Spontaneous central venous thrombosis and shunt occlusion following peritoneovenous shunt placement for intractable ascites

A 43-year-old man had a peritoneovenous shunt inserted for the treatment of chylous ascites secondary to myelofibrosis. Despite being on anticoagulation for superior mesenteric vein thrombosis, he developed shunt dysfunction within two weeks of insertion. Superior venacavography showed multiple filling defects in the right axillary vein, no filling of the right brachiocephalic and right subclavian vein, and thrombotic occlusion of the internal jugular veins bilaterally. The shunt was removed 11 days after insertion, and there was extensive thrombosis of the venous end of the shunt and the compressible pump chamber. Shunt thrombosis is known to occur but remains a rare complication, with 87% of such obstructions being due to a thrombus at the tip of the venous end of the shunt. Extensive thrombosis of the shunt (as in the present case) is very rare

A009 Importance of tweak-CD163 system in peripheral artery disease

IntroductionCD163 is a macrophage receptor of haptoglogin/ haemoglobin complexes responsible for clearance of hemogloin. It has been recently suggested to be a potential scavenger receptor for TWEAK (Tumor necrosis factor-like weak inducer of apoptosis). TWEAK levels were reported to be decreased in carotid atherosclerosis. Our hypothesis is that decreased circulating TWEAK could be paralleled by an increased presence of CD163-expressing macrophage in atherosclerotic plaques. Since peripheral artery disease (PAD) is an important manifestation of systemic atherosclerosis, we have assessed the levels of circulating TWEAK-CD163 in PAD.Methods and ResultsPatients with PAD (n=184) had lower TWEAK (169.2±8.3vs 211.9±15.4pg/mL; p<0.05) and higher sCD163 (408.1±14.5vs 317.4±8.4ng/mL; p<0.05) plasma concentration than age-matched controls (n=330). After stratification according to the severity of disease, we observed that TWEAK/sCD163 ratio was significantly decreased in those patients with higher degree of disease (0.39±0.06vs 0.66±0.08, p<0.05) relative to the other groups. Analysis of conditioned medium obtained from cultured human atherosclerotic femoral plaque samples (n=38) and healthy aortas (n=14) revealed that higher amount of sCD163 was released by the atherosclerotic tissue, whereas TWEAK presented the opposite trend.ConclusionsOur results suggest that CD163/TWEAK plasma ratio could be a potential biomarker of clinical peripheral artery disease. We can hypothesized that decreased levels of circulating TWEAK observed in atherosclerosis may be the result of a trapping by plaque macrophages through their CD163

Initial Hubble Diagram Results from the Nearby Supernova Factory

The use of Type Ia supernovae as distance indicators led to the discovery of the accelerating expansion of the universe a decade ago. Now that large second generation surveys have significantly increased the size and quality of the high-redshift sample, the cosmological constraints are limited by the currently available sample of ~50 cosmologically useful nearby supernovae. The Nearby Supernova Factory addresses this problem by discovering nearby supernovae and observing their spectrophotometric time development. Our data sample includes over 2400 spectra from spectral timeseries of 185 supernovae. This talk presents results from a portion of this sample including a Hubble diagram (relative distance vs. redshift) and a description of some analyses using this rich dataset.Comment: Short version of proceedings for ICHEP08, Philadelphia PA, July 2008; see v1 for full-length versio

The Nearby Supernova Factory

The Nearby Supernova Factory (SNfactory) is an ambitious project to find and study in detail approximately 300 nearby Type Ia supernovae (SNe~Ia) at redshifts 0.03<z<0.08. This program will provide an exceptional data set of well-studied SNe in the nearby smooth Hubble flow that can be used as calibration for the current and future programs designed to use SNe to measure the cosmological parameters. The first key ingredient for this program is a reliable supply of Hubble-flow SNe systematically discovered in unprecedented numbers using the same techniques as those used in distant SNe searches. In 2002, 35 SNe were found using our test-bed pipeline for automated SN search and discovery. The pipeline uses images from the asteroid search conducted by the Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction techniques and analysis have allowed us to increase our effective SN discovery rate to ~12 SNe/month in 2003.Comment: 7 pages, 3 figures to be published in New Astronomy Review

The Extinction Properties of and Distance to the Highly Reddened Type Ia Supernova SN 2012cu

Correction of Type Ia Supernova brightnesses for extinction by dust has proven to be a vexing problem. Here we study the dust foreground to the highly reddened SN 2012cu, which is projected onto a dust lane in the galaxy NGC 4772. The analysis is based on multi-epoch, spectrophotometric observations spanning 3,300 - 9,200 {\AA}, obtained by the Nearby Supernova Factory. Phase-matched comparison of the spectroscopically twinned SN 2012cu and SN 2011fe across 10 epochs results in the best-fit color excess of (E(B-V), RMS) = (1.00, 0.03) and total-to-selective extinction ratio of (RV , RMS) = (2.95, 0.08) toward SN 2012cu within its host galaxy. We further identify several diffuse interstellar bands, and compare the 5780 {\AA} band with the dust-to-band ratio for the Milky Way. Overall, we find the foreground dust-extinction properties for SN 2012cu to be consistent with those of the Milky Way. Furthermore we find no evidence for significant time variation in any of these extinction tracers. We also compare the dust extinction curve models of Cardelli et al. (1989), O'Donnell (1994), and Fitzpatrick (1999), and find the predictions of Fitzpatrick (1999) fit SN 2012cu the best. Finally, the distance to NGC4772, the host of SN 2012cu, at a redshift of z = 0.0035, often assigned to the Virgo Southern Extension, is determined to be 16.6$\pm$1.1 Mpc. We compare this result with distance measurements in the literature.Comment: 48 pages, 13 figures. Accepted for publication in The Astrophysical Journal. The spectral time series data presented in this article can be found at http://snfactory.lbl.gov/snf/data

Improving Cosmological Distance Measurements Using Twin Type Ia Supernovae

We introduce a method for identifying "twin" Type Ia supernovae, and using them to improve distance measurements. This novel approach to Type Ia supernova standardization is made possible by spectrophotometric time series observations from the Nearby Supernova Factory (SNfactory). We begin with a well-measured set of supernovae, find pairs whose spectra match well across the entire optical window, and then test whether this leads to a smaller dispersion in their absolute brightnesses. This analysis is completed in a blinded fashion, ensuring that decisions made in implementing the method do not inadvertently bias the result. We find that pairs of supernovae with more closely matched spectra indeed have reduced brightness dispersion. We are able to standardize this initial set of SNfactory supernovae to 0.083 +/- 0.012 magnitudes, implying a dispersion of 0.072 +/- 0.010 magnitudes in the absence of peculiar velocities. We estimate that with larger numbers of comparison SNe, e.g, using the final SNfactory spectrophotometric dataset as a reference, this method will be capable of standardizing high-redshift supernovae to within 0.06-0.07 magnitudes. These results imply that at least 3/4 of the variance in Hubble residuals in current supernova cosmology analyses is due to previously unaccounted-for astrophysical differences among the supernovaeComment: 37 pages, 9 figures, 5 tables. Accepted for publication in ApJ. Fixed typo in arXiv abstrac

Standardizing Type Ia Supernova Absolute Magnitudes Using Gaussian Process Data Regression

We present a novel class of models for Type Ia supernova time-evolving spectral energy distributions (SED) and absolute magnitudes: they are each modeled as stochastic functions described by Gaussian processes. The values of the SED and absolute magnitudes are defined through well-defined regression prescriptions, so that data directly inform the models. As a proof of concept, we implement a model for synthetic photometry built from the spectrophotometric time series from the Nearby Supernova Factory. Absolute magnitudes at peak $B$ brightness are calibrated to 0.13 mag in the $g$-band and to as low as 0.09 mag in the $z=0.25$ blueshifted $i$-band, where the dispersion includes contributions from measurement uncertainties and peculiar velocities. The methodology can be applied to spectrophotometric time series of supernovae that span a range of redshifts to simultaneously standardize supernovae together with fitting cosmological parameters.Comment: 47 pages, 15 figures, accepted for publication by Astrophysical Journa

Atmospheric extinction properties above Mauna Kea from the Nearby Supernova Factory spectro-photometric data set

We present a new atmospheric extinction curve for Mauna Kea spanning 3200--9700 \AA. It is the most comprehensive to date, being based on some 4285 standard star spectra obtained on 478 nights spread over a period of 7 years obtained by the Nearby SuperNova Factory using the SuperNova Integral Field Spectrograph. This mean curve and its dispersion can be used as an aid in calibrating spectroscopic or imaging data from Mauna Kea, and in estimating the calibration uncertainty associated with the use of a mean extinction curve. Our method for decomposing the extinction curve into physical components, and the ability to determine the chromatic portion of the extinction even on cloudy nights, is described and verified over the wide range of conditions sampled by our large dataset. We demonstrate good agreement with atmospheric science data obtain at nearby Mauna Loa Observatory, and with previously published measurements of the extinction above Mauna Kea.Comment: 22 pages, 24 figures, 6 table