Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain

Background/Objective: Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP). Objective: The aim of this study was to analyze outcomes in patients with AP from regions in Spain with different patterns of dietary fat intake. Materials and Methods: A retrospective analysis was performed with data from 1,655 patients with AP from a Spanish prospective cohort study and regional nutritional data from a Spanish cross-sectional study. Nutritional data considered in the study concern the total lipid consumption, detailing total saturated fatty acids, UFAs and monounsaturated fatty acids (MUFAs) consumption derived from regional data and not from the patient prospective cohort. Two multivariable analysis models were used: (1) a model with the Charlson comorbidity index, sex, alcoholic etiology, and recurrent AP; (2) a model that included these variables plus obesity. Results: In multivariable analysis, patients from regions with high UFA intake had a significantly increased frequency of local complications, persistent organ failure (POF), mortality, and moderate-to-severe disease in the model without obesity and a higher frequency of POF in the model with obesity. Patients from regions with high MUFA intake had significantly more local complications and moderate-to-severe disease; this significance remained for moderate-to-severe disease when obesity was added to the model. Conclusions: Differences in dietary fat patterns could be associated with different outcomes in AP, and dietary fat patterns may be a pre-morbid factor that determines the severity of AP. UFAs, and particulary MUFAs, may influence the pathogenesis of the severity of AP

Generación de imágenes 3D a partir de fotogramas

Navarro Soriano, J. (2011). Generación de imágenes 3D a partir de fotogramas. http://hdl.handle.net/10251/11128.Archivo delegad

Supporting Dynamic Service Composition at Runtime based on End-user Requirements

Network-based software application services are receiving a lot of attention in recent years, as observed in developments as Internet of Services, Software as a Service and Cloud Computing. A service-oriented computing ecosystem is being created where the end-user is having an increasingly more active role in the service creation process. However, supporting end-users in the creation process, at runtime, is a difficult undertaking. Users have different requirements and preferences towards application services, use services in different situations and expect highly abstract mechanisms in the creation process. Furthermore, there are different types of end-users: some can deliver more detailed requirements or can be provided with more advanced request interface, while others can not. To tackle these issues and provide end-users with personalised service delivery, we claim that runtime automated service composition mechanisms are required. In this paper we present the DynamiCoS framework, which aims at supporting the different phases required to provide end-users with automatic service discovery, selection and composition process. In this paper we also present the developed prototype and its evaluation

A Peptide/Fullerene Hybrid for Multivalent Recognition of E-Selectin

Molecular recognition through ligand-receptor interactions is a very important mechanism for metastatic processes. Among all of them, multivalent protein-carbohydrate interactions play a fundamental role in tumor cell-endothelial cell recognition processes. In particular, the interaction between SLex and SLea expressed in circulating tumor cells and proteins of the family of selectins, overexpressed in endothelial cells. Unlike tumor cells, vascular endothelial cells receptors are a stable target not subjected to genetic modifications. In addition, the elimination of a single endothelial cell involves the death of hundreds of tumor cells. Targeting endothelial receptors cells offers a high potential in tumor diagnosis and therapy. SLex and SLea are the natural ligands of selectins, but their complicated chemical synthesis and their low affinity for selectins made difficult to continue with their development. Recently, through "phase display" it was identified a simple peptide with a linear sequence of seven amino acids (Ile-Glu-Leu-Leu-Gln-Ala-Arg) called IELLQAR that interacts specifically with selectins. IELLQAR is a very simple compound, which can be synthesized using SPPS. IELLQAR can be functionalized and easily conjugated to fullerenes for its multivalent presentation. In addition, it can be combined with diagnostic and therapeutic agents. References [1] Smith, B. A. H.; Bertozzi, C. Nat. Rev. Drug Discov. 2021, 20, 217.243. [2] Fukuda, M. N. et al. Cancer Res. 2000, 60, 450-456 [3] (a) Ramos-Soriano, J. et al. Chem. Commun. 2016, 52, 10544-10546; (b) Ramos-Soriano, J. et al. J. Org. Chem. 2018, 83, 1727-1736.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

The approximate f-core and the utopia payoff for infinite assignment games

Assignment problems where both sets of agents are countably infinite, the so-called infinite assignment problems, are studied as well as the related assignment games. Further, two solutions for these games are studied. The first one is the approximate f-core for games with a finite value. This particular solution takes into account that due to organisational limitations only finite groups of agents can protest against proposals of profit distributions. Second, we study the utopia payoff, the perfect proposal in which each agent receives the maximal amount he can get. \u

Convex Games with Countable Number of Players and Sequencing Situations

AMS classification: 91A12;Cooperative games;countable number of players;convexity;infinite sequencing situations

Multi-Choice Total Clan Games: Characterizations and Solution Concepts

This paper deals with a new class of multi-choice games, the class of multi- choice total clan games. The structure of the core of a multi-choice clan game is explicitly described. Furthermore, characterizations of multi-choice total clan games are given and bi-monotonic allocation schemes related to players' levels are introduced for such games. It turns out that some elements in the core of a multi- choice total clan game are extendable to such bi-monotonic allocation schemes via suitable compensation-sharing rules on the domain of multi-choice (total) clan games.Multi-choice games;Clan games;Monotonic allocation schemes

The Owen Set and the Core of Semi-Infinite Linear Production Situations

AMS classifications: 90D12, 90C05, 90C34.cooperative games;linear production;core;duality gap

On the Core of Semi-Infinite Transportation Games with Divisible Goods

AMS classifications: 90D12; 90C05; 90C34;cooperative games

Egalitarianism in Multi-Choice Games

In this paper we introduce the equal division core for arbitrary multi-choice games and the constrained egalitarian solution for con- vex multi-choice games, using a multi-choice version of the Dutta-Ray algorithm for traditional convex games. These egalitarian solutions for multi-choice games have similar properties as their counterparts for traditional cooperative games. On the class of convex multi-choice games, we axiomatically characterize the constrained egalitarian solu- tion.Multi-choice games;Convex games;Equal division core;Constrained egalitarian solution