Risk and Business Goal Based Security Requirement and Countermeasure Prioritization

Companies are under pressure to be in control of their assets but at the same time they must operate as efficiently as possible. This means that they aim to implement “good-enough security” but need to be able to justify their security investment plans. Currently companies achieve this by means of checklist-based security assessments, but these methods are a way to achieve consensus without being able to provide justifications of countermeasures in terms of business goals. But such justifications are needed to operate securely and effectively in networked businesses. In this paper, we first compare a Risk-Based Requirements Prioritization method (RiskREP) with some requirements engineering and risk assessment methods based on their requirements elicitation and prioritization properties. RiskREP extends misuse case-based requirements engineering methods with IT architecture-based risk assessment and countermeasure definition and prioritization. Then, we present how RiskREP prioritizes countermeasures by linking business goals to countermeasure specification. Prioritizing countermeasures based on business goals is especially important to provide the stakeholders with structured arguments for choosing a set of countermeasures to implement. We illustrate RiskREP and how it prioritizes the countermeasures it elicits by an application to an action case

Effects of wind turbines on area use and behaviour of semi-domestic reindeer in enclosures

In recent decades, industrial developments have expanded into reindeer ranges in the arctic and adjacent higher latitudes in search for energy, minerals, timber and other resources. Several wind turbine parks are under planning in reindeer ranges in Norway, and there is concern about possible negative effects on behaviour and area use of wild and semi-domestic reindeer. We tested whether a wind turbine and its rotor movement had any effect on area use, activity changes, vigilance bouts, and restless behaviour like running, walking, and standing for enclosed semi-domestic reindeer. Five different groups of reindeer in a 450 m long, 8 hectare, enclosure close to a wind turbine were manipulated by turning the wind turbine rotor on and off, and compared with reindeer in a control enclosure without wind turbine exposure. When exposed to rotor movement, two groups used locations farther from the wind turbine, two groups showed no shift, while one group moved closer to the wind turbine. The reindeer showed no systematic differences in the measured behaviour patterns between the two enclosures that could indicate fright or stress as a consequence of the wind turbine or rotor movement. We conclude that semi-domestic reindeer in an enclosure showed no negative behavioural response and little or no aversion towards a wind turbine. The possibility of rapid habituation in a small enclosure with continuous wind turbine exposure suggests that effects on area use should be studied at a larger scale or with free-ranging reindeer.Abstract in Norwegian / Sammendrag:I løpet av de senere tiår har industriell utbygging til utnytting av energi, mineraler, tømmer og andre ressurser ekspandert inn i reinens beiteområder i nordområdene. Flere vindmølleparker er under planlegging i norske reinbeiteområder, og det spekuleres i mulige konsekvenser av disse på atferd og arealbruk hos villrein og tamrein. Vi testet om en vindmølle og dens rotorbevegelse hadde noen effekt på arealbruk, aktivitetsskifter, vaktsomhetsatferd, og rastløshetsatferd i form av løp, gange og ståing for tamrein i innhegning. I en 450 m lang innhegning på 8 hektar som var plassert tett opp til en vindmølle, ble fem forskjellig grupper av reinsdyr manipulert ved å slå vindmøllerotoren av og på. Reinsdyrene i innhegningen ved vindmøllen ble sammenlignet med reinsdyr i en kontrollinnhegning som var uten påvirkning fra vindmøller. Når reinsdyrene ble utsatt for vindmøllerotoren i bevegelse, viste to grupper av dyr et skifte i arealbruk til områder av innhegningen som var lenger unna møllen, to grupper av dyr viste ikke noe skifte i arealbruk, mens en gruppe dyr beveget seg nærmere vindmøllen. Sammenligning av atferden hos reinsdyrene i vindmølleinnhegningen og kontrollinnhegningen viste ingen systematisk forskjell som kunne indikere frykt eller stress som en effekt av vindmøllen eller rotorbevegelsen. Vi konkluderer med at tamrein i innhegning ikke viser negative atferdsresponser og viser lite eller ingen reduksjon i arealbruken tett opp til en vindmølle. Muligheten for at det skjer en rask tilvenning i en liten innhegning der dyrene er i kontinuerlig påvirkning av vindmøllen betyr at effekter på arealbruk bør studeres i et større arealperspektiv eller på frittgående rein

The intensity paradox:A systematic review and meta‐analysis of its impact on the cardiorespiratory fitness of older adults

Aim: The present systematic review and meta‐analysis aimed to compare the effect of moderate‐ versus high‐intensity aerobic exercise on cardiorespiratory fitness (CRF) in older adults, taking into account the volume of exercise completed. Methods: The databases MEDLINE (Ovid), EMBASE (Ovid), and CENTRAL (Cochrane Library) were searched to identify randomized controlled trials (RCTs). Two reviewers extracted data and assessed bias. Comprehensive Meta‐Analysis software calculated overall effect size, intensity differences, and performed meta‐regression analyses using pre‐to‐post intervention or change scores of peak oxygen uptake (V̇O2peak). The review included 23 RCTs with 1332 older adults (intervention group: n = 932; control group: n = 400), divided into moderate‐intensity (435 older adults) and high‐intensity (476 older adults) groups. Results: Meta‐regression analysis showed a moderate, but not significant, relationship between exercise intensity and improvements in V̇O2peak after accounting for the completed exercise volume (β = 0.31, 95% CI = [−0.04; 0.67]). Additionally, studies comparing moderate‐ versus high‐intensity revealed a small, but not significant, effect in favor of high‐intensity (Hedges' g = 0.20, 95% CI = [−0.02; 0.41]). Finally, no significant differences in V̇O2peak improvements were found across exercise groups employing various methods, modalities, and intensity monitoring strategies. Conclusion: Findings challenge the notion that high‐intensity exercise is inherently superior and indicate that regular aerobic exercise, irrespective of the specific approach and intensity, provides the primary benefits to CRF in older adults. Future RCTs should prioritize valid and reliable methodologies for monitoring and reporting exercise volume and adherence among older adults

miRNAs Predicted to Regulate Host Anti-viral Gene Pathways in IPNV-Challenged Atlantic Salmon Fry Are Affected by Viral Load, and Associated With the Major IPN Resistance QTL Genotypes in Late Infection

Infectious pancreatic necrosis virus (IPNV) infection has been a major problem in salmonid aquaculture. Marker-assisted selection of individuals with resistant genotype at the major IPN quantitative trait locus (IPN-QTL) has significantly reduced mortality in recent years. We have identified host miRNAs that respond to IPNV challenge in salmon fry that were either homozygous resistant (RR) or homozygous susceptible (SS) for the IPN-QTL. Small RNA-sequenced control samples were compared to samples collected at 1, 7, and 20 days post challenge (dpc). This revealed 72 differentially expressed miRNAs (DE miRNAs). Viral load (VL) was lower in RR vs. SS individuals at 7 and 20 dpc. However, analysis of miRNA expression changes revealed no differences between RR vs. SS individuals in controls, at 1 or 7 dpc, while 38 “high viral load responding” miRNAs (HVL-DE miRNAs) were identified at 20 dpc. Most of the HVL-DE miRNAs showed changes that were more pronounced in the high VL SS group than in the low VL RR group when compared to the controls. The absence of differences between QTL groups in controls, 1 and 7 dpc indicates that the QTL genotype does not affect miRNA expression in healthy fish or their first response to viral infections. The miRNA differences at 20 dpc were associated with the QTL genotype and could, possibly, contribute to differences in resistance/susceptibility at the later stage of infection. In silico target gene predictions revealed that 180 immune genes were putative targets, and enrichment analysis indicated that the miRNAs may regulate several major immune system pathways. Among the targets of HVL-DE miRNAs were IRF3, STAT4, NFKB2, MYD88, and IKKA. Interestingly, TNF-alpha paralogs were targeted by different DE miRNAs. Most DE miRNAs were from conserved miRNA families that respond to viral infections in teleost (e.g., miR-21, miR-146, miR-181, miR-192, miR-221, miR-462, miR-731, and miR-8159), while eight were species specific. The miRNAs showed dynamic temporal changes implying they would affect their target genes differently throughout disease progression. This shows that miRNAs are sensitive to VL and disease progression, and may act as fine-tuners of both immediate immune response activation and the later inflammatory processes

Enhanced nutrient supply and intestinal microbiota development in very low birth weight infants

BACKGROUND: Promoting a healthy intestinal microbiota may have positive effects on short- and long-term outcomes in very low birth weight (VLBW; BW = 28 weeks) infants and a steeper decrease in relative Staphylococcus abundance in extremely preterm (EP, gestational age <28 weeks) infants as compared to controls. Relative Bifidobacterium abundance tended to increase more in MVP controls compared to the intervention group. Abundance of pathogens was not increased in the intervention group. Higher relative Bifidobacterium abundance was associated with improved weight gain. CONCLUSION: Nutrition may affect richness, diversity, and microbiota composition. There was no increase in relative abundance of pathogens among infants receiving enhanced nutrient supply. Favorable microbiota development was associated with improved weight gain.Peer reviewe

Identifying Implicit Vulnerabilities through Personas as Goal Models

When used in requirements processes and tools, personas have the potential to identify vulnerabilities resulting from misalignment between user expectations and system goals. Typically, however, this potential is unfulfilled as personas and system goals are captured with different mindsets, by different teams, and for different purposes. If personas are visualised as goal models, it may be easier for stakeholders to see implications of their goals being satisfied or denied, and designers to incorporate the creation and analysis of such models into the broader RE tool-chain. This paper outlines a tool-supported approach for finding implicit vulnerabilities from user and system goals by reframing personas as social goal models. We illustrate this approach with a case study where previously hidden vulnerabilities based on human behaviour were identified

Effectiveness of individualized training based on force–velocity profiling on physical function in older men

The study aimed to investigate the effectiveness of an individualized power training program based on force–velocity (FV) profiling on physical function, muscle morphology, and neuromuscular adaptations in older men. Forty-nine healthy men (68 ± 5 years) completed a 10-week training period to enhance muscular power. They were randomized to either a generic power training group (GPT) or an individualized power training group (IPT). Unlike generic training, individualized training was based on low- or high-resistance exercises, from an initial force–velocity profile. Lower-limb FV profile was measured in a pneumatic leg-press, and physical function was assessed as timed up-and-go time (TUG), sit-to-stand power, grip strength, and stair-climbing time (loaded [20kg] and unloaded). Vastus lateralis morphology was measured with ultrasonography. Rate of force development (RFD) and rate of myoelectric activity (RMA) were measured during an isometric knee extension. The GPT group improved loaded stair-climbing time (6.3 ± 3.8 vs. 2.3% ± 7.3%, p = 0.04) more than IPT. Both groups improved stair-climbing time, sit to stand, and leg press power, grip strength, muscle thickness, pennation angle, fascicle length, and RMA from baseline (p < 0.05). Only GPT increased loaded stair-climbing time and RFD (p < 0.05). An individualized power training program based on FV profiling did not improve physical function to a greater degree than generic power training. A generic power training approach combining both heavy and low loads might be advantageous through eliciting both force- and velocity-related neuromuscular adaptions with a concomitant increase in muscular power and physical function in older men.publishedVersio

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) 2016/429): infection with Gyrodactylus salaris (GS)

Infection with Gyrodactylus salaris was assessed according to the criteria of the Animal Health Law (AHL), in particular, the criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its categorisation according to disease prevention and control rules as laid down in Article 9 and Article 8 for listing animal species related to infection with G. salaris. The assessment was performed following the ad hoc method for data collection and assessment previously developed by AHAW panel and already published. The outcome reported is the median of the probability ranges provided by the experts, which indicates whether each criterion is fulfilled (lower bound &gt;= 66%) or not (upper bound &lt;= 33%), or whether there is uncertainty about fulfilment. Reasoning points are reported for criteria with an uncertain outcome. According to the assessment here performed, it is uncertain whether infection with G. salaris can be considered eligible to be listed for Union intervention according to Article 5 of the AHL (33-70% probability). According to the criteria in Annex IV, for the purpose of categorisation related to the level of prevention and control as in Article 9 of the AHL, the AHAW Panel concluded that Infection with G. salaris does not meet the criteria in Section 1 and 3 (Category A and C; 1-5% and 10-33% probability of fulfilling the criteria, respectively) and it is uncertain whether it meets the criteria in Sections 2, 4 and 5 (Categories B, D and E; 33-80%, 33-66% and 33-80% probability of meeting the criteria, respectively). The animal species to be listed for infection with G. salaris according to Article 8 criteria are provided

Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) 2016/429): Bacterial kidney disease (BKD)

Bacterial kidney disease (BKD) was assessed according to the criteria of the Animal Health Law (AHL), in particular the criteria of Article 7 on disease profile and impacts, Article 5 on its eligibility to be listed, Annex IV for its categorisation according to disease prevention and control rules as laid out in Article 9 and Article 8 for listing animal species related to BKD. The assessment was performed following the ad hoc method on data collection and assessment developed by AHAW Panel and already published. The outcome reported is the median of the probability ranges provided by the experts, which indicates whether each criterion is fulfilled (lower bound &lt;= 66%) or not (upper bound &gt;= 33%), or whether there is uncertainty about fulfilment. Reasoning points are reported for criteria with an uncertain outcome. According to this assessment, BKD can be considered eligible to be listed for Union intervention according to Article 5 of the AHL (66-90% probability). According to the criteria in Annex IV, for the purpose of categorisation related to the level of prevention and control as in Article 9 of the AHL, the AHAW Panel concluded that BKD does not meet the criteria in Sections 1, 2 and 3 (Categories A, B and C; 1-5%, 33-66% and 33-66% probability of meeting the criteria, respectively) but meets the criteria in Sections 4 and 5 (Categories D and E; 66-90% and 66-90% probability of meeting the criteria, respectively). The animal species to be listed for BKD according to Article 8 criteria are provided