10 research outputs found

    [Chapter 1 from] The Power of Invisible Leadership: How a Compelling Common Purpose Inspires Exceptional Leadership

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    A powerful force draws people to leadership in countless businesses, nonprofits, government agencies, and social movements—we call it invisible leadership. Invisible leadership embodies situations in which dedication to a compelling and deeply held common purpose is the motivating force for leadership. Common purpose is more than a mission statement. It is a profound sense of common destiny, a life course or calling, aligned with a mission that resonates profoundly with our values and our sense of ourselves and others. This readable, research-based book shows readers how invisible leadership exists in the space between leaders and followers, artists and subjects, and purposes and people. Rather than reinforcing the idea that leadership is embodied in celebrity leaders or in gifted and charismatic individuals, the well known and highly admired authors of this insightful new book identify “charisma of purpose” as the motivating force for invisible leadership. A brief discussion of how invisible leadership impacts businesses, nonprofits, government agencies, and social movements guides the reader toward an understanding of the antecedents and possibilities of this way of thinking.https://scholarship.richmond.edu/bookshelf/1012/thumbnail.jp

    The Enduring and Elusive Quest for a General Theory of Leadership: Initial Efforts and New Horizons

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    When the idea of convening a group of scholars to formulate a general theory of leadership was first proposed, one of those who eventually became a key member remarked that the idea of such a project was \u27quixotic\u27. Professor Joanne Ciulla used the term exactly as it is defined - as the American Heritage Dictionary (2009) has it, \u27idealistic or romantic without regard to practicality.\u27 What a charming, silly idea. And in the end, the quest and idealism endures but the goal of a general theory remains elusive. However, as Ciulla herself documents, we went far, and learned a great deal along the way

    Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients

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    Objective. To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods. We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. Change in cognitive/behavioral subgroups was assessed using one-way analyses of covariance. Results. Participants with follow-up data had fewer baseline behavior problems compared to patients without follow-up data. We found significant worsening of behavior (ALS Cognitive Behavioral Screen (ALS CBS) behavioral scale, p \u3c 0.001; Frontal Behavioral Inventory-ALS (FBI-ALS) disinhibition subscale, p = 0.044). Item analysis suggested change in frustration tolerance, insight, mental rigidity, and interests (p \u3c 0.05). Changes in ALSFRS-R correlated with the ALS CBS. Worsening disinhibition (FBI-ALS) did not correlate with ALSFRS-R, FVC, or disease duration. Conclusion. We did not detect cognitive change. Behavioral change was detected, and increased disinhibition was found among patients with abnormal baseline behavioral scores. Disinhibition changes did not correlate with disease duration or progression. Baseline behavioral problems were associated with advanced, rapidly progressive disease and study attrition

    Association between dietary intake and function in amyotrophic lateral sclerosis

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    IMPORTANCE There is growing interest in the role of nutrition in the pathogenesis and progression of amyotrophic lateral sclerosis (ALS). OBJECTIVE To evaluate the associations between nutrients, individually and in groups, and ALS function and respiratory function at diagnosis. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional baseline analysis of the Amyotrophic Lateral Sclerosis Multicenter Cohort Study of Oxidative Stress study was conducted from March 14, 2008, to February 27, 2013, at 16 ALS clinics throughout the United States among 302 patients with ALS symptom duration of 18 months or less. EXPOSURES Nutrient intake, measured using a modified Block Food Frequency Questionnaire (FFQ). MAIN OUTCOMES AND MEASURES Amyotrophic lateral sclerosis function, measured using the ALS Functional Rating Scale-Revised (ALSFRS-R), and respiratory function, measured using percentage of predicted forced vital capacity (FVC). RESULTS Baseline data were available on 302 patients with ALS (median age, 63.2 years [interquartile range, 55.5-68.0 years]; 178 men and 124 women). Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC. Empirically weighted indices using the weighted quantile sum regression method of "good" micronutrients and "good" food groups were positively associated with ALSFRS-R scores (β [SE], 2.7 [0.69] and 2.9 [0.9], respectively) and percentage FVC (β [SE], 12.1 [2.8] and 11.5 [3.4], respectively) (all P < .001). Positive and significant associations with ALSFRS-R scores (β [SE], 1.5 [0.61]; P = .02) and percentage FVC (β [SE], 5.2 [2.2]; P = .02) for selected vitamins were found in exploratory analyses. CONCLUSIONS AND RELEVANCE Antioxidants, carotenes, fruits, and vegetableswere associated with higher ALS function at baseline by regression of nutrient indices and weighted quantile sum regression analysis.We also demonstrated the usefulness of the weighted quantile sum regression method in the evaluation of diet. Those responsible for nutritional care of the patient with ALS should consider promoting fruit and vegetable intake since they are high in antioxidants and carotenes

    Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs - a PEARRL review

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    β-cell failure as a complication of diabetes

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