Intra-hospital complications in acute traumatic spinal cord injury

Há poucos dados sobre complicações hospitalares em pacientes com LMT aguda. Objetivo: Reportar as características de complicações em pacientes com LMT em um grande centro de trauma. Método: Estudo transversal com 434 pacientes com LMT aguda de 2004 a 2014. Os desfechos foram a frequência e característica das complicações, o tempo de internação (TDI), e fatores associados com seu aumento. Resultados: Incidência de complicações foi 82,2%, sendo as mais frequentes: infecção do trato urinário (ITU)=64,4%, úlcera de pressão (UP)= 50,6% e pneumonia= 23,7%. Pneumonia, intubação, e ser submetido a qualquer cirurgia para UP foram independentemente associados com aumento do TDI. Conclusão: ITUs e UP foram as complicações mais prevalentes, e devem ser melhor estudadas para melhor atenção a LMT. As investigações sobre as complicações na lesão medular traumática devem ser mandatórias nos centros e unidades dedicadas ao tratamento da Lesão Medular.There is scarce data about intra-hospital complications in acute traumatic spinal cord injury (TSCI). Objective: To report characteristics of complications in patients with TSCI in a major trauma center. Method: This is a cross-sectional study with 434 patients with acute TSCI from 2004 to 2014. Outcomes were frequency and description of complications, length of hospital stay (LOS), and causes of increased LOS. Results: Patients presented at least 1 complication in 82.2% of the cases: urinary tract infection (UTI) = 64.4%, pressure ulcers (PU) = 50.6%, and pneumonia = 23.7%. Pneumonia, intubation and cases of surgical corrections for PU were independently associated with increased LOS. Conclusion: UTIs and PUs were the most frequent complications. Investigating its causes and consequences is paramount in the care of patients with SCI. Possible reasons for such complications could comprise time, and frequency of repositioning in bed. Investigating intra-hospital complications is paramount in SCI centers

Modelo de reabilitação hospitalar após acidente vascular cerebral em país em desenvolvimento

Os serviços de reabilitação intensiva para os sobreviventes de acidente vascular cerebral (AVC) com tratamento padronizado são desejáveis porque esses programas de reabilitação contribuem para a melhoria funcional em contextos com menos recursos. Objetivo: Verificar se o programa de reabilitação hospitalar contribui para a melhora da funcionalidade em indivíduos com sequela de AVC. Método: Trata-se de um estudo transversal retrospectivo dos primeiros (2009-2010) e últimos 100 (2014-2015) pacientes neurológicos consecutivos admitidos na Rede de Reabilitação Lucy Montoro (Unidade Morumbi). Para esta análise, os pacientes foram analisados no dia da admissão e no dia de alta, utilizando a Escala de Rankin modificada (mRS). Para a comparação dos resultados foi utilizado o teste t para amostras independentes. A análise intragrupal com base no mRS foi realizada com o teste não paramétrico de Wilcoxon. Por outro lado, a análise intergrupos utilizou o teste não paramétrico de MannWhitney. O nível de significância para todos os testes estatísticos foi p <0,05. Os resultados funcionais ≤ 3 na alta foram considerados favoráveis. Resultados: As Pontuações de Rankin modificadas (mRS) foram avaliadas imediatamente antes do início das terapias e na alta dos pacientes. O escore mRS mediano na admissão foi de 4 e 3 no momento da alta (p=0,0001), após 4 a 6 semanas no programa de AVC para ambos os grupos. Conclusão: O modelo de admissão em um serviço de reabilitação hospitalar que inclui terapias multidisciplinares promove ganhos funcionais em indivíduos com sequelas de AVC e ressaltase que esses ganhos são obtidos em um curto espaço de tempo.Intensive rehabilitation services with standardized treatment for stroke survivors are desirable once they contribute to the patients' functional improvement even in facilities with restricted financial resources. Objective: To verify whether the stroke program at our public inpatient Rehabilitation Center contributes to improvements in functional outcome. Method: This is a retrospective cross-sectional study of the first and last 100 neurological patients (2009-2010 and 2014-2015) admitted at the Lucy Montoro Rehabilitation Network (Morumbi Unit). For this study, the patients were analyzed at admission and at discharge by the modified Rankin Scale (mRS). After testing for normality, an unpaired t-test was on the patients' clinical and demographic characteristics. Intragroup analysis was performed by the nonparametric Wilcoxon test. The intergroup analysis used the Mann-Whitney nonparametric test. Functional outcome scores < 3 at discharge were considered favorable. Results: The modified Rankin Scores (mRS) were assessed just before the initiation of the therapies and at the patients' discharge. Median mRS score at admission was 4 compared to 3 at discharge (p=0.0001), after 4 to 6 weeks in the stroke program. Conclusions: Short term, standardized intensive rehabilitation program with multidisciplinary therapies, in which the patient remains hospitalized, promote functional improvements of patients with stroke sequelae

Modelo intensivo de reabilitação na síndrome de Guillain-Barré: um relato de caso

Existem poucas informações na literatura médica sobre a reabilitação de pacientes com a Síndrome de Guillain-Barré (SGB). Há estudos clínicos que demonstram a eficácia do programa de reabilitação por meio de uma equipe interdisciplinar, porém sem protocolos bem definidos e apenas realizados em regime ambulatorial. Este relato de caso tem como objetivo descrever a evolução de um paciente com SGB, durante o programa de reabilitação multiprofissional intensivo em regime de internação, discutindo as possibilidades terapêuticas para reabilitação da doençaThere is little information in the medical literature on the rehabilitation of patients with GuillainBarre Syndrome (GBS). There are clinical studies that demonstrate the effectiveness of a rehabilitation program using an interdisciplinary team, but without well-defined protocols and only performed on an outpatient basis. This case report aims to describe the evolution of a patient with GBS during the intensive multidisciplinary inpatient rehabilitation program, discussing the therapeutic possibilities for rehabilitation of the diseas

The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers.

The biology of breast cancer response to neoadjuvant therapy is underrepresented in the literature and provides a window-of-opportunity to explore the genomic and microenvironment modulation of tumours exposed to therapy. Here, we characterised the mutational, gene expression, pathway enrichment and tumour-infiltrating lymphocytes (TILs) dynamics across different timepoints of 35 HER2-negative primary breast cancer patients receiving neoadjuvant eribulin therapy (SOLTI-1007 NEOERIBULIN-NCT01669252). Whole-exome data (N = 88 samples) generated mutational profiles and candidate neoantigens and were analysed along with RNA-Nanostring 545-gene expression (N = 96 samples) and stromal TILs (N = 105 samples). Tumour mutation burden varied across patients at baseline but not across the sampling timepoints for each patient. Mutational signatures were not always conserved across tumours. There was a trend towards higher odds of response and less hazard to relapse when the percentage of subclonal mutations was low, suggesting that more homogenous tumours might have better responses to neoadjuvant therapy. Few driver mutations (5.1%) generated putative neoantigens. Mutation and neoantigen load were positively correlated (R2 = 0.94, p = 2 = 0.16, p = 0.02). An enrichment in pathways linked to immune infiltration and reduced programmed cell death expression were seen after 12 weeks of eribulin in good responders. VEGF was downregulated over time in the good responder group and FABP5, an inductor of epithelial mesenchymal transition (EMT), was upregulated in cases that recurred (p < 0.05). Mutational heterogeneity, subclonal architecture and the improvement of immune microenvironment along with remodelling of hypoxia and EMT may influence the response to neoadjuvant treatment

Lesão medular: reabilitação

This study revised articles from the MEDLINE (PubMed) databases and other research sources, with no time limit. To do so, the search strategy adopted was based on (P.I.C.O.) structured questions (from the initials "Patient"; "Intervention"; "Control" and "Outcome".&nbsp;&nbsp;With the above keywords crossings were performed according to the proposed theme in each topic of the (P.I.C.O.) questions. After analyzing this material,&nbsp;therapy narrow&nbsp;articles regarding the questions were selected and, by studying those, the evidences that fundamented the directives of this document were established.Este estudo revisou artigos nas bases de dados do MEDLINE (PubMed) e demais fontes de pesquisa, sem limite de tempo. Para tan-to, adotou-se a estratégia de busca baseada em perguntas estruturadas na forma (P.I.C.O.) das iniciais: "Paciente"; "Intervençao"; "Controle" e "Outcome".&nbsp;&nbsp;Com esses descritores efetivaram-se cruzamentos de acordo com o tema proposto em cada tópico das perguntas (P.I.C.O.). Analisado esse material, foram selecionados os artigos&nbsp;therapy narrow&nbsp;relativos às perguntas e, por meio do estudo dos mesmos, estabeleceram-se as evidências que fundamentaram às diretrizes do presente documento

Development of a protocol for the assessment of patients with pressure ulcers through telemedicine and digital images

Introduction: Pressure ulcers are frequent complications in patients with spinal cord injuries. These ulcers need an early diagnosis and a strict follow-up to prevent a more severe evolution and delays in the rehabilitation process. Unfortunately, patients do not always have access to a center specialized in the treatment of wounds, and thus, telemedicine can be useful in such cases. Objective: To evaluate the effectiveness of a protocol for the assessment of pressure ulcers through digital images. Methods: 15 patients were selected, totaling 33 ulcers. The patients were separately assessed by 2 on-site physiatrists, who filled out the first part of the protocol (patients’ clinical data) at the time of the consultation and took the photographs. These were sent to the physiatrists at-distance, who evaluated the wounds through the photographs and the data sent by the on-site physician. The similarities and differences between the two on-site physicians, between the on-site physicians and the physicians at-distance and between the two physicians at-distance were compared regarding the degree, necrosis, infection, fistula, secretion, wound border and depth aspect and conduct. The statistical analysis was based on Kappa calculations, a confidence interval and P value. Results: The highest Kappa values were observed when the on-site assessments were compared. For necrosis, degree and infection, the On-site Assessment (S) x Assessment at distance (D) Kappas were substantial and moderate. For the item conduct, the Kappa varied from weak to almost perfect. As for the evaluations of the borders, depth, secretion and fistula, there were divergences. Conclusion: The protocol is effective to assess wound necrosis, degree and infection. There is some difficulty in using the method to evaluate the border and depth aspect, secretion and fistula. The method showed to be more satisfactory for the assessment of pressure ulcers grade I and II.Introdução: As úlceras de pressão são complicações freqüentes em pacientes com lesão medular. Estas precisam de um diagnóstico precoce e um acompanhamento rigoroso para que não evoluam para um quadro mais grave e para não retardar o processo de reabilitação. Infelizmente, não é sempre que o paciente consegue acesso a um centro especializado no tratamento de feridas e, por isso, a telemedicina pode ser útil nesses casos. Objetivo: Avaliar a eficácia de um protocolo de avaliação de úlceras de pressão através de fotografias digitais. Métodos: Selecionamos 15 pacientes, totalizando 33 úlceras. Os pacientes foram avaliados por 2 médicos fisiatras presenciais, separadamente, que no momento do exame, preencheram a primeira parte do protocolo (dados clínicos do paciente) e tiraram as fotografias. Estas foram encaminhadas aos médicos fisiatras à distância, que avaliaram as feridas através das fotos e dos dados enviados pelo médico presencial. Comparamos as semelhanças e diferenças das avaliações entre os dois médicos presenciais, entre presencial e a distancia e entre os dois médicos à distância nos quesitos grau, necrose, infecção, fístula, secreção, aspecto da borda e do fundo e conduta. A Análise estatística se baseou nos cálculos de Kappa, intervalo de confiança e P valor. Resultados: Encontramos os maiores valores de Kappa quando comparamos as avaliações presenciais. Para necrose, grau e infecção, os kappas Avaliação Presencial (P) x Avaliação à distância (D) foram substantial e moderate. No item conduta, o Kappa variou de fraco a almost perfect. Nas avaliações das bordas, fundo, secreção e fístula foram encontradas divergências. Conclusão: O protocolo é eficaz para avaliar necrose, grau e infecção das úlceras. Existe dificuldade no uso do método para avaliar o aspecto de borda, fundo, secreção e fístula. Houve maior satisfação com o método para úlceras de pressão grau I e II

Safety of Adding Oats to a Gluten-free Diet for Patients with Celiac Disease: Systematic Review and Meta-analysis of Clinical and Observational Studies

Background & Aims: Patients with celiac disease should maintain a gluten-free diet (GFD), excluding wheat, rye, and barley. Oats might increase the nutritional value of a GFD, but their inclusion is controversial. We performed a systematic review and meta-analysis to evaluate the safety of oats as part of a GFD in patients with celiac disease. Methods: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, and EMBASE databases for clinical trials and observational studies of the effects of including oats in GFD of patients with celiac disease. The studies reported patients’ symptoms, results from serology tests, and findings from histologic analyses. We used the GRADE approach to assess the quality of evidence. Results: We identified 433 studies; 28 were eligible for analysis. Of these, 6 were randomized and 2 were not randomized controlled trials comprising a total of 661 patients—the remaining studies were observational. All randomized controlled trials used pure/uncontaminated oats. Oat consumption for 12 months did not affect symptoms (standardized mean difference: reduction in symptom scores in patients who did and did not consume oats, −0.22; 95% CI, −0.56 to 0.13; P = .22), histologic scores (relative risk for histologic findings in patients who consumed oats, 0.24; 95% CI, 0.01–4.8; P = .35), intraepithelial lymphocyte counts (standardized mean difference, 0.21; 95% CI, reduction of 1.44 to increase in 1.86), or results from serologic tests. Subgroup analyses of adults vs children did not reveal differences. The overall quality of evidence was low. Conclusions: In a systematic review and meta-analysis, we found no evidence that addition of oats to a GFD affects symptoms, histology, immunity, or serologic features of patients with celiac disease. However, there were few studies for many endpoints, as well as limited geographic distribution and low quality of evidence. Rigorous double-blind, placebo-controlled, randomized controlled trials, using commonly available oats sourced from different regions, are needed

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700