"Feeling at home” for people with dementia in care environments : the role of built environment factors. A critical literature review

ABSTRACT: This review summarises the challenges of applying evidence that built environment factors contribute to people with dementia feeling at home in long-term care institutions. Eighteen reviewed publications are classified into research-focused and practice-focused study. Research-focused studies from scientific epistemology focus on physical environment aspects that influence residents feeling at home in the care institution. Design-focused studies develop specific design strategies based on evidence from research-focused studies. However, there are limitations in transforming research evidence into design practice due to a mismatched knowledge foundation. Future research should consider standing on design epistemology to gain new insights which reflect built environment contributions to the sense of home for people with dementia living in care institutions by Research through Design approach.RESUMEN : La presente revisión resume los desafíos de la aplicación, a la practica del Diseño, de las evidencias que los factores del ambiente construido contribuyen a que las personas con demencia perciban el sentido del hogar dentro de un centro de cuidado de ancianos. Diecisiete publicaciones has sido revisadas y clasificadas según fueran estúdios basados en la investigación, o basados en la practica del diseño. Los estudios basados en la investigación, derivado de la epistemologia científica, se enfocan en los aspectos del ambiente físico que influencian el sentido del hogar en los residentes de centro de cuidado de ancianos. Los estudios basados en la practica del diseño, desarrollan especificas estrategias basadas en evidencia de los estudios basado en la investigación. Sin embargo, en la transformación de evidencia, proveniente de la investigación, en practica de diseño, hay limitaciones debida a discordancia entre conocimiento de base y presentación de la evidencia. La investigación futura podría considerar la posibilidad de situarse en la epistemología del diseño para obtener nuevos conocimientos que inspiren la práctica del diseño mediante el enfoque dela investigación a través del diseño.info:eu-repo/semantics/publishedVersio

Vulnerability of hydropower installations to climate change : preliminary study

The climate trends observed worldwide over the past few decades appear to corroborate the concerns of the scientific community about the many threats posed by global warming. Future changes of the current climate are expected to occur on different scales all around the globe, hence modifying the environmental background on the basis of which technological installations have been designed and operated. This can potentially threat the safety of the installations as well as their. The development of suitable tools aiming to predict the impact of climate change on technological installations is then essential in the wider context of climate change mitigation. Hydropower installations play often a crucial role not only as a long-term renewable resource of energy but also for flood control and water supply in the case of droughts. All these aspects highlight the increasing importance of such installations as well as their growing vulnerability to natural hazards. It is hence essential to enlarge the current understanding of the interaction mechanisms between such installations and the changing surrounding environment in order to take adequate measures for climate change adaptation and ensure the future safety and productivity of hydropower production. The current study aims to provide a novel model for the evaluation of the impact of climate change on the safety of hydropower stations. The approach adopted allows to include in the model the uncertainty inevitably associated with the input variables and to propagate such uncertainty within the analysis. The model proposed is finally applied to a realistic case-study in order to highlight its potential and limitations

Classification Framework and Structure-Activity-Relationship (SAR) of Tetracycline-Structure-Based Drugs

By studying the literature about Tetracyclines (TCs), it becomes clearly evident that TCs are very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are known, especially against bacteria, while against other targets, they are virtually unknown. In other diverse yields of research, such as neurology, oncology and virology the utility and activity of the tetracyclines are being discovered and are also emerging as new technological fronts. The first aim of this paper is classify the compounds already used in therapy and prepare the schematic structure in which include the next generation of TCs. The aim of this work is introduce a new framework for the classification of old and new TCs, using a medicinal chemistry approach to the structure of that drugs. A fully documented Structure-Activity-Relationship (SAR) is presented with the analysis data of antibacterial and nonantibacterial (antifungal, antiviral and anticancer) tetracyclines. Lipophilicity of functional groups and conformations interchangeably are determining rules in biological activities of TCs.Comment: 13 pages, 3 figures, 2 schemes, 1 table; http://www.mdpi.com/2079-6382/1/1/

A sense of home for people with dementia in a long-term care facility: A design perspective

The study aims to provide new insights into the approach to the spatial design of homelike dementia care facilities. This paper builds on Molony's (2010) findings that home meaning in care facilities is a process of people-place integration, and then proposes that people living with dementia can accomplish this process through their bodily habit. This research adopted an ethnographic case study approach. Three cases from a long-term care facility were studied by using semi-structured interviews and observations. According to the findings, having a sense of home for people living with dementia can be understood as a process of re-establishing people-place integration through their bodily habits in a long-term care facility. As a result, designers can consider which design features can assist people living with dementia in re-establishing this integration through bodily habit to create home feelings in a dementia care facility

Low clonal propagation in Atlantic and Mediterranean populations of the red gorgonian Paramuricea clavata (Octocorallia)

Clonal propagation is a common feature of benthic marine organisms. In the present study, we investigated the contribution of clonal reproduction in the red gorgonian Paramuricea clavata. Mediterranean populations of P. clavata were severely affected by mass mortality events caused by increased water temperature in 1999 and 2003. The populations are characterized by slow growth and episodic recruitment, but after the observed mortalities, an unexpectedly high recovery rate was observed in the severely affected populations from the Ligurian Sea, NW Mediterranean. Ten years after the last mortality event, we investigated the contribution of clonal propagation in populations from the Ligurian Sea, where some populations were highly affected by mass mortality events, and from the Atlantic, where mortality was never observed. All individuals were genotyped for nine microsatellite loci. The contribution of clonal reproduction varied from 0% to 13% and did not differ significantly between affected and unaffected populations. We confirm by using genetic markers that clonal propagation in P. clavata is not common, and that the contribution of clones is too low to play an important role in red gorgonian reproduction and cannot contribute to population recovery at sites that have been affected by mass mortality events.Fundacao para a Ciencia e Tecnologia (FCT) under the COMPETE program - European Regional Development Fund [PTDC/BIA-BIC/114526/2009]; MARES Grant; Erasmus Mundus [FPA 2011-0016

Mutations in Exons 8 and 11 of c-kit Gene in Canine Subcutaneous Mast Cell Tumors and Their Association with Cell Proliferation

The prognostic significance of internal tandem duplication (ITD) mutations in exons 8 and 11 of c-kit has been well-described for canine cutaneous mast cell tumors (MCTs), but c-kit mutations have rarely been reported in subcutaneous MCTs. The objective of this study was to identify the prevalence of ITD mutations in exons 8 and 11 of c-kit in canine subcutaneous MCTs and to investigate its association with histologic grade, KIT pattern, and proliferation markers. ITD mutations in exons 8 and 11 of c-kit, mitotic count, Ki67 index, AgNOR number, Ki67xAgNOR score, KIT pattern, and histologic grade (two-tier system) were retrospectively recorded for 216 dogs with subcutaneous MCTs. ITD mutations in exons 8 and 11 of c-kit were detected in 23 (10.6%) and 12 (5.56%) subcutaneous MCTs, respectively. Exon 11 mutations were significantly associated with Kiupel high grade (p < 0.001) and increased mitotic count (p < 0.001) compared to subcutaneous MCTs with no mutations in exons 8 or 11 (p = 0.002) or subcutaneous MCTs with a mutation in exon 8 (p = 0.001). There was no significant association of either c-kit mutation with KIT patterns or proliferation activity. This study identified a higher prevalence of ITD mutations in exons 8 and 11 of c-kit in subcutaneous MCTs than previously reported. Like their cutaneous counterpart, subcutaneous MCTs with exon 11 mutations were more likely to be histologically high grade and have a higher mitotic count, whereas such associations were not observed in subcutaneous MCTs with exon 8 mutations

Are relative educational inequalities in multiple health behaviors widening? A longitudinal study of middle-aged adults in Northern Norway

Introduction: Educational inequality in multiple health behaviors is rarely monitored using data from the same individuals as they age. The aim of this study is to research changes in relative educational inequality in multiple variables related to health behavior (smoking, physical activity, alcohol intake, and body mass index), separately and collectively (healthy lifestyle), among middle-aged adults living in Northern Norway. Methods: Data from adult respondents aged 32–87 in 2008 with repeated measurements in 2016 (N = 8,906) were drawn from the sixth and seventh waves of the Tromsø Study. Logistic regression was used to assess the relative educational inequality in the variables related to health behavior. The analyses were performed for the total sample and separately for women and men at both baseline and follow-up. Results: Educational inequality was observed in all the variables related to health behavior at baseline and follow-up, in both men and women. Higher levels of educational attainment were associated with healthier categories (non-daily smoking, physical activity, normal body mass index, and a healthy lifestyle), but also with high alcohol intake. The prevalence of daily smoking and physical inactivity decreased during the surveyed period, while high alcohol intake, having a body mass index outside of the normal range and adhering to multiple health recommendations simultaneously increased. The magnitude of relative educational inequality measured at baseline increased at the follow-up in all the variables related to health behavior. Differences were larger among women when compared to men, except in physical inactivity. Conclusion: Persistent and increasing relative disparities in health behavior between the highest education level and lower education levels are found in countries with well-established and comprehensive welfare systems like Norway. Addressing these inequalities is essential for reducing both the chronic disease burden and educational disparities in health