Preliminary results of pheromone identification in Zygaena loti, and the potential for pheromones in burnet moth conservation.

Zygaena loti scotica (Denis & Schiffermüller, 1775) is a threatened species endemic to Western Scotland. Its known distribution is currently limited to approximately 10km2 in Western Argyll, which are under careful management for the insect’s conservation as a Biodiversity Action Plan (BAP) priority species. In 2014, a small number of Z. loti were collected from Scotland and reared for pheromone identification. Headspace collection and gland extraction was carried out on two female moths, from which compounds were subsequently analysed by Gas Chromatogram Mass Spectrometry (GC/MS). Potential pheromone compounds eliciting an antennal response in males were assessed by GC-linked Electro-Antennographic-Detection (GC/EAD). Analyses revealed one potential compound present in female glands and headspace samples. Candidate pheromone lures were produced and tested at various sites in Western Argyll in order to determine behavioural responses of male Z. loti to a synthetic blend containing the previously identified compound. In this presentation the study is discussed as well as the potential for pheromones as a tool for monitoring and studying rare zygaenids

Population history from the Neolithic to present on the Mediterranean island of Sardinia: an ancient DNA perspective

Recent ancient DNA studies of western Eurasia have revealed a dynamic history of admixture, with evidence for major migrations during the Neolithic and Bronze Age. The population of the Mediterranean island of Sardinia has been notable in these studies –} Neolithic individuals from mainland Europe cluster more closely with Sardinian individuals than with all other present-day Europeans. The current model to explain this result is that Sardinia received an initial influx of Neolithic ancestry and then remained relatively isolated from expansions in the later Neolithic and Bronze Age that took place in continental Europe. To test this model, we generated genome-wide capture data (approximately 1.2 million variants) for 43 ancient Sardinian individuals spanning the Neolithic through the Bronze Age, including individuals from Sardinia{’}s Nuragic culture, which is known for the construction of numerous large stone towers throughout the island. We analyze these new samples in the context of previously generated genome-wide ancient DNA data from 972 ancient individuals across western Eurasia and whole-genome sequence data from approximately 1,500 modern individuals from Sardinia. The ancient Sardinian individuals show a strong affinity to western Mediterranean Neolithic populations and we infer a high degree of genetic continuity on the island from the Neolithic (around fifth millennium BCE) through the Nuragic period (second millennium BCE). In particular, during the Bronze Age in Sardinia, we do not find significant levels of the {“}Steppe{” ancestry that was spreading in many other parts of Europe at that time. We also characterize subsequent genetic influx between the Nuragic period and the present. We detect novel, modest signals of admixture between 1,000 BCE and present-day, from ancestry sources in the eastern and northern Mediterranean. Within Sardinia, we confirm that populations from the more geographically isolated mountainous provinces have experienced elevated levels of genetic drift and that northern and southwestern regions of the island received more gene flow from outside Sardinia. Overall, our genetic analysis sheds new light on the origin of Neolithic settlement on Sardinia, reinforces models of genetic continuity on the island, and provides enhanced power to detect post-Bronze-Age gene flow. Together, these findings offer a refined demographic model for future medical genetic studies in Sardinia

Flows of people in villages and large centres in Bronze Age Italy through strontium and oxygen isotopes

This study investigates to what extent Bronze Age societies in Northern Italy were permeable accepting and integrating non-local individuals, as well as importing a wide range of raw materials, commodities, and ideas from networks spanning continental Europe and the Mediterranean. During the second millennium BC, the communities of Northern Italy engaged in a progressive stabilization of settlements, culminating in the large polities of the end of the Middle/beginning of the Late Bronze Age pivoted around large defended centres (the Terramare). Although a wide range of exotic archaeological materials indicates that the inhabitants of the Po plain increasingly took part in the networks of Continental European and the Eastern Mediterranean, we should not overlook the fact that the dynamics of interaction were also extremely active on local and regional levels. Mobility patterns have been explored for three key-sites, spanning the Early to Late Bronze Age (1900–1100 BC), namely Sant’Eurosia, Casinalbo and Fondo Paviani, through strontium and oxygen isotope analysis on a large sample size (more than 100 individuals). The results, integrated with osteological and archaeological data, document for the first time in this area that movements of people occurred mostly within a territorial radius of 50 km, but also that larger nodes in the settlement system (such as Fondo Paviani) included individuals from more distant areas. This suggests that, from a demographic perspective, the process towards a more complex socio-political system in Bronze Age Northern Italy was triggered by a largely, but not completely, internal process, stemming from the dynamics of intra-polity networks and local/regional power relationships

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

\ua9 The Author(s) 2023. Published by Oxford University Press on behalf of the British Society for Rheumatology.The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in ‘Creating Clinical Guidelines: Our Protocol’ by the British Society for Rheumatology

Identifying the connection between Roman Conceptions of ‘Pure Air’ and Physical and Mental Health in Pompeian Gardens (c. 150 BC-AD 79): A Multi-Sensory Approach to Ancient Medicine

Different genres of Roman literature commented on the relationship between the condition of the environment and physical and mental health. They often refer to clear, pure, or good air as a beneficial aspect of the environment. Yet, unlike fetid air, they provide few descriptions of what constituted healthy air quality. Moreover, aside from pointing out the association between the environment and bodily condition, the writers also did not explain precisely how the link between the two was made. This paper utilizes a comparative study of ancient literature and the archaeological remains of Roman gardens in Pompeii: archaeobotanical samples, fresco paintings, location, and surviving features. Three questions are addressed in this study: First, how did the Romans identify and define pure? Second, how did air connect to the body? Third, what were the qualities of pure air and how did they benefit the body? Not only was inhalation a means of linking air to the body, but the two were also related through sensory perception. I argue that sight, sound, and olfaction were used to identify the qualities of pure air. Through the sensory process of identification, the beneficial properties of pure air were, in accordance with ancient perceptions of sensory function, taken into the body and affected health. Thus, sensory perception acted as the bridge between the environment and health

Genetic history from the Middle Neolithic to present on the Mediterranean island of Sardinia

The island of Sardinia has been of particular interest to geneticists for decades. The current model for Sardinia's genetic history describes the island as harboring a founder population that was established largely from the Neolithic peoples of southern Europe and remained isolated from later Bronze Age expansions on the mainland. To evaluate this model, we generate genome-wide ancient DNA data for 70 individuals from 21 Sardinian archaeological sites spanning the Middle Neolithic through the Medieval period. The earliest individuals show a strong affinity to western Mediterranean Neolithic populations, followed by an extended period of genetic continuity on the island through the Nuragic period (second millennium BCE). Beginning with individuals from Phoenician/Punic sites (first millennium BCE), we observe spatially-varying signals of admixture with sources principally from the eastern and northern Mediterranean. Overall, our analysis sheds light on the genetic history of Sardinia, revealing how relationships to mainland populations shifted over time.Joseph H. Marcus ... Wolfgang Haak ... et al

Do Caves Have Agency?

Recent studies of later prehistoric cave use have stressed the affective qualities of these natural spaces. Certain properties of caves, darkness, constriction and their active geomorphology for example, can lead to caves be characterised as active agents, natural places with profound powers. However, is it really plausible to interpret caves, inanimate geological formations, as active agents? This paper will review arguments on social, environmental and material agency. This will include Structuration theory, with its emphasis on human consciousness as a key aspect of agency, Ingold's 'Dwelling perspective', which allows the possibility of non-human agents, the work of Alfred Gell and Actor Network Theory. Two common threads are drawn from these approaches to describe the way that things act. Things act in accordance with the properties they have and in a way that is structured and enabled by their past history. From this perspective caves can be shown to act and therefore caves would have been perceived as having agency

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

The objective of this guideline is to provide up-to-date, evidence-based recommendations for the management of SLE that builds upon the existing treatment guideline for adults living with SLE published in 2017. This will incorporate advances in the assessment, diagnosis, monitoring, non-pharmacological and pharmacological management of SLE. General approaches to management as well as organ-specific treatment, including lupus nephritis and cutaneous lupus, will be covered. This will be the first guideline in SLE using a whole life course approach from childhood through adolescence and adulthood. The guideline will be developed with people with SLE as an important target audience in addition to healthcare professionals. It will include guidance related to emerging approved therapies and account for National Institute for Health and Care Excellence Technology Appraisals, National Health Service England clinical commissioning policies and national guidance relevant to SLE. The guideline will be developed using the methods and rigorous processes outlined in ‘Creating Clinical Guidelines: Our Protocol’ by the British Society for Rheumatology

Management and treatment of children, young people and adults with systemic lupus erythematosus: British Society for Rheumatology guideline scope

Lay Summary: Systemic lupus erythematosus (SLE) is a lifelong condition in which the immune system damages the body’s own tissues, causing various symptoms including rashes, hair loss, mouth ulcers, joint pain and overwhelming tiredness. It can also affect major organs including the kidneys, heart, lungs and brain. SLE can present during childhood, but most commonly affects young and middle-aged females. It is approximately nine times more common in females than males. The disease can lead to disability, poor quality of life and even death in severe cases. Treatments can often be difficult to tolerate and can cause both short- and long-term side effects. Guidelines developed by the British Society for Rheumatology aim to provide guidance for diagnosing and treating people with SLE. This is necessary to ensure that the most up-to-date approach is followed, utilising the safest and most effective treatments. This article describes the plan for a guideline in SLE that is being updated to cover new evidence that has been published since 2017 relating to the treatment and management of SLE. The guideline will take a whole life course approach, from childhood to adulthood, and is being undertaken by a working group consisting of paediatric and adult rheumatologists and nephrologists, SLE experts, general practitioners, specialist nurses and other healthcare professionals, together with people with SLE and representatives from patient organizations. The guideline will be developed using the methods and processes outlined in the British Society for Rheumatology document ‘Creating Clinical Guidelines: Our Protocol’

Ten millennia of hepatitis B virus evolution

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health problem, but its past diversity and dispersal routes are largely unknown. We generated HBV genomic data from 137 Eurasians and Native Americans dated between similar to 10,500 and similar to 400 years ago. We date the most recent common ancestor of all HBV lineages to between similar to 20,000 and 12,000 years ago, with the virus present in European and South American hunter-gatherers during the early Holocene. After the European Neolithic transition, Mesolithic HBV strains were replaced by a lineage likely disseminated by early farmers that prevailed throughout western Eurasia for similar to 4000 years, declining around the end of the 2nd millennium BCE. The only remnant of this prehistoric HBV diversity is the rare genotype G, which appears to have reemerged during the HIV pandemic.Molecular Technology and Informatics for Personalised Medicine and Healt