In vitro evaluation of the influence of bone cortical thickness on the primary stability of conventional- and short-sized implants

The aim of this in vitro study was to evaluate the influence of the cortical thickness on the primary stability of short and conventional-sized implants with two types of prosthetic connection. Seventy-two implants were used. These implants were place

Indomethacin can downregulate the levels of inflammatory mediators in the hippocampus of rats submitted to pilocarpine-induced status epilepticus

OBJECTIVE: Refractory status epilepticus is one of the most life-threatening neurological emergencies and is characterized by high morbidity and mortality. Additionally, the use of anti-inflammatory drugs during this period is very controversial. Thus, this study has been designed to analyze the effect of a low dose of indomethacin (a COX inhibitor) on the expression of inflammatory molecules. METHOD: The hippocampus of rats submitted to pilocarpine-induced long-lasting status epilepticus was analyzed to determine the expression of inflammatory molecules with RT-PCR and immunohistochemistry. RESULTS: Compared with controls, reduced levels of the kinin B2 receptors IL1β and TNFα were found in the hippocampus of rats submitted to long-lasting status epilepticus and treated with indomethacin. CONCLUSIONS: These data show that low doses of indomethacin could be employed to minimize inflammation during long-lasting status epilepticus

ESTUDO SOBRE A VIABILIDADE DA ALTERAÇÃO DOS PADRÕES CONSTRUTIVOS DOS ELETRODOS DE ATERRAMENTO VISANDO A UTILIZAÇÃO E FISCALIZAÇÃO EM PROJETOS

O presente artigo aborda um estudo sobre a viabilidade da alteração dos padrões construtivos dos eletrodos de aterramento visando sua utilização e fiscalização em projetos e principalmente no auxílio da fiscalização das montagens de padrões de entrada de energia elétrica. O estudo se iniciou devido a impossibilidade da fiscalização de hastes de aterramento instaladas em padrões de entrada por parte dos profissionais que fiscalizam e aprovam as montagens dos padrões de ligação solicitados pelos clientes. Infelizmente a montagem desses padrões nem sempre são realizadas por profissionais da área e por este motivo em alguns casos, a haste de aterramento é seccionada com o objetivo de facilitar a sua aplicação no solo, essa ação pode prejudicar de forma significativa o aterramento da instalação em questão, pois em casos que a resistência de aterramento fica menor nas camadas mais profundas do solo, o comprimento da haste exerce influência significativa nos valores de resistência de aterramento e seu comprimento inferior ao recomendado pode não oferecer uma resistência operativa satisfatória e segura a instalação elétrica a ser atendida. Outro fato relevante é o descumprimento das regulamentações para ligação de padrões de entrada definido pelas concessionárias de energia elétrica do país

High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain

The assessment of neuronal number, spatial organization and connectivity is fundamental for a complete understanding of brain function. However, the evaluation of the three-dimensional (3D) brain cytoarchitecture at cellular resolution persists as a great challenge in the field of neuroscience. In this context, X-ray microtomography has shown to be a valuable non-destructive tool for imaging a broad range of samples, from dense materials to soft biological specimens, arisen as a new method for deciphering the cytoarchitecture and connectivity of the brain. In this work we present a method for imaging whole neurons in the brain, combining synchrotron-based X-ray microtomography with the Golgi-Cox mercury-based impregnation protocol. In contrast to optical 3D techniques, the approach shown here does neither require tissue slicing or clearing, and allows the investigation of several cells within a 3D region of the brain

PROJETO PARA IMPLEMENTAÇÃO DE UM SISTEMA FOTOVOLTAICO CONECTADO À REDE ELÉTRICA EM JARDIM GRAMACHO, EM DUQUE DE CAXIAS - RJ

Este trabalho apresenta um modelo de projeto para implementação de um sistema fotovoltaico (SF) conectado à uma rede elétrica em uma área rural do município de Jardim Gramacho, em Duque de Caxias, Região Metropolitana do Rio de Janeiro, local onde se localizava o antigo aterro sanitário de Jardim Gramacho, hoje desativado, visando a melhoria do fornecimento de energia elétrica no local e possibilitando a geração de energia limpa. Além disso, é apresentada uma análise de viabilidade teórica e as variáveis projetadas. Ao longo do estudo é feito o dimensionamento dos principais componentes do sistema fotovoltaico, levando em conta considerações técnicas e econômicas. Dessa forma, realizada a projeção dos balanços e demonstrativos de resultados anuais e, com os valores projetados, é realizada uma análise sobre os valores obtidos

Current and future aspects of TIM-3 as biomarker or as potential targeted in non-small cell lung cancer scope: is there a role in clinical practice?

Lung cancer is an aggressive disease with a high rate of mortality (1). Non-small cell lung cancer (NSCLC) constitutes approximately 85% of all histology types (2). In the 1990’s, chemotherapy was the standard of care for the treatment of metastatic NSCLC (3). Since 2005, targeted therapies have emerged as a new cornerstone in the treatment of NSCLC. These include epidermal growth factor receptor tyrosine kinase inhibitors (EGFRTKI) such as gefitinib, erlotinib, afatinib, osimertinib, and dacomitinib (4) as well as the anaplastic lymphoma kinase (ALK) inhibitors crizotinib, alectinib, ceritinib, brigatinib and lorlatinib (5,6). Improving our understanding of tumor biology has therefore become a fundamental issue among oncologists to optimize these novel treatment strategies (7). In 2018, James P. Allison and Tasuku Honjo (8) won the Nobel prize for their research on the mechanisms of the tumor immune escape, which led to the first immunotherapy drugs to be utilized in clinical practice: nivolumab and ipilimumab (3,9). The Karolinska Institute Nobel Prize Committee declared that Allison and Honjo’s findings constituted the fourth cornerstone of cancer treatment, alongside surgery, radiotherapy and chemotherapy (1,9).National Council for Scientific and Technological Development (CNPq) 402621/2016-6info:eu-repo/semantics/publishedVersio

Proteomic Analysis of Cattle Tick Rhipicephalus (Boophilus) microplus Saliva: A Comparison between Partially and Fully Engorged Females

The cattle tick Rhipicephalus (Boophilus) microplus is one of the most harmful parasites affecting bovines. Similarly to other hematophagous ectoparasites, R. microplus saliva contains a collection of bioactive compounds that inhibit host defenses against tick feeding activity. Thus, the study of tick salivary components offers opportunities for the development of immunological based tick control methods and medicinal applications. So far, only a few proteins have been identified in cattle tick saliva. The aim of this work was to identify proteins present in R. microplus female tick saliva at different feeding stages. Proteomic analysis of R. microplus saliva allowed identifying peptides corresponding to 187 and 68 tick and bovine proteins, respectively. Our data confirm that (i) R. microplus saliva is complex, and (ii) that there are remarkable differences in saliva composition between partially engorged and fully engorged female ticks. R. microplus saliva is rich mainly in (i) hemelipoproteins and other transporter proteins, (ii) secreted cross-tick species conserved proteins, (iii) lipocalins, (iv) peptidase inhibitors, (v) antimicrobial peptides, (vii) glycine-rich proteins, (viii) housekeeping proteins and (ix) host proteins. This investigation represents the first proteomic study about R. microplus saliva, and reports the most comprehensive Ixodidae tick saliva proteome published to date. Our results improve the understanding of tick salivary modulators of host defense to tick feeding, and provide novel information on the tick-host relationship