appears to characterize early Eocene climate, it remains to be investigated how the biosphere responded to these warming events. We studied the Esna Formation at Dababiya (Nile Basin, Egypt), in order to identify Eocene thermal maximum 2 (ETM-2) and to evaluate the foraminiferal and ostracode patterns. The studies interval generally consists of gray-brown marls and shales and is interrupted by a sequence of deviating lithologies, representing an early Eocene Egyptian environmental perturbation that can be linked to ETM-2. The ETM-2 interval consists of brownish shales (bed 1) to marls (bed 2) at the base that grade into a foraminifera-rich chalky limestone (bed 3) at the top. This conspicuous white limestone bed forms the base of the Abu Had Member. A distinct negative d13C excursion of approximately 1.6‰ is recorded encompassing this interval and a second negative d13C shift of 1‰ occurs 5 m higher. These two isotope events are situated respectively in the basal and lower part of the calcareous nannoplankton zone NP11 and appear to correlate with the H1 and H2(?) excursions observed in the deep-sea records. The lower d13C excursion is associated with benthic foraminiferal and ostracode changes and settlement of impoverished anomalous foraminiferal (planktic and benthic) assemblages, indicating a transient environmental anomaly, disrupting the entire marine ecosystem during ETM-2. Our observations indicate some similarities between the sedimentary and biotic expressions of ETM-2 and the PETM at Dababiya, pointing to similar processes operating in the Egyptian Basin during these global warming events

Reconstruction of a latest Paleocene shallow-marine eutrophic paleoenvironment at Sidi Nasseur (Central Tunisia) based on foraminifera, ostracoda, calcareous nannofossils and stable isotopes (d13C, d18O)

In order to unravel faunal and paleoenvironmental parameters in shallow marine settings prior to the Paleocene- Eocene thermal maximum, we investigated the Sidi Nasseur section (NAS) in Central Tunisia. This section exposes Paleocene to lower Eocene shales and marls of the El Haria Formation. The uppermost Paleocene part of the Sidi Nasseur section is marked by poor to moderately rich, but fairly diversified nannofossil associations, containing the typical latest Paleocene taxa of the top of NP9a. The ostracode record displays an almost continuous record in the uppermost Paleocene part of the section. Representatives of Aegyptiana, Paracosta, Reticulina and Reymenticosta make up the major part of the ostracode fauna. The benthic foraminiferal assemblage consists of numerous small calcareous benthic foraminifera, like Anomalinoides midwayensis and Lenticulina spp. and many large Frondicularia phosphatica, Pyramidulina spp. These, together with the non-calcareous agglutinated foraminifera and the rare planktic foraminifera, indicate an inner neritic to coastal environment with eutrophic conditions, regularly interrupted by oxygen deficiency. The dominance of non-calcareous benthic foraminifera between intervals with abundant calcareous benthic foraminifera suggests post-mortem dissolution. The foraminiferal d13C record (based upon Pyramidulina latejugata) of the latest Paleocene in the Sidi Nasseur area is very similar to these from coeval sediments at Gebel Duwi and Gebel Aweina in Egypt. Oxygen isotopic ratios indicate a marine setting with a water composition affected by evaporation. During the latest Paleocene, the highly productive shallow water environment evolved to shallower water depths with higher salinity and increasing dominance of A. midwayensis

Reconstruction of a latest Paleocene shallow-marine eutrophic paleoenvironment at Sidi Nasseur (Central Tunisia) based on foraminifera, ostracoda, calcareous nannofossils and stable isotopes (delta¹³C delta¹⁸O)

In order to unravel faunal and paleoenvironmental parameters in shallow marine settings prior to the Paleocene-Eocene thermal maximum, we investigated the Sidi Nasseur section (NAS) in Central Tunisia. This section exposes Paleocene to lower Eocene shales and marls of the El Haria Formation. The uppermost Paleocene part of the Sidi Nasseur section is marked by poor to moderately rich, but fairly diversified nannofossil associations, containing the typical latest Paleocene taxa of the top of NP9a. The ostracode record displays an almost continuous record in the uppermost Paleocene part of the section. Representatives of Aegyptiana, Paracosta, Reticulina and Reymenticosta make up the major part of the ostracode fauna. The benthic foraminiferal assemblage consists of numerous small calcareous benthic foraminifera, like Anomalinoides midwayensis and Lenticulina spp. and many large Frondicularia phosphatica, Pyramidulina spp. These, together with the non-calcareous agglutinated foraminifera and the rare planktic foraminifera, indicate an inner neritic to coastal environment with eutrophic conditions, regularly interrupted by oxygen deficiency. The dominance of non-calcareous benthic foraminifera between intervals with abundant calcareous benthic foraminifera suggests post-mortem dissolution. The foraminiferal d13C record (based upon Pyramidulina latejugata) of the latest Paleocene in the Sidi Nasseur area is very similar to these from coeval sediments at Gebel Duwi and Gebel Aweina in Egypt. Oxygen isotopic ratios indicate a marine setting with a water composition affected by evaporation. During the latest Paleocene, the highly productive shallow water environment evolved to shallower water depths with higher salinity and increasing dominance of A. midwayensis

High precision beam momentum determination in a synchrotron using a spin resonance method

In order to measure the mass of the eta meson with high accuracy using the d+p -> 3He+eta reaction, the momentum of the circulating deuteron beam in the Cooler Synchrotron COSY of the Forschungszentrum Juelich has to be determined with unprecedented precision. This has been achieved by studying the spin dynamics of the polarized deuteron beam. By depolarizing the beam through the use of an artificially induced spin resonance, it was possible to evaluate its momentum p with a precision of dp/p < 10-4 for a momentum of roughly 3 GeV/c. Different possible sources of error in the application of the spin resonance method are discussed in detail and its possible use during a standard experiment is considered.Comment: 10 pages, 6 figures, 2 tables, published versio