Flight Data Analysis of HyShot 2

The development of scramjet propulsion for alternative launch and payload delivery capabilities has comprised largely of ground experiments for the last 40 years. With the goal of validating the use of short duration ground test facilities, the University of Queensland, supported by a large international contingency, devised a ballistic re-entry vehicle experiment called HyShot to achieve supersonic combustion in flight above Mach 7.5. It consisted of a double wedge intake and two back-to-back constant area combustors; one supplied with hydrogen fuel at an equivalence ratio of 0.33 and the other un-fueled. Following a first launch failure on October 30th 2001, the University of Queensland conducted a successful second launch on July 30th, 2002. Post-flight data analysis of the second launch confirmed the presence of supersonic combustion during the approximately 3 second test window at altitudes between 35 and 29 km. Reasonable correlation between flight and some pre-flight shock tunnel tests was observed

Physiotherapy for pain and disability in adults with complex regional pain syndrome (CRPS) types I and II (Review)

Background: Complex regional pain syndrome (CRPS) is a painful and disabling condition that usually manifests in response to trauma or surgery. When it occurs, it is associated with significant pain and disability. It is thought to arise and persist as a consequence of a maladaptive pro-inflammatory response and disturbances in sympathetically-mediated vasomotor control, together with maladaptive peripheral and central neuronal plasticity. CRPS can be classified into two types: type I (CRPS I) in which a specific nerve lesion has not been identified, and type II (CRPS II) where there is an identifiable nerve lesion. Guidelines recommend the inclusion of a variety of physiotherapy interventions as part of the multimodal treatment of people with CRPS, although their effectiveness is not known. Objectives: To determine the effectiveness of physiotherapy interventions for treating the pain and disability associated with CRPS types I and II. Search methods: We searched the following databases from inception up to 12 February 2015: CENTRAL (the Cochrane Library), MEDLINE, EMBASE, CINAHL, PsycINFO, LILACS, PEDro, Web of Science, DARE and Health Technology Assessments, without language restrictions, for randomised controlled trials (RCTs) of physiotherapy interventions for treating pain and disability in people CRPS. We also searched additional online sources for unpublished trials and trials in progress. Selection criteria: We included RCTs of physiotherapy interventions (including manual therapy, therapeutic exercise, electrotherapy, physiotherapist administered education and cortically directed sensory-motor rehabilitation strategies) employed in either a stand-alone fashion or in combination, compared with placebo, no treatment, another intervention or usual care, or of varying physiotherapy interventions compared with each other in adults with CRPS I and II. Our primary outcomes of interest were patient-centred outcomes of pain intensity and functional disability. Data collection and analysis: Two review authors independently evaluated those studies identified through the electronic searches for eligibility and subsequently extracted all relevant data from the included RCTs. Two review authors independently performed ’Risk of bias’ assessments and rated the quality of the body of evidence for the main outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Main results: We included 18 RCTs (739 participants) that tested the effectiveness of a broad range of physiotherapy-based interventions. Overall, there was a paucity of high quality evidence concerning physiotherapy treatment for pain and disability in people with CRPS I. Most included trials were at ’high’ risk of bias (15 trials) and the remainder were at ’unclear’ risk of bias (three trials). The quality of the evidence was very low or low for all comparisons, according to the GRADE approach. We found very low quality evidence that graded motor imagery (GMI; two trials, 49 participants) may be useful for improving pain (0 to 100 VAS) (mean difference (MD) −21.00, 95% CI −31.17 to −10.83) and functional disability (11-point numerical rating scale) (MD 2.30, 95% CI 1.12 to 3.48), at long-term (six months) follow-up, in people with CRPS I compared to usual care plus physiotherapy; very low quality evidence that multimodal physiotherapy (one trial, 135 participants) may be useful for improving ’impairment’ at long-term (12 month) follow-up compared to a minimal ’social work’ intervention; and very low quality evidence that mirror therapy (two trials, 72 participants) provides clinically meaningful improvements in pain (0 to 10 VAS) (MD 3.4, 95% CI −4.71 to −2.09) and function (0 to 5 functional ability subscale of the Wolf Motor Function Test) (MD −2.3, 95% CI −2.88 to −1.72) at long-term (six month) follow-up in people with CRPS I post stroke compared to placebo (covered mirror). There was low to very low quality evidence that tactile discrimination training, stellate ganglion block via ultrasound and pulsed electromagnetic field therapy compared to placebo, and manual lymphatic drainage combined with and compared to either anti-inflammatories and physical therapy or exercise are not effective for treating pain in the short-termin people with CRPS I. Laser therapy may provide small clinically insignificant, short-term, improvements in pain compared to interferential current therapy in people with CRPS I. Adverse events were only rarely reported in the included trials. No trials including participants with CRPS II met the inclusion criteria of this review. Authors’ conclusions: The best available data show that GMI and mirror therapy may provide clinically meaningful improvements in pain and function in people with CRPS I although the quality of the supporting evidence is very low. Evidence of the effectiveness of multimodal physiotherapy, electrotherapy and manual lymphatic drainage for treating people with CRPS types I and II is generally absent or unclear. Large scale, high quality RCTs are required to test the effectiveness of physiotherapy-based interventions for treating pain and disability of people with CRPS I and II. Implications for clinical practice and future research are considered

Jahn-Teller distortions and phase separation in doped manganites

A "minimal model" of the Kondo-lattice type is used to describe a competition between the localization and metallicity in doped manganites and related magnetic oxides with Jahn-Teller ions. It is shown that the number of itinerant charge carriers can be significantly lower than that implied by the doping level x. A strong tendency to the phase separation is demonstrated for a wide range of intermediate doping concentrations vanishing at low and high doping. The phase diagram of the model in the x-T plane is constructed. At low temperatures, the system is in a state with a long-range magnetic order: antiferromagnetic (AF), ferromagnetic (FM), or AF-FM phase separated (PS) state. At high temperatures, there can exist two types of the paramagnetic (PM) state with zero and nonzero density of the itinerant electrons. In the intermediate temperature range, the phase diagram includes different kinds of the PS states: AF-FM, FM-PM, and PM with different content of itinerant electrons. The applied magnetic field changes the phase diagram favoring the FM ordering. It is shown that the variation of temperature or magnetic field can induce the metal-insulator transition in a certain range of doping levels.Comment: 14 pages, 7 figures, submitted to Phys. Rev. B.; v.2 contains the changes introduced according to comments of the PRB Referees; in v. 3, some misprints are correcte

An easy proof of Jensen's theorem on the uniqueness of infinity harmonic functions

We present a new, easy, and elementary proof of Jensen's Theorem on the uniqueness of infinity harmonic functions. The idea is to pass to a finite difference equation by taking maximums and minimums over small balls.Comment: 4 pages; comments added, proof simplifie

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates

BB/H012494/1/ Biotechnology and Biological Sciences Research Counci

Tailored fuel injection within a Mach 12 shape transitioning scramjet

Three-dimensional computational fluid dynamic simulations were performed for the Mach 12 Rectangular-to-Elliptical Shape-Transitioning scramjet. Present injector arrangements at the combustor entrance displayed low jet penetration, resulting in a oxygen-based combustion efficiency of 84.9%. It is proposed to convert three cowl-side injectors into one larger injector located further upstream. To support this, injector configurations were investigated computationally, taking injectors optimised for penetration at lower Mach numbers, and evaluating their performance at higher Mach number flight conditions. It was determined that reduced performance of these optimised injectors was encountered at scramjet flight conditions above their design point, with circular injectors at equal or greater injection angles displaying greater penetration and mixing capabilities

Soil morphology, depth and grapevine root frequency influence microbial communities in a Pinot noir vineyard

The composition of microbial communities responds to soil resource availability, and has been shown to vary with increasing depth in the soil profile. Soil microorganisms partly rely on root-derived carbon (C) for growth and activity. Roots in woody perennial systems like vineyards have a deeper vertical distribution than grasslands and annual agriculture. Thus, we hypothesized that vineyard soil microbial communities along a vertical soil profile would differ from those observed in grassland and annual agricultural systems. In a Pinot noir vineyard, soil pits were excavated to ca. 1.6–2.5m, and microbial community composition in ‘bulk’ (i.e., no roots) and ‘root’ (i.e., roots present) soil was described by phospholipid ester-linked fatty acids (PLFA). Utilization of soil taxonomy aided in understanding relationships between soil microbial communities, soil resources and other physical and chemical characteristics. Soil microbial communities in the Ap horizon were similar to each other, but greater variation in microbial communities was observed among the lower horizons. Soil resources (i.e., total PLFA, or labile C, soil C and nitrogen, and exchangeable potassium) were enriched in the surface horizons and significantly explained the distribution of soil microbial communities with depth. Soil chemical properties represented the secondary gradient explaining the differentiation between microbial communities in the B-horizons from the C-horizons. Relative abundance of Gram-positive bacteria and actinomycetes did not vary with depth, but were enriched in ‘root’ vs. ‘bulk’ soils. Fungal biomarkers increased with increasing depth in ‘root’ soils, differing from previous studies in grasslands and annual agricultural systems. This was dependent on the deep distribution of roots in the vineyard soil profile, suggesting that the distinct pattern in PLFA biomarkers may have been strongly affected by C derived from the grapevine roots. Gram-negative bacteria did not increase in concert with fungal abundance, suggesting that acidic pHs in lower soil horizons may have discouraged their growth. These results emphasize the importance of considering soil morphology and associated soil characteristics when investigating effects of depth and roots on soil microorganisms, and suggest that vineyard management practices and deep grapevine root distribution combine to cultivate a unique microbial community in these soil profiles

Spring Clipping, Fire, and Simulated Increased Atmospheric Nitrogen Deposition Effects on Tallgrass Prairie Vegetation

Defoliation aimed at introduced cool-season grasses, which uses similar resources of native grasses, could substantially reduce their competitiveness and improve the quality of the northern tallgrass prairie. The objective was to evaluate the use of early season clipping and fire in conjunction with simulated increased levels of atmospheric nitrogen deposition on foliar canopy cover of tallgrass prairie vegetation. This study was conducted from 2009 to 2012 at two locations in eastern South Dakota. Small plots arranged in a split-plot treatment design were randomized in four complete blocks on a warm-season grass interseeded and a native prairie site in east-central South Dakota. The whole plot consisted of seven treatments: annual clip, biennial clip, triennial clip, annual fire, biennial fire, triennial fire, and undefoliated control. The clip plots consisted of weekly clipping in May to simulate heavy grazing. Fire was applied in late April or early May. The subplot consisted of nitrogen applied at 0 or 15 kg N · ha−1 in early June. All treatments were initially applied in 2009. Biennial and triennial treatments were reapplied in 2011 and 2012, respectively. Canopy cover of species/major plant functional groups was estimated in late August/early September. Annual clipping was just as effective as annual fire in increasing native warm-season grass and decreasing introduced cool-season grass cover. Annual defoliation resulted in greater native warm-season grass cover, less introduced cool-season grass cover, and less native cool-season grass cover than biennial or triennial defoliation applications. Low levels of nitrogen did not affect native warm-season grass or introduced cool-season cover for any of the defoliation treatments, but it increased introduced cool-season grass cover in the undefoliated control at the native prairie site. This study supports the hypothesis that appropriately applied management results in consistent desired outcomes regardless of increased simulated atmospheric nitrogen depositions

Spitzer Mid-Infrared Photometry of 500 - 750 K Brown Dwarfs

Mid-infrared data, including Spitzer warm-IRAC [3.6] and [4.5] photometry, is critical for understanding the cold population of brown dwarfs now being found, objects which have more in common with planets than stars. As effective temperature (T_eff) drops from 800 K to 400 K, the fraction of flux emitted beyond 3 microns increases rapidly, from about 40% to >75%. This rapid increase makes a color like H-[4.5] a very sensitive temperature indicator, and it can be combined with a gravity- and metallicity-sensitive color like H-K to constrain all three of these fundamental properties, which in turn gives us mass and age for these slowly cooling objects. Determination of mid-infrared color trends also allows better exploitation of the WISE mission by the community. We use new Spitzer Cycle 6 IRAC photometry, together with published data, to present trends of color with type for L0 to T10 dwarfs. We also use the atmospheric and evolutionary models of Saumon & Marley to investigate the masses and ages of 13 very late-type T dwarfs, which have H-[4.5] > 3.2 and T_eff ~ 500 K to 750 K.Comment: To be published in the on-line version of the Proceedings of Cool Stars 16 (ASP Conference Series). This is an updated version of Leggett et al. 2010 ApJ 710 1627; a photometry compilation is available at http://www.gemini.edu/staff/slegget