Proton Driven Plasma Wakefield Acceleration

Plasma wakefield acceleration, either laser driven or electron-bunch driven, has been demonstrated to hold great potential. However, it is not obvious how to scale these approaches to bring particles up to the TeV regime. In this paper, we discuss the possibility of proton-bunch driven plasma wakefield acceleration, and show that high energy electron beams could potentially be produced in a single accelerating stage.Comment: 13 pages, 4 figure

DNA-Based Diet Analysis for Any Predator

Background: Prey DNA from diet samples can be used as a dietary marker; yet current methods for prey detection require a priori diet knowledge and/or are designed ad hoc, limiting their scope. I present a general approach to detect diverse prey in the feces or gut contents of predators. Methodology/Principal Findings: In the example outlined, I take advantage of the restriction site for the endonuclease Pac I which is present in 16S mtDNA of most Odontoceti mammals, but absent from most other relevant non-mammalian chordates and invertebrates. Thus in DNA extracted from feces of these mammalian predators Pac I will cleave and exclude predator DNA from a small region targeted by novel universal primers, while most prey DNA remain intact allowing prey selective PCR. The method was optimized using scat samples from captive bottlenose dolphins (Tursiops truncatus) fed a diet of 6–10 prey species from three phlya. Up to five prey from two phyla were detected in a single scat and all but one minor prey item (2% of the overall diet) were detected across all samples. The same method was applied to scat samples from free-ranging bottlenose dolphins; up to seven prey taxa were detected in a single scat and 13 prey taxa from eight teleost families were identified in total. Conclusions/Significance: Data and further examples are provided to facilitate rapid transfer of this approach to any predator. This methodology should prove useful to zoologists using DNA-based diet techniques in a wide variety of study systems

A GMSK VHF-uplink/UHF-downlink transceiver for the CubeSat missions: Thermo-functional performance

© 2018, CEAS. Functional and thermal performance characteristics of a very high frequency/ultra high frequency (VHF/UHF) transceiver based on Gaussian minimum shift keying (GMSK) modulation are presented. The transceiver has been designed for CubeSats telemetry and commanding needs or low rate data download. The design is validated at 27 dBm, 30 dBm and 33 dBm transmitting powers over −20 ∘C to +51 ∘C. Under these thermal conditions, the transmitter spurious dynamic response shows little if any change and the average sensitivity of receiver at the 12 dB signal noise and distortion (SINAD) is −116.7 dBm at 140 MHz and −116.78 dBm at 149.98 MHz. The transmitter and receiver frequencies are stable and the current consumption as well the output RF levels are steady. The design has been verified against a simulation model which allows system tradeoff analysis. The measurements demonstrate the transceiver made with commercial grade parts has dependable performance at the low earth altitudes and orbital heating conditions

Local Entrepreneurship in Vietnam’s Rural Transformation. A Case Study from the Mekong Delta

Empirical evidence from developing countries has illuminated the vital role private business development plays in rural transformation and the creation of off‐farm livelihoods. Since ‘renovation’ (Đổi mới) was promulgated by the Vietnamese Communist Party in 1986, Vietnam has experienced rapid growth and development through the transition from state to market. While de‐collectivization and the return to householdbased rural production reduced poverty and increased growth, entrepreneurship development in the form of Small and Medium Enterprises(SME) has emerged as a strong agent for socio‐economic diversification. The Mekong Delta, located in the Southwest of Vietnam, is a rural setting traditionally reliant on agriculture but has been facing rapid rural transformation over the past three decades. Against a background of agrarian modernization, economic liberalization, international integration and environmental change, this report explores the diversity of entrepreneurial activities and SME development in typical peri‐urban and rural settings of the region. Empirical findings on the trajectory of rural entrepreneurship development, enterprise characteristics, and the social profiles of business owners are presented. Beyond that, changes brought about by rural enterprises for livelihood diversification, social security and labor market dynamics are disaggregated and discussed by different business types and corresponding modus operandi (growth‐oriented vs. livelihood‐oriented enterprises). Finally, the results are contrasted with current government notions of promoting SMEs development as a driver of economic growth. Diverging from the government’s vision for boosting SME development in the context of rural industrialization, the large majority of private business establishments in the Mekong Delta are micro‐enterprises which operate at subsistence levels, while growth‐oriented SMEs remain the exception. Consequently, there is a need to reconsider policy formulation for more sustainability in the rural SME sector

Local Entrepreneurship in Vietnam’s Rural Transformation. A Case Study from the Mekong Delta

Empirical evidence from developing countries has illuminated the vital role private business development plays in rural transformation and the creation of off‐farm livelihoods. Since ‘renovation’ (Đổi mới) was promulgated by the Vietnamese Communist Party in 1986, Vietnam has experienced rapid growth and development through the transition from state to market. While de‐collectivization and the return to householdbased rural production reduced poverty and increased growth, entrepreneurship development in the form of Small and Medium Enterprises(SME) has emerged as a strong agent for socio‐economic diversification. The Mekong Delta, located in the Southwest of Vietnam, is a rural setting traditionally reliant on agriculture but has been facing rapid rural transformation over the past three decades. Against a background of agrarian modernization, economic liberalization, international integration and environmental change, this report explores the diversity of entrepreneurial activities and SME development in typical peri‐urban and rural settings of the region. Empirical findings on the trajectory of rural entrepreneurship development, enterprise characteristics, and the social profiles of business owners are presented. Beyond that, changes brought about by rural enterprises for livelihood diversification, social security and labor market dynamics are disaggregated and discussed by different business types and corresponding modus operandi (growth‐oriented vs. livelihood‐oriented enterprises). Finally, the results are contrasted with current government notions of promoting SMEs development as a driver of economic growth. Diverging from the government’s vision for boosting SME development in the context of rural industrialization, the large majority of private business establishments in the Mekong Delta are micro‐enterprises which operate at subsistence levels, while growth‐oriented SMEs remain the exception. Consequently, there is a need to reconsider policy formulation for more sustainability in the rural SME sector

Superconducting nanowire photon number resolving detector at telecom wavelength

The optical-to-electrical conversion, which is the basis of optical detectors, can be linear or nonlinear. When high sensitivities are needed single-photon detectors (SPDs) are used, which operate in a strongly nonlinear mode, their response being independent of the photon number. Nevertheless, photon-number resolving (PNR) detectors are needed, particularly in quantum optics, where n-photon states are routinely produced. In quantum communication, the PNR functionality is key to many protocols for establishing, swapping and measuring entanglement, and can be used to detect photon-number-splitting attacks. A linear detector with single-photon sensitivity can also be used for measuring a temporal waveform at extremely low light levels, e.g. in long-distance optical communications, fluorescence spectroscopy, optical time-domain reflectometry. We demonstrate here a PNR detector based on parallel superconducting nanowires and capable of counting up to 4 photons at telecommunication wavelengths, with ultralow dark count rate and high counting frequency

Ubiquitous Crossmodal Stochastic Resonance in Humans: Auditory Noise Facilitates Tactile, Visual and Proprioceptive Sensations

BACKGROUND: Stochastic resonance is a nonlinear phenomenon whereby the addition of noise can improve the detection of weak stimuli. An optimal amount of added noise results in the maximum enhancement, whereas further increases in noise intensity only degrade detection or information content. The phenomenon does not occur in linear systems, where the addition of noise to either the system or the stimulus only degrades the signal quality. Stochastic Resonance (SR) has been extensively studied in different physical systems. It has been extended to human sensory systems where it can be classified as unimodal, central, behavioral and recently crossmodal. However what has not been explored is the extension of this crossmodal SR in humans. For instance, if under the same auditory noise conditions the crossmodal SR persists among different sensory systems. METHODOLOGY/PRINCIPAL FINDINGS: Using physiological and psychophysical techniques we demonstrate that the same auditory noise can enhance the sensitivity of tactile, visual and propioceptive system responses to weak signals. Specifically, we show that the effective auditory noise significantly increased tactile sensations of the finger, decreased luminance and contrast visual thresholds and significantly changed EMG recordings of the leg muscles during posture maintenance. CONCLUSIONS/SIGNIFICANCE: We conclude that crossmodal SR is a ubiquitous phenomenon in humans that can be interpreted within an energy and frequency model of multisensory neurons spontaneous activity. Initially the energy and frequency content of the multisensory neurons' activity (supplied by the weak signals) is not enough to be detected but when the auditory noise enters the brain, it generates a general activation among multisensory neurons of different regions, modifying their original activity. The result is an integrated activation that promotes sensitivity transitions and the signals are then perceived. A physiologically plausible model for crossmodal stochastic resonance is presented

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and elsewhere in the genome - trans effects. The role of genetic variation in determining protein levels has not been systematically assessed. Using a genome-wide association approach we show that common genetic variation influences levels of clinically relevant proteins in human serum and plasma. We evaluated the role of 496,032 polymorphisms on levels of 42 proteins measured in 1200 fasting individuals from the population based InCHIANTI study. Proteins included insulin, several interleukins, adipokines, chemokines, and liver function markers that are implicated in many common diseases including metabolic, inflammatory, and infectious conditions. We identified eight Cis effects, including variants in or near the IL6R (p = 1.8×10 -57), CCL4L1 (p = 3.9×10-21), IL18 (p = 6.8×10-13), LPA (p = 4.4×10-10), GGT1 (p = 1.5×10-7), SHBG (p = 3.1×10-7), CRP (p = 6.4×10-6) and IL1RN (p = 7.3×10-6) genes, all associated with their respective protein products with effect sizes ranging from 0.19 to 0.69 standard deviations per allele. Mechanisms implicated include altered rates of cleavage of bound to unbound soluble receptor (IL6R), altered secretion rates of different sized proteins (LPA), variation in gene copy number (CCL4L1) and altered transcription (GGT1). We identified one novel trans effect that was an association between ABO blood group and tumour necrosis factor alpha (TNF-alpha) levels (p = 6.8×10-40), but this finding was not present when TNF-alpha was measured using a different assay , or in a second study, suggesting an assay-specific association. Our results show that protein levels share some of the features of the genetics of gene expression. These include the presence of strong genetic effects in cis locations. The identification of protein quantitative trait loci (pQTLs) may be a powerful complementary method of improving our understanding of disease pathways. © 2008 Melzer et al

Hybrid managers, career narratives and identity work: a contextual analysis of UK healthcare organizations

While hybrid managers are increasingly important in contemporary organizations (especially in the public sector), we know little about why or how they become hybrid managers, or how this is shaped by the interplay of professional experience and organizational circumstances. In pursuit of a more variegated, contextualised and dynamic understanding of hybrid management, this paper focuses on how individuals transition into managerial hybrids, emphasizing the dynamic and emergent nature of hybrid management identity. Studying managers in English healthcare, we employ the concept of identity work as expressed through career narratives to examine the influence of career trajectories and organizational experiences on emerging hybrid manager identity. The study identifies three broad managerial career narratives – aspirational, ambivalent and agnostic – and relates them to experiences of doctor and nurse hybrid managers in three healthcare settings. An interpretive analysis of these narratives reveals a more variegated, situated and dynamic interpretation of hybrid managerial identities than previously considered and underscores the importance of personal and organizational experiences in shaping emergent hybrid professional/managerial identity