Visual detail and its effects on character attachment in video games

The video game industry has been experiencing a trend toward independent game developers making their own games, as well as large companies opening smaller divisions to work on smaller games. This can be looked at from a purely financial perspective, given that smaller games will inevitably consume a smaller budget; however, there is also good reason to believe there can be substantial creative benefits to companies indulging in this trend. This research is concerned with the effect that visual detail can have on a players emotional attachment to characters in video games-otherwise known as character attachment. While intuition may often tell people that more is more, this paper considers the possibility that less may, in fact be more. However, upon developing a game with four different levels of visual detail and testing participants who were only exposed to one version of the game, no significant relationship was found between character attachment and the level of visual detail. Possible explanations for the lack of observed effects are detailed and discussed

Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity

This work is licensed under a Creative Commons Attribution 4.0 International License.Neuromuscular control of voluntary movement may be simplified using muscle synergies similar to those found using non-negative matrix factorization. We recently identified synergies in electromyography (EMG) recordings associated with both voluntary movement and movement evoked by high-frequency long-duration intracortical microstimulation applied to the forelimb representation of the primary motor cortex (M1). The goal of this study was to use stimulus-triggered averaging (StTA) of EMG activity to investigate the synergy profiles and weighting coefficients associated with poststimulus facilitation, as synergies may be hard-wired into elemental cortical output modules and revealed by StTA. We applied StTA at low (LOW, ∼15 μA) and high intensities (HIGH, ∼110 μA) to 247 cortical locations of the M1 forelimb region in two male rhesus macaques while recording the EMG of 24 forelimb muscles. Our results show that 10–11 synergies accounted for 90% of the variation in poststimulus EMG facilitation peaks from the LOW-intensity StTA dataset while only 4–5 synergies were needed for the HIGH-intensity dataset. Synergies were similar across monkeys and current intensities. Most synergy profiles strongly activated only one or two muscles; all joints were represented and most, but not all, joint directions of motion were represented. Cortical maps of the synergy weighting coefficients suggest only a weak organization. StTA of M1 resulted in highly diverse muscle activations, suggestive of the limiting condition of requiring a synergy for each muscle to account for the patterns observed

Low-Velocity Halo Clouds

Models that reproduce the observed high-velocity clouds (HVCs) also predict clouds at lower radial velocities that may easily be confused with Galactic disk (|z| < 1 kpc) gas. We describe the first search for these low-velocity halo clouds (LVHCs) using IRAS data and the initial data from the Galactic Arecibo L-band Feed Array survey in HI (GALFA-HI). The technique is based upon the expectation that such clouds should, like HVCs, have very limited infrared thermal dust emission as compared to their HI column density. We describe our 'displacement-map' technique for robustly determining the dust-to-gas ratio of clouds and the associated errors that takes into account the significant scatter in the infrared flux from the Galactic disk gas. We find that there exist lower-velocity clouds that have extremely low dust-to-gas ratios, consistent with being in the Galactic halo - candidate LVHCs. We also confirm the lack of dust in many HVCs with the notable exception of complex M, which we consider to be the first detection of warm dust in HVCs. We do not confirm the previously reported detection of dust in complex C. In addition, we find that most Intermediate- and Low-Velocity clouds that are part of the Galactic disk have a higher 60 micron/100 micron flux ratio than is typically seen in Galactic HI, which is consistent with a previously proposed picture in which fast-moving Galactic clouds have smaller, hotter dust grains.Comment: 30 pages, 7 figures. Accepted to the Ap

The Star Formation History of M32

We use deep HST ACS/HRC observations of a field within M32 (F1) and an M31 background field (F2) to determine the star formation history (SFH) of M32 from its resolved stellar population. We find that 2-5Gyr old stars contribute \som40%+/- 17% of M32's mass, while 55%+/-21% of M32's mass comes from stars older than 5 Gyr. The mass-weighted mean age and metallicity of M32 at F1 are =6.8+/-1.5 Gyr and =-0.01+/-0.08 dex. The SFH additionally indicates the presence of young (<2 Gyr old), metal-poor ([M/H]\sim-0.7) stars, suggesting that blue straggler stars contribute ~2% of the mass at F1; the remaining \sim3% of the mass is in young metal-rich stars. Line-strength indices computed from the SFH imply a light-weighted mean age and metallicity of 4.9 Gyr and [M/H] = -0.12 dex, and single-stellar-population-equivalent parameters of 2.9+/-0.2 Gyr and [M/H]=0.02+/-0.01 dex at F1 (~2.7 re). This contradicts spectroscopic studies that show a steep age gradient from M32's center to 1re. The inferred SFH of the M31 background field F2 reveals that the majority of its stars are old, with \sim95% of its mass already acquired 5-14 Gyr ago. It is composed of two dominant populations; \sim30%+/-7.5% of its mass is in a 5-8 Gyr old population, and \sim65%+/-9% of the mass is in a 8-14 Gyr old population. The mass-weighted mean age and metallicity of F2 are =9.2+/-1.2 Gyr and =-0.10+/-0.10 dex, respectively. Our results suggest that the inner disk and spheroid populations of M31 are indistinguishable from those of the outer disk and spheroid. Assuming the mean age of M31's disk at F2 (\sim1 disk scale length) to be 5-9 Gyr, our results agree with an inside-out disk formation scenario for M31's disk.Comment: Accepted to ApJ. 24 pages, 18 figures. A high-resolution version can be downloaded from http://www.astro.rug.nl/~monachesi/monachesi-sfh.pd

Epigenetic changes in myelofibrosis:Distinct methylation changes in the myeloid compartments and in cases with <i>ASXL1</i> mutations

Abstract This is the first study to compare genome-wide DNA methylation profiles of sorted blood cells from myelofibrosis (MF) patients and healthy controls. We found that differentially methylated CpG sites located to genes involved in ‘cancer’ and ‘embryonic development’ in MF CD34+ cells, in ‘inflammatory disease’ in MF mononuclear cells, and in ‘immunological diseases’ in MF granulocytes. Only few differentially methylated CpG sites were common among the three cell populations. Mutations in the epigenetic regulators ASXL1 (47%) and TET2 (20%) were not associated with a specific DNA methylation pattern using an unsupervised approach. However, in a supervised analysis of ASXL1 mutated versus wild-type cases, differentially methylated CpG sites were enriched in regions marked by histone H3K4me1, histone H3K27me3, and the bivalent histone mark H3K27me3 + H3K4me3 in human CD34+ cells. Hypermethylation of selected CpG sites was confirmed in a separate validation cohort of 30 MF patients by pyrosequencing. Altogether, we show that individual MF cell populations have distinct differentially methylated genes relative to their normal counterparts, which likely contribute to the phenotypic characteristics of MF. Furthermore, differentially methylated CpG sites in ASXL1 mutated MF cases are found in regulatory regions that could be associated with aberrant gene expression of ASXL1 target genes

Evaluation and Validation of a Real-Time PCR Assay for Detection and Quantitation of Human Adenovirus 14 from Clinical Samples

In 2007, the Centers for Disease Control and Prevention (CDC) reported that Human adenovirus type 14 (HAdV-14) infected 106 military personnel and was responsible for the death of one U.S. soldier at Lackland Air Force Base in Texas. Identification of the responsible adenovirus, which had not previously been seen in North America and for which rapid diagnostic tools were unavailable, required retrospective analysis at reference laboratories. Initial quarantine measures were also reliant on relatively slow traditional PCR analysis at other locations. To address this problem, we developed a real-time PCR assay that detects a 225 base pair sequence in the HAdV-14a hexon gene. Fifty-one oropharyngeal swab specimens from the Naval Health Research Center, San Diego, CA and Advanced Diagnostic Laboratory, Lackland AFB, TX were used to validate the new assay. The described assay detected eight of eight and 19 of 19 confirmed HAdV-14a clinical isolates in two separate cohorts from respiratory disease outbreaks. The real-time PCR assay had a wide dynamic range, detecting from 102 to 107 copies of genomic DNA per reaction. The assay did not cross-react with other adenoviruses, influenza, respiratory syncytial virus, or common respiratory tract bacteria. The described assay is easy to use, sensitive and specific for HAdV-14a in clinical throat swab specimens, and very rapid since turnaround time is less than four hours to obtain an answer

Automated imaging technologies for the diagnosis of glaucoma: a comparative diagnostic study for the evaluation of the diagnostic accuracy, performance as triage tests and cost-effectiveness (GATE study)

BACKGROUND: Many glaucoma referrals from the community to hospital eye services are unnecessary. Imaging technologies can potentially be useful to triage this population. OBJECTIVES: To assess the diagnostic performance and cost-effectiveness of imaging technologies as triage tests for identifying people with glaucoma. DESIGN: Within-patient comparative diagnostic accuracy study. Markov economic model comparing the cost-effectiveness of a triage test with usual care. SETTING: Secondary care. PARTICIPANTS: Adults referred from the community to hospital eye services for possible glaucoma. INTERVENTIONS: Heidelberg Retinal Tomography (HRT), including two diagnostic algorithms, glaucoma probability score (HRT-GPS) and Moorfields regression analysis (HRT-MRA); scanning laser polarimetry [glaucoma diagnostics (GDx)]; and optical coherence tomography (OCT). The reference standard was clinical examination by a consultant ophthalmologist with glaucoma expertise including visual field testing and intraocular pressure (IOP) measurement. MAIN OUTCOME MEASURES: (1) Diagnostic performance of imaging, using data from the eye with most severe disease. (2) Composite triage test performance (imaging test, IOP measurement and visual acuity measurement), using data from both eyes, in correctly identifying clinical management decisions, that is 'discharge' or 'do not discharge'. Outcome measures were sensitivity, specificity and incremental cost per quality-adjusted life-year (QALY). RESULTS: Data from 943 of 955 participants were included in the analysis. The average age was 60.5 years (standard deviation 13.8 years) and 51.1% were females. Glaucoma was diagnosed by the clinician in at least one eye in 16.8% of participants; 37.9% of participants were discharged after the first visit. Regarding diagnosing glaucoma, HRT-MRA had the highest sensitivity [87.0%, 95% confidence interval (CI) 80.2% to 92.1%] but the lowest specificity (63.9%, 95% CI 60.2% to 67.4%) and GDx had the lowest sensitivity (35.1%, 95% CI 27.0% to 43.8%) but the highest specificity (97.2%, 95% CI 95.6% to 98.3%). HRT-GPS had sensitivity of 81.5% (95% CI 73.9% to 87.6%) and specificity of 67.7% (95% CI 64.2% to 71.2%) and OCT had sensitivity of 76.9% (95% CI 69.2% to 83.4%) and specificity of 78.5% (95% CI 75.4% to 81.4%). Regarding triage accuracy, triage using HRT-GPS had the highest sensitivity (86.0%, 95% CI 82.8% to 88.7%) but the lowest specificity (39.1%, 95% CI 34.0% to 44.5%), GDx had the lowest sensitivity (64.7%, 95% CI 60.7% to 68.7%) but the highest specificity (53.6%, 95% CI 48.2% to 58.9%). Introducing a composite triage station into the referral pathway to identify appropriate referrals was cost-effective. All triage strategies resulted in a cost reduction compared with standard care (consultant-led diagnosis) but with an associated reduction in effectiveness. GDx was the least costly and least effective strategy. OCT and HRT-GPS were not cost-effective. Compared with GDx, the cost per QALY gained for HRT-MRA is £22,904. The cost per QALY gained with current practice is £156,985 compared with HRT-MRA. Large savings could be made by implementing HRT-MRA but some benefit to patients will be forgone. The results were sensitive to the triage costs. CONCLUSIONS: Automated imaging can be effective to aid glaucoma diagnosis among individuals referred from the community to hospital eye services. A model of care using a triage composite test appears to be cost-effective