General computational spectroscopic framework applied to Z-pinch dynamic hohlraum K-shell argon spectra

We describe a general computational spectroscopic framework for interpreting observed spectra. The framework compares synthetic spectra with measured spectra, then optimizes the agreement using the Dakota toolkit to minimize a merit function that incorporates established spectroscopic techniques. We generate synthetic spectra using the self-consistent nonlocal thermodynamic equilibrium atomic kinetics and radiative transfer code Cretin, relativistic atomic structure and cross section data from Hullac, and detailed spectral line shapes from Totalb. We test the capabilities of both our synthetic spectra model and general spectroscopic framework by analyzing a K-shell argon spectrum from a Z-pinch dynamic hohlraum inertial confinement fusion capsule implosion experiment. The framework obtains close agreement between an experimental spectrum measured by a time integrated focusing spectrometer and the optimal synthetic spectrum. The synthetic spectra show that considering the spatial extent of the capsule and including the effects of optically thick resonance lines significantly affects the interpretation of measured spectra

Z-Beamlet (ZBL) Multi-Frame Back-lighter (MFB) System for ICF/Plasma Diagnostics

Z-Beamlet [1] is a single-beam high-energy Nd:glass laser used for backlighting high energy density (HED) plasma physics experiments at Sandia's Z-accelerator facility. The system currently generates a single backlit image per experiment, and has been employed on approximately 50% of Z-accelerator system shots in recent years. We have designed and are currently building a system that uses Z-Beamlet to generate two distinct backlit images with adjustable time delay ranging from 2 to 20 ns between frames. The new system will double the rate of data collection and allow the temporal evolution of high energy density phenomena to be recorded on a single shot

Management of cytoskeleton architecture by molecular chaperones and immunophilins

Cytoskeletal structure is continually remodeled to accommodate normal cell growth and to respond to pathophysiological cues. As a consequence, several cytoskeleton-interacting proteins become involved in a variety of cellular processes such as cell growth and division, cell movement, vesicle transportation, cellular organelle location and function, localization and distribution of membrane receptors, and cell-cell communication. Molecular chaperones and immunophilins are counted among the most important proteins that interact closely with the cytoskeleton network, in particular with microtubules and microtubule-associated factors. In several situations, heat-shock proteins and immunophilins work together as a functionally active heterocomplex, although both types of proteins also show independent actions. In circumstances where homeostasis is affected by environmental stresses or due to genetic alterations, chaperone proteins help to stabilize the system. Molecular chaperones facilitate the assembly, disassembly and/or folding/refolding of cytoskeletal proteins, so they prevent aberrant protein aggregation. Nonetheless, the roles of heat-shock proteins and immunophilins are not only limited to solve abnormal situations, but they also have an active participation during the normal differentiation process of the cell and are key factors for many structural and functional rearrangements during this course of action. Cytoskeleton modifications leading to altered localization of nuclear factors may result in loss- or gain-of-function of such factors, which affects the cell cycle and cell development. Therefore, cytoskeletal components are attractive therapeutic targets, particularly microtubules, to prevent pathological situations such as rapidly dividing tumor cells or to favor the process of cell differentiation in other cases. In this review we will address some classical and novel aspects of key regulatory functions of heat-shock proteins and immunophilins as housekeeping factors of the cytoskeletal network.Fil: Quintá, Héctor Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Galigniana, Natalia Maricel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Erlejman, Alejandra Giselle. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaFil: Lagadari, Mariana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Piwien Pilipuk, Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Galigniana, Mario Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentin

Lawson criterion for ignition exceeded in an inertial fusion experiment

For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion

X pinch as a source for X-ray radiography

This article describes several applications and methods using the X pinch as a source of X-ray radiation for the radiography of dense plasma objects. These methods, in general, do not use pinholes, and instead take the advantage of the small size (<1 mm, and in some cases <3 mm) and a short X-ray emission duration (<1 ns) of the radiation source produced by an X pinch. Two of these methods, monochromatic and direct point-projection backlighting, are discussed. Experimental images of exploding wires and wire arrays obtained on the BIN, XP, and MAGPIE generators using these techniques are presented. Also included are detailed measurements made on the XP generator of the emission characteristics of X pinches using different wire materials