50 research outputs found
Comparative proteomics of adult Paragonimus kellicotti excretion/secretion products released in vitro or present in the lung cyst nodule
- Author
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/08/2022
- Field of study
Paragonimus kellicotti is a zoonotic lung fluke infection, the agent of North American paragonimiasis, and an excellent model for other Paragonimus infections. The excretory/secretory proteins (ESP) released by parasites and presented at the parasite-host interface are frequently proposed to be useful targets for drugs and/or vaccines In vitro culture conditions may alter ESP compared to those produced in vivo. In order to investigate ESPs produced in vivo we took advantage of the fact that adult P. kellicotti reproduce in the lungs of experimentally infected gerbils in tissue cysts. We performed a mass-spectrometric analysis of adult P. kellicotti soluble somatic protein (SSPs) extracts, excreted/secreted proteins (ESPs) produced by adult worms during in vitro culture, and lung cyst fluid proteins (CFPs) from experimentally infected gerbils. We identified 2,137 P. kellicotti proteins that were present in at least two of three biological replicates and supported by at least two peptides. Among those were 1,914 proteins found in SSP, 947 in ESP and 37 in CFP. In silico analysis predicted that only 141 of the total 2,137 proteins were secreted via classical or non-classical pathways. The most abundant functional categories in SSP were storage and oxidative metabolism. The most abundant categories in ESP were proteins related to metabolism and signal transduction. The 37 parasite-related proteins in CFP belonged to 11 functional categories. The largest groups were proteins with unknown function, cytoskeletal proteins and proteasome machinery. 29 of these 37 proteins were shared among all three sample types. To our knowledge, this is the first study that compares in vitro and in vivo ESP for any Paragonimus species. This study has provided new insights into ESPs of food-borne trematodes that are produced and released in vivo. Proteins released at the host-parasite interface may help the parasite evade host immunity and may represent new targets for novel treatments or diagnostic tests for paragonimiasis
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein
- Author
- Publication venue
- Digital Commons@Becker
- Publication date
- 07/12/2023
- Field of study
Several canonical translocations produce oncofusion genes that can initiate acute myeloid leukemia (AML). Although each translocation is associated with unique features, the mechanisms responsible remain unclear. While proteins interacting with each oncofusion are known to be relevant for how they act, these interactions have not yet been systematically defined. To address this issue in an unbiased fashion, we fused a promiscuous biotin ligase (TurboID) in-frame with 3 favorable-risk AML oncofusion cDNAs (PML::RARA, RUNX1::RUNX1T1, and CBFB::MYH11) and identified their interacting proteins in primary murine hematopoietic cells. The PML::RARA- and RUNX1::RUNX1T1-TurboID fusion proteins labeled common and unique nuclear repressor complexes, implying their nuclear localization. However, CBFB::MYH11-TurboID-interacting proteins were largely cytoplasmic, probably because of an interaction of the MYH11 domain with several cytoplasmic myosin-related proteins. Using a variety of methods, we showed that the CBFB domain of CBFB::MYH11 sequesters RUNX1 in cytoplasmic aggregates; these findings were confirmed in primary human AML cells. Paradoxically, CBFB::MYH11 expression was associated with increased RUNX1/2 expression, suggesting the presence of a sensor for reduced functional RUNX1 protein, and a feedback loop that may attempt to compensate by increasing RUNX1/2 transcription. These findings may have broad implications for AML pathogenesis
Targeted proteomic quantitation of NRF2 signaling and predictive biomarkers in HNSCC
- Author
- Publication venue
- Digital Commons@Becker
- Publication date
- 01/11/2023
- Field of study
The NFE2L2 (NRF2) oncogene and transcription factor drives a gene expression program that promotes cancer progression, metabolic reprogramming, immune evasion, and chemoradiation resistance. Patient stratification by NRF2 activity may guide treatment decisions to improve outcome. Here, we developed a mass spectrometry-based targeted proteomics assay based on internal standard-triggered parallel reaction monitoring to quantify 69 NRF2 pathway components and targets, as well as 21 proteins of broad clinical significance in head and neck squamous cell carcinoma (HNSCC). We improved an existing internal standard-triggered parallel reaction monitoring acquisition algorithm, called SureQuant, to increase throughput, sensitivity, and precision. Testing the optimized platform on 27 lung and upper aerodigestive cancer cell models revealed 35 NRF2 responsive proteins. In formalin-fixed paraffin-embedded HNSCCs, NRF2 signaling intensity positively correlated with NRF2-activating mutations and with SOX2 protein expression. Protein markers of T-cell infiltration correlated positively with one another and with human papilloma virus infection status. CDKN2A (p16) protein expression positively correlated with the human papilloma virus oncogenic E7 protein and confirmed the presence of translationally active virus. This work establishes a clinically actionable HNSCC protein biomarker assay capable of quantifying over 600 peptides from frozen or formalin-fixed paraffin-embedded archived tissues in under 90 min
Precision of Multiple Reaction Monitoring Mass Spectrometry Analysis of Formalin-Fixed, Paraffin-Embedded Tissue
- Author
- Addona T. A.
- Amy-Joan L. Ham
- Carlos L. Arteaga
- Codony-Servat J.
- Daniel C. Liebler
- Elias J. E.
- Guo T.
- Guzel C.
- Hood B. L.
- Huang S. K.
- Kristen L. Carpenter
- Liu X.
- MacLean B.
- Mary Kay Washington
- Melinda E. Sanders
- Metz B.
- Metz B.
- Misti A. Martinez
- Morgan J. M.
- Namimatsu S.
- Nishimura T.
- Palmer-Toy D. E.
- Qian W. J.
- Robert W. Sprung
- Seyfried T. N.
- Shi S. R.
- Shi S. R.
- Shi S. R.
- Sprung R. W.
- Wang H.
- Whiteaker J. R.
- Wolff A. C.
- Yamashita S.
- Zhang B.
- Zhang H.
- Zhang H.
- Publication venue
- American Chemical Society
- Publication date
- Field of study
Proteomic Consequences of a Single Gene Mutation in a Colorectal Cancer Model
- Author
- Ahrens C. H.
- Baehs S.
- Bardelli A.
- Bing Zhang
- Bozic I.
- Chen X.
- Chen X.
- Chiosea S.
- Chiosea S.
- Collier T. S.
- Daniel C. Liebler
- DiFeo A.
- Faber C.
- Fackenthal J. D.
- Faux M. C.
- Fearon E. R.
- Fearon E. R.
- Gerber S. A.
- Hanash S.
- Huang X. H.
- Iliopoulos D.
- Jang G. F.
- Karube Y.
- Kessner D.
- Kim D. W.
- Kirov S. A.
- Krupnik V. E.
- Li M.
- Licklider L. J.
- Liu H.
- Long J. C.
- Ma Z. Q.
- MacDonald B. T.
- MacLean B.
- Mao L.
- Matsuzawa S. I.
- Merritt W. M.
- Niehrs C.
- Nishisho I.
- Old W. M.
- Patrick J. Halvey
- Paulovich A. G.
- Picotti P.
- Reimers M.
- Robbert J. C. Slebos
- Robert J. Coffey
- Sahai E.
- Sanchez-Tillo E.
- Selbach M.
- Sever N.
- Slebos R. J.
- Sprung R. W.
- Tabb D. L.
- Tabb D. L.
- Tu C.
- Vandewalle C.
- Wang L.
- Winter-Vann A. M.
- Wood L. D.
- Zhang B.
- Zhang B.
- Zhang H.
- Publication venue
- American Chemical Society
- Publication date
- Field of study
Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine
- Author
- A Boing
- A Gaspari
- A Kübler
- A Marudi
- A Matheson
- A Tridente
- A. A. Amelia
- A. Abbas
- A. Adams
- A. Agnoli
- A. Al Khulaifi
- A. Al Khulaifi
- A. Aldawood
- A. AlHussain
- A. Ali
- A. Almenyar
- A. Alrashid
- A. Alsheikhly
- A. Alves
- A. Ankuli
- A. Arbouti
- A. Armaganidis
- A. Artigas
- A. Asimakos
- A. B. Belli
- A. B. Cayci Sivri
- A. Bandyopadhyay
- A. Basu
- A. Bedova
- A. Belli
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Ben Souissi
- A. Bond
- A. Borgman
- A. Borowska
- A. Boutin
- A. Boutin
- A. Boyce
- A. Braschi
- A. Budnyuk
- A. C. Rodrigues
- A. Cariou
- A. Casazza
- A. Chakraborty
- A. Cirodde
- A. Crizaldo Toledo
- A. Cudia
- A. Cuoghi
- A. D. Dubrawski
- A. Dardashti
- A. Dean
- A. Dean
- A. Delfosse
- A. Dhaliwal
- A. Dhaliwal
- A. Dobru
- A. Docherty
- A. Doronzio
- A. Douvdevani
- A. Dukoff-Gordon
- A. Durward
- A. E Van den Berg
- A. Eden
- A. Eissa
- A. Enguix-Armada
- A. Escalante
- A. Escalante
- A. Ezzamouri
- A. F. Francke
- A. F. Turgeon
- A. F. Turgeon
- A. F. Van Rootselaar
- A. F. Van Rootselaar
- A. Fayed
- A. Fernandez
- A. Fischer
- A. Fogagnolo
- A. Fuller
- A. Fuller
- A. G. Murchison
- A. G. Proudfoot
- A. Garcia
- A. Garcia-Alcantara
- A. Garcia-De la Torre
- A. Garland
- A. Garland
- A. Gaspari
- A. Ghuysen
- A. Giannini
- A. Gobatto
- A. Goloubev
- A. Grubb
- A. Gruber
- A. Gultekin
- A. H. Zwinderman
- A. Hagiwara
- A. Hana
- A. Hana
- A. Harts
- A. Hejazi
- A. Hernández-Lozano
- A. Hernández-Lozano
- A. Hovingh
- A. Huber
- A. Itani
- A. J. Groeneveld
- A. J. Hoogendijk
- A. K. Kink
- A. K. Kuzovlev
- A. K. Tashima
- A. Kapuagasi
- A. Kar
- A. Kaskovagheorgescu
- A. Kaushal
- A. Khaghani
- A. Kindawi
- A. Kleinsasser
- A. Kodaira
- A. Kutz
- A. Kuzovlev
- A. Körner
- A. L Luciani
- A. L. Lange
- A. Lepape
- A. Lesmes
- A. Lima
- A. Lima
- A. Linder
- A. Loza
- A. López Lago
- A. M. Magnuson
- A. M. Tuip-de Boer
- A. Maaoui
- A. Machado
- A. Mahrous
- A. Malamas
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Marinho
- A. Martins
- A. Marudi
- A. Marudi
- A. Matroud
- A. Mebazaa
- A. Mignon
- A. Min
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Molokhia
- A. Morelli
- A. Morris
- A. Motos
- A. N. Ahmad
- A. Nadeem
- A. Nau
- A. Neill
- A. Nyman
- A. Núñez
- A. Oglinda
- A. Omar
- A. Omar
- A. Omar
- A. Omar
- A. Orlando
- A. Osipov
- A. Ozcan
- A. O’Loughlin
- A. O’Sullivan
- A. O’Sullivan
- A. O’Sullivan
- A. P. Pagano
- A. P. Torelly
- A. Pagano
- A. Patarchi
- A. Pautova
- A. Pavli
- A. Pesenti
- A. Prekates
- A. Psirides
- A. Puerto-Morlan
- A. Puxty
- A. Pérez-Calatayud
- A. R. Robles Caballero
- A. Radford
- A. Raithatha
- A. Raithatha
- A. Raithatha
- A. Reiter
- A. Rhodes
- A. Rhodes
- A. Rhodes
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riahi
- A. Riviere
- A. Riviere
- A. Riviere
- A. Robles
- A. Rogers
- A. Rousseau
- A. Roze des Ordons
- A. Ruijter
- A. Rutten
- A. S. Alsaawi
- A. S. Stieglitz
- A. Salgueiro
- A. Salgueiro
- A. Salgueiro
- A. Sarmento
- A. Sarmento
- A. Savitsky
- A. Scheirer
- A. Schiavi
- A. Seldon
- A. Sell
- A. Sen
- A. Sergeev
- A. Shabanov
- A. Shafie
- A. Shafquat
- A. Shiraishi
- A. Silva-Pinto
- A. Silva-Pinto
- A. Spassov
- A. Stella
- A. Steuber
- A. Stieglitz
- A. Stilwell
- A. Sánchez-López
- A. Sánchez-López
- A. Taha
- A. Taha
- A. Taskin
- A. Temple
- A. Tinmouth
- A. Tinmouth
- A. Torres
- A. Torres
- A. Torres
- A. Touborg Lassen
- A. Tridente
- A. Tridente
- A. Tridente
- A. Tridente
- A. Trifi
- A. Trifi
- A. Tsimogianni
- A. Turgeon
- A. Turgeon
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Vakalos
- A. Van Assche
- A. Van Assche
- A. Varma
- A. Vassi
- A. Vercueil
- A. Vieillard-Baron
- A. Violaki
- A. Violaki
- A. Vuylsteke
- A. W. Waldmann
- A. Wald
- A. Waldmann
- A. Waldmann
- A. Webber
- A. Wheeler
- A. Yalcin
- A. Zepeda-Mendoza
- A. Zerman
- AF Donneau
- AK Güler
- AT Tesnieres
- B Adamik
- B Avard
- B. Al Raiy
- B. AlGhamdi
- B. Alhamadi
- B. Alotaibi
- B. Avard
- B. Avard
- B. Balicco
- B. Basarýk Aydogan
- B. Besen
- B. Bilgili
- B. Bilgili
- B. Borgatta
- B. Bouhemad
- B. C. Civantos
- B. Carr
- B. Civantos
- B. De Cagny
- B. De Cagny
- B. De Cagny
- B. De Cagny
- B. De Laat
- B. Delwarde
- B. Eilers
- B. François
- B. François
- B. Fyntanidou
- B. Fyntanidou
- B. Fyntanidou
- B. Goncalves
- B. Guidet
- B. J. Hunt
- B. Jeribi
- B. Jones
- B. K. Lopansri
- B. Khwannimit
- B. Khwannimit
- B. Köves
- B. Laribi
- B. Laribi
- B. Lord
- B. Loureiro
- B. López Matamala
- B. Miles
- B. Mueller
- B. Mueller
- B. Mueller
- B. Nyamaizi
- B. O. Alotabi
- B. Oliveira
- B. Oliveira
- B. Oliveira
- B. P. Scicluna
- B. Pasquet
- B. Peroni
- B. Saugel
- B. Sauneuf
- B. Shenkman
- B. Sloan
- B. Stessel
- B. Stessel
- B. Söderquist
- B. Tudor
- B. Vidal
- B. Waldum-Grevbo
- B. Wanta
- B. Xavier
- C. A. Volta
- C. Aldecoa
- C. Aldecoa
- C. Arrowsmith
- C. Ashton
- C. Battle
- C. Battle
- C. Battle
- C. Bell
- C. Bor
- C. Bor
- C. Brunborg
- C. Carvalho
- C. Chaddock
- C. Chiurazzi
- C. Choong
- C. Cobilinschi
- C. Cobilinschi
- C. Cobilinschi
- C. Cobilinschi
- C. Cohen
- C. Dalrymple
- C. De Deyne
- C. De Haro
- C. Dinter
- C. Doig
- C. Doree
- C. Downey
- C. Dridi
- C. E. Luyt
- C. Ertmer
- C. Ertmer
- C. F. Fuchs
- C. Feldmann
- C. Fenlon
- C. Fitton
- C. Fleischmann
- C. Fleischmann
- C. G. Ellis
- C. Gemelli
- C. Genbrugge
- C. Gerrard
- C. Glynos
- C. Gogos
- C. Goldfuss
- C. Goossens
- C. Gu
- C. H. Toh
- C. Haas
- C. Haas
- C. Hamilton-Davies
- C. Hawthorne
- C. Heidegger
- C. Hoermann
- C. Hoffmann
- C. Hymers
- C. Ince
- C. Ince
- C. Ince
- C. J. Hodiamont
- C. J. Kirwan
- C. J. Kirwan
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. J. Voscopoulos
- C. K. Karagiannidis
- C. Karagiannidis
- C. Karagiannidis
- C. Karnjanarachata
- C. Katsenos
- C. Kaymak
- C. Kirwan
- C. Kongkamol
- C. Koutsogiannidis
- C. Krenn
- C. Kruger
- C. L. Sprung
- C. Lee
- C. Lemaire
- C. Leon
- C. Leães
- C. Lister
- C. Lum
- C. Lum
- C. Lynch
- C. Magalhaes
- C. Magalhaes
- C. Marenghi
- C. Martín Parra
- C. Martínez Díaz
- C. Maury
- C. Mazo Torre
- C. McBride
- C. Mcgrath
- C. Mitaka
- C. Oglinda
- C. Ostrowska
- C. P. Lee
- C. Palazzi
- C. Park
- C. Patet
- C. Pelletier
- C. Pereira
- C. Peters
- C. Pichard
- C. Pierrakos
- C. Plourde
- C. Poi
- C. Pretty
- C. Pretty
- C. Pritchett
- C. Reutelingsperger
- C. Rodrigues
- C. Rodríguez Gallego
- C. Routsi
- C. Ryan
- C. S. Bouman
- C. S. Scheer
- C. S. Serra
- C. Sampson
- C. Scarrot
- C. Senver
- C. Sittipunt
- C. Skourtis
- C. Stone
- C. Suthisisang
- C. Svensen
- C. Tordoff
- C. Travierso
- C. Turrini
- C. Ugur Yilmaz
- C. Ulusoy
- C. Valdez
- C. Valencia
- C. Van Walraven
- C. Van Walraven
- C. Volta
- C. Volta
- C. Vrettou
- C. W. Park
- C. W. Park
- C. W. Park
- C. Walsh
- C. Willars
- C. Wissmann
- D Bryden
- D Jakubczyk
- D. A. Fergusson
- D. Adukauskiene
- D. Amin
- D. Ballesteros
- D. Bastoni
- D. Benoit
- D. Berger
- D. Bergmans
- D. Brown
- D. Bryden
- D. Bryden
- D. C. Angus
- D. Castanares-Zapatero
- D. Chroni
- D. Ciprandi
- D. Dawson
- D. De Bels
- D. Diedrich
- D. Dreyfuss
- D. Dreyfuss
- D. Du Cheyron
- D. Enoch
- D. Eschbach
- D. Eversole
- D. Evoy
- D. Fergusson
- D. Fergusson
- D. Fineberg
- D. Forte
- D. Forte
- D. Forte
- D. Freitag
- D. Gavrychenko
- D. Gavrychenko
- D. Gineityte
- D. Gokmen
- D. Griesdale
- D. Griesdale
- D. Griesdale
- D. Griesdale
- D. Heyland
- D. Heyland
- D. Heyland
- D. Huskens
- D. Inverarity
- D. Jacobsen
- D. Jarczak
- D. Kindgen-Milles
- D. Koutete
- D. L. Lucchesi
- D. M. Dalcomune
- D. M. Dalcomune
- D. M. Dalcomune
- D. Macias
- D. Mackle
- D. Mackle
- D. Markopoulou
- D. Memis
- D. Miller
- D. Moisidou
- D. Moisidou
- D. Moisidou
- D. Monkhouse
- D. Mota
- D. O. Thomas-Rüddel
- D. Pandit
- D. Pavlovic
- D. Pilsgaard Henriksen
- D. R. Cranendonk
- D. Reuter
- D. Ricci
- D. Ringaitiene
- D. S. Stavi
- D. Sangaran
- D. Sbiti-Rohr
- D. Silva
- D. Stott
- D. Thevenin
- D. Thomas-Rueddel
- D. Titeca
- D. Titeca
- D. Titeca
- D. Titeca
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Tomescu
- D. Valanciene
- D. Wyncoll
- D. Ysebaert
- E Bertellini
- E George
- E Prandi
- E. A Volakli
- E. A. Osawa
- E. A. Volakli
- E. Aguilera
- E. Akin Korhan
- E. Akýn Korhan
- E. Almeida
- E. Antoniadou
- E. Antypa
- E. Arch-Tirado
- E. Arita
- E. B. Dias
- E. Bellazzi
- E. Bertellini
- E. Bertellini
- E. Boezeman
- E. Borg-Seng-Shu
- E. C. Carella
- E. Carlson
- E. Cerrato
- E. Chernevskaya
- E. Chinou
- E. Chochliourou
- E. Chochliourou
- E. Colombaroli
- E. Colombaroli
- E. Colombaroli
- E. D. Arul
- E. Dalampini
- E. Dalampini
- E. Der Kinderen
- E. Derom
- E. Doumaki
- E. Dubief
- E. Fan
- E. Frenoy
- E. G. Gayat
- E. George
- E. George
- E. Ghosh
- E. Giamarellos-Bourboulis
- E. Grins
- E. Gómez-Pesquera
- E. Gómez-Pesquera
- E. Gómez-Sánchez
- E. Gómez-Sánchez
- E. Helme
- E. Helme
- E. Herrera-Ramos
- E. Hoste
- E. Ischaki
- E. Jeong
- E. Joelsson-Alm
- E. K. Kishinevsky
- E. Kaya
- E. Kompanje
- E. Koonthalloor
- E. Kotzapanagiotou
- E. L. V. Costa
- E. Lafuente
- E. Lafuente
- E. Lafuente
- E. Llopart
- E. M. Siqueira
- E. Mancini
- E. Marrinan
- E. McCarron
- E. McCarron
- E. Michael
- E. Moltchanova
- E. Moreira
- E. Mukeria
- E. Mukeria
- E. Nakstad
- E. Nieuwkoop
- E. Nsutebu
- E. Nyberg
- E. Oloktsidou
- E. Oloktsidou
- E. Orenbuch-Harroch
- E. Papapostolou
- E. Peronnet
- E. Peters
- E. Pokorna
- E. R. Ruggiero
- E. Rodríguez Ruíz
- E. Samkinidou
- E. Samkinidou
- E. Scarlatescu
- E. Schurgers
- E. Senturk
- E. Senturk
- E. Tamayo
- E. Tamayo
- E. Tamberg
- E. Tamberg
- E. Tina
- E. Toth-martin
- E. Tuzun
- E. Tuzun
- E. Varo Pérez
- E. Vasilarou
- E. Vasilarou
- E. Vicaut
- E. Volakli
- E. Walter
- E. Zoumpelouli
- E. Álvarez-Fuente
- E. Álvarez-Fuente
- F Leleu
- F. A. Bozza
- F. A. Bozza
- F. A. Rocha
- F. AlEid
- F. Alenezi
- F. Ampatzidou
- F. Ampatzidou
- F. Ampatzidou
- F. Asota
- F. B. Borrelli
- F. B. Jatene
- F. Bloos
- F. Boutouta
- F. Brazier
- F. Brazier
- F. Brazier
- F. Brazier
- F. Breckenridge
- F. Cadamuro
- F. Candidi
- F. Cardoso
- F. Ceia
- F. Coelho
- F. Dalla Corte
- F. Daly
- F. Daly
- F. Elkmann
- F. Esen
- F. Esen
- F. Faria
- F. Frame
- F. Gaioto
- F. Galas
- F. Galas
- F. Gargano
- F. Gul
- F. Güiza
- F. Haddad
- F. Idone
- F. Jans
- F. Kelly
- F. Kunimoto
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- Publication date
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- Field of study
[This corrects the article DOI: 10.1186/s13054-016-1208-6.]
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
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- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
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- Chouvarda I
- Christopher KB
- Chrétien JM
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- Chumaev A
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- Cinel I
- Cinnella G
- Citerio G
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- Clemente EA
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- Colombo A
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- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
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- Conti G
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- Coombs M
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- Cordovilla-Guardia S
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- Corona A
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- Corzo L
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- Cuthbertson BH
- Cutuli SL
- Câmara M
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- Dalhuisen A
- Dalorzo M
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- David H
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- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
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- De La Fuente-Martos C
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- Engelberts D
- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- Fleischmann E
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- Follin A
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Ignacio ML
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
- Juanas CA
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- Kumbamu A
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- Olaechea P
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- Pienovi R
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- Poukkanen M
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- Pozzebon S
- Pozzi M
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- Pozzi M
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- Pugliese F
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- Pérez LP
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- Pérez LP
- Qiu H
- Quinart A
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- Quinza A
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- Radjou A
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Reusch S
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- Revel N
- Revuelto-Rey J
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- Rodrigues NJ
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- Rodríguez FG
- Roesthuis L
- Rogero S
- Rolin N
- Rolla F
- Rolland-Debord C
- Romero DG
- Romero I
- Romero JC
- Romero JC
- Romero JC
- Romero JC
- Romeu JD
- Rood PJ
- Ros Martínez J
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rosario LE
- Rossetti AO
- Rossi S
- Rossini P
- Rosstalnaya A
- Rota L
- Roth GA
- Rottoli MR
- Rotzel HB
- Rousseau AF
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- Rouw N
- Rouzé A
- Rowlerson A
- Ruberto F
- Rubiera M
- Rubio RJ
- Rudiger A
- Ruffini C
- Ruffini C
- Ruijter A
- Ruiz A
- Ruiz BL
- Ruiz FC
- Ruiz J
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- Ruiz-Rodriguez JC
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- Runge I
- Runge I
- Runge I
- Rutherford WB
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- Saadat F
- Sabetian G
- Sabeļņikovs O
- Sabirov D
- Sadamoto Y
- Sadamoto Y
- Sadamoto Y
- Saeed S
- Saha T
- Saigal S
- Saito M
- Saito N
- Saitou N
- Sakai Y
- Sakieva FI
- Sakuma M
- Sakuraya M
- Sales G
- Salgado DR
- Salluh J
- Sampath S
- Sampath S
- Sampley S
- Sampson D
- Samuels T
- Samy W
- Sanchez A
- Sanchez JA
- Sanchez-Orézzoli MG
- Sandiumenge A
- Sandiumenge A
- Sandroni C
- Sani D
- Santacruz C
- Santana JD
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- Santana MC
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- Santiago AI
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- Santos F
- Sanui M
- Sanz ER
- Sanz ER
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- Sanz ER
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- Sanz NM
- Sanz NM
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- Sato K
- Savi C
- Savin I
- Savvidou S
- Sawamura A
- Sawamura A
- Sawamura A
- Sawamura A
- Scala S
- Scales DC
- Scanziani E
- Scanziani E
- Schaller SJ
- Schlaepfer P
- Schleifer J
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- Schmidt M
- Schneider AG
- Schoenenberger JA
- Schortgen F
- Schortgen F
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- Schröder T
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- Sciurti R
- Scott SH
- Sedlák P
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- Sellés MD
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- Sigurta A
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- Smekal D
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- Sobhanian S
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- Spronk PE
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- St George’s University of London
- Stamm J
- Stamouli M
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- Staszewsky L
- Stauffert N
- Stella A
- Stephens T
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- Street H
- Stretti F
- Struijs A
- Stubbs C
- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
- Stümpfle R
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- Su F
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- Suchomel P
- Suh GJ
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- Sáez VC
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- Sánchez B
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- Tokyo Womens Medical University
- Tomas E
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- Torrent RL
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- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vincent JL
- Vinje LJ
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- Vitaller S
- Vittone F
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- Volta CA
- Volta CA
- Vondrakova D
- Vondrakova D
- Vondrakova D
- Vong LV
- Vourli S
- Vrettou C
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- Vázquez CF
- Vázquez CF
- Wada T
- Wada T
- Wada T
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- Waldauf P
- Wand S
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- Wang H
- Wann SR
- Wann SR
- Wann SR
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- Wathanawatthu T
- Wee S
- Welte T
- Welters I
- Wetz A
- Weyer CM
- White C
- Wiesner O
- Wijayatilake DS
- Wildenberg L
- Wilks M
- Wilson ME
- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
- Wolff M
- Wong Y
- Wood B
- Wood CA
- Wood D
- Wood M
- Wray J
- Xie Z
- Xini A
- Xini A
- Xiol EA
- Xu M
- Yager T
- Yaguchi A
- Yaguchi A
- Yamaguchi O
- Yamaguchi O
- Yamaguchi Y
- Yamaguchi Y
- Yamamoto H
- Yamamoto N
- Yaman G
- Yamashita K
- Yamazaki A
- Yan WW
- Yan WW
- Yang JH
- Yang JS
- Yang YL
- Yasuda H
- Yatabe T
- Yebenes JC
- Yeh YC
- Yemets H
- Yergaliyeva A
- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
- Yoshida K
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
- Yuzawa J
- Yuzawa J
- Zabaletta WJ
- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
- Zeroual N
- Zerva L
- Zhang J
- Zhou JC
- Zhou JC
- Zhou JX
- Zhovnir V
- Zibandah N
- Zijlstra F
- Zimmerman J
- Zogheib E
- Zogheib E
- Zogheib E
- Zullino V
- Zwaag J
- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Recommended from our members
Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial
- Author
- Abelha Fernando
- Abitagaglu Suheyla
- Achilles Marc
- Adebesin Afeez
- Altermatt Fernando
- Aurilio Caterina
- Ayanoglu Hilmi Omer
- Bacuzzi Alessandro
- Baig Harris R.
- Balaji Packianathaswamy
- Balonov Konstantin
- Bergamaschi Alice
- Bergmann Lars
- Beurskens Charlotte
- Biosca Pérez Elena
- Bluth T.
- Bobek I.
- Boer Christa
- Bos Elke
- Brugnoni Elisa
- Brull Sorin J.
- Busch Cornelius
- Canet J.
- Canet Jaume
- Carboni Adrea
- Carmona Javiera
- Carvalho Marta
- Castro Diogo Sousa
- Cavaleiro Carla
- Cebrian Moreno Alba
- Ciardo Stefano
- Cinnella G.
- Clinical Trial Network of the European Society of Anaesthesiology (ESA)
- Corman Dincer Pelin
- Corvetto Marcia A.
- Davies Simon
- De Baerdemaeker L.
- De Baerdemaeker Luc
- De Hert Stefan
- Delphin Ellise
- Di Colandrea Salvatore
- Dinc Bora
- Donatiello Valerio
- Dullenkopf Alexander
- Dzurnakov Paula
- Ebner Felix
- Elgendy Hamed
- Erdogan Dilek
- Fernandez-Bustamante Ana
- Ferrando Carlos
- Ferreira Cristina
- Freesemann Harbert
- Fronchko Valentyna
- Gama de Abreu M.
- Gaszynski Thomasz
- Gobbi Luca
- Godfried Marc
- Godoroja Daniela
- Goettel Nicolai
- González Miriam
- Goren Or
- Granell Gil Manuel
- Gratarola Angelo
- Gregoretti C.
- Gómez Noemí
- Güldner Andreas
- Hedenstierna G.
- Hemmes S. N.
- Hernández Cádiz María José
- Heyse Bjorn
- Hiesmayr M.
- Hollmann M. W.
- Huercio Iván
- Huhle Robert
- Izquierdo Ana
- Jaber S.
- Kabon Barbara
- Kacha Aalok
- Kahn David
- Karadeniz Meltem
- Karaman Ilic Maja
- Kavas Ayse Duygu
- Kellogg Todd A.
- Kienbaum Peter
- Kiss T.
- Klaric Vlasta
- Koksal Ceren
- Kuvaki Bahar
- Laffey J. G.
- Laffey Jon
- Laufenberg-Feldmann Rita
- Licker M. J.
- Licker Marc-Joseph
- Lopez-Baamonde Manuel
- Lopez-Martinez Mercedes
- Mac Gregor Mark
- Machado Humberto
- Malerbi Patrizia
- Margarson Mike
- Markstaller K.
- Martin Yvette N.
- Martin-Loeches Martin
- Maseda Emilio
- Matot I.
- Matot Idit
- Mattera Silvana
- McKenzie Travis J.
- Menzen Angelika
- Mertens Els
- Micalizzi Camilla
- Milic Morena
- Mills G. H.
- Mills Gary
- Mulier J. P.
- Mulier Jan
- Mölders Patrick
- Müller G.
- Nalwaya Pramod
- Nazareno Palange
- Nesek Adam Visnja
- Newell Christopher
- Neyrinck Arne
- Ozbilgin Sule
- Pace Caterina Maria
- Paddle Jonathan
- Papaspyros Fotios
- Paredes Sebastian
- Pedemonte Juan C.
- Pelosi P.
- Pinho Daniela
- Pinho Sílvia
- PROBESE investigators
- PROtective VEntilation Network (PROVEnet)
- Putensen C.
- Putensen Christian
- Rabico Rui
- Ragazzi Riccardo
- Ramakrishna Harish
- Rangarajan Desikan
- Reiterer Christian
- Renew J. Ross
- Rivas Eva
- Robitzky Luisa
- Rolle Augusto
- Rossaint Rolf
- Rossaint Rolf
- Rubulotta Francesca
- Sansone Pasquale
- Sayedalahl Mohamed
- Schaefer Maximilian
- Schmitt J.
- Schultz M. J.
- Sendra Mar
- Senturk M.
- Serpa Neto A.
- Severgnini P.
- Severgnini Paolo
- Shosholcheva Mirjana
- SIibai Abdul Razak
- Simonassi Francesca
- Sivrikoz Nukhet
- Skandalou Vasiliki
- Soares Maria
- Socorro Tania
- Soro Marina
- Spadaro Savino
- Sprung J.
- Sprung Juraj
- Stevanovic Ana
- Suarez-de-la-Rica Alejandro
- Teichmann R.
- Thiel Bram
- Tolós Raquel
- Tore Altun Gulbin
- Treschan Tanja
- Uhlig Christopher
- Unterberg Matthias
- Van Limmen Jurgen
- Van Nieuwenhove Yves
- Veering B.
- Vidal Melo M. F.
- Vitkovic Bibiana
- Vivona Luigi
- Volta Carlo Alberto
- Vorotyntsev Sergiy
- Weingarten Toby N.
- Wrigge H.
- Yagüe Julio
- Yavru Aysen
- Zac Lilach
- Zonneveldt Harry
- Zupcic Miro
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background: Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on PPCs are uncertain. We hypothesized that intraoperative mechanical ventilation using high PEEP with periodic recruitment maneuvers, as compared with low PEEP without recruitment maneuvers, prevents PPCs in obese patients. Methods/design The PRotective Ventilation with Higher versus Lower PEEP during General Anesthesia for Surgery in OBESE Patients (PROBESE) study is a multicenter, two-arm, international randomized controlled trial. In total, 2013 obese patients with body mass index ≥35 kg/m2 scheduled for at least 2 h of surgery under general anesthesia and at intermediate to high risk for PPCs will be included. Patients are ventilated intraoperatively with a low tidal volume of 7 ml/kg (predicted body weight) and randomly assigned to PEEP of 12 cmH2O with lung recruitment maneuvers (high PEEP) or PEEP of 4 cmH2O without recruitment maneuvers (low PEEP). The occurrence of PPCs will be recorded as collapsed composite of single adverse pulmonary events and represents the primary endpoint. Discussion To our knowledge, the PROBESE trial is the first multicenter, international randomized controlled trial to compare the effects of two different levels of intraoperative PEEP during protective low tidal volume ventilation on PPCs in obese patients. The results of the PROBESE trial will support anesthesiologists in their decision to choose a certain PEEP level during general anesthesia for surgery in obese patients in an attempt to prevent PPCs. Trial registration ClinicalTrials.gov identifier: NCT02148692. Registered on 23 May 2014; last updated 7 June 2016. Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-1929-0) contains supplementary material, which is available to authorized users
Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance
- Author
- Publication venue
- 'American Physiological Society'
- Publication date
- Field of study
Detecting local order beyond the pair correlations in hard sphere systems
- Author
- Publication venue
- Publication date
- 01/01/2012
- Field of study