Da transnacionalidade como instrumento de governança aplicada ao registro imobiliário

Enfrentando a abordagem dos povos por várias razões, como interesses econômicos, filosofias, troca de experiências entre outros, a governança transnacional brilha com a remoção de escudos e a criação de pontes com pretensões comuns. Nesse cenário, o presente estudo busca como objetivo geral, abordar objetivamente os desafios pendentes da Governança Transnacional, relacionando-os com o Registro Imobiliário de Imóveis. Para tanto, como objetivos específicos destacamos: a) apresentar uma abordagem de implementação de desafios da Governança Transnacional; b) Detectar semelhanças entre o sistema de registro espanhol e brasileiro; c) Identificar possibilidades de aplicações transnacionais na exploração de sistemas.Nas linhas finais, o objetivo foi apresentar características comparativas entre os sistemas e possibilidades de uma abordagem transnacional entre estados.Quanto à metodologia utilizada, observa-se que na Fase de Investigação utilizou-se o Método Indutivo, na Fase de Processamento de Dados o Método Cartesiano e o Relatório de Resultados expressos neste artigo foram compostos com base na lógica indutiva

Toxoplasmose disseminada sepse símile em dois pacientes com AIDS

O presente relato descreve dois pacientes que apresentaram toxoplasmose aguda, disseminada e grave como primeira manifestação oportunista da síndrome da imunodeficiência adquirida. Os achados clínicos e laboratoriais foram similares aos de sepse ou choque séptico e, em ambos os casos houve evolução rápida para óbito. À necropsia, foi observada reação inflamatória e presença de taquizoítos e cistos de Toxoplasma gondii na maioria dos órgãos examinados.This report describes two patients who presented acute disseminated and severe toxoplasmosis as the first opportunistic disease related to acquired immunodeficiency syndrome. At admission, clinical and laboratory findings were similar to sepsis or septic shock and a fast evolutive course to death occurred in both cases. At necropsy, an inflammatory reaction and presence of a great number of Toxoplasma gondii cysts and tachyzoites were observed in most organs examined

Recurrent Implantation Failure: The Role of Anatomical Causes

Recurrent implantation failure (RIF) is one of the great challenges of current reproductive medicine. The term refers to the failure of repeated transfers of embryos of good morphological quality. Embryo implantation is a crucial moment in in vitro fertilization (IVF) treatments. A successful pregnancy depends on a synchronized interaction between a good quality embryo and a receptive endometrium. Its failure may be a consequence of embryo quality, anatomical or immunological factors. The anatomic causes constitute an important factor for RIF, although they are usually manageable. Fibroids, polyps and adhesions that develop after a surgical procedure or infection can hamper the embryo - endometrium attachment process. In addition, Mullerian abnormalities and hydrosalpinx can cause a negative impact on implantation rates and should also be taken into account in patients with RIF. In this chapter, we will address the main anatomical causes that may impact the implantation rates of patients undergoing IVF, as well as recommendations on management and its treatment

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

A afirmação dos direitos humanos a partir de uma proposta de (re)definição do conceito de prisão arbitrária

O presente Artigo tem como objeto um estudo sobre as prisões cautelares no Brasil sob o prisma do artigo nono da Declaração Universal dos Direitos Humanos, que veda a prisão, detenção ou exílio arbitrário. O seu objetivo é reafirmar os Direitos Humanos – inseridos na Declaração Universal há setenta anos – a partir de uma análise história do pensamento que normatizou as prisões cautelares no Brasil e da busca por uma (re)definição (crítica) do conceito de prisão arbitrária. Para tanto, o artigo está dividido em quatro itens. No primeiro tratando da Declaração Universal dos Direitos Humanos acentua-se a Dignidade da Pessoa Humana como seu valor central e a influência da consagração da Dignidade Humana também na Constituição da República Federativa do Brasil de 1988. No segundo item aborda-se a necessidade da constante reafirmação dos Direitos Humanos, ressaltando não só a necessidade de novas declarações e interpretações, como a busca incessante pela sua efetivação.  No terceiro, destaca-se o artigo nono da Declaração (que veda as prisões arbitrárias) e as prisões cautelares no Brasil, com ênfase ao pensamento que orientou a sua regulamentação no ordenamento jurídico brasileiro. No quarto item propõe-se uma redefinição do conceito de prisão arbitrária para assentar a necessidade de impedir que a decretação das prisões cautelares no Brasil sujeite-se ao arbítrio das autoridades judiciárias, como condição à preservação da Dignidade da Pessoa Humana. O presente Artigo encerra-se com as Considerações Finais, nas quais são apresentados aspectos destacados do trabalho e estimulada a continuidade dos estudos e das reflexões sobre o tema. Quanto à Metodologia empregada, na Fase de Investigação foi utilizado o Método Indutivo, na Fase de Tratamento de Dados o Método Cartesiano, e, o Relatório dos Resultados é composto na base lógica indutiva

Synergistic Effects of Subsoil Calcium in Conjunction with Nitrogen on the Root Growth and Yields of Maize and Soybeans in a Tropical Cropping System

A large part of Brazilian maize is double-cropped after soybeans, when water shortages are very frequent. A larger root system can mitigate drought stress and enable better nitrogen (N) use. Alleviating acidity and applying gypsum can increase root growth and N-use efficiency in maize, which has a more aggressive root system than soybeans. However, it is not known how these factors interact in integrated cropping systems, or how soybeans respond to them. Soybean and maize root growth and grain yields as affected by soil Ca enrichment using lime and gypsum, along with the N rates applied to maize intercropped with Guinea grass (Megathyrsus maximus), were assessed in a medium-term field experiment. Liming resulted in greater root growth for both crops; however, when lime was used in conjunction with gypsum, root growth was further enhanced. The total maize grain yield was 35% higher compare to the control when gypsum was used in conjunction with lime; however, subsoil Ca enrichment increased the total soybean grain yield by 8% compared to the control. Nitrogen fertilization increased the total maize grain yield by 36%, with a more expressive increase when applying 160 kg ha−1 or more, and despite a positive effect on soybean grain yields in the long term, this response seems not to be a direct effect of the N applied to the maize. Both subsoil Ca enrichment and N application to maize increase root growth and the total yield of the system

Genome-wide identification and expression analysis of dormancy-associated gene 1/auxin repressed protein (DRM1/ARP) gene family in Glycine max

Dormancy-Associated gene 1/Auxin Repressed protein (DRM1/ARP) genes are responsive to hormones involved in defense response to biotic stress, such as salicylic acid (SA) and methyl jasmonate (MeJA), as well as to hormones that regulate plant growth and development, including auxins. These characteristics suggest that this gene family may be an important link between the response to pathogens and plant growth and development. In this investigation, the DRM1/ARP genes were identified in the genome of four legume species. The deduced proteins were separated into three distinct groups, according to their sequence conservation. The expression profile of soybean genes from each group was measured in different organs, after treatment with auxin and MeJA and in response to the nematode Meloidogyne javanica. The results demonstrated that this soybean gene family is predominantly expressed in root. The time auxin takes to alter DRM1/ARP expression suggests that these genes can be classified as a late response to auxin. Nevertheless, only the groups 1 and 3 are induced in roots infected by M. javanica and only group 3 is induced by MeJA, which indicates a high level of complexity in expression control mechanisms of DRM1/ARP family in soybean