20 research outputs found
Quality in Industrial Engineering School: Universidad Tecnica De Manabi
The paper presents a conceptual analysis related to quality in higher education, highlighting the peculiarities in Ecuador, presenting the content structure of the evaluation system of the quality required by the CEAACES and quality environment is addressed in the UTM, analysis related to the results of research on the quality of development in the career of Industrial Engineering of higher learning was obtained, proving that there are still weaknesses that can affect academic excellence, so it requires constant effort on the part of the institutions, which can be realized through research projects aimed at maintaining self-control of quality in universities
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra
Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases
BOTĂNICA E FISIOLOGIA/ BOTANY AND PHYSIOLOGY ANTIOXIDANT ACTIVITY AND PHYSICOCHEMICAL PARAMETERS IN âCUERNAVAQUEĂAâ MEXICAN PLUM (Spondias purpurea L.) AT DIFFERENT RIPENING STAGES
A global experiment on motivating social distancing during the COVID-19 pandemic
Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This cross-country, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on oneâs core values) or behavioral intentions. Results supported hypothesized associations between peopleâs existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges
Preclinical evaluation of the antimicrobial-immunomodulatory dual action of xenohormetic molecules against haemophilus influenzae respiratory infection
Chronic obstructive pulmonary disease (COPD) is characterized by abnormal inflammation
and impaired airway immunity, providing an opportunistic platform for nontypeable Haemophilus
influenzae (NTHi) infection. In this context, therapies targeting not only overactive inflammation
without significant adverse effects, but also infection are of interest. Increasing evidence suggests that
polyphenols, plant secondary metabolites with anti-inflammatory and antimicrobial properties, may
be protective. Here, a Cistus salviifolius plant extract containing quercetin, myricetin, and punicalagin
was shown to reduce NTHi viability. Analysis of these polyphenols revealed that quercetin has a
bactericidal effect on NTHi, does not display synergies, and that bacteria do not seem to develop
resistance. Moreover, quercetin lowered NTHi airway epithelial invasion through a mechanism
likely involving inhibition of Akt phosphorylation, and reduced the expression of bacterially-induced
proinflammatory markers il-8, cxcl-1, il-6, pde4b, and tnfα. We further tested quercetinâs effect on NTHi
murine pulmonary infection, showing a moderate reduction in bacterial counts and significantly
reduced expression of proinflammatory genes, compared to untreated mice. Quercetin administration
during NTHi infection on a zebrafish septicemia infection model system showed a bacterial clearing
effect without signs of host toxicity. In conclusion, this study highlights the therapeutic potential of
the xenohormetic molecule quercetin against NTHi infection
Smokers with CT detected emphysema and no airway obstruction have decreased plasma levels of EGF, IL-15, IL-8 and IL-1ra
Current or former smokers expressing a well-defined disease characteristic such as emphysema, has a specific plasma cytokine profile. This includes a decrease of cytokines mainly implicated in activation of apoptosis or decrease of immunosurveillance. This information should be taken into account when evaluated patients with tobacco respiratory diseases
On the Fertilizer Three Element Treatments of Rice Crops Sampled for Leaf Analysis by Field
Rice crops field experiment grown on fertilizer three element treatments was carried out in 1952-54. at Fukigami, Takigun, Hyogo Pref. The effect of N element was most remarkable from 1st year in total yield, and that of P was not significant until 3rd year. K effect was not significant in 1st year, but gradually became significant since 2nd year. Details of growth and yield results are shown in the tables
N
The ÎČ-lactone ring of N-(2-oxo-3-oxetanyl)amides, a class of N-acylethanolamine acid amidase (NAAA) inhibitors endowed with anti-inflammatory properties, is responsible for both NAAA inhibition and low compound stability. Here, we investigate the structureâactivity and structureâproperty relationships for a set of known and new ÎČ-lactone derivatives, focusing on the new class of N-(2-oxo-3-oxetanyl)carbamates. Replacement of the amide group with a carbamate one led to different stereoselectivity for NAAA inhibition and higher intrinsic stability, because of the reduced level of intramolecular attack at the lactone ring. The introduction of a syn methyl at the ÎČ-position of the lactone further improved chemical stability. A tert-butyl
substituent in the side chain reduced the reactivity with bovine serum albumin. (2S,3R)-2-Methyl-4-oxo-3-oxetanylcarbamic acid 5-phenylpentyl ester (27, URB913/ARN077) inhibited NAAA with good in vitro potency (IC50 = 127 nM) and showed improved stability. It is rapidly cleaved in plasma, which supports its use for topical applications