Pericardial tamponade masking associated pulmonary thrombo embolism in a case of adeno carcinoma of lung

This case report describes a patient admitted with shortness of breath of 15 days duration and found to have cardiac tamponade, which masked concomitant pulmonary embolism that was diagnosed by echocardiographic signs of dilate RA/RV with PAH only after successful pericardiocentesis. Subsequently patient was found to have widely metastatic adenocarcinoma of lungs. This case emphasizes the diagnostic challengewhen cardiac tamponade is associated with pulmonary thromboembolism and requires high index of clinical suspicion in patients with underlying malignancy

An overview of lymphatic vessels and their emerging role in cardiovascular disease

Over the past decade, molecular details of lymphatic vessels (lymphatics) have been rapidly acquired due to the identification of lymphatic endothelial-specific markers. Separate from the cardiovascular system, the lymphatic system is also an elaborate network of vessels that are important in normal physiology. Lymphatic vessels have the unique task to regulate fluid homeostasis, assist in immune surveillance, and transport dietary lipids. However, dysfunctional lymphatic vessels can cause pathology, while normal lymphatics can exacerbate pathology. This review summarizes the development and growth of lymphatic vessels in addition to highlighting their critical roles in physiology and pathology. Also, we discuss recent work that suggests a connection between lymphatic dysfunction and cardiovascular disease

Protein-altering germline mutations implicate novel genes related to lung cancer development

Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2.22 × 10−3) that is more pronounced in females (adjusted OR = 6.81 and 3.19 and for discovery and replication). We observe an excess loss of heterozygosity in lung tumors among ATM L2307F allele carriers. L2307F is more frequent (4%) among Ashkenazi Jewish populations. We also observe an association in discovery (adjusted OR = 2.61, P = 7.98 × 10−22) and replication datasets (adjusted OR = 1.55, P = 0.06) with a loss-of-function mutation, Q4X (rs150665432) of an uncharacterized gene, KIAA0930. Our findings implicate germline genetic variants in ATM with lung cancer susceptibility and suggest KIAA0930 as a novel candidate gene for lung cancer risk

Apex Feed Microstrip Printed Hybrid Dielectric Resonator Antenna for Wireless Application

The paper introduces a fractal geometry utilizing an Octagonal Split Ring Resonator (SRR) hybrid DRA as its basis. The primary antenna consists of a conventional Octagonal patch, which is then scaled down by 0.5 in the first iteration and further by 0.25 in the second and then the DRA is utilized to enhance its performance. Remarkably compact at 6 × 6.2 cm, the antenna demonstrates effectiveness across frequencies of 5.1, 6.8, and 7.2 GHz notably; it maintains a gain above 3.3 dBi and directivity above 4.1 dBi in all operational bands. Analysis employing surface current and return loss substantiates the impact of the fractal design with DR. These simulations and measured results affirm the proposed antenna\u27s suitability for robust C band wireless applications, offering promising performance in antenna parameters

Fault-Tolerant Facility Location: a randomized dependent LP-rounding algorithm

We give a new randomized LP-rounding 1.725-approximation algorithm for the metric Fault- Tolerant Uncapacitated Facility Location problem. This improves on the previously best known 2.076-approximation algorithm of Swamy & Shmoys. To the best of our knowledge, our work provides the first application of a dependent-rounding technique in the domain of facility location. The analysis of our algorithm benefits from, and extends, methods developed for Uncapacitated Facility Location; it also helps uncover new properties of the dependent-rounding approach. An important concept that we develop is a novel, hierarchical clustering scheme. Typically, LP-rounding approximation algorithms for facility location problems are based on partitioning facilities into disjoint clusters and opening at least one facility in each cluster. We extend this approach and construct a laminar family of clusters, which then guides the rounding procedure. It allows to exploit properties of dependent rounding, and provides a quite tight analysis resulting in the improved approximation ratio