Monthly maps of sea surface height in the North Atlantic and zonal indices for the Gulf Stream using TOPEX/Poseidon altimeter data

Monthly Maps of sea surface height are constructed for the North Atlantic Ocean using TOPEX/Poseidon altimeter data, Mean sea surface height is reconstructed using a weighted combination of historical, hydrographic data and a synthetic mean obtained by fitting a Gaussian model of the Gulf Stream jet to altimeter data. The resultant mean shows increased resolution over the hydrographic mean, and incorporates recirculation information that is absent in the synthetic mean. Monthly maps, obtained by adding the mean field to altimeter sea surface height residuals, are used to derive a set of zonal indices that describe the annual cycle of meandering as well as position and strength of the Gulf Stream.Funding was provided by the National Aeronautics and Space Administration through Contract Nos. NAGW-1666 and NAGW-4806

Demo Abstract: NILMTK v0.2: A Non-intrusive Load Monitoring Toolkit for Large Scale Data Sets

In this demonstration, we present an open source toolkit for evaluating non-intrusive load monitoring research; a field which aims to disaggregate a household's total electricity consumption into individual appliances. The toolkit contains: a number of importers for existing public data sets, a set of preprocessing and statistics functions, a benchmark disaggregation algorithm and a set of metrics to evaluate the performance of such algorithms. Specifically, this release of the toolkit has been designed to enable the use of large data sets by only loading individual chunks of the whole data set into memory at once for processing, before combining the results of each chunk.Comment: 1st ACM International Conference on Embedded Systems For Energy-Efficient Buildings, 201

NILMTK: An Open Source Toolkit for Non-intrusive Load Monitoring

Non-intrusive load monitoring, or energy disaggregation, aims to separate household energy consumption data collected from a single point of measurement into appliance-level consumption data. In recent years, the field has rapidly expanded due to increased interest as national deployments of smart meters have begun in many countries. However, empirically comparing disaggregation algorithms is currently virtually impossible. This is due to the different data sets used, the lack of reference implementations of these algorithms and the variety of accuracy metrics employed. To address this challenge, we present the Non-intrusive Load Monitoring Toolkit (NILMTK); an open source toolkit designed specifically to enable the comparison of energy disaggregation algorithms in a reproducible manner. This work is the first research to compare multiple disaggregation approaches across multiple publicly available data sets. Our toolkit includes parsers for a range of existing data sets, a collection of preprocessing algorithms, a set of statistics for describing data sets, two reference benchmark disaggregation algorithms and a suite of accuracy metrics. We demonstrate the range of reproducible analyses which are made possible by our toolkit, including the analysis of six publicly available data sets and the evaluation of both benchmark disaggregation algorithms across such data sets.Comment: To appear in the fifth International Conference on Future Energy Systems (ACM e-Energy), Cambridge, UK. 201

Virtuous Insightfulness

Insight often strikes us blind; when we aren’t expecting it, we suddenly see a connection that previously eluded us—a kind of ‘Aha!’ experience. People with a propensity to such experiences are regarded as insightful, and insightfulness is a paradigmatic intellectual virtue. What’s not clear, however, is just what it is in virtue of which being such that these experiences tend to happen to one renders one intellectually virtuous. This paper draws from both virtue epistemology as well as empirical work on the psychology of problem solving and creativity to make some inroads in accounting for insightfulness as an intellectual virtue. Important to the view advanced is that virtuously insightful individuals manifest certain skills which both cultivate insight experiences (even if not by directly bringing them about) and enable such individuals to move in an epistemically responsible way from insight experience to epistemic endorsement

On Non-Abelian Thomas-Fermi Screening

The Thomas-Fermi screening of non-Abelian gauge fields by fermions or screening of gluon fields in quark matter is discussed. It is described by an effective mass term which is, as with hard thermal loops, related to the eikonal for a Chern-Simons theory and the Wess-Zumino-Witten action.Comment: 7 pages, plain Tex, no figures; one reference added, note added at the en

The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin.

Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite-specific thiol, by glutathione. Here we show that TcGPXI activity can also be linked to trypanothione reduction by an alternative pathway involving the thioredoxin-like protein tryparedoxin. The presence of this new pathway was first detected using dialyzed soluble fractions of parasite extract. Tryparedoxin was identified as the intermediate molecule following purification, sequence analysis, antibody studies, and reconstitution of the redox cycle in vitro. The system can be readily saturated by trypanothione, the rate-limiting step being the interaction of trypanothione with the tryparedoxin. Both tryparedoxin and TcGPXI operate by a ping-pong mechanism. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides. TcGPXI contains a carboxyl-terminal tripeptide (ARI) that could act as a targeting signal for the glycosome, a kinetoplastid-specific organelle. Using immunofluorescence, tagged fluorescent proteins, and biochemical fractionation, we have demonstrated that TcGPXI is localized to both the glycosome and the cytosol. The ability of TcGPXI to use alternative electron donors may reflect their availability at the corresponding subcellular sites

Field day annual report 2022

"This field day annual report includes brief reports on the research conducted at the research farms under the Northern Missouri Research, Extension and Education Center. The research farms under the Northern Missouri Research, Extension and Education Center are the Cornett Farm, Lee Greenley Jr. Memorial Farm, and Thompson Farm. The report also includes the names of the advisory board members, faculty and staff, and graduate students of the Northern Missouri Research, Extension and Education Center. The list of published peer-reviewed journal articles based on the research conducted at the farms of the Northern Missouri Research, Extension and Education Center has also been included in this report."--Extension website, viewed September 19, 2022.Includes bibliographical reference

Molecular and Cellular Characterization of an AT-Hook Protein from Leishmania

AT-rich DNA, and the proteins that bind it (AT-hook proteins), modulate chromosome structure and function in most eukaryotes. Unlike other trypanosomatids, the genome of Leishmania species is unusually GC-rich, and the regulation of Leishmania chromosome structure, replication, partitioning is not fully understood. Because AT-hook proteins modulate these functions in other eukaryotes, we examined whether AT-hook proteins are encoded in the Leishmania genome, to test their potential functions. Several Leishmania ORFs predicted to be AT-hook proteins were identified using in silico approaches based on sequences shared between eukaryotic AT-hook proteins. We have used biochemical, molecular and cellular techniques to characterize the L. amazonensis ortholog of the L. major protein LmjF06.0720, a potential AT-hook protein that is highly conserved in Leishmania species. Using a novel fusion between the AT-hook domain encoded by LmjF06.0720 and a herpesviral protein, we have demonstrated that LmjF06.0720 functions as an AT-hook protein in mammalian cells. Further, as observed for mammalian and viral AT-hook proteins, the AT-hook domains of LmjF06.0720 bind specific regions of condensed mammalian metaphase chromosomes, and support the licensed replication of DNA in mammalian cells. LmjF06.0720 is nuclear in Leishmania, and this localization is disrupted upon exposure to drugs that displace AT-hook proteins from AT-rich DNA. Coincidentally, these drugs dramatically alter the cellular physiology of Leishmania promastigotes. Finally, we have devised a novel peptido-mimetic agent derived from the sequence of LmjF06.0720 that blocks the proliferation of Leishmania promastigotes, and lowers amastigote parasitic burden in infected macrophages. Our results indicate that AT-hook proteins are critical for the normal biology of Leishmania. In addition, we have described a simple technique to examine the function of Leishmania chromatin-binding proteins in a eukaryotic context amenable to studying chromosome structure and function. Lastly, we demonstrate the therapeutic potential of compounds directed against AT-hook proteins in Leishmania