Maksiller sinüs hacminin ve septum morfolojisinin Angle Sınıf I, II ve III iskeletsel ilişkiye sahip bireylerde üç boyutlu olarak değerlendirilmesi

Amaç: Çalışmada üç farklı iskeletsel ilişkiye sahip bireylerin konik ışınlı bilgisayarlı tomografi (KIBT) görüntülerinde maksiller sinüslerin hacim ve septumlarının analiz ederek gruplar-arası değerlendirilmelerin yapılması amaçlanmıştır.Gereç ve Yöntemler: Arşiv görüntülerinden seçilmiş, maksiller sinüslerinde kist ve/veya tümoral değişiklik olmayan, ortodontik tedavi görmemiş, tam dişli, 18-50 yaşları arasında 90 (47♀, 43♂) hastaya ait KIBT görüntülerinde (Planmeca Romexis®) sefalometrik analizle (NEMOCEPH Imaging 11.5) iskeletsel Angle Sınıf I, II, III ile normal, düşük ve yüksek dikey boyut grupları oluşturulmuştur. Maksiller sinüslerin hacimleri 3D Doctor (Able Software Corp, USA) yazılım programında ölçülmüş ve mevcut septumlar sagittal yönde ön, orta, arka olarak ve bukkopalatal, anteroposterior veya horizontal olarak ve ayrıca tam ve tam olmayan septumlar olarak sınıflandırılmış ve bulgular istatistiksel olarak değerlendirilmiştir.Bulgular: Maksiller sinüs hacmi erkeklerde (34.32 ± 10.94 cm³) kadınlara göre (26.94±9.86 cm³) yüksek bulunmuştur (p< 0.001). Yaş grupları, Angle sınıflaması ve dikey boyuta göre değerlendirildiklerinde ise istatiksel olarak anlamlı bir fark saptanmamıştır. Sağ maksiller sinüste septum görülme sıklığı 18-30 yaş grubunda 31- 50 yaş grubundan fazla (p<0.01) ve tam septum görülme oranı Angle Sınıf II’ de AngleSınıf III’ e anlamlı şekilde yüksektir (p<0.05). Tüm bireylerde en sık orta bölgede (% 41.8) ve bukkopalatal (%93.5) yönde septuma rastlanmıştır.Sonuç: Bu çalışmada üç farklı iskeletsel ilişkiye sahip bireylerin maksiller sinüs hacimleri arasında anlamlı farklılık görülmemekle birlikte tüm gruplarda erkeklerin maksiller sinüs hacimleri kadınlardan yüksek bulunmuştur. Sağ maksiller sinüste Angle Sınıf II’de daha sık görülen tam septum bu vakalardaki pre-operatif değerlendirmede önemli olabilir. ANAHTAR KELİMELER KIBT, Maksiller sinüs, hacim, septu

Screening of polymorphisms in the folate pathway in Turkish pediatric Acute Lymphoblastic Leukemia patients

Background and aim: Folate metabolic pathway plays a significant role in leukemogenesis because of its necessity for nucleotide synthesis and DNA methylation. Folate deficiency causes DNA damage. Thus polymorphisms of folate-related genes may affect the susceptibility to childhood Acute Lymphoblastic Leukemia (ALL). MTHFR (Methylenetetrahydrofolate Reductase), DHFR (Dihydrofolate reductase), CBS (Cystathionine b-synthase) and TYMS (Thymidylate Synthase) have an important role in folate pathway because their activated variants modulate synthesis of DNA and levels of folate. In this study, we aimed to investigate whether polymorphisms in genes related to folate metabolic pathway influence the risk to childhood ALL.Subject and methods: The patient groups who were diagnosed with childhood ALL at Losante Pediatric Hematology-Oncology Hospital and healthy control groups were included in the study. MTHFR 677 CT, MTHFR 1298 A-C, CBS 844ins68, DHFR 19-bp and TYMS 1494del6 polymorphisms were screened. Genotyping of these polymorphisms was performed by Restriction Fragment Length Polymorphism (RFLP) analysis and Real Time Polymerase chain Reaction (Real Time-PCR).Results: In total, we have screened 5 polymorphisms in the studied genes. The results were compared between childhood ALL patients and healthy groups. Genotype frequencies of MTHFR 677 C-T, MTHFR 1298 A-C, CBS 844ins68 and DHFR 19-bp del were similar for childhood ALL patients and healthy groups. However, statistical results showed that TYMS 1494del6 may be associated with ALL pathogenesis (p < 0.001).Conclusion: We showed that TYMS polymorphism (rs2853542) may be associated with ALL pathogenesis. In addition, our results demonstrated that MTHFR, DHFR and CBS do not affect development of leukemia. Our study displays also importance as it is the first screening results to identify association with the studied polymorphisms in Turkish patients with childhood ALL and determination of the frequency in Turkish population

γA gene repeats polymorphism for the analysis of haplotypes of abnormal hemoglobins

Aim of this study was to analyze γ A gene repeat polymorphism for the analysis of haplotypes of hemoglobin (Hb) variants such as Hb S, Hb D-Punjab, Hb O-Arab. Sickle cell cases had mainly Benin and Arab/Indian haplotype. We found three different haplotypes among Hb S, Hb O Arab and Hb D-Punjab cases. We named these three variants as Anatolian-1 and Anatolian-2 and Asian. Our data revealed that Hb O Arab may arise twice one from Asia and the other from Europe

Occupational Burnout Levels of Workers employed as Regular and Permanent Workers in the Affiliated Institutions of Konya Provincial Directorate of Family and Social Policies

The purpose of this study is to examine the occupational burnout levels of Personnel Employed in Provincial Directorate of Konya Family and Social Policies and its Institutions according to different variables. The sample of the study is the Provincial Directorate of Konya Family and Social Policies and affiliated organizations. Maslach Burnout Inventory was used in the study. As a result of the research; it is observed that burnout sub-levels of Konya Family and Social Provincial Directorate employees was significant in the level of personal achievement according to age status and it is observed the presence of desensitization in gender category. In other categories, no findings were found in the name of burnout

Sıçan kadmiyum toksisitesi modelinde eser elementler: Taurin, Melatonin ve N-asetilsisteinin etkileri

Amaç: Bu çalışma kadmiyum toksisitesi oluşturulan sıçan modelinde bakır, çinko, demir ve selenyum düzeylerini araştırmak ve taurin, melatonin ve N-asetilsisteinin etkilerini belirlemek amacıyla yapılmıştır. Gereçler ve Yöntemler: Doksan erkek Sprague Dawley sıçan dokuz gruba ayrıldı. Hayvanlara serbestçe ulaşabilecekleri pellet yem ve su verildi. Grup 1'e çeşme suyu verildi ve kontrol olarak kullanıldı, diğer sekiz grup üç ay süreyle 200 µg/ml kadmiyum klorid (CdCl2) aldı. Grup 2, CdCl2, Grup 3, 4, ve 5 CdCl2 ile birlikte sırasıyla taurin, melatonin ve N-asetilsistein aldı. Grup 6, 7, 8, ve 9 üç ay süreyle CdCl2 ve sonra yedi gün süreyle kontrol olarak sadece su veya antioksidan aldı. Kalp ve beyinde kadmiyum, bakır, çinko, demir, ve selenyum düzeyleri atomik absorpsiyon spektrofotometresi ile ölçüldü. Bulgular: Kontrollerle karşılaştırıldığında kadmiyum beyin ve kalpte anlamlı düzeylerde birikim gösterdi. Grup 1 ve Grup 2 CdCl2 düzeyleri sırasıyla kalpte 2.56±0.77 ve 27.2±5.82, beyinde ise 46.16±14.81 ve 300.34±58.19 idi (p<0.001). Kadmiyum birikimine karşı koruyucu olan en etkili maddenin beyin dokusunda melatonin (p<0.05), kalpte ise N-asetilsistein (p<0.001) olduğunu bulduk. Sonuç: Bu bulgular kadmiyumun beyin ve kalpte birikimine karşı taurin, melatonin ve N-asetilsisteinin bazı koruyucu etkileri olduğunu düşündürdü. Ayrıca, eser element düzeylerinin taurin, melatonin veya N-asetilsistein uygulaması ile farklı düzeylerde olsa da kontrol değerlerine yaklaştığı gözlendi.Objectives: This study was undertaken to investigate copper, zinc, iron, and selenium in a rat model of cadmium toxicity and effects of antioxidant substances such as taurine, melatonin and N-acetylcysteine. Materials and Methods: Ninety male Sprague Dawley rats were divided into nine groups. Group 1 received tap water comprising the controls; the remaining eight groups received 200 &micro;g/ml cadmium chloride (CdCl2) for three months. Group 2 had CdCl2. Groups 3, 4, and 5 were administered taurine, melatonin and N-acetylcystein for three months together with CdCl2. Groups 6, 7, 8, and 9 had CdCl2 for three months and then only water as the second control or antioxidants for seven days. Cadmium, copper, zinc, iron, and selenium levels of heart and brain were measured by atomic absorption spectrophotometer. Results: Cadmium accumulated in significant amounts in brain and heart tissues when compared with controls. CdCl2 levels in Group 1 and Group 2 were 2.56&plusmn;0.77 and 27.2&plusmn;5.82 in the heart, 46.16&plusmn;14.81 and 300.34&plusmn;58.19 in the brain, respectively (p&lt;0.001). We found that melatonin was more effective in brain tissue (p&lt;0.05) whereas N-acetylcysteine was more effective in heart tissue (p&lt;0.001) against cadmium accumulation. Conclusion: We suggest that taurine, melatonin and N-acetylcysteine have some protective effects in brain and heart tissues against cadmium accumulation. Furthermore, trace element levels were restorated in different degrees after taurine, melatonin and N-acetylcysteine administration

Accelerated versus classical hepatitis B virus vaccination programs in healthcare workers accelerated vs. classical HBV vaccination

WOS: 000242137900010PubMed ID: 17072271The aim of this study was to compare the efficacy of a standard hepatitis B virus vaccination program (day 0-30-60) with an accelerated vaccination program (day 0-10-21) in healthy healthcare workers. Participants were randomly assigned to a classical (group 1, days 0, 30, and 60) or an accelerated vaccination program (group 2, days 0, 10, and 21). The vaccine used was 20 mu g recombinant hepatitis B vaccine (recombinant hepatitis B vaccine derived from yeast cells, Engerix B, Smith Cline Beachum). HBV markers were re-examined for the emergence of anti-HBsAg and also to detect the development of a possible acute HBV infection one, two, and three months after the last dose of vaccine. Anti-HBsAg titers > 10 mIU/1 were accepted as protective. The seroprotection rates were similar one, two, and three months after the last dose of vaccine in both groups. Anti-HBsAg titers in group 1 were higher than in group 2 two and three months after the last dose of vaccination (p < 0.05). Our data indicate that the accelerated HBV vaccination program was as effective as the classical vaccination program

Less invasive surgical implant strategy and right heart failure after LVAD implantation

BACKGROUND: Conventional median sternotomy (CMS) is still the standard technique utilized to implant left ventricular assist devices (LVADs). Recent studies suggest that less invasive surgery (LIS) may be beneficial; however, robust data on differences in right heart failure (RHF) are lacking. This study aimed to determine the impact of LIS compared with that of CMS on RHF outcomes after LVAD implantation. METHODS: An international multicenter retrospective cohort study was conducted across 5 centers. Patients were grouped according to their implantation technique (LIS vs CMS). Only centrifugal devices were included. RHF was defined as severe or severe acute RHF according to the 2013 Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definition. Logistic multivariate regression and propensity score‒matched analyses were performed to account for confounding. RESULTS: Overall, 427 implantations occurred during the study period, with 305 patients implanted using CMS and 122 using LIS. Pre-operative extracorporeal membrane oxygenation (ECMO) and intra-aortic balloon pump (IABP) use was more common in the CMS group; off-pump implantation was more common in the LIS group. Other pre-implant variables, including age, creatinine, hemodynamics, and tricuspid regurgitation, did not differ between the 2 groups. Post-operative RHF was less common in the patients who underwent LIS than in those who underwent CMS as was post-operative right ventricular assist device (RVAD) use. LIS remained associated with less RHF in the multivariate analysis. After propensity score matching conditional for age, sex, INTERMACS profile, ECMO, and IABP use in a ratio of 2:1 (CMS to LIS), RHF (29.9% vs 18.6%, p = 0.001) and the need for post-operative RVAD (18.6% vs 8.2%; p = 0.009) remained more common in the CMS group than in the LIS group. There were no significant differences in survival up to 1 year between the groups. CONCLUSIONS: LIS may be associated with less RHF after LVAD implantation compared with CMS. Despite the possible reduction in RHF, there was no difference in 1-year survival. LIS is an alternative to traditional CMS

Pregnancy and its outcomes in hemodialysis patients in Turkey

Background/aim: This study aimed to investigate pregnancy frequency and evaluate the factors affecting live births in hemodialysis (HD) patients. Materials and methods: Female HD patients whose pregnancy was retrospectively reported between January 1, 2014, and December 31, 2019. The duration of HD, primary disease, and the information on whether the pregnancy resulted in abortion, stillbirth, or live birth, whether the HD duration was prolonged after diagnosing the pregnancy and whether it accompanied preeclampsia were recorded. Results: In this study, we reached 9038 HD female patients' data in the study. A total of 235 pregnancies were detected in 145 patients. The mean age was 35.42 (35 +/- 7.4) years. The mean age at first gestation was 30.8 +/- 6.5 years. The average birth week was 32 (28 -36) weeks. A total of 53.8% (no = 78) of the patients had live birth, 51.7% (no = 70) had at least one abortion in the first 20 weeks, and 13.1% (no = 19) had at least one stillbirth after 20 weeks. The rate of patients' increased numbers of dialysis sessions during pregnancy was 71.7%. The abortion rate was 22.4% in those with increased HD sessions, whereas 79.3% in those not increased HD sessions (p < 0.001). Live birth frequency was 67.2% in the increased HD sessions group and 3.4% in those who did not differ in HD sessions (p < 0.001). Conclusion: For the first time, we reported pregnancy outcomes in HD female patients, covering all regions of Turkey. It has been observed that; increasing the number of HD sessions in dialysis patients will decrease fetal and maternal complications and increase live birth rates