The magnetic field of the plasma tail of Comet 1P/Halley

The photometric scans of the plasma tail of Comet Halley from four observation series are compared with the profiles of brightness distribution along the tail streams which were calculated on the basis of the diffusion model of the plasma tail. The magnetic field induction and the lifetime of ions in the tail of Comet Halley as well as the coefficients of diffusion are estimated. A probable connection between cometary magnetic field changes and cometary tail structure ones are discussed

Trophoblastic and decidual response to RU486: effects on human chorionic gonadotrophin, human placental lactogen, prolactin and pregnancy-associated plasma protein-A production in vitro

RU486 [17β-hydroxy-11β-(4-dimethylaminophenyl)-17α-(prop-1-ynyl)-oestra-4,9-dien-3-one] a potent progesterone antagonist, was shown to induce abortions in humans. Human chorionic gonadotrophin (HCG) and pregnancy-associated plasma protein-A (PAPP-A) decreased after RU486 administration, but it was not clear whether these effects were due to RU486 or secondary to trophoblast damage. To answer this question we tested the in-vitro effects of RU486 on short-term cultures of trophoblastic and decidual explants. It was observed that RU486 induced a significant inhibition of the trophoblastic production rate of βHCG and PAPP-A but not human placental lactogen. This effect could be overcome by addition of progesterone (for PAPP-A and βHCG) or cortisol (for βHCG). Decidual prolactin (Prl) or PAPP-A secretions were also inhibited by RU486. Progesterone antagonized these effects, whereas cortisol was ineffective. These results suggest that PAPP-A is a progesterone-dependent protein and that the abortifacknt effect of RU486 in humans could at least partially be due to an inhibition of the production of HCG and/or PAPP-

The photometric study of the plasma tail of Comet Hyakutake (C/1996 B2)

The brightness distribution for the plasma tail of Comet Hyakutake is obtained. The photometric scans along the unusually long jet directed at the tail side are studied. The photometric scans along the main streams in plasma tail are compared with the brightness profiles calculated on the basis of the diffusion model of the plasma tail. The magnetic field induction and the lifetime of ions in the tail of Comet Hyakutake as well as the coefficients of diffusion are estimated

Functional Deficit and Recovery of Developing Sensorimotor Networks following Neonatal Hypoxic-Ischemic Injury in the Rat

Neonatal hypoxia-ischemia (HI) is the most important cause of brain injury in the newborn. Here we studied structural alterations and functional perturbations of developing large-scale sensorimotor cortical networks in a rat model of moderate HI at postnatal day 3 (P3). At the morphological level, HI led to a disorganized barrel pattern in the somatosensory cortex without detectable histological changes in the motor cortex. Functional effects were addressed by means of epicranial mapping of somatosensory-evoked potentials (SEPs) during the postischemic recovery period. At P10, SEPs were immature and evoked activity was almost restricted to the somatosensory and motor cortices of the contralateral hemisphere. Peak and topographic analyses of epicranial potentials revealed that responses were profoundly depressed in both sensory and motor areas of HI-lesioned animals. At the end of the postnatal period at P21, responses involved networks in both hemispheres. SEP amplitude was still depressed in the injured sensory region, but it completely recovered in the motor area. These results suggest a process of large-scale network plasticity in sensorimotor circuits after perinatal ischemic injury. The model provides new perspectives for investigating the temporal and spatial characteristics of the recovery process following HI and eventually developing therapeutic intervention

Multi-modal assessment of long-term erythropoietin treatment after neonatal hypoxic-ischemic injury in rat brain.

Erythropoietin (EPO) has been recognized as a neuroprotective agent. In animal models of neonatal brain injury, exogenous EPO has been shown to reduce lesion size, improve structure and function. Experimental studies have focused on short course treatment after injury. Timing, dose and length of treatment in preterm brain damage remain to be defined. We have evaluated the effects of high dose and long-term EPO treatment in hypoxic-ischemic (HI) injury in 3 days old (P3) rat pups using histopathology, magnetic resonance imaging (MRI) and spectroscopy (MRS) as well as functional assessment with somatosensory-evoked potentials (SEP). After HI, rat pups were assessed by MRI for initial damage and were randomized to receive EPO or vehicle. At the end of treatment period (P25) the size of resulting cortical damage and white matter (WM) microstructure integrity were assessed by MRI and cortical metabolism by MRS. Whisker elicited SEP were recorded to evaluate somatosensory function. Brains were collected for neuropathological assessment. The EPO treated animals did not show significant decrease of the HI induced cortical loss at P25. WM microstructure measured by diffusion tensor imaging was improved and SEP response in the injured cortex was recovered in the EPO treated animals compared to vehicle treated animals. In addition, the metabolic profile was less altered in the EPO group. Long-term treatment with high dose EPO after HI injury in the very immature rat brain induced recovery of WM microstructure and connectivity as well as somatosensory cortical function despite no effects on volume of cortical damage. This indicates that long-term high-dose EPO induces recovery of structural and functional connectivity despite persisting gross anatomical cortical alteration resulting from HI

Administrative processes in the field of providing administrative services.

The article analyzes the approaches to the definition of management processes, defines the common characteristics of managerial processes in various fields of activity. The system of principles of managerial processes in the field of providing administrative services is considered. The management of technological processes in the field of providing administrative services is studied. The types and structure of the administrative service delivery centers of the Odessa region are analyzed. The level of provision of administrative services in the regions of the Odessa region was investigated and analyzed. The main recommendations for improving the existing mechanism for the provision of administrative services are substantiated. A number of management processes and measures are proposed to ensure the quality of administrative services

ЗАСТОСУВАННЯ ІНТЕРАКТИВНОЇ ПЛАТФОРМИ «TEACH. TIME» У ПРОЦЕСІ НАВЧАННЯ ДІТЕЙ МОЛОДШОГО ШКІЛЬНОГО ВІКУ

In this article the authors investigated the learning process of children in primary school. Theoretical analysis of the research literature on the subject has shown that the problem of formation of fully developed personality pupils of primary school is relevant and needs constantly search to improve the educational process in primary school. In this regard, it was identified the peculiarities of interactive learning technology, was presented an interactive platform «Teach. Time», its essence and opportunities in the formation of fully developed personality of primary schoolchildren in the educational and creative activities in primary school.В статье авторами исследован процесс обучения детей младшего школьного возраста. Теоретический анализ литературы по предмету исследования показал, что проблема формирования всесторонне развитой личности учеников младшего школьного возраста является актуальной и требует постоянного поиска с целью совершенствования образовательного процесса в начальной школе. В связи с этим определены особенности интерактивных технологий обучения, представлено интерактивную платформу «Teach. Time», раскрыто сущность, освещены ее возможности в формировании всесторонне развитой личности младших школьников в процессе учебно-творческой деятельности в начальной школе.У статті авторами досліджено процес навчання дітей молодшого шкільного віку. Теоретичний аналіз літератури з предмету дослідження показав, що проблема формування всебічно розвиненої особистості учнів молодшого шкільного віку є актуальною і потребує постійного пошуку з метою вдосконалення освітнього процесу в початковій школі. У зв’язку з цим визначено особливості інтерактивних технології навчання, представлено інтерактивну платформу «Teach. Time», розкрито сутність, висвітлено її можливості у формуванні всебічно розвиненої особистості молодших школярів у процесі навчально-творчої діяльності у початковій школі

Dynamics of charge transfer along hydrogen bond

The pseudospin-electron model is formulated for the description of the correlated proton-electron charge transfer in the complex with hydrogen bonds. The energy spectrum of the model is obtained. The ground state diagram is built. The frequency dependence of the real part of conductivity is calculated. The time evolution of the proton and electron transfer along the hydrogen bond is studied. The time dependences of the mean occupancies of proton positions and electron states are obtained by solving the equations of motion for the density matrix components. The conditions, at which the motion of the proton and electron charges are mutually correlated, are considered.Запропоновна псевдоспін-електронна модель для опису скорельованого протон-електронного переносу заряду на комплексі з водневим зв’язком. Отримано енергетичний спектр моделі. Побудовано фазову діаграму основного стану. Розраховано частотну залежність дійсної частини динамічної провідності. Досліджена часова еволюція протонного і електронного транспорту вздовж водневого зв’язку. Розв’язані рівняння руху для компонент матриці густини, отримана часова залежність середньої заселеності протонних позицій і електронних станів. Встановлені умови, при яких рух протонів і електронів є скорельований

Інноваційна модернізація економіки як основа реалізації національних економічних інтересів

The need for this study can be explained by the fact that the solution of the problems in the development of the system of management that have emerged under critical conditions of permanent political and economic instability, institutional uncertainty requires the development of the system of measures aimed at engaging driving forces of economic transformation. The basis for such social transformation is the implementation of social–economic transformations of efficient models of the ratio of economic interests and innovative modernization of economy as the basis for their achievements.  The aim of the research is revealing the role of the innovative modernization of the economy in the formation and implementation of the national economic interests. The methods of scientific research are abstract–logical, statistical, induction and deduction. Based on the evaluation of activation of the driving forces of economic transformation, we defined the need for implementing in the transformation practice of the efficient models of formation of economic interests. The necessity was substantiated of the formation and development of the innovative modernization of the economy as a basis for achieving the level of competitiveness of the national economic system, adequate to the goals and needs of the transformational period under conditions of growing global competition. We proposed the ways of reconciling the economic interests of representatives of business structures with the national economic interests of Ukraine. The article reveals the role of the state in creating the institutional environment, the most efficient forms and methods of economic management of innovative modernization of the national economy were determined. We proposed the measures to consolidate the efforts of all the participants of the innovative modernization of the economy, which imply a synthesis of the provisions of the neoclassical and Keynesian doctrine with the activities of the state, adapted to modern realities of Ukraine, the mechanisms of self––regulation of the market. In subsequent research it is suggested to implement the development of the institutional environment of competing economic interests of economic entities, to motivate them to engage into activities in the field of new technologies