Contemplating the ancients: aesthetic and social issues in early Chinese portraiture

Drawing on a wide variety of contemporaneous sources from Chinese history, literature, religious writings, and art and literary criticism, Spiro provides the modern reader with an aesthetic and social context for understanding early Chinese portraiture. Contemplating the Ancients introduces portraits that were never intended to be physical likenesses of their subjects and illuminates the meaning they held for the viewers for whom they were made.Spiro focusses on fourth- and fifth-century sets of almost identi- cal portraits of individuals known collectively in Chinese history as the Seven Worthies of the Bamboo Grove. Unlike the earlier Han dynasty portraits whose messages were universal, these exemplary portraits addressed a specific elitist audience. The subjects of these portraits served as idealized representations for a largely nouvel-arrivé aristocracy.Spiro examines the complex and sometimes ironic changes that occur when historical individuals are transformed by tradition into classical exemplars. She shows how the visual arts translate ideals of personal character into stylistic cues and how these cues, in turn, affect the values and behavior of human beings

Quantifying the Effects of 16p11.2 Copy Number Variants on Brain Structure: A Multisite Genetic-First Study

International audienceBackground: 16p11.2 breakpoint 4 to 5 copy number variants (CNVs) increase the risk for developing autism spectrum disorder, schizophrenia, and language and cognitive impairment. In this multisite study, we aimed to quantify the effect of 16p11.2 CNVs on brain structure.Methods: Using voxel- and surface-based brain morphometric methods, we analyzed structural magnetic resonance imaging collected at seven sites from 78 individuals with a deletion, 71 individuals with a duplication, and 212 individuals without a CNV.Results: Beyond the 16p11.2-related mirror effect on global brain morphometry, we observe regional mirror differences in the insula (deletion > control > duplication). Other regions are preferentially affected by either the deletion or the duplication: the calcarine cortex and transverse temporal gyrus (deletion > control; Cohen's d > 1), the superior and middle temporal gyri (deletion duplication; -0.5 > Cohen's d > -1). Measures of cognition, language, and social responsiveness and the presence of psychiatric diagnoses do not influence these results.Conclusions: The global and regional effects on brain morphometry due to 16p11.2 CNVs generalize across site, computational method, age, and sex. Effect sizes on neuroimaging and cognitive traits are comparable. Findings partially overlap with results of meta-analyses performed across psychiatric disorders. However, the lack of correlation between morphometric and clinical measures suggests that CNV-associated brain changes contribute to clinical manifestations but require additional factors for the development of the disorder. These findings highlight the power of genetic risk factors as a complement to studying groups defined by behavioral criteria