Measurement of dry deposition to bulk precipitation collectors using a novel flushing sampler

Bulk precipitation samplers, which are continuously open, also sample gases and particles deposited on the funnel surface. Wet-only samplers, which open only during precipitation, avoid this problem, but can be bulky (leading to disruption of air flow and droplet collection) and need electrical power. We describe here a simple battery-powered modification to a standard bulk sampler that allows the separate measurement of deposition to the funnel surface and wet deposition by washing the funnel surface when precipitation is detected. Comparison of this design with a standard bulk sampler over 3 months at a site in eastern Scotland showed that dry deposition to the funnel surface contributed around 20% of sulphate, 20-30% of nitrate and 20-40% of ammonium ions. There was also a significant loss of ammonium and nitrate in the modified sampler, presumably in the tubing, even though a biocide had been added to the sample bottles. This observation has implications for bulk samplers of similar design, with a sample bottle at ground level. Deposition of sea salts and calcium was greater to the flushing collectors than to the bulk collectors, implying that regular cleaning of funnel surfaces with 10% methanol solution subtly alters the capture efficiency for larger particles

Epigenetics in diagnosis, prognostic assessment and treatment of cancer:An update

Cancer cells contain multiple genetic and epigenetic changes. The relative specificity of many epigenetic changes for neoplastic cells has allowed the identification of diagnostic, prognostic and predictive biomarkers for a number of solid tumors and hematological malignancies. Moreover, epigenetically-acting drugs are already in routine use for cancer and numerous additional agents are in clinical trials. Here, we review recent progress in the development and application of epigenetic strategies for the diagnosis, risk stratification and treatment of cancer

Differentiated regulation: the case of charities

The increasing number and influence of charities in the economy, allegations and evidence of fraud and mismanagement, and the need for information to inform policy, are all reasons for the establishment of charity regulators. Public interest and public choice provide underlying theories explaining charity regulation which aims to increase public trust and confidence in charities (and thus increases philanthropy), and to limit tax benefits to specific organisations and donors. Disclosure-based regulatory regimes are a common model for charities regulation in many jurisdictions. Nevertheless, these can be resource intensive for the regulator and regulated charities, and growing pressure on government budgets requires efficiencies to be found. This paper proposes regulation differentiated according to charities’ main resource providers. This could reduce cost and increase the regulator’s effectiveness through focusing effort. In addition, this differentiation segments charity types according to the theories that explain why these organisations form and operate. We demonstrate the feasibility of such segmentation by use of cluster analysis of data on New Zealand registered charities and show which charities could benefit from differentiated regulation

Spectral sequences of Type Ia supernovae. I. Connecting normal and sub-luminous SN Ia and the presence of unburned carbon

Type Ia supernovae are generally agreed to arise from thermonuclear explosions of carbon-oxygen white dwarfs. The actual path to explosion, however, remains elusive, with numerous plausible parent systems and explosion mechanisms suggested. Observationally, type Ia supernovae have multiple subclasses, distinguished by their lightcurves and spectra. This raises the question whether these reflect that multiple mechanisms occur in nature, or instead that explosions have a large but continuous range of physical properties. We revisit the idea that normal and 91bg-like supernovae can be understood as part of a spectral sequence, in which changes in temperature dominate. Specifically, we find that a single ejecta structure is sufficient to provide reasonable fits of both the normal type Ia supernova SN~2011fe and the 91bg-like SN~2005bl, provided that the luminosity and thus temperature of the ejecta are adjusted appropriately. This suggests that the outer layers of the ejecta are similar, thus providing some support of a common explosion mechanism. Our spectral sequence also helps to shed light on the conditions under which carbon can be detected in pre-maximum SN~Ia spectra -- we find that emission from iron can "fill in" the carbon trough in cool SN~Ia. This may indicate that the outer layers of the ejecta of events in which carbon is detected are relatively metal poor compared to events where carbon is not detected

Type Ia Supernovae and Accretion Induced Collapse

Using the population synthesis binary evolution code StarTrack, we present theoretical rates and delay times of Type Ia supernovae arising from various formation channels. These channels include binaries in which the exploding white dwarf reaches the Chandrasekhar mass limit (DDS, SDS, and helium-rich donor scenario) as well as the sub-Chandrasekhar mass scenario, in which a white dwarf accretes from a helium-rich companion and explodes as a SN Ia before reaching the Chandrasekhar mass limit. We find that using a common envelope parameterization employing energy balance with alpha=1 and lambda=1, the supernova rates per unit mass (born in stars) of sub-Chandrasekhar mass SNe Ia exceed those of all other progenitor channels at epochs t=0.7 - 4 Gyr for a burst of star formation at t=0. Additionally, the delay time distribution of the sub-Chandrasekhar model can be divided in to two distinct evolutionary channels: the `prompt' helium-star channel with delay times < 500 Myr, and the `delayed' double white dwarf channel with delay times > 800 Myr spanning up to a Hubble time. These findings are in agreement with recent observationally-derived delay time distributions which predict that a large number of SNe Ia have delay times < 1 Gyr, with a significant fraction having delay times < 500 Myr. We find that the DDS channel is also able to account for the observed rates of SNe Ia. However, detailed simulations of white dwarf mergers have shown that most of these mergers will not lead to SNe Ia but rather to the formation of a neutron star via accretion-induced collapse. If this is true, our standard population synthesis model predicts that the only progenitor channel which can account for the rates of SNe Ia is the sub-Chandrasekhar mass scenario, and none of the other progenitors considered can fully account for the observed rates.Comment: 6 pages, 1 figure, 1 table, to appear in proceedings for "Binary Star Evolution: Mass Loss, Accretion and Mergers

The Merger Rate of Binary White Dwarfs in the Galactic Disk

We use multi-epoch spectroscopy of about 4000 white dwarfs in the Sloan Digital Sky Survey to constrain the properties of the Galactic population of binary white dwarf systems and calculate their merger rate. With a Monte Carlo code, we model the distribution of DRVmax, the maximum radial velocity shift between exposures of the same star, as a function of the binary fraction within 0.05 AU, fbin, and the power-law index in the separation distribution at the end of the common envelope phase, alpha. Although there is some degeneracy between fbin and alpha, the the fifteen high DRVmax systems that we find constrain the combination of these parameters, which determines a white dwarf merger rate per unit stellar mass of 1.4(+3.4,-1.0)e-13 /yr/Msun (1-sigma limits). This is remarkably similar to the measured rate of Type Ia supernovae per unit stellar mass in Milky-Way-like Sbc galaxies. The rate of super-Chandrasekhar mergers is only 1.0(+1.6,-0.6)e-14 /yr/Msun. We conclude that there are not enough close binary white dwarf systems to reproduce the observed Type Ia SN rate in the 'classic' double degenerate super-Chandrasekhar scenario. On the other hand, if sub-Chandrasekhar mergers can lead to Type Ia SNe, as recently suggested by some studies, they could make a major contribution to the overall Type Ia SN rate. Although unlikely, we cannot rule out contamination of our sample by M-dwarf binaries or non-Gaussian errors. These issues will be clarified in the near future by completing the follow-up of all 15 high DRVmax systems.Comment: 5 pages, 3 figures, 1 table, ApJL, accepted (modified abstract, this version should match the published one

Magnetic Quantum Dot: A Magnetic Transmission Barrier and Resonator

We study the ballistic edge-channel transport in quantum wires with a magnetic quantum dot, which is formed by two different magnetic fields B^* and B_0 inside and outside the dot, respectively. We find that the electron states located near the dot and the scattering of edge channels by the dot strongly depend on whether B^* is parallel or antiparallel to B_0. For parallel fields, two-terminal conductance as a function of channel energy is quantized except for resonances, while, for antiparallel fields, it is not quantized and all channels can be completely reflected in some energy ranges. All these features are attributed to the characteristic magnetic confinements caused by nonuniform fields.Comment: 4 pages, 4 figures, to be published in Physical Review Letter

Interpreting the near-infrared spectra of the 'golden standard' Type Ia supernova 2005cf

We present nine near-infrared (NIR) spectra of supernova (SN) 2005cf at epochs from -10 d to +42 d with respect to B-band maximum, complementing the existing excellent data sets available for this prototypical Type Ia SN at other wavelengths. The spectra show a time evolution and spectral features characteristic of normal Type Ia SNe, as illustrated by a comparison with SNe 1999ee, 2002bo and 2003du. The broad-band spectral energy distribution (SED) of SN 2005cf is studied in combined ultraviolet (UV), optical and NIR spectra at five epochs between ~ 8 d before and ~ 10 d after maximum light. We also present synthetic spectra of the hydrodynamic explosion model W7, which reproduce the key properties of SN 2005cf not only at UV-optical as previously reported, but also at NIR wavelengths. From the radiative-transfer calculations we infer that fluorescence is the driving mechanism that shapes the SED of SNe Ia. In particular, the NIR part of the spectrum is almost devoid of absorption features, and instead dominated by fluorescent emission of both iron-group material and intermediate-mass elements at pre-maximum epochs, and pure iron-group material after maximum light. A single P-Cygni feature of Mg II at early epochs and a series of relatively unblended Co II lines at late phases allow us to constrain the regions of the ejecta in which the respective elements are abundant.Comment: 11 pages, 6 figures, accepted for publication in MNRA

Genome-wide saturation mutagenesis of Burkholderia pseudomallei K96243 predicts essential genes and novel targets for antimicrobial development.

UNLABELLED: Burkholderia pseudomallei is the causative agent of melioidosis, an often fatal infectious disease for which there is no vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its natural resistance to most antibiotics, the development of new antimicrobial therapies is imperative. To identify drug targets and better understand the complex B. pseudomallei genome, we sought a genome-wide approach to identify lethal gene targets. As B. pseudomallei has an unusually large genome spread over two chromosomes, an extensive screen was required to achieve a comprehensive analysis. Here we describe transposon-directed insertion site sequencing (TraDIS) of a library of over 10(6) transposon insertion mutants, which provides the level of genome saturation required to identify essential genes. Using this technique, we have identified a set of 505 genes that are predicted to be essential in B. pseudomallei K96243. To validate our screen, three genes predicted to be essential, pyrH, accA, and sodB, and a gene predicted to be nonessential, bpss0370, were independently investigated through the generation of conditional mutants. The conditional mutants confirmed the TraDIS predictions, showing that we have generated a list of genes predicted to be essential and demonstrating that this technique can be used to analyze complex genomes and thus be more widely applied. IMPORTANCE: Burkholderia pseudomallei is a lethal human pathogen that is considered a potential bioterrorism threat and has limited treatment options due to an unusually high natural resistance to most antibiotics. We have identified a set of genes that are required for bacterial growth and thus are excellent candidates against which to develop potential novel antibiotics. To validate our approach, we constructed four mutants in which gene expression can be turned on and off conditionally to confirm that these genes are required for the bacteria to survive