Evaluation of the impact of the Covid-19 pandemic on people and organisations in long-term care facilities of Catalonia and proposals for improving the care model: the resicovid-19 project

Background: During the first wave of the COVID-19 pandemic, it is estimated that around 25% of infected residents in Nursing Homes in Catalonia died, which accounted for more than 50% of total COVID-19 deaths in the region. This devastating impact not only highlights the structural deficits of the long-term care facilities system, but it also provides a unique opportunity to gather evidence to support a redesign of the health and social care models–a redesign that focuses on individuals and their singularities, and is equipped with the staff and infrastructure required to meet their needs. Methods: The ResiCOVID-19 project will include five work packages to assess the impact of the COVID-19 pandemic (from March 2020 to June 2022) on the individuals living in long-term care facilities in Catalonia, their family members, health care workers, and the organisations themselves. In this project, we will develop proposals for improvement and indicators for the long-term care model in Catalonia to better adapt to the current and future needs of people-centred care through conducting a rapid review, analysis of international experiences, retrospective analysis, and a cross-sectional study. The analysis will be conducted both from a quantitative and a qualitative perspective, measuring the impact at a system level as well as at a setting and individual level, including residents, families, professionals, and managers of longterm care facilities. Conclusions: The ResiCOVID-19 project is expected to have a significant impact at different dimensions, including the care model, social and organisational aspects (on professionals and facilities), systemic efforts (both for the healthcare and the social systems), and scientific contributions (providing evidence in a field of limited research in Catalonia)

Pla estratègic d’atenció geriàtrica especialitzada de Catalunya: bases del model de futur

Pla estratègic; Atenció geriàtrica; Atenció centrada en la personaPlan estratégico; Atención geriátrica; Atención centrada en la personaStrategic plan; Geriatric care; Attention focused on the personAquest Pla aborda la planificació estratègica de l’atenció a les persones grans per part dels equips i dispositius geriàtrics especialitzats (atenció geriàtrica especialitzada), mentre que de forma conjunta amb la direcció estratègica d’atenció primària serà necessari el replantejament de l’atenció a la gent gran de forma transversal, així com amb Salut Pública

Pla estratègic d'atenció geriàtrica i pal·liativa especialitzada de Catalunya: línies estratègiques, projectes i actuacions

Pla estratègic; Atenció pal·liativa; Atenció centrada en la personaPlan estratégico; Atención paliativa; Atención centrada en la personaStrategic plan; Palliative care; Person centered careAquest document conté les línies estratègiques, projectes i actuacions del Pla estratègic d'atenció geriàtrica i pal·liativa especialitzada de Catalunya

Tractament de manteniment amb metadona: manual de pràctica clínica

Tractament de manteniment amb metadona; Pràctica clínica; DrogodependènciesTratamiento de mantenimiento con metadona; Práctica clínica; DrogodependenciasMethadone maintenance treatment; Clinical practice; Drug addictionsEl Manual pretén ser una eina útil per disminuir la variabilitat de la pràctica clínica i garantir un nivell òptim de qualitat i millora de l'atenció sanitària en el tractament de manteniment amb metadona (TMM). Aplica les normes bàsiques utilitzades per a la preparació de guies de pràctica clínica; en primer lloc, incloent-hi la millor evidència possible sobre la base de revisions sistemàtiques de la literatura, en segon lloc, amb recomanacions clares i curtes, i en tercer lloc, en absència d’una evidència fiable en la literatura, incorporant-hi la opinió d’experts per mitjà de tècniques de consens com el mètode Delphi

ALLEVIATING SOCIAL ISOLATION AND LONELINESS AMONG CARE HOME RESIDENTS DURING THE COVID PANDEMIC: A SCOPING REVIEW USING THE PRINCIPLES OF A REALIST SYNTHESIS

Restrictions in visiting and isolation policies to control the COVID pandemic in care homes have increased the burden of loneliness and social isolation among residents, while creating an enormous challenge for care professionals trying to address their social needs. In this emergency context, several initiatives, from stand-alone actions to programmes, have been implemented to alleviate older people’s loneliness and social isolation. We aim to synthesise knowledge about the ways in which loneliness and social isolation could be alleviated among older people living in care homes during the COVID pandemic. Specifically, we aim to understand ways in which loneliness and social isolation could be alleviated and the mechanisms that were expected to (or were found to) lead to these improvements among older people living in care homes. Our research question is: which practices aimed at increasing social connection or at preventing or alleviating social isolation or loneliness have worked on any health and wellbeing outcome for older people living in care homes and their families, and in which circumstances during the COVID pandemic. We are conducting a scoping review using the principles of realist synthesis. We search for articles published from January 2020 from to June 2022 conducted in care homes targeting older residents and we include any study describing or evaluating a programme or initiative that sought to alleviate loneliness or social isolation among care home residents. Data are extracted and analysed narratively. We use the dimensions of intervention components, context, mechanisms, and outcomes for the synthesis of the data. Any outcome reported quantitatively or qualitatively including adverse effects is extracted. These results will help to build on learnings from the response to the pandemic and support the recovery of the care and social wellbeing in care home settings

Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

Altres ajuts: Fundació La Marató de TV3 (SGR2014-0984)GuA1-containing AMPA receptors play a key role in synaptic plasticity and cognition. Casas et al. demonstrate that the sensing of nutrients by CPT1C regulates the phosphatase activity of SAC1, and consequently PI(4)P levels, at the contact sites between the endoplasmic reticulum and the trans-Golgi network to control the trafficking of GluA1 receptors to the cell surface of neurons. Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key role in synaptic plasticity. In the present study, we demonstrate across different metabolic stress conditions that modulate malonyl-CoA levels in cortical neurons that CPT1C regulates the trafficking of the major AMPAR subunit, GluA1, through the phosphatidyl-inositol-4-phosphate (PI(4)P) phosphatase SAC1. In normal conditions, CPT1C down-regulates SAC1 catalytic activity, allowing efficient GluA1 trafficking to the plasma membrane. However, under low malonyl-CoA levels, such as during glucose depletion, CPT1C-dependent inhibition of SAC1 is released, facilitating SAC1's translocation to ER-TGN contact sites to decrease TGN PI(4)P pools and trigger GluA1 retention at the TGN. Results reveal that GluA1 trafficking is regulated by CPT1C sensing of malonyl-CoA and provide the first report of a SAC1 inhibitor. Moreover, they shed light on how nutrients can affect synaptic function and cognition